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La Jolla Institute for Immunology Cryo-EM Core Facility

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La Jolla, California, US

About La Jolla Institute for Immunology Cryo-EM Core Facility

The electron cryo-microscopy facility (cryoEM) at La Jolla Institute is equipped to provide visualization of important biological macromolecules at the finest level of detail. Armed with this knowledge, scientists can find information such as vulnerabilities of viruses, interactions between proteins, form and function of organelles, binding sites for ligands, etc. The development of various technologies, such as direct electron detectors, energy filters, and better electron microscopes has made possible to see unprecedented levels of detail in the electron microscope. These advances and the demonstrated usefulness of cryoEM led to three of its pioneers to be awarded the Nobel prize in Chemistry in 2017. The cryoEM facility at LJI is equipped with two state-of-the-art transmission electron microscopes, a Titan Halo and a Titan Krios, made by ThermoScientific; it also has an Aquilos dual beam electron microscope (ThermoScientific), which is used to make lamella of frozen cells for electron tomography, and a Leica light microscope with a cryo-stage to determine the areas to target in the frozen cells (correlative light-electron microscopy). In addition, there are ancillary pieces of equipment at the disposal of the facility users, such as a plasma cleaner (Fischione); plunge freezers (Vitrobot and Leica GP2); a Leica high-vacuum evaporator, and computing facilities to process the data. We offer services including sample preparation and data collection for single particle analysis, electron cryo-tomography, and data processing. In the near future, we expect to provide microED in addition to the already mentioned services.

Our Services (4)


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Cryo-Electron Microscopy

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Transmission Electron Microscopy (TEM)

Transmission Electron Microscopy services
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Cryo-Electron Tomography

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Single Particle Analysis

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Ruben Diaz Avalos

Scientific Associate

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