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Lonza Antibody Services

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Basel, CH

About Lonza Antibody Services

We offer a complete line of in silico and in vitro services for manufacturability, immunogenicity, humanization, and protein engineering.  These technologies include our award winning and patented Epibase® T cell epitope screening platform for immunogenicity assessment along with our proprietary technology platform for structural protein engineering.  Our Cambridge, UK-based Applied Protein Services scientists will help you determine a testing strategy, analyze and interpret the data, and recommend next steps throughout the process. 

Lonza’s protein design and optimization services were developed to mitigate risks, reduce attrition, and improve the quality and safety of therapeutic proteins.  They also address the challenges and accelerate the design and development of efficacious vaccines.  These services provide a complete portfolio for your late discovery and early development needs.

In addition to our protein design and optimization services, we also offer a protein production service for mg to kg quantities of both non-GMP and cGMP material.  Lonza’s Light Path™ programs are streamlined and minimal scope development and manufacturing services available for both mammalian and microbial applications.

 

Our Services (24)


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Protein Services

Price on request

In silico, in vitro PTM prediction and testing, Antibody aggregation propensity prediction. Protein re-engineering to improve developability


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Protein Expression Screening and Optimization

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Protein Formulation

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Cytokine Release Assay

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Endotoxin Testing

Price on request

IIRMI Assessment

Detection of Innate Immune Response Modulating Impurities of protein therapeutics caused by process impurities, degradation, or formulation changes.


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Antibody Engineering

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In silico Immunogenicity Assay

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Custom Cell-Based Assay Development

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Receptor Binding Assays

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ADCC and CDC Assays

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T Cell Activation and Proliferation Assays

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Antibody Services

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Antibody Humanization

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Protein Engineering/Directed Evolution

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Feasibility Studies

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Protein Aggregation Analysis

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Clinical Immunogenicity Testing

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Epitope Mapping

Price on request

T cell epitope prediction

Epibase in silico T cell epitope prediction from protein sequences. Applied to avoid unwanted immunogenicity for therapeutic proteins and wanted immunogenicity for vaccines


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Cell-Based Assays

Price on request
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MAPPS

MHC-associated peptide proteomics
Price on request
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In silico Antibody Humanization

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In vitro Immunogenicity Assays

Price on request

A wide range of cellular assays using Human PBMCs to identify protein Immunogenicity risk


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Post-Translational Modification Analysis

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Antibody Deimmunization

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Reducing antibody immunogenicity by removing T helper epitopes


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