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Leucine Rich Bio Pvt Ltd.

Bangalore Karnataka

Leucine Rich Bio has been selected as the award recipient for the"2016 Frost & Sullivan India Award for Enabling Technology in the Cloud-enabled Genomics Industry, APAC"
Leucine Rich Bio Private Limited is a Bioinformatics driven company based in the Silicon Valley of India, Bangalore, specializing in Next Generation Sequencing (NGS) Data Analysis & Interpretation. Our area of focus is in Human Genome Interpretation, especially for clinical and research use. We use advances in the area of Computer Science, Information Science, Data Management, Statistics and Systems Biology to solve complex problems in Genomics. We envision using cutting edge big data approaches along with machine learning algorithms to delve deeper into the understanding of the human genome and develop novel solutions to drug discovery.

At Leucine Rich Bio we have in-depth knowledge on Cancer Genomics, Genetic Conditions caused... Show more »

Leucine Rich Bio has been selected as the award recipient for the"2016 Frost & Sullivan India Award for Enabling Technology in the Cloud-enabled Genomics Industry, APAC"
Leucine Rich Bio Private Limited is a Bioinformatics driven company based in the Silicon Valley of India, Bangalore, specializing in Next Generation Sequencing (NGS) Data Analysis & Interpretation. Our area of focus is in Human Genome Interpretation, especially for clinical and research use. We use advances in the area of Computer Science, Information Science, Data Management, Statistics and Systems Biology to solve complex problems in Genomics. We envision using cutting edge big data approaches along with machine learning algorithms to delve deeper into the understanding of the human genome and develop novel solutions to drug discovery.

At Leucine Rich Bio we have in-depth knowledge on Cancer Genomics, Genetic Conditions caused by Rare Variants and Drug Response. We have collated information on Genetic Variants, Mendelian Inheritance, Genome Wide Association Studies and Pharmacogenomics data. Our in-house curated database (LRB – Human Genome Variation Database) is developed that cross-checks all information with the original scientific literature to ensure data is accurate, clinically relevant and up to date. The database provides functional information, mutation impact on disease, drug response and variant impact on protein structure and functions, with its relevant references.

Our pipelines are tailored to accurately generate a report in a clinically relevant time frame. Our proprietary platform AGIS based customized report translates complex genomic data into clinically relevant and actionable biological information. At Leucine Rich Bio we help clinicians appreciate the value of Personalized Medicine. Our in house curated database LRB-HGVD is tailored to provide variant functional information to AGIS

Our dynamic genome interpretation service provides researchers in pharmaceutical industry and top research labs worldwide with choice of bioinformatics suite to interpret, analyse and act on relevant information derived from ever evolving NGS data.

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Leucine Rich Bio Pvt Ltd. has not listed any services.

Data mining
Price on request

Human Genome Variation Database (HGVD) provides comprehensive information about Variations found in the Human Genome. HGVD focuses on the relationship between human genome variations and phenotypes. Information in the database is manually curated, verified and updated periodically.

HGVD can be integrated to genome analytical... Show more »

Human Genome Variation Database (HGVD) provides comprehensive information about Variations found in the Human Genome. HGVD focuses on the relationship between human genome variations and phenotypes. Information in the database is manually curated, verified and updated periodically.

HGVD can be integrated to genome analytical tools to annotate & rank variants based on phenotype and clinical significance. At present HGVD is integrated with Leucine Rich Bio’s Human Genome Variant Analysis platform, AGIS.

HGVD is developed and maintained by Leucine Rich Bio.

For customized data mining and database creation using state of the art graphic user interface, please contact us

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Bioinformatics
Price on request

Leucine Rich Bio Private Limited is a Bioinformatics driven company based in the Silicon Valley of India, Bangalore, specializing in Next Generation Sequencing (NGS) Data Analysis & Interpretation. Our area of focus is in Human Genome Interpretation, especially for clinical and research use. We use advances in the area of... Show more »

Leucine Rich Bio Private Limited is a Bioinformatics driven company based in the Silicon Valley of India, Bangalore, specializing in Next Generation Sequencing (NGS) Data Analysis & Interpretation. Our area of focus is in Human Genome Interpretation, especially for clinical and research use. We use advances in the area of Computer Science, Information Science, Data Management, Statistics and Systems Biology to solve complex problems in Genomics. We envision using cutting edge big data approaches along with machine learning algorithms to delve deeper into the understanding of the human genome and develop novel solutions to drug discovery.

At Leucine Rich Bio we have in-depth knowledge on Cancer Genomics, Genetic Conditions caused by Rare Variants and Drug Response. We have collated information on Genetic Variants, Mendelian Inheritance, Genome Wide Association Studies and Pharmacogenomics data. Our in-house curated database (LRB - Human Genome Variation Database) is developed that cross-checks all information with the original scientific literature to ensure data is accurate, clinically relevant and up to date. The database provides functional information, mutation impact on disease, drug response and variant impact on protein structure and functions, with its relevant references. Our pipelines are tailored to accurately generate a report in a clinically relevant time frame. Our proprietary platform AGIS based customized report translates complex genomic data into clinically relevant and actionable biological information. At Leucine Rich Bio we help clinicians appreciate the value of Personalized Medicine. Our in house curated database LRB-HGVD is tailored to provide variant functional information to AGIS

Our dynamic genome interpretation service provides researchers in pharmaceutical industry and top research labs worldwide with choice of bioinformatics suite to interpret, analyse and act on relevant information derived from ever evolving NGS data.

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In Silico Cancer Genomics/Cancer Transcriptomics Analysis
Price on request

Next Generation Sequencing technologies is revolutionizing Personalized Medicine especially in Oncology. From ambiguous tumors to prevalent cancer, advances in sequencing technologies are predicting the right therapy for patients.

Leucine Rich Bio's AGIS platform elucidates the right therapy for Cancer Patients. AGIS... Show more »

Next Generation Sequencing technologies is revolutionizing Personalized Medicine especially in Oncology. From ambiguous tumors to prevalent cancer, advances in sequencing technologies are predicting the right therapy for patients.

Leucine Rich Bio's AGIS platform elucidates the right therapy for Cancer Patients. AGIS provides information about cancer-related somatic and germline mutations, curated from published research and calls out the relevant mutations (including substitutions, insertions, deletions, and indels) associated with various cancer types, and provides the resulting data as a report. Our physician tailored reports offers clinically significant analysis of actionable mutations for better Theranostic Value.

Application of NGS in oncology is warranted by the following facts:-

NGS can and is being used to identify germline mutations linked to familial cancer syndrome. Eg. BRCA1/2 for familial breast and ovarian cancer NGS is being used to identify somatic mutations in the genes which are of therapeutic importance in tumors. Eg. Mutations in the B-Raf/MEK pathway in melanoma patients. Melanoma patients who have a V600E BRAF mutation can be prescribed Vemurafinib as a potential targeted therapy.

How does NGS benefit an Oncologist?
There are many ways by which NGS technology can aid an oncologist:

  1. Proper Diagnosis - Tumor subtypes that only a few years ago were defined by morphologic criteria are now defined by genetic mutations, either inclusively or exclusively.

  2. Appropriate targeted therapy – NGS aids in finding an appropriate “targeted therapy”, as an increasing number of therapies have indications based on DNA sequencing results. Patients who lack the mutation targeted by a drug will not only fail to benefit, but can actually be harmed by inappropriate targeted therapies

  3. Monitoring resistance – Resistance mutations can lead to patients not responding to therapies. For example, resistance to EGFR targeted therapies in cancer very frequently involves a single point mutation, and can possibly be overcome by merely switching to a different agent. NGS allows a more complete overview of tumor dynamics, and is more likely to shed light on idiopathic resistance mechanisms than a single gene assay.

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Genomics Data Analysis
Price on request

Research in genomics has taken a new turn with the advent of Next Generation Sequencing Technology. Understanding genes on a deep level may help to unlock many of the mysteries surrounding our most intractable diseases, including cancer, heart disease and degenerative conditions such as Alzheimer’s. One of the main advantages of... Show more »

Research in genomics has taken a new turn with the advent of Next Generation Sequencing Technology. Understanding genes on a deep level may help to unlock many of the mysteries surrounding our most intractable diseases, including cancer, heart disease and degenerative conditions such as Alzheimer’s. One of the main advantages of modern sequencing technologies is that the researchers can actually detect many different types of genetic alterations at once.
For researchers in academia, pharmaceutical and biotechnology industries, utilizing the advancement in the Next Generation Sequencing technology can lead to early target identification, new genetic lesions associated with disease can be found and overall development times associated with therapeutics and diagnostics to newly identified targets can be significantly shortened.

The cost of sequencing has come down drastically which has led to data deluge. It is important therefore to properly analyze the data to get meaningful results. Researchers from academia and pharmaceutical and biotechnology industries are utilizing this wealth of information to delve deeper into the biology of normal life and disease.

We at Leucine Rich Bio understand the complexity of the NGS data analysis and would offer our proprietary data analysis platforms to researchers so as to enable discovering and deciphering of the genomic data in a simple, efficient and effective manner.

For Researchers in Academia - In the post-genomic era, new technologies like NGS and microarray have revealed an outbreak of prerequisite genomic sequences and supporting data to understand genome wide functional regulation of gene expression and metabolic pathways reconstruction. However, the availability of this plethora of genomic data presents a significant challenge for storage, analyses and data management. Analysis of this mega-data requires the development and application of novel bioinformatics tools that must include unified functional annotation, structural search and comprehensive analysis and identification of new genes in a wide range of species. We partner with researchers and help them elucidate and interpret the voluminous data in a cost-effective and time bound way. We differentiate ourselves as a company that tries to interpret the data in a “biologist friendly manner”.

For Researchers in Pharmaceutical and Biotechnological industries - Our analytical team understands the nuances of research in industry. We can integrate all ‘omics’ data, use machine learning, language processing technologies to integrate and query large data sets to come up with solutions for industry researchers. NGS or microarray data analysis is one of the many offerings that we provide to our industry partners.
Get in touch with us for more information or visit our transcriptome, exome, small RNA sequencing analysis, custom projects pages for more details.

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Metagenomics Data Analysis
Price on request

Leveraging this expanding prospect of metagenomics, we have constructed a robust computational pipeline, “MetaRich”, for analysis, identification and interpretation of metagenomic data in order to assist research in pursuit of discovering biological insights of complex microbial communities. The utility of our pipeline rests in an... Show more »

Leveraging this expanding prospect of metagenomics, we have constructed a robust computational pipeline, “MetaRich”, for analysis, identification and interpretation of metagenomic data in order to assist research in pursuit of discovering biological insights of complex microbial communities. The utility of our pipeline rests in an accurate functional interpretation of a microbial community under study, to address questions regarding their complexity, regulation and reciprocal genetic control within the community and between host and microbiota. Our comprehensive pipeline concentrates on delineating such cross talks within microbial communities and with that of the host, which can further be validated on a bench top, enabling research with opportunities to understand key orchestrating mechanisms.

We have constructed the pipeline by selecting best available algorithm(s), most relevant and updated resources (databases) and literature-derived knowledge, with an objective of creating a state-of-the-art metagenomics analysis tool. By integrating a combination of these resources, along with a thorough benchmark testing and validation, we have built a computational pipeline for sequential and comprehensive analyses of metagenomic data. Our objective behind this robust benchmarking and validation was clearly to pick the most accurate algorithms, but not necessarily the widely used tools. These validations are critical for the functional capacity of all the analyses to be performed involving MetaRich, since the conclusions drawn out of the prediction algorithms are affected by inherent errors. Further, there is a high degree of variability between the available tools with respect to the time required to perform the analyses, with a common perception that the most accurate tools are the most time consuming ones. However, our validations indicated that the most accurate tools are not necessarily the most time consuming ones. This, aided by our strong computing power, have provided us with the added advantage of performing these analyses in a short time, without compromising the accuracy.

The utility of “MetaRich” relies in the top-down approach of metagenomics, along with the established bottom-up approach of classical microbiology and organism-level genomics. Our supplementary pipelines involving several exploratory analyses including pathway analysis, gene set enrichment, variation calling etc., would ensure a comprehensive investigation of any metagenomics data. Our commitment is to take the arduous task of such large scale metagenomics data analysis off your plate, provide you with the best possible interpretation, enabling you to focus on the critical aspect functional validation of the data into translatable research.

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miRNA-Sequencing Data Analysis
Price on request

The microRNAs (miRNA) constitute one of the largest subsets of the small non-coding RNAs (ncRNAs) that are recognized to play key roles in post-transcriptional regulation. They perform their function through cleaving or destabilizing the transcribed mRNA or making the translation of the expressed mRNA least efficient by blocking... Show more »

The microRNAs (miRNA) constitute one of the largest subsets of the small non-coding RNAs (ncRNAs) that are recognized to play key roles in post-transcriptional regulation. They perform their function through cleaving or destabilizing the transcribed mRNA or making the translation of the expressed mRNA least efficient by blocking ribosomal functions, overall sustaining the tightly controlled expression levels of a cell. Profiling the miRNA expression offers an accurate resolution of their regulatory functions, considering their impactful role and recent revelations of their involvement in a dynamic range of disease manifestations and microbial pathogenesis. Since their impact and more importantly their utility is poorly understood, researchers are routinely characterizing miRNAs in pursuit of identifying potential miRNAs which can act as markers of various diseases or their sub-types, with eventual goal of developing an accurate diagnostic or therapeutic tool.

In this regard, we have constructed a robust computational pipeline for analysis, identification and interpretation of miRNA data in order to assist researchers in pursuit of discovering potential diagnostic and therapeutic markers. The utility of our pipeline rests in an accurate functional interpretation of a significant set of miRNAs, identified through a comprehensive differential analysis of the expression data, to address questions regarding their transcriptional complexity and regulation. In addition to this, our pipeline can also identify and computationally validate “Novel miRNAs” which can further be validated on a bench top, enabling researchers with opportunities to understand and uniquely target the disease under study. The pipeline surely complements our clinical genomic analysis platforms providing a panoramic understanding of any research problem at hand.

Our commitment is to take the arduous task of large scale miRNA data analysis off your plate, provide you with the best possible interpretation, enabling you to focus on the critical aspect functional validation of the data into translatable research.

At Leucine Rich Bio, our team has tested many algorithms in-house to finally develop a pipeline that provides the best possible analysis for miRNA sequencing.

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Microarray data analysis
Price on request

We provide biologist friendly data analysis report. All our projects start with a questionnaire that helps us to align with the client's requirements. Our turn around time ranges from 7-21 working days depending on the data. Our main USP is to create reports that would help the researcher understand the complexity of the data.

We provide biologist friendly data analysis report. All our projects start with a questionnaire that helps us to align with the client's requirements. Our turn around time ranges from 7-21 working days depending on the data. Our main USP is to create reports that would help the researcher understand the complexity of the data.

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RNA-seq Data Analysis
RNA Sequencing Data Analysis
Price on request

Transcriptome Sequencing analyses provide information to detect novel transcribed regions, splice events, additional promoters, exons, or 3′ untranscribed regions. Transcript annotation studies also help to analyze the impact of transcriptional complexity on current models of key signaling pathways. Next Generation Sequencing can... Show more »

Transcriptome Sequencing analyses provide information to detect novel transcribed regions, splice events, additional promoters, exons, or 3′ untranscribed regions. Transcript annotation studies also help to analyze the impact of transcriptional complexity on current models of key signaling pathways. Next Generation Sequencing can also provide aberrant transcription events, like pseudogenes, fusion genes, and genome rearrangements.

Based on our AGIS Platform our analytics service solution is ideal for researchers seeking the most comprehensive and accurate, yet cost-effective results. Our reports are ‘researcher friendly’ that help simplify even the complex data for further analysis at the researchers’ end. An automated analysis pipeline provides high-powered mutation analysis with support for the IGV- and USCS browsers as well as VarSifter. Results are delivered via a secure FTP site or are shipped on a portable hard drive depending upon the size of the dataset. We provide biologist friendly data analysis report. All our projects start with a questionnaire that helps us to align with the client's requirements. Our turn around time ranges from 7-21 working days depending on the data. Our main USP is to create reports that would help the researcher understand the complexity of the data.

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Whole Exome Sequencing Data Analysis
Price on request

Targeted resequencing by massively parallel sequencing, which includes whole-exome sequencing (WES), is a well-established and cost-effective means to analyse specific regions of a genome. Reducing the target size and focusing on the regions most likely to yield relevant data enhances sensitivity through increasing depth of... Show more »

Targeted resequencing by massively parallel sequencing, which includes whole-exome sequencing (WES), is a well-established and cost-effective means to analyse specific regions of a genome. Reducing the target size and focusing on the regions most likely to yield relevant data enhances sensitivity through increasing depth of coverage, and therefore the likelihood of new discoveries.

The protein coding, or exonic regions, constitute ~1.5% of the human genome. An estimated 85% of known variations/mutations underlying disease-related traits occur in the exons of the genome. Exome sequencing provides a cost-effective alternative to whole genome sequencing and has been instrumental in applications such as:

Characterization of mutations in inherited disorders
Cancer gene mutation analysis
Understanding of complex genetic disorders
Effective treatment strategies for cancer
We provide biologist friendly data analysis report. All our projects start with a questionnaire that helps us to align with the client's requirements. Our turn around time ranges from 7-21 working days depending on the data. Our main USP is to create reports that would help the researcher understand the complexity of the data.

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Human
Microbes
Rabbit
Mouse
Rat
Whole Genome Sequencing Data Analysis
Price on request

Whole genome sequencing generates the most comprehensive sequence dataset for an individual organism and allows detailed evaluation of all genetic variations on in an individual or strain. LRB’s robust analysis pipeline will help you to analyze the data with quick turn-around time and effective output. Based on our AGIS Platform... Show more »

Whole genome sequencing generates the most comprehensive sequence dataset for an individual organism and allows detailed evaluation of all genetic variations on in an individual or strain. LRB’s robust analysis pipeline will help you to analyze the data with quick turn-around time and effective output. Based on our AGIS Platform our analytics service solution is ideal for researchers seeking the most comprehensive and accurate, yet cost-effective results. Our reports are ‘researcher friendly’ that help simplify even the complex data for further analysis at the researchers’ end. An automated analysis pipeline provides high-powered mutation analysis with support for the IGV- and USCS browsers as well as VarSifter. Results are delivered via a secure FTP site or are shipped on a portable hard drive depending upon the size of the dataset. We provide biologist friendly data analysis report. All our projects start with a questionnaire that helps us to align with the client's requirements. Our turn around time ranges from 7-21 working days depending on the data. Our main USP is to create reports that would help the researcher understand the complexity of the data.

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NGS data analysis
Next generation sequencing data analysis
Price on request

In this era of personalized/precision medicine, fast and accurate diagnosis is key for proper prognosis and treatment of diseases. We at Leucine Rich Bio understand the relevance and scope of NGS data that can deliver meaningful and actionable information to diagnostic companies and clinicians.

NGS technologies are able detect... Show more »

In this era of personalized/precision medicine, fast and accurate diagnosis is key for proper prognosis and treatment of diseases. We at Leucine Rich Bio understand the relevance and scope of NGS data that can deliver meaningful and actionable information to diagnostic companies and clinicians.

NGS technologies are able detect all kinds of sequence variants in a single experiment, including SNVs, InDels and SVs, providing investigators access to a large spectrum of de novo and rare inherited variant (those with frequencies <1%) mutations, which are often omitted in standard genotyping panels.

We analyze and interpret human genome data to provide a comprehensive view of the Mutations. The variants are ranked to best match the disease or phenotype in question. Our reports provide clear information on actionable and clinically relevant gene mutation and variation. Variants are also analysed to report drug response and pharmacogenomic data.

We curate information from various databases to unearth the role of mutations in disease and drug response. All information is validated thoroughly and cross checked for clinical relevance.
We provide biologist friendly data analysis report. All our projects start with a questionnaire that helps us to align with the client's requirements. Our turn around time ranges from 7-21 working days depending on the data. Our main USP is to create reports that would help the researcher understand the complexity of the data.

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Small RNA Sequencing Data Analysis
Price on request

Small non-conding RNAs such as small nuclear and small nucleolar RNA, micro RNA (miRNA), and small interfering RNA (siRNA), are not translated into proteins. Several of these ncRNA species, like micro RNAs or small interfering RNAs, are of major interest to transcriptomic research, since they are implicated in post-transcriptional... Show more »

Small non-conding RNAs such as small nuclear and small nucleolar RNA, micro RNA (miRNA), and small interfering RNA (siRNA), are not translated into proteins. Several of these ncRNA species, like micro RNAs or small interfering RNAs, are of major interest to transcriptomic research, since they are implicated in post-transcriptional regulation of numerous biological processes. The availability of NGS technologies has led to the discovery of several new species of ncRNAs. In contrast to microarray technologies, NGS has the potential to detect variants in mature small ncRNA length and ncRNA editing. Moreover, NGS technologies enable the profiling of known and novel small RNA genes.

Leucine Rich Bio’s small RNA sequencing analysis platform utilizes powerful algorithms to study these subset of RNA in various organism species.
We provide biologist friendly data analysis report. All our projects start with a questionnaire that helps us to align with the client's requirements. Our turn around time ranges from 7-21 working days depending on the data. Our main USP is to create reports that would help the researcher understand the complexity of the data.

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