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Lena Biosciences, Inc.

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Atlanta, Georgia, US

About Lena Biosciences, Inc.

Lena Biosciences develops, markets, and sells cutting-edge tools and services that enable the use of human cells in culture in a physiologically relevant setting. The proprietary multiwell-plate perfusion system, PerfusionPal, mimics interstitial delivery of nutrients and drugs to organoids, 3D cell cultures,... Show more »

Lena Biosciences develops, markets, and sells cutting-edge tools and services that enable the use of human cells in culture in a physiologically relevant setting. The proprietary multiwell-plate perfusion system, PerfusionPal, mimics interstitial delivery of nutrients and drugs to organoids, 3D cell cultures, and tissue explants for translatable results. Our SeedEZ scaffold enables cells to utilize both their cadherin (cell-cell) and integrin (cell-ECM) receptors that are vital for tissue-representative cell behavior, drug- and cell therapy outcomes. Lastly, our Blood Substitute facilitates superior interstitial delivery of all gases to cells, thus increasing cellular respiratory, and drug metabolism by at least an order of magnitude compared to cells in a dish.

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Our Services (16)


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Neuronal Assays

Price on request

Neuronal assays in 2D and 3D. Testing may also be performed in our cortical model comprising tri-culture of neurons, astrocytes and microglia. Cells may be further supported by our Blood Substitute that increases cellular respiratory metabolism several-fold and reduces cell death. Cultures can also be perfused in our proprietary... Show more »

Neuronal assays in 2D and 3D. Testing may also be performed in our cortical model comprising tri-culture of neurons, astrocytes and microglia. Cells may be further supported by our Blood Substitute that increases cellular respiratory metabolism several-fold and reduces cell death. Cultures can also be perfused in our proprietary PerfusionPal organ-on-a-chip-like system providing month-long support.

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Organ-on-a-Chip

Starting at $350.00 per base

Our PerfusionPal platform enables testing of 12 statistically-independent organ cultures in one plate. The price of plate is $350.

Our PerfusionPal platform enables testing of 12 statistically-independent organ cultures in one plate. The price of plate is $350.

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Organoids

Price on request

Organoids are formed using co-cultures of iPSCs and primary cells and cultured in our proprietary PerfusionPal organ-on-a-chip-like system.

Organoids are formed using co-cultures of iPSCs and primary cells and cultured in our proprietary PerfusionPal organ-on-a-chip-like system.

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3D Cell-Based Assays

Price on request

The assays are run in our proprietary SeedEZ scaffold that enables both cadherine and integrine signaling in 3D. Commons assays include: CellTiter-Glo, alamarBlue, LDH release, etc. We routinely run assays with primary cells and iPSCs and have extensive experience with brain co-cultures, liver, cancers such as breast, liver, lung etc.

The assays are run in our proprietary SeedEZ scaffold that enables both cadherine and integrine signaling in 3D. Commons assays include: CellTiter-Glo, alamarBlue, LDH release, etc. We routinely run assays with primary cells and iPSCs and have extensive experience with brain co-cultures, liver, cancers such as breast, liver, lung etc.

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In vitro Hepatotoxicity Testing

Price on request

We are offering short-term and long-term DILI using primary liver cells with log-fold increase in Phase I drug metabolism and multifold increase in cell respiratory metabolism.

We are offering short-term and long-term DILI using primary liver cells with log-fold increase in Phase I drug metabolism and multifold increase in cell respiratory metabolism.

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Off-Target Drug Effects

Price on request

Off-target toxicity is evaluated in our 12-well organ-on-a-chip-like system PerfusionPal. For in vitro cell therapy testing the toxicity of activated immune cells is measured after co-culture with 3D human organ models, or after incubation of 3D organ models in activated immune cell medium.

Off-target toxicity is evaluated in our 12-well organ-on-a-chip-like system PerfusionPal. For in vitro cell therapy testing the toxicity of activated immune cells is measured after co-culture with 3D human organ models, or after incubation of 3D organ models in activated immune cell medium.

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Cytotoxicity Assays

Price on request

Cytotoxicity is offered in 2D and 3D, and in advanced, synthetically vascularized models supported by blood substitute and interstitial perfusion. Assays may be performed using a client's cells and standard assays (CellTiter-Glo or total LDH, kinetic LDH release etc.) For immune cell therapy toxicity, immune cells may be... Show more »

Cytotoxicity is offered in 2D and 3D, and in advanced, synthetically vascularized models supported by blood substitute and interstitial perfusion. Assays may be performed using a client's cells and standard assays (CellTiter-Glo or total LDH, kinetic LDH release etc.) For immune cell therapy toxicity, immune cells may be co-cultured with the organ models, or the organ models exposed to activated immune cell medium to assess toxicity in vitro.

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CYP Induction Assay

Price on request

We perform CYP induction assays using primary human hepatocytes in 2D and 3D. Advanced, perfused liver models are also available. Such models provide log-fold increase in CYP450 activity relative to 2D.

We perform CYP induction assays using primary human hepatocytes in 2D and 3D. Advanced, perfused liver models are also available. Such models provide log-fold increase in CYP450 activity relative to 2D.

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CYP Inhibition Assay

Price on request

We perform CYP inhibition assays using primary human hepatocytes in 2D and 3D. Advanced, perfused liver models are also available. Such models provide log-fold increase in CYP450 activity relative to 2D.

We perform CYP inhibition assays using primary human hepatocytes in 2D and 3D. Advanced, perfused liver models are also available. Such models provide log-fold increase in CYP450 activity relative to 2D.

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3D Cell Culture Models

Price on request

We can generate advanced 3D tissue models using co-cultures of primary cells or cell lines based on your specifications, or using cells provided by you. Models may be perfused (interstitial perfusion) and vascularized in our proprietary PerfusionPal system.

We can generate advanced 3D tissue models using co-cultures of primary cells or cell lines based on your specifications, or using cells provided by you. Models may be perfused (interstitial perfusion) and vascularized in our proprietary PerfusionPal system.

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In vitro Toxicity Testing

Price on request

We are offering in vitro toxicity testing services in 2D and 3D.

We are offering in vitro toxicity testing services in 2D and 3D.

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In vitro ADME/DMPK Studies

Price on request

We are offering Phase I drug metabolism services using perfused 3D cultures of primary human hepatocytes with log-fold increase in CYP450 activity.

We are offering Phase I drug metabolism services using perfused 3D cultures of primary human hepatocytes with log-fold increase in CYP450 activity.

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Mammalian Cell Culture

Price on request

We create perfused 3D culture models using cells provided by a client.

We create perfused 3D culture models using cells provided by a client.

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Cell and Tissue Culture

Price on request

We routinely culture in 2D and 3D, and generate organoid-like and perfused 3D cultures. Using our proprietary Blood Substitute and/or perfusion we can support tissue slice cultures longer.

We routinely culture in 2D and 3D, and generate organoid-like and perfused 3D cultures. Using our proprietary Blood Substitute and/or perfusion we can support tissue slice cultures longer.

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Induced Pluripotent Stem Cell (iPSC) Culture

Price on request

Routine 2D and 3D iPSC cell cultures and co-cultures. 3D cell cultures can also be perfused in our proprietary PerfusionPal system.

Routine 2D and 3D iPSC cell cultures and co-cultures. 3D cell cultures can also be perfused in our proprietary PerfusionPal system.

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Educational Services

Price on request

Prepare the next generation of biomedical students for the future! Teach them about the advantages of growing cells in three dimensions, as in living tissues. We are happy to demo our 3D cell culture scaffold and organ-on-a-chip-like PerfusionPal system for your undergraduate instructional laboratories. Please reach out if you... Show more »

Prepare the next generation of biomedical students for the future! Teach them about the advantages of growing cells in three dimensions, as in living tissues. We are happy to demo our 3D cell culture scaffold and organ-on-a-chip-like PerfusionPal system for your undergraduate instructional laboratories. Please reach out if you would like to try our product samples. We look forward to working with you.

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James Shoemaker

Chief Science Officer
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Jelena Vukasinovic

President and CEO

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