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Key-Obs SAS

Orléans, FR

Key-Obs is a preclinical Contract Research Organisation (CRO) specialized in central nervous system in vivo pharmacological studies. Key-Obs offers in vivo models and screening assays in the fields of psychiatry (schizophrenia, depression, anxiety, and addiction), cognition, neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease), juvenile diseases (ADHD, autism), rare diseases (Huntington’s disease, CMT), ALS, as well as genotyping/phenotyping of various transgenic rodents.

We complete behavioural studies with histological and immunological studies to provide a multifactor analysis and optimise the information level for our clients.

Key-Obs works for major pharmaceutical and Biotech companies all over the world, as well as academic partners.

Our models are well validated, we also customize models and tests to your specific needs.

We can administrate treatments via all routes, and collect... Show more »

Key-Obs is a preclinical Contract Research Organisation (CRO) specialized in central nervous system in vivo pharmacological studies. Key-Obs offers in vivo models and screening assays in the fields of psychiatry (schizophrenia, depression, anxiety, and addiction), cognition, neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease), juvenile diseases (ADHD, autism), rare diseases (Huntington’s disease, CMT), ALS, as well as genotyping/phenotyping of various transgenic rodents.

We complete behavioural studies with histological and immunological studies to provide a multifactor analysis and optimise the information level for our clients.

Key-Obs works for major pharmaceutical and Biotech companies all over the world, as well as academic partners.

Our models are well validated, we also customize models and tests to your specific needs.

We can administrate treatments via all routes, and collect tissues samples (plasma, CSF, brain) in relation to biomarkers analysis and histological staining.
To facilitate the screening of drugs of our clients, we are also offering in vivo screening package in psychiatry at competitive price.

Publications

  1. The Combination of Marketed Antagonists of α1b-Adrenergic and 5-HT2A Receptors Inhibits Behavioral Sensitization and Preference to Alcohol in Mice: A Promising Approach for the Treatment of Alcohol Dependence. Trovero F, David S, Bernard P, Puech A, Bizot JC, Tassin JP. PLoS One. 2016 Mar 11;11(3).
  2. Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models. Souchet B, Guedj F, Penke-Verdier Z, Daubigney F, Duchon A, Herault Y, Bizot JC, Janel N, Créau N, Delatour B, Delabar JM. Front Behav Neurosci. 2015 Oct 20;9:267
  3. D-amphetamine improves attention performance in adolescent Wistar, but not in SHR rats, in a two-choice visual discrimination task. Bizot JC, Cogrel N, Massé F, Chauvin V, Brault L, David S, Trovero F. Psychopharmacology (Berl). 2015 Sep;232(17):3269-86
  4. Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region. Brault V, Duchon A, Romestaing C, Sahun I, Pothion S, Karout M, Borel C, Dembele D, Bizot JC, Messaddeq N, Sharp AJ, Roussel D, Antonarakis SE, Dierssen M, Hérault Y. PLoS Genet. 2015 Mar 24;11(3)
  5. Effects of sarizotan in animal models of ADHD: challenging pharmacokinetic-pharmacodynamic relationships. Danysz W, Flik G, McCreary A, Tober C, Dimpfel W, Bizot JC, Kostrzewa R, Brown RW, Jatzke CC, Greco S, Jenssen AK, Parsons CG. J Neural Transm (Vienna). 2015 Sep;122(9):1221-38.
  6. Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: implications for Down syndrome. Mouton-Liger F, Sahún I, Collin T, Lopes Pereira P, Masini D, Thomas S, Paly E, Luilier S, Même S, Jouhault Q, Bennaï S, Beloeil JC, Bizot JC, Hérault Y, Dierssen M, Créau N. Neurobiol Dis. 2014 Mar;63:92-106.
  7. Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans. De la Torre R, De Sola S, Pons M, Duchon A, de Lagran MM, Farré M, Fitó M, Benejam B, Langohr K, Rodriguez J, Pujadas M, Bizot JC, Cuenca A, Janel N, Catuara S, Covas MI, Blehaut H, Herault Y, Delabar JM, Dierssen M. Mol Nutr Food Res. 2014 Feb;58(2):278-88.
  8. Myotonic dystrophy CTG expansion affects synaptic vesicle proteins, neurotransmission and mouse behaviour. Hernández-Hernández O, Guiraud-Dogan C, Sicot G, Huguet A, Luilier S, Steidl E, Saenger S, Marciniak E, Obriot H, Chevarin C, Nicole A, Revillod L, Charizanis K, Lee KY, Suzuki Y, Kimura T, Matsuura T, Cisneros B, Swanson MS, Trovero F, Buisson B, Bizot JC, Hamon M, Humez S, Bassez G, Metzger F, Buée L, Munnich A, Sergeant N, Gourdon G, Gomes-Pereira M. Brain. 2013 Mar;136(Pt 3):957-70.
  9. Vezatin is essential for dendritic spine morphogenesis and functional synaptic maturation. Danglot L, Freret T, Le Roux N, Narboux Nême N, Burgo A, Hyenne V, Roumier A, Contremoulins V, Dauphin F, Bizot JC, Vodjdani G, Gaspar P, Boulouard M, Poncer JC, Galli T, Simmler MC. J Neurosci. 2012 Jun 27;32(26):9007-22.
  10. Absence of TI-VAMP/Vamp7 leads to increased anxiety in mice.
    Danglot L, Zylbersztejn K, Petkovic M, Gauberti M, Meziane H, Combe R, Champy MF, Birling MC, Pavlovic G, Bizot JC, Trovero F, Della Ragione F, Proux-Gillardeaux V, Sorg T, Vivien D, D'Esposito M, Galli T. J Neurosci. 2012 Feb 8;32(6):1962-8
  11. Brain phenotype of transgenic mice overexpressing cystathionine β-synthase. Régnier V, Billard JM, Gupta S, Potier B, Woerner S, Paly E, Ledru A, David S, Luilier S, Bizot JC, Vacano G, Kraus JP, Patterson D, Kruger WD, Delabar JM, London J. PLoS One. 2012;7(1)
  12. Characterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTB. Brault V, Martin B, Costet N, Bizot JC, Hérault Y. PLoS One. 2011;6(11)
  13. Effects of atomoxetine, desipramine, d-amphetamine and methylphenidate on impulsivity in juvenile rats, measured in a T-maze procedure. Bizot JC, David S, Trovero F. Neurosci Lett. 2011 Feb 1;489(1):20-4
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Rodent Breeding
Price on request

We have the capacitý and expertise to breed rodents for our clients, and take various fluid samples during the breeding if needed. Phenotyping, genotyping can also be done during the breeding period.

We have the capacitý and expertise to breed rodents for our clients, and take various fluid samples during the breeding if needed. Phenotyping, genotyping can also be done during the breeding period.

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ALS Animal Models
Amyotrophic Lateral Sclerosis Animal Models
Price on request

We validated the mice and rat SOD1 G93A model.
Motor functions are scored as read-outs.
Various biochemical biomarkers can be scored as well.

We validated the mice and rat SOD1 G93A model.
Motor functions are scored as read-outs.
Various biochemical biomarkers can be scored as well.

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Charcot-Marie-Tooth Disease Animal Models
Price on request

Tg rats PMP22 impaired on motor behaviour and grip strength from week 11 to 20 allowing chronic in vivo studies.

Tg rats PMP22 impaired on motor behaviour and grip strength from week 11 to 20 allowing chronic in vivo studies.

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ADHD Animal Models
Attention Deficit/Hyperactivity Disorder Animal Models
Price on request

We have two models for the two main deficits in ADHD:
- Impulsivity: Delayed discounting Task in T-maze in rats.
- Attention: Two-choice visual discrimination task in operant chamber with juvenile rats
The broad validation of our tests allow a bench-marking evaluation of your new compounds.

We have two models for the two main deficits in ADHD:
- Impulsivity: Delayed discounting Task in T-maze in rats.
- Attention: Two-choice visual discrimination task in operant chamber with juvenile rats
The broad validation of our tests allow a bench-marking evaluation of your new compounds.

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Huntington's Disease Animal Models
Price on request
  • R6/1 Tg mice
    Read-outs: motor deficits (LMA, grip strength, body clasping, rotarod), cognitive deficits (Y-maze)
  • 3-Nitropropionic acid in rats
  • R6/2 Tg mice
  • R6/1 Tg mice
    Read-outs: motor deficits (LMA, grip strength, body clasping, rotarod), cognitive deficits (Y-maze)
  • 3-Nitropropionic acid in rats
  • R6/2 Tg mice
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Autism Animal Models
Price on request
  • Social deficit induced by prenatal exposure to Valproic Acid (VPA) in Wistar rats.
    Read-outs: Social behavior in social cages, Repetitive behavior in Y-maze.
  • BTBR Tg mice.
    Read-outs: Social behavior in 3-chambers test, Repetitive behaviors.
  • Social deficit induced by prenatal exposure to Valproic Acid (VPA) in Wistar rats.
    Read-outs: Social behavior in social cages, Repetitive behavior in Y-maze.
  • BTBR Tg mice.
    Read-outs: Social behavior in 3-chambers test, Repetitive behaviors.
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Parkinsons Disease Animal Models
Price on request
  • MPTP: Motor deficit DA depletion in mice C57
  • 6-OHDA unilateral lesion in SD rats.
  • MPTP: Motor deficit DA depletion in mice C57
  • 6-OHDA unilateral lesion in SD rats.
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Alzheimer's Disease Animal Models
Price on request
  • Memory deficit induced by scopolamine
  • Memory deficit in APP-Tg2576: memory deficit (MWM, object recognition).
  • In complement several of our tests in cognition are validated with drugs like Memantine and Donepezil.
  • Memory deficit induced by scopolamine
  • Memory deficit in APP-Tg2576: memory deficit (MWM, object recognition).
  • In complement several of our tests in cognition are validated with drugs like Memantine and Donepezil.
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Animal Learning, Memory, and Behavior Tests
Price on request
  • Spontaneous alternation in Y-maze
  • Novel Object Recognition
  • Social recognition
  • Passive avoidance
  • Habituation in open-field
  • Morris Water Maze
  • Spontaneous alternation in Y-maze
  • Novel Object Recognition
  • Social recognition
  • Passive avoidance
  • Habituation in open-field
  • Morris Water Maze
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Morris Water Maze Assay
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Novel Object Recognition Test
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Animal Motor Function and Activity Testing
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  • Spontaneous activity in open-field
  • Rotarod
  • Grip strength
  • Bar test
  • Inclined plane test
  • Negative geotaxis
  • Spontaneous activity in open-field
  • Rotarod
  • Grip strength
  • Bar test
  • Inclined plane test
  • Negative geotaxis
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Animal Grip Strength Test
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Rotarod Performance Test
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Schizophrenia Animal Models
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  • Apomorphine test (hypothermia, stereotypy, climbing)
  • Amphetamine hyperactivity
  • MK-801, PCP hyperactivity
  • MK-801 amnesia in Y-maze
  • Social deficit induced by MK-801
  • Catalepsy: bar test
  • Apomorphine test (hypothermia, stereotypy, climbing)
  • Amphetamine hyperactivity
  • MK-801, PCP hyperactivity
  • MK-801 amnesia in Y-maze
  • Social deficit induced by MK-801
  • Catalepsy: bar test
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Alcohol Addiction Animal Models
Price on request
  • Alcohol intake in mice C57BL/6J
  • drug effects in chronically (one month) alcoholized C57BL/6J mice
  • Alcohol intake in mice C57BL/6J
  • drug effects in chronically (one month) alcoholized C57BL/6J mice
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Substance Abuse Animal Models
Price on request

We have several models validated for evaluation of the drug addictive effects:
- Behavioral sensitization in mice C57BL/6J
- Conditioned place preference in mice C57BL/6J
- Opiate withdrawal in SD rats
- Benzodiazepine withdrawal in mice CD1

We have several models validated for evaluation of the drug addictive effects:
- Behavioral sensitization in mice C57BL/6J
- Conditioned place preference in mice C57BL/6J
- Opiate withdrawal in SD rats
- Benzodiazepine withdrawal in mice CD1

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Tail Suspension Test
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Forced Swim Test
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Anxiety Animal Models
Price on request
  • Elevated plus maze (EPM) in SD rats and CD1 mice
  • Four-plate in CD1 mice
  • Elevated plus maze (EPM) in SD rats and CD1 mice
  • Four-plate in CD1 mice
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T Maze Spontaneous Alternation Test
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Animal Behavior Studies
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Benefit from our strong expertise in specialized areas to conduct your specific research projects in the following fields.

  • Memory, learning : Aging, Alzheimer disease… Drug preparation
  • Depression, Anxiety, Psychosis
  • Drug abuse, Pharmacodependence
  • Vigilance, Attention, Impulsivity
  • Attention Deficit/Hyperactivity... Show more »

Benefit from our strong expertise in specialized areas to conduct your specific research projects in the following fields.

  • Memory, learning : Aging, Alzheimer disease… Drug preparation
  • Depression, Anxiety, Psychosis
  • Drug abuse, Pharmacodependence
  • Vigilance, Attention, Impulsivity
  • Attention Deficit/Hyperactivity Disorder
  • Motor disorders : Parkinson and Huntington diseases
  • Immunology
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Behavioral Phenotyping
Price on request

All the relevant tools for an evaluation of the functional consequences of genomic mutations.

  • The primary screen, a test battery for a first evaluation of behavior and sensori-motor functions.
  • Specific tests.
  • An internal data base from various mice strains.

The internal data base : an essential tool for functional... Show more »

All the relevant tools for an evaluation of the functional consequences of genomic mutations.

  • The primary screen, a test battery for a first evaluation of behavior and sensori-motor functions.
  • Specific tests.
  • An internal data base from various mice strains.

The internal data base : an essential tool for functional genomic research and a guide for the selection of suitable strains for pharmacological studies. Numerous inbred and outbred mice strains have been studied in the Key-Obs’ laboratory for their behavioral performance in various tests.

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Chronic Stress Animal Models
Price on request

Stress-induced anxiety in Elevated Plus-Maze in SD rats
Stress-induced hyperthermia in CD1 mice

Stress-induced anxiety in Elevated Plus-Maze in SD rats
Stress-induced hyperthermia in CD1 mice

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Cognitive, Behavioral, and Psychiatric Animal Models
Starting at $32,000.00 per study

To accelerate the discovery of new active compounds in the field of Psychiatry, Key-Obs offers a fast in-vivo screen in CD1 mice using the most predictive tests in depression, anxiety, schizophrenia, bipolar disorder and obsessive-compulsive disorders. Your active compounds are rapidly positioned in a therapeutic indication.
This... Show more »

To accelerate the discovery of new active compounds in the field of Psychiatry, Key-Obs offers a fast in-vivo screen in CD1 mice using the most predictive tests in depression, anxiety, schizophrenia, bipolar disorder and obsessive-compulsive disorders. Your active compounds are rapidly positioned in a therapeutic indication.
This package includes:
- Depression: Forced Swimming Test (FST)
- Anxiety: Elevated-Plus-Maze Test (EPM)
- OCD, Anxiety: Marble Burying Test
- Schizophrenia: MK-801 hyperactivity
- Bipolar disorder: Chlordiazepoxide/D-amphetamine hyperactivity

The study includes 4 dose groups, one vehicle group, and one positive control.

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In vivo Antischizophrenic Drug Screening
Starting at $18,500.00 per study

We are offering for a limited cost, a simplified package for in-vivo screen in the domain of schizophrenia.
In 1 month, we screen in CD1 mice, three compounds single dose each in reproducible and well validated models of positive symptoms, cognitive symptoms of schizophrenia, and for side effects.

Positive symptoms:... Show more »

We are offering for a limited cost, a simplified package for in-vivo screen in the domain of schizophrenia.
In 1 month, we screen in CD1 mice, three compounds single dose each in reproducible and well validated models of positive symptoms, cognitive symptoms of schizophrenia, and for side effects.

Positive symptoms: Amphetamine-induced hyperactivity and MK-801-induced hyperactivity
Cognitive symptoms: MK-801 induced amnesia in Y-maze test
Sedation: Spontaneous locomotor activity
Extrapyramidal side effects: Catalepsy at 30, 60, 120 min

The study includes one vehicle group, and one positive control.

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In vivo Antidepressant Screening
Starting at $9,900.00 per study

Depression:
We are offering a screening package for antidepressant, testing consecutively 16 compounds single dose in the well validated Forced Swim Test in mouse CD1, or C57. One Vehicle group and one positive control (Imipramine) included.

Depression:
We are offering a screening package for antidepressant, testing consecutively 16 compounds single dose in the well validated Forced Swim Test in mouse CD1, or C57. One Vehicle group and one positive control (Imipramine) included.

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Animal Husbandry
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Project Management, Consulting, & Support Services
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Animal Models and Studies
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Neurodegeneration Animal Models
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Animal Model in vivo Analyses
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Rare Disease Animal Models
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Animal Models of Disease
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Animal Model Housing and Maintenance
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Animal Anxiety and Depression Tests
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CNS/Neurology Animal Models
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Animal Cognition & Behavior Tests
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Animal Motor Function Tests
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Genetic Disorder Animal Models
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Animal Neurologic Evaluation
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2018-02-23 08:05:41 -0800

Net Promoter Score of 10 received for Alcohol Addiction Animal Models.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.

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