Umtylyqscp5n7sg5aaha oakland

Liu Lab

Rochester, MI, US

Led by Associate Professor Zijuan Liu at Oakland University, the Liu Lab explores the biological roles and the mechanisms of action of two important biometals: arsenic and selenium. The aim is to elucidate the molecular bases for these important biometals’ function in two animal models: zebrafish and mouse models. Since membrane transport is the rate-limiting step for cellular availability, the overall cellular function of these biometals is determined by membrane transporters. Currently, the lab is identifying these biometal transporters and studying their transport mechanism. The future goal is to better understand beneficial or adverse effects of arsenic and selenium and to improve strategies for future clinical applications.

Selected Publications

  • Hamdi M*, Yoshinaga M, Packianathan C, Qin J, Hallauer J*, McDermott JR*, Yang HC, Tsai KJ, Liu Z. Identification of an S-adenosylmethionine (SAM) dependent... Show more »

Led by Associate Professor Zijuan Liu at Oakland University, the Liu Lab explores the biological roles and the mechanisms of action of two important biometals: arsenic and selenium. The aim is to elucidate the molecular bases for these important biometals’ function in two animal models: zebrafish and mouse models. Since membrane transport is the rate-limiting step for cellular availability, the overall cellular function of these biometals is determined by membrane transporters. Currently, the lab is identifying these biometal transporters and studying their transport mechanism. The future goal is to better understand beneficial or adverse effects of arsenic and selenium and to improve strategies for future clinical applications.

Selected Publications

  • Hamdi M*, Yoshinaga M, Packianathan C, Qin J, Hallauer J*, McDermott JR*, Yang HC, Tsai KJ, Liu Z. Identification of an S-adenosylmethionine (SAM) dependent arsenic methyltransferase in Danio rerio. Toxicol Appl Pharmacol July; 262(2):185-93 (2012)
  • Beene LC*, Hallauer J*, Yoshinaga M, Hamdi M*, Liu Z. Pentavalent Arsenate Transport by Zebrafish Phosphate Transporter NaPi-IIb1. Zebrafish, Sep;8(3):125-31. (2011)
    McDermott JR*, Jiang X*, Beene LC*, Rosen BP, Liu Z. Pentavalent methylated arsenicals are substrates of human AQP9. Biometals. Feb 23 (1) 119-27 (2010)
  • Jiang X*, McDermott, JR*, Ajees, AA, Rosen BP and Liu Z. Trivalent arsenicals and glucose use different translocation pathways in mammalian GLUT1. Metallomics. 2 (3) 211-9. (Cover story) (2010)
  • McDermott JR*, Rosen BP, Liu Z. Jen1p: A High Affinity Selenite Transporter in Yeast. Mol Biol Cell. Nov;21(22):3934-41 (2010)
    Hamdi M*, Sanchez MA, Beene LC*, Liu Q, Landfear SM, Rosen BP, Liu Z. - Arsenic transport by zebrafish aquaglyceroporins. BMC Mol Biol. Nov 25;10:104 (2009).
  • Liu Z, Sanchez MA, Jiang X, Boles E, Landfear SM, Rosen BP. Mammalian glucose permease GLUT1 facilitates transport of arsenic trioxide and methylarsonous acid. Biochem Biophys Res Commun. Dec. 15;351(2):424-30. (2006)
  • Liu Z, Styblo, M., Rosen, B. P. Methylarsonous acid transport by aquaglyceroporins. Environ Health Perspect. Apr;114(4):527-31 (2006).
  • Liu Z, Boles, E. and Rosen, B.P. Arsenic trioxide accumulation by hexose permeases in Saccharomyces cerevisiae. J. Biol. Chem. 279. 17312-17318 (2004).
  • Liu Z, Carbrey J.M, Agre P and Rosen, B.P. Arsenic trioxide uptake by human and rat aquaglyceroporins. Biochem. Biophys. Res. Commun. 316, 1178-1185 (2004).
  • Meng Y, Liu Z and Rosen, B.P. As(III) and Sb(III) uptake and efflux in Escherichia coli J. Biol. Chem. 279, 18334-18341 (2004).
  • Li P, Uddin A.N., Liu Z, Mukhopadhyay R, Komissarova E.V., Rosen B.P. and Rossman T.G. Variability in sensitivity to arsenite does not correlate with arsenic accumulation rate in normal human lymphoblasts. Mol. Cell. Biochem. 255, 79-85 (2004).
  • Liu Z, Shen J, Carbrey J.M., Mukhopadhyay R, Agre P and Rosen, B.P. Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. Proc. Natl. Acad. Sci. 99,6053-6058(2002).
« Show less

Liu Lab has not listed any services.

In vitro ADME
Price on request

We study the absorption and metabolism of all types of platinum drugs in cells and animal tissues (mouse model). Quantification of trace amount drugs will be achieved by using ICP-MS (Inductively-coupled-plasma-mass- spectrometer, Perkin Elmer, Nexion 300).

We study the absorption and metabolism of all types of platinum drugs in cells and animal tissues (mouse model). Quantification of trace amount drugs will be achieved by using ICP-MS (Inductively-coupled-plasma-mass- spectrometer, Perkin Elmer, Nexion 300).

« Show less
In vivo PK/PD Studies
Price on request

We study the absorption and metabolism of all types of platinum drugs in cells and animal tissues (mouse model). Quantification of trace amount drugs will be achieved by using ICP-MS (Inductively-coupled-plasma-mass- spectrometer, Perkin Elmer, Nexion 300).

We study the absorption and metabolism of all types of platinum drugs in cells and animal tissues (mouse model). Quantification of trace amount drugs will be achieved by using ICP-MS (Inductively-coupled-plasma-mass- spectrometer, Perkin Elmer, Nexion 300).

« Show less
Platinum drugs
Trace Metal Analysis
Price on request

Quantification of trace amout of metals and metalloid, platinum drugs in biosamples.

Quantification of trace amout of metals and metalloid, platinum drugs in biosamples.

« Show less
Metal/Metalloid Cellular Transport and Accumulation Assays
Price on request
Request a quote for more information about this service.
Biology
Price on request
Request a quote for more information about this service.
Pharmacology & Toxicology
Price on request
Request a quote for more information about this service.
Transporter & Cell Uptake Assays
Price on request
Request a quote for more information about this service.
Analytical Chemistry Services
Price on request
Request a quote for more information about this service.
Chemistry and Materials
Price on request
Request a quote for more information about this service.
Cell-Based Assays
Price on request
Request a quote for more information about this service.
Ask A Question Find what you're looking for? If not, you can ask this lab a question:

Liu Lab has not received any ratings.

Be the first to endorse Liu Lab

Endorse this lab