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Longevity Biotech

3 Orders Completed
Philadelphia, Pennsylvania, US

About Longevity Biotech

Longevity Biotech is a preclinical research and development company. Our efforts are centered on the development of novel therapeutics that will have direct clinical impacts on patients lives. All of our programs are based on our proprietary Hybridtide peptide scaffold technology.

Diversity Certificates

Small business

Our Services (31)


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Ex vivo Intestinal Tissue Model

Price on request

High throughput Ussing chamber for drug permeability

Ussing chambers are used to determine ex-vivo permeability (Papp) of various molecules across different segments of intestinal tissue epithelium while also providing a variety of toxicology options (MTT, IHC, H&E and more).

Contact us to discuss your specific project designs.... Show more »

High throughput Ussing chamber for drug permeability

Ussing chambers are used to determine ex-vivo permeability (Papp) of various molecules across different segments of intestinal tissue epithelium while also providing a variety of toxicology options (MTT, IHC, H&E and more).

Contact us to discuss your specific project designs. We can survey a large number of conditions and provide a 'heat map' of results that indicate permeability and safety trends.

Various species available (rat, pig, dog, human) - request a quote for more information about this service.

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Human Pig Rat

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Flow Cytometry

Starting at $100.00 per sample

High throughput multi-color panel flow cytometry, up to 11 channels in 96 well plate format. We would be happy to help you design a flow panel to interrogate the specific cells in your study. We can accommodate pre-labled (ready to run) samples or we can label them for you. Please contact us to discuss project specifics.

High throughput multi-color panel flow cytometry, up to 11 channels in 96 well plate format. We would be happy to help you design a flow panel to interrogate the specific cells in your study. We can accommodate pre-labled (ready to run) samples or we can label them for you. Please contact us to discuss project specifics.

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Gastric Stability Studies

Starting at $400.00 per sample

Time course profile (5 time points) of percent of test article remaining over a two hour incubation with simulated gastric or intestinal fluid. Results determined using standard or user provided LCMS methods.

Contact us for study customization.

Time course profile (5 time points) of percent of test article remaining over a two hour incubation with simulated gastric or intestinal fluid. Results determined using standard or user provided LCMS methods.

Contact us for study customization.

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In vitro Bioavailability/Bioequivalence Studies

Starting at $400.00 per sample

Time course profile (5 time points) of percent of test article remaining over a two hour incubation with plasma. (Human, rat, mouse, porcine and canine available) - determined using standard or user provided LCMS methods.

Contact us for study customization.

Time course profile (5 time points) of percent of test article remaining over a two hour incubation with plasma. (Human, rat, mouse, porcine and canine available) - determined using standard or user provided LCMS methods.

Contact us for study customization.

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Solubility and Dissolution Testing

Starting at $650.00 per sample

Overnight (or longer) solubility analysis of your API via LCMS. You can choose the buffers / solvents we use or we can use our standard biocompatible panels.

Prices are for a single time point (e.g. 24 hour) in triplicate for 12 buffers and or solvents to be screened (36 total samples). Results will be reported as... Show more »

Overnight (or longer) solubility analysis of your API via LCMS. You can choose the buffers / solvents we use or we can use our standard biocompatible panels.

Prices are for a single time point (e.g. 24 hour) in triplicate for 12 buffers and or solvents to be screened (36 total samples). Results will be reported as percent of control (e.g. neat DMSO, water, acetonitrile, etc..).

Contact us to customize your study design.

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HT ADME

Price on request

High throughput Ussing chamber for drug permeability

Ussing chambers are used to determine ex-vivo permeability (Papp) of various molecules across different segments of intestinal tissue epithelium while also providing a variety of toxicology options (MTT, IHC, H&E and more).

Contact us to discuss your specific project... Show more »

High throughput Ussing chamber for drug permeability

Ussing chambers are used to determine ex-vivo permeability (Papp) of various molecules across different segments of intestinal tissue epithelium while also providing a variety of toxicology options (MTT, IHC, H&E and more).

Contact us to discuss your specific project designs. We can survey a large number of conditions and provide a 'heat map' of results that indicate permeability and safety trends.

Various species available (rat, pig, dog, human) - request a quote for more information about this service.

Show less
Human Pig Rat Dog

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In vivo Pharmacology Studies

Price on request

A typical study design includes IV/SC/OG/IP/IM delivery of test article followed by a time course quantification via LC/MS/MS. A prerequisite method development step of sample preparation and quantification from spiked plasma is required first to ensure adequate sensitivity.

Mouse & rat PK profiles currently available.

Contact us for more details.

A typical study design includes IV/SC/OG/IP/IM delivery of test article followed by a time course quantification via LC/MS/MS. A prerequisite method development step of sample preparation and quantification from spiked plasma is required first to ensure adequate sensitivity.

Mouse & rat PK profiles currently available.

Contact us for more details.

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Blood-Brain Barrier Permeability Studies

Price on request

A typical study design includes IV delivery of test article followed by a time course quantification via LC/MS/MS. A prerequisite method development step of sample preparation and quantification from spiked tissue homogenate is required first to ensure adequate sensitivity. Data analysis is available per quadrant of brain. ... Show more »

A typical study design includes IV delivery of test article followed by a time course quantification via LC/MS/MS. A prerequisite method development step of sample preparation and quantification from spiked tissue homogenate is required first to ensure adequate sensitivity. Data analysis is available per quadrant of brain. Results typically reported as percent of plasma (collected at the same time points).

Studies typically performed in rats and mice.

Contact us for more details.

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LC-MS

Liquid Chromatography-Coupled Mass Spectrometry
Starting at $100.00 per sample per analyte

Standard LCMS quantification analysis with either user provided methods or we can optimize and develop for customers. High volume samples (96/384/1536) are prefered, we offer discounts dependent on number of samples. Complex matrices (plasma, tissue, buffers, etc...) are accepted.

Standard LCMS quantification analysis with either user provided methods or we can optimize and develop for customers. High volume samples (96/384/1536) are prefered, we offer discounts dependent on number of samples. Complex matrices (plasma, tissue, buffers, etc...) are accepted.

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LC-MS/MS

Liquid chromatography tandem mass spectrometry
Starting at $150.00 per sample per analyte

Standard LCMS/MS quantification analysis with either user provided methods or we can optimize and develop for customers. High volume samples (96/384/1536) are prefered, we offer discounts dependent on number of samples / analytes. Complex matrices (plasma, tissue, buffers, etc...) are accepted.

Standard LCMS/MS quantification analysis with either user provided methods or we can optimize and develop for customers. High volume samples (96/384/1536) are prefered, we offer discounts dependent on number of samples / analytes. Complex matrices (plasma, tissue, buffers, etc...) are accepted.

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RP-HPLC

Reversed Phase high-performance liquid chromatography
Starting at $200.00 per hour

Standard RP-HPLC UV-based (multiple wavelength) purification (analytical to preparative scale, C4-C18 and others) with either user provided methods or we can optimize and develop HPLC methods for customers. We offer discounts dependent on number / volume of samples.

We can also provide lyophilization / aliquoting services as well.

Standard RP-HPLC UV-based (multiple wavelength) purification (analytical to preparative scale, C4-C18 and others) with either user provided methods or we can optimize and develop HPLC methods for customers. We offer discounts dependent on number / volume of samples.

We can also provide lyophilization / aliquoting services as well.

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Peptide Synthesis

Price on request

We are able to produce custom peptide sequences using CEM Liberty Blue synthesizer. Multiple scale and purity options available (see our other services). Unnatural amino acids and other modifications are our specialty.

Each project will be quoted based on scale, purity and length of sequence. Please contact us for more information.

We are able to produce custom peptide sequences using CEM Liberty Blue synthesizer. Multiple scale and purity options available (see our other services). Unnatural amino acids and other modifications are our specialty.

Each project will be quoted based on scale, purity and length of sequence. Please contact us for more information.

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Analytical Chemistry Services

Price on request
Request a quote for more information about this service.

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Synthetic Chemistry

Price on request
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Separation/Purification Services

Price on request
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Spectroscopy

Price on request
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In vivo PK/PD Studies

Price on request
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Mass Spectrometry

Price on request
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Chromatography

Price on request
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Pharmacology & Toxicology

Price on request
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Imaging & Spectroscopy

Price on request
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Liquid Chromatography (LC)

Price on request
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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
Price on request
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In vitro ADME/DMPK Studies

Price on request
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Liquid Chromatography Coupled Mass Spectrometry Methods

Price on request
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Chemistry and Materials

Price on request
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Drug Discovery & Development

Price on request

Drug Discovery & Development Services

Drug Discovery & Development Services

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Pharmacology

Price on request

Pharmacology Services

Pharmacology Services

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Biology

Price on request

Biology Services

Biology Services

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Cells and Tissues

Price on request

Cells and Tissues Services

Cells and Tissues Services

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Cytometry

Price on request

Cytometry Services

Cytometry Services

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Scott Shandler

Founder and CEO
  • Positive review for LC-MS/MS:

    March 2018

    "They provide excellent and very helpful service, quite ready to fill in any gaps in knowledge on the part of the requester with their own experience in the field."

Longevity Biotech has not received any endorsements.