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Jubilant Biosys Limited

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Noida, Uttar Pradesh, IN

About Jubilant Biosys Limited

Jubilant Biosys Limited (JBL) is a sister concern of Jubilant Life Sciences (a $1,310 MM Sales Corporation) providing innovative drug discovery services to the global life sciences, agro-chemicals and specialty chemicals industry through its research centers in India.

Jubilant’s services in discovery research includes;

·         Target identification/ target validation to lead optimization/ preclinical candidate, for multiple therapeutic areas viz; oncology, metabolic disorders, CNS, pain, inflammation, fibrosis and respiratory diseases.

·         Functional services comprising of computational chemistry/ molecular modeling, medicinal chemistry, synthetic chemistry, scale-up (Non-GMP & GMP), structural biology, ADME-PK, in-vitro and in-vivo biology and IND enabling GLP toxicology.

 

1.      Key Statistics:
·         Founded in 2000; worked with global top-10 pharma, mid-sized and biotech companies.

·         750+ people working on drug discovery services business.

·         75+ integrated programs experience with 12 successfully delivered at lead optimization/ IND stage.

·         Multi-location: Research centers spread across two locations Noida and Bengaluru in India.

·         Customized business models fit to serve customer needs;

o   Full Time Equivalent (FTE) based,

o   Fee For Service (FFS) based,

o   Risk share and Milestone based for integrated research programs

Certifications & Qualifications

AAALAC GLP GMP ISO 14001 ISO 18001 ISO 9001

Our Services (69)


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Machine Learning and AI Solutions

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Co-Crystallization

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Protein Production

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Western Blot

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Process and Scale-Up Chemistry

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Chemistry, Manufacturing and Controls (CMC)

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Integrated Drug Discovery

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Computational Drug Discovery

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Compound Library Design

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Drug Target Validation

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Bioinformatics, Target proposal (line-of-sight to IND), Target Validation (siRNA, tool compounds, expression)
Build: Target and pathway expression in human disease tissue, patient stratification.


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Drug Target Identification

Price on request

Bioinformatics, Target proposal (line-of-sight to IND), Target Validation (siRNA, tool compounds, expression)
Build: Target and pathway expression in human disease tissue, patient stratification.


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Hit to Lead and Lead Optimization

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HTS, Structural Biology (protien, X-ray crystallography), Med/Comp Chem, in vitro ADME, in vitro/Cell Biology
Build: Fragment and Lead Library synthesis, human cells (primary).


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In vivo PK/PD Studies

Price on request

Assessment of physicochemical and in vitro ADME properties:
In silico properties, Solubility, Log D, Microsomal stability, CYP inhibition

Optimization of druggable properties, IVIVC, PK/PD correlation:
In vivo PK (Rodent and Non- Rodent), PK/PD, Plasma protein binding, Blood/Plasma partioning


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Medicinal Chemistry

Price on request

Expanded Synthetic Chemistry, Scale-Up facility, Pre-formulation and formulation development

Special Expertise: Carbohydrate Chemistry, Nucleoside Chemistry, Focused Libraries


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Informatics

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Jubilant Biosys Discovery Informatics provides a wide array of Informatics services that would save the time spent in processing the research data. Thereby, allowing customers to focus on research.

Our Informatics services and solutions are aimed to solve the data challenges that arise at each stage of drug discovery. Jubilant informatics team has a large pool of qualified professionals with high level of proficiency in technology platforms and leverages Jubilant’s vast experience in Pharma and Life Science industry to offer innovative solutions across many therapeutic and disease areas.

Jubilant Discovery informatics offers following services:

  • Custom Curation Services(Biology, Chemistry and Clinical Trial )
  • Genome Data Analysis
  • Target Intelligence and Analytics
  • Clinical Trial Intelligence
  • Commercial Products


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Cell Culture Scale-Up

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Process Research and Development, Multi Kg (Non-GMP) manufacturing upto 10Kg of GMP material manufacturing capability


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In vitro Disease Models

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The In Vitro Biology Group at Jubilant has state-of-the-art infrastructure and the expertise to perform a variety of biochemical and cellular assays against most target classes, including enzymes, GPCR’s, ion channels (e-phys), NHR’s and transporters.

The department is equipped with state-of-the-art facilities to enable these assays, including sophisticated liquid-handling, compound-handling and assay-detection systems. With a high ratio of PhD scientists, the group also has the expertise to take on target validation and mechanism studies.

  • Biochemical & cell based assay development & validation
  • State-of-the-art instrumentation for screening
  • Fully automated compound management system
  • Statistical support with IT enabled screening tools
  • Advanced algorithms for data processing and quality evaluation


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Chemical Synthesis

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Synthesis of scaffolds, building blocks, intermediates, reference compounds. Expert in Synthetic Organic Chemistry

milligram gram kilogram

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Assay Development

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Biology Assay Development & Validation

Biochemical and Cell Based Assays

  • ELISA
  • Radioactive Binding Assays
  • FRET
  • HTRF
  • Kinetic Assays
  • Filter Binding Assays
  • Scintillation Proximity Assays
  • Calcium dye based FLIPR and FDSS assays
  • hERG Assays
  • Cell based ELISA
  • Whole Blood Assays
  • Cell Viability (LDH, MTT, Alamar Blue)
  • Flow Cytometry Assays
  • Western Blotting and In Cell ELISA

Target or Pathway Specific Assay

DiscoverX Platform, including Beta-arrest in Assays (PathHunter and PathFinder Assays)


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Compound Library Synthesis

Price on request

Library Design and Synthesis of Compounds and Focused Library Design


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Drug Discovery

Price on request

Comprehensive Drug Discovery services - from target discovery to candidate selection in partnership with leading healthcare companies, spanning Target Identification/Validation to Lead Optimisation/Pre-clinical candidate selection. With focus on Oncology, Metabolic Disorders, Central Nervous System diseases, Pain and Inflammation,GI diseases, Respiratory Diseases and Fibrosis


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Combinatorial Chemistry

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Jubilant also has Combinatorial Chemistry expertise


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Project Management

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Chiral Resolution

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Chiral Resolution of Compounds, SFC, Other advanced Analytical Services are offered as support to synthesis quotations and on a standalone basis.


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Computational Chemistry

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Computational chemistry - Molecular modelling studies - pharmacophore and QSAR modeling, protein structure based drug design, ligand based drug design, homology modeling, docking and scoring.


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Chemical Stability Testing

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Melting Point Determination

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Computational Modeling

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Optical Rotation

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UV-VIS Spectroscopy

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Nucleic Acid Services

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Animal Models and Studies

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Structure-Based Drug Design

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Lead Identification and Validation

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Toxicology

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Bioconjugation/Chemical Crosslinking

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Synthetic Building Blocks and Intermediates

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Elemental Analysis

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Drug Release Studies/In Vitro Release Testing (IVRT)

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LogP/LogD Determination

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pKa Measurement

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Residual Impurity Analysis

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In vitro ADME/DMPK Studies

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
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ADME and DMPK Studies Services


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Systems Biology

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Peptide Synthesis

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Hit Identification

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In vitro Pharmacology Studies

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Drug Development

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Structural Biology

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Compound Libraries

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Chemistry and Materials

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Cells and Tissues

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Spectroscopy

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Drug Discovery & Development

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DNA Library Services

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Analytical Chemistry Services

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Pharmacology & Toxicology

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DNA Services

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Imaging & Spectroscopy

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Contract Research

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Contract Services Directory

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X-ray Crystallography

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Synthetic Chemistry

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Biology

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Biochemistry & Molecular Biology

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Separation/Purification Services

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Spectrophotometry

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Mammalian Cell Culture

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