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Key Organics Inc.

Bedford, Massachusetts, US

Key Organics is a leading UK-based chemistry CRO providing a range of discovery, research and development services to the international life sciences industries. With over 26 years’ experience, we can offer customers an integrated service from computational drug design using our “KeyFinderTM” service through to hit-to-lead optimisation and late stage development services. We offer our Services expertise on a custom or FTE basis.

As the exclusive owners of BIONET, we can back-integrated to a proprietary collection of over 100,000 intermediates, fragments, biochemicals and building blocks. All are available ex stock and in >95% purity with same day dispatch. We offer a “no-quibble guarantee”.

Key Organics Inc. has not listed any services.

Chemical Synthesis
Price on request

Key Organics’ team of highly experienced chemists have acquired extensive synthetic organic chemistry capabilities and expertise that cover the following areas:

Chemistry Services
•Multi-step complex custom synthesis
•Asymmetric synthesis
•Heterocyclic chemistry
•Synthesis of literature standards
•Cold labelled... Show more »

Key Organics’ team of highly experienced chemists have acquired extensive synthetic organic chemistry capabilities and expertise that cover the following areas:

Chemistry Services
•Multi-step complex custom synthesis
•Asymmetric synthesis
•Heterocyclic chemistry
•Synthesis of literature standards
•Cold labelled compounds
•Pro-drug synthesis
•Manufacturing impurities and metabolite
•High pressure reactions (100mL – 4L autoclaves) •Hydrogenations
•Carbonylations
•High temperature ammonia reactions
•Microwave synthesis
•Parallel synthesis •Lead-seeking libraries
•Hit-to-lead SAR development
•Process development and Scale-up
•Non-GMP kilo-scale intermediate/final compound supply

Please contact us for further information on how we can add value to your projects and programmes

  • Asymmetric synthesis
  • Heterocyclic chemistry
  • Synthesis of literature standards
  • Cold labeled compounds
  • Stable labeled synthesis
  • Pro-drug synthesis
  • Manufacturing impurities and metabolite
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milligram
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Chemical Reference Standards
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Microwave-Assisted Synthesis
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Hit to Lead and Lead Optimization
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Compound Library Synthesis
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Compound Library Design
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Process and Scale-Up Chemistry
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At Key Organics, we are able to carry out process and scale-up chemistry. This facilitates a smooth transition from discovery into pre-clinical development, and subsequent GMP manufacture. Our capabilities include:

Scale Up
•Scale-up of intermediates and final compounds (20 Kg scale)
•Synthesis of development quantities... Show more »

At Key Organics, we are able to carry out process and scale-up chemistry. This facilitates a smooth transition from discovery into pre-clinical development, and subsequent GMP manufacture. Our capabilities include:

Scale Up
•Scale-up of intermediates and final compounds (20 Kg scale)
•Synthesis of development quantities of intermediates and of final compounds
•Optimisation of synthetic routes away from medicinal chemistry approaches
•Production of the necessary documentation to assist the transition into GMP manufacture

Our dynamic team is eager to take on any challenge including process rapid development, scale-up to produce material for pre-clinical trials, or development of a cost-effective and robust manufacturing process.

Please contact us for further information on how we can add value to your projects and programmes

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Drug Development
Price on request

Key Organics’ team of highly experienced chemists have acquired extensive synthetic organic chemistry capabilities and expertise that cover the following areas:

Chemistry Services
•Multi-step complex custom synthesis
•Asymmetric synthesis
•Heterocyclic chemistry
•Synthesis of literature standards
•Cold labelled... Show more »

Key Organics’ team of highly experienced chemists have acquired extensive synthetic organic chemistry capabilities and expertise that cover the following areas:

Chemistry Services
•Multi-step complex custom synthesis
•Asymmetric synthesis
•Heterocyclic chemistry
•Synthesis of literature standards
•Cold labelled compounds
•Pro-drug synthesis
•Manufacturing impurities and metabolite
•High pressure reactions (100mL – 4L autoclaves)
•Hydrogenations
•Carbonylations
•High temperature ammonia reactions
•Microwave synthesis
•Parallel synthesis
•Lead-seeking libraries
•Hit-to-lead SAR development
•Process development and Scale-up
•Non-GMP kilo-scale intermediate/final compound supply

Please contact us for further information on how we can add value to your projects and programmes

  • Custom Fragment libraries
  • Focused hit to lead libraries
  • Route Scouting
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Synthetic Chemistry
Price on request
  • High pressure reactions (100mL – 4L autoclaves)
    • Hydrogenations -Carbonylations
    • High temperature ammonia reactions
  • Microwave synthesis
  • Parallel synthesis
    • Lead-seeking libraries
    • Hit-to-lead SAR development
      Our analytical department is equipped with state-of-the-art instrumentation, which... Show more »
  • High pressure reactions (100mL – 4L autoclaves)
    • Hydrogenations -Carbonylations
    • High temperature ammonia reactions
  • Microwave synthesis
  • Parallel synthesis
    • Lead-seeking libraries
    • Hit-to-lead SAR development
      Our analytical department is equipped with state-of-the-art instrumentation, which includes;
      •NMR
      Bruker 400MHz AVIII NMR equipped with a 1H/13C multinuclear probe. Utilising Topspin and ICONNMR software, the instrument is capable of performing routine 1D experiments and 2D experiments such as COSY, HSQC, HMBC, and NOESY –plus variable temperature and solvent suppression experiments.
      •LCMS
      Agilent LCMS, comprising an Agilent 1260 LC, equipped with a binary gradient pump and a multiple wavelength UV/Vis detector. Coupled to an Agilent 6130 Single Quadrupole Mass Spectrometer, the instrument is capable of analysing a wide range of samples.
      Waters LCMS, coupled to a Micromass ZQ 2000 mass spectrometer, with ESCi probe.
      •Preparative LC
      Our Waters LCMS is also equipped with a preparative-scale pump, sample manager and fraction collectors –to perform mass-directed fraction collection.
      •HPLC
      Agilent 1100/1200 HPLC systems, equipped with binary gradient pumps and diode array detectors.
      •Gas Chromatography
      Agilent 6890 GC, equipped with autosampler, split/splitless inlet and flame ionisation detector.

Whatever your requirement; from single analyses to more complex projects, we will be happy to review your request and provide a quotation.

Please contact us for further information on how we can add value to your projects and programmes

« Show less
Drug Discovery & Development
Price on request

Synthetic Organic Chemistry

Key Organics’ team of highly experienced chemists have acquired extensive synthetic organic chemistry capabilities and expertise that cover the following areas:
ChemistryServices
•Multi-step complex custom synthesis •Asymmetric synthesis
•Heterocyclic chemistry
•Synthesis of literature... Show more »

Synthetic Organic Chemistry

Key Organics’ team of highly experienced chemists have acquired extensive synthetic organic chemistry capabilities and expertise that cover the following areas:
ChemistryServices
•Multi-step complex custom synthesis •Asymmetric synthesis
•Heterocyclic chemistry
•Synthesis of literature standards
•Cold labelled compounds
•Pro-drug synthesis
•Manufacturing impurities and metabolite

•High pressure reactions (100mL – 4L autoclaves) •Hydrogenations
•Carbonylations
•High temperature ammonia reactions

•Microwave synthesis
•Parallel synthesis •Lead-seeking libraries
•Hit-to-lead SAR development

•Process development and Scale-up •Non-GMP kilo-scale intermediate/final compound supply

Please contact us for further information on how we can add value to your projects and programmes

« Show less
Chemistry and Materials
Price on request

Our analytical department is equipped with state-of-the-art instrumentation, which includes;

NMR

  • Bruker 400MHz AVIII NMR equipped with a 1H/13C multinuclear probe. Utilising Topspin and ICONNMR software, the instrument is capable of performing routine 1D experiments and 2D experiments such as COSY, HSQC, HMBC, and... Show more »

Our analytical department is equipped with state-of-the-art instrumentation, which includes;

NMR

  • Bruker 400MHz AVIII NMR equipped with a 1H/13C multinuclear probe. Utilising Topspin and ICONNMR software, the instrument is capable of performing routine 1D experiments and 2D experiments such as COSY, HSQC, HMBC, and NOESY –plus variable temperature and solvent suppression experiments.

LCMS

  • Agilent LCMS, comprising an Agilent 1260 LC, equipped with a binary gradient pump and a multiple wavelength UV/Vis detector. Coupled to an Agilent 6130 Single Quadrupole Mass Spectrometer, the instrument is capable of analysing a wide range of samples.
  • Waters LCMS, coupled to a Micromass ZQ 2000 mass spectrometer, with ESCi probe.

Preparative LC

  • Our Waters LCMS is also equipped with a preparative-scale pump, sample manager and fraction collectors –to perform mass-directed fraction collection.

HPLC

  • Agilent 1100/1200 HPLC systems, equipped with binary gradient pumps and diode array detectors.

Gas Chromatography

  • Agilent 6890 GC, equipped with autosampler, split/splitless inlet and flame ionisation detector.

Whatever your requirement; from single analyses to more complex projects, we will be happy to review your request and provide a quotation.

Please contact us for further information on how we can add value to your projects and programmes

« Show less
Bruker Avance AVIII 400 MHz NMR
Photochemical Synthesis
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Impurity Synthesis
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Bulk Chemicals
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Combinatorial Chemistry
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Synthetic Building Blocks and Intermediates
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Specialty and Fine Chemicals
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Analytical Chemistry Services
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Compound Sourcing and Management
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Project Management
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Lead Identification and Validation
Price on request

Lead Identification and Validation Services

Lead Identification and Validation Services

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Compound Libraries
Price on request

Compound Libraries Services

Compound Libraries Services

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Drug Discovery
Price on request

Drug Discovery Services

Drug Discovery Services

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2018-06-04 09:24:13 -1000

Net Promoter Score of 9 received for Chemical Synthesis.

2018-02-01 08:51:54 -1000

Net Promoter Score of 10 received for Chemical Synthesis.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 9.

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