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Konzept Drug Development Consulting

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Berkeley, California, US

About Konzept Drug Development Consulting

Dr. Brotz is a drug discovery and development consultant working with emerging biopharmaceutical companies on drug development strategy, R&D operations and due diligence projects. He has over 15 years of experience in the biopharmaceutical industry, where he led small molecule development from discovery through phase 3. Having fostered a strong entrepreneurial spirit during his career in small company environments, Dr. Brotz is uniquely positioned to understand and address the specific challenges and needs of his clients.

Selected Publications

  • Gaztanaga, J., Farkouh, M., Rudd, J.H.F, Brotz T.M., Rosenbaum, D., Venkatesh, M., Taub, R, Tardif, J.-C.; Tawakol, A., Fayad, Z.A.: A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of the Effect of VIA-2291, a 5-Lipoxygenase Inhibitor, on Vascular Inflammation in Patients After an Acute Coronary Syndrome. Atherosclerosis (2015) 240 (1):53-60.
  • Tardif, J-C.; L'Allier, P.L.; Ibrahim, R., GrĂ©goire, J.C., Nozza, A., Cossette, M., Kouz, S. Lavoie, M-A., Paquin, J., Brotz, T.M., Taub, R., Pressacco, J.: Treatment with 5-Lipoxygenase Inhibitor VIA-2291 (Atreleuton) in Patients with Recent Acute Coronary Syndrome. Circulation Cardiovasc. Imaging 3 (2010): 298-307.
  • Stoll, S., Delon,J., Brotz ,T.M., Germain, R.N.: Dynamic imaging of T cell - dendritic cell interactions in lymph nodes. Science 296 (2002): 1873-1876.
  • Packard,B.Z., Komoriya, A., Brotz,T.M., Henkart,P.A.: Caspase 8 activity in membrane blebs after anti-Fas ligation. J. Immunology 67 (2001): 5061-5066.
  • Mansfield,E., Chae,J.J., Komarow,H.D., Brotz,T.M., Frucht,D.M. Aksentijevich,I., Kastner,D.L.: The familial Mediterranean fever protein, pyrin, associates with microtubules and colocalizes with actin filaments. Blood 98 (2000): 851-859.
  • Oertner,T.G., Brotz, T.M., Borst, A.: Mechanisms of dendritic calcium signaling in fly neurons. (2001) J. Neurophysiol., 85: 439-447.
  • Huh,G.S., Boulanger,L.M., Du.H., Riquelme, P.A., Brotz, T.M., Shatz,C.J.: Functional requirement for class I MHC in development and plasiticity of connections in the central nervous system. Science 290 (2000), 2155-2159.
  • Chen,H.T., Bhandoola,A., Difilippantonio,M.J., Zhu,J. Brown,M.J., Tai,X., Rogakou,E.P., Brotz,T.M., Bonner,W.M., Ried,T., Nussenzweig,A.: NBS1 and H2AX respond to RAG-induced DNA double strand breaks in developing thymocytes. Science 290 (2000), 1962-1964.

Our Services (10)


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Preclinical Study Design

Price on request
Request a quote for more information about this service.

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Drug Development Consulting

Starting at $300.00 per hour
  • Program and project management for drug discovery and development projects
  • Creating of development strategy, development plans, target product profiles, timelines, and project budgets
  • Leading internal, distributed and virtual project teams
  • Due diligence

Neurodegenerative diseases Alzheimers Disease Amyotrophic Lateral Sclerosis (ALS) Multiple sclerosis (MS) Spinal cord injury Neuropathy Atherosclerosis Drug Discovery Biology CNS/Neurology Cardiovascular Immunology Infectious Disease Pain Pediatrics Antibiotic Development Show 16 more tags Show less

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Regulatory Affairs Consulting

Price on request
  • Drafting and reviewing of regulatory documents including:
  • INDs, NDAs, Investigator Brochures, Meeting Briefing Packages, PSPs, PIPs, Annual Reports, Tabulated Summaries (CTD)

Antibiotic Development Inflammatory Bowel Disease Neurodegenerative diseases Alzheimers Disease Amyotrophic Lateral Sclerosis (ALS) Atherosclerosis Neuropathy Multiple sclerosis (MS) Autoimmune disease Spinal cord injury Drug Discovery biomarker Infectious Disease Pain Immunology Cardiovascular CNS/Neurology Show 17 more tags Show less

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Clinical Pharmacology

Price on request
  • Phase 1 strategy and planning
  • Assessing need for specialty studies including human mass-balance and drug-drug interaction studies
  • Estimating and setting human dose
  • Oversight of Pharmacometrics projects (Modeling & Simulation)

Antibiotic Development Neurodegenerative diseases Alzheimers Disease Amyotrophic Lateral Sclerosis (ALS) Neuropathy Atherosclerosis Drug Discovery Biology biomarker Infectious Disease Cardiovascular CNS/Neurology Pain Immunology Show 14 more tags Show less

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Toxicology

Price on request
  • Outsourcing and oversight of toxicology studies
  • Protocol development and report review
  • Data interpretation

Drug Discovery Repeated dose Toxicology 14, 28, 90 days neurotoxicity Safety Pharmacology Reproductive Toxicology Genotoxicity Mouse Rat Rabbit Dog Infectious Disease Cardiovascular CNS/Neurology Alzheimers Disease Pain Non-human primates (NHP) Show 16 more tags Show less

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
Starting at $300.00 per hour
  • Outsourcing and oversight of ADME/PK studies including: PK, in-vitro metabolism, in-vitro drug-drug-interaction, mass-balance studies

Drug Discovery Mouse Rat Dog Non-human primates (NHP)

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Drug Development Project Management

Price on request
  • Leading internal, distributed and/or virtual project teams
  • developing project strategy, timelines and budgets

Infectious Disease Pain CNS/Neurology Cardiovascular

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Project Management

Price on request
Request a quote for more information about this service.

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Pharmacology & Toxicology

Price on request
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Editorial and Writing Services

Price on request
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Tilmann Brotz

Principal Consultant

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