JOANNEUM RESEARCH Forschungsgesellschaft mbH develops solutions and technologies for businesses and industries across a wide range of sectors and conducts top-level research at an international level. With a focus on applied research and technology development, the INNOVATION COMPANY plays a key role in transfer of technology and know-how in South-East-Austria.
Selected Publications
We are actively developing innovative and optimized analytical methods that can be used to investigate metabolic processes. Toward this end, we pool our bio-analytical, statistical, medical, biological and biochemical expertise and conjoin it with advanced information technology. This strategy allows us to offer a wide range of customer-oriented services in the field of metabolomics and metabolic research.
Our services
Quantification of metabolites
Complete quantification of metabolites using isotope-labeled internal standards.
Profiling classes of metabolites
Metabolic fingerprinting
Profiling small molecules in biological samples using chromatography coupled with high-resolution mass spectrometry (Orbitrap). Alterations in patterns of small molecules are examined using sophisticated statistical methods that have tailored for biomarker identification.
Profiling classes of metabolites - targeted / untargeted metabolomics
LC coupled to high-resolution mass spectrometry based on Orbitrap technology allows the identification of metabolites in fingerprints on the basis of their exact molecular mass and retention time. This technology enables the user to study small molecule profiles while simultaneously targeting specific substances and substance classes.
Application: hypothesis-driven biomarker discovery, characterization of pharmaceuticals from natural sources (tea, plant extracts), metabolic research.
Optimized methods for quenching cellular metabolism
Specific metabolites resulting from energy metabolism are, in turn, metabolized at a high conversion speed. In order to carry out investigations on these metabolites, the background enzymatic reactions must be stopped (quenched) quickly and exactly at the desired time point. The metabolite concentrations are then preserved in the sample. This can be achieved by optimizing the methods for quenching cellular metabolism.
We carry out biomarker-based and metabolomic studies to pinpoint the causes of inflammatory diseases.
As a service to the pharmaceutical industry, we investigate the pharmacokinetics (PK) and pharmacodynamics (PD) of new drugs as well as the bioequivalence (BE) of new pharmaceutical formulations. We also carry out biomarker-based and metabolomic studies to pinpoint the causes of inflammatory diseases. We perform preclinical ex vivo and in vivo, as well as clinical in vivo, studies. During these studies, we use microdialysis and our patented Open Flow Microperfusion (OFM).
We focus on the targeted tissue
Open-flow microperfusion
Target tissues Skin: transport routes and effects of drugs within the dermal layer after topical or systemic administration, e.g. topical glucocorticoids or systemic antibodies in the case of psoriasis. Brain: transport across the blood-brain barrier (BBB), dose-response effects when the BBB is bypassed, monitoring of BBB function, e.g. highly lipophilic substances, psycho- and neuropharmaceuticals. Adipose tissue: transport routes and effects of drugs in adipose tissue, e.g. insulins.
arget tissues Skin: transport routes and effects of drugs within the dermal layer after topical or systemic administration, e.g. topical glucocorticoids or systemic antibodies in the case of psoriasis.
transport across the blood-brain barrier (BBB), dose-response effects when the BBB is bypassed, monitoring of BBB function, e.g. highly lipophilic substances, psycho- and neuropharmaceuticals.
We support you by offering unbiased, evidence- and science-based expertise in the areas of health care and pharmacoeconomics, market analysis, horizon scanning, regulatory affairs and reimbursement, as well as in the scientific and economic evaluation of health care programs.
Our Services
Know-how
As a service to the pharmaceutical industry, we investigate the pharmacokinetics (PK) and pharmacodynamics (PD) of new drugs as well as the bioequivalence (BE) of new pharmaceutical formulations. We also carry out biomarker-based and metabolomic studies to pinpoint the causes of inflammatory diseases. We perform preclinical ex vivo and in vivo, as well as clinical in vivo, studies. During these studies, we use microdialysis and our patented Open Flow Microperfusion (OFM).
We focus on the targeted tissue
Open-flow microperfusion
Our expertise ranges from the development of innovative analytical solutions to quality-assured sample analyses for clinical studies. For many years, we have cooperated closely with research groups that are working in medical and academic research. Our portfolio also includes numerous research contracts with pharmaceutical industries. We offer:
Bioanalytical Assays Services
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