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Linnaeus Bioscience Inc.

1 Order Completed
San Diego, California, US

About Linnaeus Bioscience Inc.

Linnaeus Bioscience Inc. is dedicated to the discovery, development and commercialization of innovative technologies that accelerate drug discovery. Our Bacterial Cytological Profiling (BCP) platform provides a revolutionary new approach for discovering new compounds to treat microbial disease and emerging drug resistant bacterial infections.

Our Services (16)


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Natural Product Screening

Price on request

Screen chemical libraries to identify novel antibiotics

Our proprietary HTP-BCP platform can screen libraries on an industrial scale and provide preliminary activity and MOA information for all of the hits.

Screen natural product libraries

One of the biggest challenges in natural product research is knowing which... Show more »

Screen chemical libraries to identify novel antibiotics

Our proprietary HTP-BCP platform can screen libraries on an industrial scale and provide preliminary activity and MOA information for all of the hits.

Screen natural product libraries

One of the biggest challenges in natural product research is knowing which strains or extracts contain interesting bioactive compounds. BCP can determine which microbial strains produce interesting activities even before extracts are created, thereby focusing the labor intensive extraction and fractionation efforts on those few strains and extracts with proven potential. BCP can then determine the MOA of crude natural product extracts to identify those that have interesting bioactivities; in fact we routinely find multiple activities in crude extracts. Finally, BCP can guide purification of the desired activities, without wasting effort on undesired compounds or inactive fractions.

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High Throughput Screening (HTS)

Price on request

Screen chemical libraries to identify novel antibiotics

Our proprietary HTP-BCP platform can screen libraries on an industrial scale and provide preliminary activity and MOA information for all of the hits.

Screen natural product libraries

One of the biggest challenges in natural product research is knowing which... Show more »

Screen chemical libraries to identify novel antibiotics

Our proprietary HTP-BCP platform can screen libraries on an industrial scale and provide preliminary activity and MOA information for all of the hits.

Screen natural product libraries

One of the biggest challenges in natural product research is knowing which strains or extracts contain interesting bioactive compounds. BCP can determine which microbial strains produce interesting activities even before extracts are created, thereby focusing the labor intensive extraction and fractionation efforts on those few strains and extracts with proven potential. BCP can then determine the MOA of crude natural product extracts to identify those that have interesting bioactivities; in fact we routinely find multiple activities in crude extracts. Finally, BCP can guide purification of the desired activities, without wasting effort on undesired compounds or inactive fractions.

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Microscopy

Price on request

High resolution microscopy of bacterial pathogens treated with antibiotics

We provide high resolution images of bacterial pathogens treated with antimicrobials and directly observe cell killing in time-lapse microscopy, providing compelling visual evidence of drug effectiveness that can be used for a variety of purposes.

High resolution microscopy of bacterial pathogens treated with antibiotics

We provide high resolution images of bacterial pathogens treated with antimicrobials and directly observe cell killing in time-lapse microscopy, providing compelling visual evidence of drug effectiveness that can be used for a variety of purposes.

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Cell-Based Assays

Price on request

Determine how compounds enter bacterial cells

We have developed assays for measuring the uptake of fluorescently labeled compounds into bacterial cells, mammalian cells, or a combination of the two, to determine a compound’s relative binding affinity for each cell type.

*Determine the subcellular location of... Show more »

Determine how compounds enter bacterial cells

We have developed assays for measuring the uptake of fluorescently labeled compounds into bacterial cells, mammalian cells, or a combination of the two, to determine a compound’s relative binding affinity for each cell type.

Determine the subcellular location of antimicrobial binding

Knowing where a compound binds to a microbial cell can provide important information about MOA. Linnaeus can determine the subcellular location of binding (e.g., outer membrane, inner membrane, DNA, cell pole, cytosolic, or other cellular location) of fluorescently labeled compounds.

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Cell-Based Compound Screening

Price on request

Screen chemical libraries to identify novel antibiotics

Our proprietary HTP-BCP platform can screen libraries on an industrial scale and provide preliminary activity and MOA information for all of the hits.

Screen natural product libraries

One of the biggest challenges in natural product research is knowing which... Show more »

Screen chemical libraries to identify novel antibiotics

Our proprietary HTP-BCP platform can screen libraries on an industrial scale and provide preliminary activity and MOA information for all of the hits.

Screen natural product libraries

One of the biggest challenges in natural product research is knowing which strains or extracts contain interesting bioactive compounds. BCP can determine which microbial strains produce interesting activities even before extracts are created, thereby focusing the labor intensive extraction and fractionation efforts on those few strains and extracts with proven potential. BCP can then determine the MOA of crude natural product extracts to identify those that have interesting bioactivities; in fact we routinely find multiple activities in crude extracts. Finally, BCP can guide purification of the desired activities, without wasting effort on undesired compounds or inactive fractions.

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Drug Mechanism of Action Studies

Mechanism of Action Studies
Price on request

Our BCP platform can be used to rapidly identify and study the mechanism of action (MOA) for compounds active against Gram positive or Gram negative bacteria.

Our BCP platform can be used to rapidly identify and study the mechanism of action (MOA) for compounds active against Gram positive or Gram negative bacteria.

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Bacterial Cytological Profiling (BCP)

Price on request
Request a quote for more information about this service.

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Drug Discovery & Development

Price on request
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Microbiology

Price on request
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Drug Discovery

Price on request
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Antimicrobial Activity Testing

Price on request
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Biology

Price on request
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Medicinal Chemistry

Price on request
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Imaging & Spectroscopy

Price on request
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Hit Identification

Price on request
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Natural Products

Price on request
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Joe Pogliano

Founder

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