D9lflsircsddcvqeh8uq konzept orange logo

Konzept Drug Development Consulting

No Reviews Yet
No Completed Orders
Berkeley, California, US

About Konzept Drug Development Consulting

Dr. Brotz is a drug discovery and development consultant working with emerging biopharmaceutical companies on drug development strategy, R&D operations and due diligence projects. He has over 15 years of experience in the biopharmaceutical industry, where he led small molecule development from discovery through phase 3. Having fostered a strong entrepreneurial spirit during his career in small company environments, Dr. Brotz is uniquely positioned to understand and address the specific challenges and needs of his clients.

Selected Publications

  • Gaztanaga, J., Farkouh, M., Rudd, J.H.F, Brotz T.M., Rosenbaum, D., Venkatesh, M., Taub, R, Tardif, J.-C.; Tawakol, A., Fayad, Z.A.: A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of the Effect of VIA-2291, a 5-Lipoxygenase Inhibitor, on Vascular Inflammation in Patients After an Acute Coronary Syndrome. Atherosclerosis (2015) 240 (1):53-60.
  • Tardif, J-C.; L'Allier, P.L.; Ibrahim, R., GrĂ©goire, J.C., Nozza, A., Cossette, M., Kouz, S. Lavoie, M-A., Paquin, J., Brotz, T.M., Taub, R., Pressacco, J.: Treatment with 5-Lipoxygenase Inhibitor VIA-2291 (Atreleuton) in Patients with Recent Acute Coronary Syndrome. Circulation Cardiovasc. Imaging 3 (2010): 298-307.
  • Stoll, S., Delon,J., Brotz ,T.M., Germain, R.N.: Dynamic imaging of T cell - dendritic cell interactions in lymph nodes. Science 296 (2002): 1873-1876.
  • Packard,B.Z., Komoriya, A., Brotz,T.M., Henkart,P.A.: Caspase 8 activity in membrane blebs after anti-Fas ligation. J. Immunology 67 (2001): 5061-5066.
  • Mansfield,E., Chae,J.J., Komarow,H.D., Brotz,T.M., Frucht,D.M. Aksentijevich,I., Kastner,D.L.: The familial Mediterranean fever protein, pyrin, associates with microtubules and colocalizes with actin filaments. Blood 98 (2000): 851-859.
  • Oertner,T.G., Brotz, T.M., Borst, A.: Mechanisms of dendritic calcium signaling in fly neurons. (2001) J. Neurophysiol., 85: 439-447.
  • Huh,G.S., Boulanger,L.M., Du.H., Riquelme, P.A., Brotz, T.M., Shatz,C.J.: Functional requirement for class I MHC in development and plasiticity of connections in the central nervous system. Science 290 (2000), 2155-2159.
  • Chen,H.T., Bhandoola,A., Difilippantonio,M.J., Zhu,J. Brown,M.J., Tai,X., Rogakou,E.P., Brotz,T.M., Bonner,W.M., Ried,T., Nussenzweig,A.: NBS1 and H2AX respond to RAG-induced DNA double strand breaks in developing thymocytes. Science 290 (2000), 1962-1964.

Our Services (22)


ic

Preclinical Study Design

Price on request
Request a quote for more information about this service.

ic

Drug Development Consulting

Price on request
  • Program and project management for drug discovery and development projects
  • Creating of development strategy, development plans, target product profiles, timelines, and project budgets
  • Leading internal, distributed and virtual project teams
  • Due diligence

Neurodegenerative diseases Alzheimers Disease Amyotrophic Lateral Sclerosis (ALS) Multiple sclerosis (MS) Spinal cord injury Neuropathy Atherosclerosis Drug Discovery Biology CNS/Neurology Cardiovascular Immunology Infectious Disease Pain Pediatrics Antibiotic Development Show 16 more tags Show less

ic

In vivo Drug Efficacy Testing

Price on request
  • Selection and management of CROs for non-clinical studies, including toxicology, ADME/PK, animal models, and biomarker development
  • Study management including protocol development, study monitoring, and report review

Neurodegenerative diseases Neuropathy Multiple sclerosis (MS) Alzheimers Disease Amyotrophic Lateral Sclerosis (ALS) Spinal cord injury Drug Discovery Repeated dose Toxicology 14, 28, 90 days Mouse Rat Dog Rabbit Pain CNS/Neurology Infectious Disease Immunology Cardiovascular Antibiotic Development Atherosclerosis biomarker Non-human primates (NHP) Show 21 more tags Show less

ic

Regulatory Affairs Consulting

Price on request
  • Drafting and reviewing of regulatory documents including:
  • INDs, NDAs, Investigator Brochures, Meeting Briefing Packages, PSPs, PIPs, Annual Reports, Tabulated Summaries (CTD)

Antibiotic Development Inflammatory Bowel Disease Neurodegenerative diseases Alzheimers Disease Amyotrophic Lateral Sclerosis (ALS) Atherosclerosis Neuropathy Multiple sclerosis (MS) Autoimmune disease Spinal cord injury Drug Discovery biomarker Infectious Disease Pain Immunology Cardiovascular CNS/Neurology Show 17 more tags Show less

ic

Grant Writing

Price on request
  • Drafting, reviewing and formatting of applications for grants and government contracts (e.g. NIH, BARDA, DARPA)

Antibiotic Development Neuropathy Amyotrophic Lateral Sclerosis (ALS) Alzheimers Disease Autoimmune disease Multiple sclerosis (MS) Neurodegenerative diseases Spinal cord injury CNS/Neurology Cardiovascular Infectious Disease Pain Immunology Show 13 more tags Show less

ic

Clinical Data Collection, Analysis and Management

Price on request
  • Exploratory analysis of clinical efficacy and biomarker data

Antibiotic Development Atherosclerosis Spinal cord injury Multiple sclerosis (MS) Stroke Neurodegenerative diseases Alzheimers Disease Amyotrophic Lateral Sclerosis (ALS) Neuropathy Drug Discovery CT imaging FDG-PET imaging biomarker Spotfire GraphPad Prism Cardiovascular CNS/Neurology Pain Immunology Infectious Disease Show 20 more tags Show less

ic

Clinical Pharmacology

Price on request
  • Phase 1 strategy and planning
  • Assessing need for specialty studies including human mass-balance and drug-drug interaction studies
  • Estimating and setting human dose
  • Oversight of Pharmacometrics projects (Modeling & Simulation)

Antibiotic Development Neurodegenerative diseases Alzheimers Disease Amyotrophic Lateral Sclerosis (ALS) Neuropathy Atherosclerosis Drug Discovery Biology biomarker Infectious Disease Cardiovascular CNS/Neurology Pain Immunology Show 14 more tags Show less

ic

Toxicology

Price on request
  • Outsourcing and oversight of toxicology studies
  • Protocol development and report review
  • Data interpretation

Drug Discovery Repeated dose Toxicology 14, 28, 90 days neurotoxicity Safety Pharmacology Reproductive Toxicology Genotoxicity Mouse Rat Rabbit Dog Infectious Disease Cardiovascular CNS/Neurology Alzheimers Disease Pain Non-human primates (NHP) Show 16 more tags Show less

ic

ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
Price on request
  • Outsourcing and oversight of ADME/PK studies including:
  • PK, in-vitro metabolism, in-vitro drug-drug-interaction, mass-balance studies

Drug Discovery Mouse Rat Dog Non-human primates (NHP)

ic

In vivo Pharmacology Studies

Price on request
  • Outsourcing and oversight of animal models of disease
  • Protocol development, data interpretation and report review

Antibiotic Development Atherosclerosis Experimental autoimmune encephalomyelitis (EAE) Multiple sclerosis (MS) Autoimmune disease Neuropathy Alzheimers Disease Amyotrophic Lateral Sclerosis (ALS) Stroke Drug Discovery Mouse Rat Dog Cardiovascular Infectious Disease CNS/Neurology Pain Immunology Non-human primates (NHP) Show 19 more tags Show less

ic

Drug Development Project Management

Price on request
  • Leading internal, distributed and/or virtual project teams
  • developing project strategy, timelines and budgets

Infectious Disease Pain CNS/Neurology Cardiovascular

ic

Editorial and Writing Services

Price on request
Request a quote for more information about this service.

ic

Drug Discovery & Development

Price on request
Request a quote for more information about this service.

ic

Pharmacology & Toxicology

Price on request
Request a quote for more information about this service.

ic

Clinical Laboratory Services

Price on request
Request a quote for more information about this service.

ic

Project Management

Price on request
Request a quote for more information about this service.

ic

Drug Development

Price on request
Request a quote for more information about this service.

ic

In vivo PK/PD Studies

Price on request
Request a quote for more information about this service.

ic

Marketing, Communication & Graphic Design Services

Price on request
Request a quote for more information about this service.

ic

Regulatory Affairs Services

Price on request
Request a quote for more information about this service.

ic

Clinical Research

Price on request
Request a quote for more information about this service.

ic

Animal Models and Studies

Price on request
Request a quote for more information about this service.

Not finding what you're looking for?

Get info on this provider's capabilities without requesting a quote.
TB

Tilmann Brotz

Principal Consultant

FileType/PDF Created with Sketch. Resume T Brotz.pdf

Click to Download

Konzept Drug Development Consulting has not received any reviews.

Konzept Drug Development Consulting has not received any endorsements.