Longevity Biotech
10.0/10 Overall Rating
100% Positive
3 Orders Completed
Philadelphia, Pennsylvania, US
Longevity Biotech is a preclinical research and development company. Our efforts are centered on the development of novel therapeutics that will have direct clinical impacts on patients lives. All of our programs are based on our proprietary Hybridtide peptide scaffold technology.
High throughput Ussing chamber for drug permeability
Ussing chambers are used to determine ex-vivo permeability (Papp) of various molecules across different segments of intestinal tissue epithelium while also providing a variety of toxicology options (MTT, IHC, H&E and more).
Contact us to discuss your specific project designs. We can survey a large number of conditions and provide a 'heat map' of results that indicate permeability and safety trends.
Various species available (rat, pig, dog, human) - request a quote for more information about this service.
High throughput multi-color panel flow cytometry, up to 11 channels in 96 well plate format. We would be happy to help you design a flow panel to interrogate the specific cells in your study. We can accommodate pre-labled (ready to run) samples or we can label them for you. Please contact us to discuss project specifics.
Time course profile (5 time points) of percent of test article remaining over a two hour incubation with simulated gastric or intestinal fluid. Results determined using standard or user provided LCMS methods.
Contact us for study customization.
Time course profile (5 time points) of percent of test article remaining over a two hour incubation with plasma. (Human, rat, mouse, porcine and canine available) - determined using standard or user provided LCMS methods.
Contact us for study customization.
Overnight (or longer) solubility analysis of your API via LCMS. You can choose the buffers / solvents we use or we can use our standard biocompatible panels.
Prices are for a single time point (e.g. 24 hour) in triplicate for 12 buffers and or solvents to be screened (36 total samples). Results will be reported as percent of control (e.g. neat DMSO, water, acetonitrile, etc..).
Contact us to customize your study design.
High throughput Ussing chamber for drug permeability
Ussing chambers are used to determine ex-vivo permeability (Papp) of various molecules across different segments of intestinal tissue epithelium while also providing a variety of toxicology options (MTT, IHC, H&E and more).
Contact us to discuss your specific project designs. We can survey a large number of conditions and provide a 'heat map' of results that indicate permeability and safety trends.
Various species available (rat, pig, dog, human) - request a quote for more information about this service.
A typical study design includes IV/SC/OG/IP/IM delivery of test article followed by a time course quantification via LC/MS/MS. A prerequisite method development step of sample preparation and quantification from spiked plasma is required first to ensure adequate sensitivity.
Mouse & rat PK profiles currently available.
Contact us for more details.
A typical study design includes IV delivery of test article followed by a time course quantification via LC/MS/MS. A prerequisite method development step of sample preparation and quantification from spiked tissue homogenate is required first to ensure adequate sensitivity. Data analysis is available per quadrant of brain. Results typically reported as percent of plasma (collected at the same time points).
Studies typically performed in rats and mice.
Contact us for more details.
Standard LCMS quantification analysis with either user provided methods or we can optimize and develop for customers. High volume samples (96/384/1536) are prefered, we offer discounts dependent on number of samples. Complex matrices (plasma, tissue, buffers, etc...) are accepted.
Standard LCMS/MS quantification analysis with either user provided methods or we can optimize and develop for customers. High volume samples (96/384/1536) are prefered, we offer discounts dependent on number of samples / analytes. Complex matrices (plasma, tissue, buffers, etc...) are accepted.
Standard RP-HPLC UV-based (multiple wavelength) purification (analytical to preparative scale, C4-C18 and others) with either user provided methods or we can optimize and develop HPLC methods for customers. We offer discounts dependent on number / volume of samples.
We can also provide lyophilization / aliquoting services as well.
We are able to produce custom peptide sequences using CEM Liberty Blue synthesizer. Multiple scale and purity options available (see our other services). Unnatural amino acids and other modifications are our specialty.
Each project will be quoted based on scale, purity and length of sequence. Please contact us for more information.
Drug Discovery & Development Services
Pharmacology Services
Biology Services
Cells and Tissues Services
Cytometry Services
"They provide excellent and very helpful service, quite ready to fill in any gaps in knowledge on the part of the requester with their own experience in the field."
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