LigaTrap® Technologies has developed a novel, patented portfolio of affinity ligands specific for the purification of monoclonal and polyclonal immunoglobulins from various species. In addition to species-specific ligands, advantages include the ability to elute bound antibodies at a milder pH (pH 4.0) than proteins A and G (pH ≤ 3.0), thus reducing the potential for precipitation and inactivation of pH sensitive antibodies. Our goal is to generate high purity antibodies using ligands superior to those currently available in the marketplace. The LigaTrap® Team has performed extensive side-by-side testing with purification products that are currently on the market. The LigaTrap® Team has also expanded our capabilities to include our expert Process Development and Downstream Optimization Services. LigaTrap® is actively partnering with technologies and platforms that are rapidly expanding in the Therapeutics Industry.
Custom and standard assay services.
10 day turn around on most projects.
LigaTrap® Technologies has many years of combined expertise in purifying a wide variety of proteins including monoclonal and polyclonal antibodies, recombinant proteins, fusion proteins, affinity-tagged proteins, and native proteins. We offer purification from many formats including (but not limited to) cell culture supernatant, ascites fluid, serum/antiserum, bacterial and mammalian expression systems, avian eggs, etc. We utilize AKTA systems to automate most purification cycles, allowing for increased efficiencies, lower costs, and shorter lead times for our customers. Typical chromatographic strategies used by our purification facility are listed below:
Analytical testing is an essential part of the proper evaluation and assurance that purified biologicals meet product specifications. Additionally, to ensure integrity of data, it is necessary to have a third-party independent analysis done to confirm internal analytical results. LigaTrap® Technologies offers a variety of different testing services for analysis of purified proteins. Some of these services include SDS-PAGE (native and denaturing), HPLC, Western Blot, ELISA, A280 determination, endotoxin, and bioburden. Discounted pricing is available for customers that have multiple samples and/or multiple assays to be conducted.
1L Cell culture and purification package
1L cell culture antibody production and purification per cell line
Product Development, Testing, and Packaging Services
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