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Jerve Scientific Consulting, Inc

San Francisco Bay Area, California, US

Jerve Scientific Consulting provides scientific consulting and laboratory support for DMPK, toxicology and bioanalytical issues. Specializing in using high resolution mass spectrometry to identify drug metabolite from in vitro (microsomes/hepatocytes) or in vivo (plasma/urine/bile) samples from drug biotransformation studies.

Sr. Principal Scientist John Erve offers:

  • Experience conducting in vitro and in vivo studies to investigate xenobiotics metabolism
  • Understanding of reactive metabolites of pharmacological and toxicological significance
  • Extensive knowledge of metabolic transformations including bioactivation pathways
  • Skilled in both protein and small molecule characterization using mass spectrometry
  • Understanding of modern drug discovery and development from an ADMET perspective
  • Board Certified in Toxicology -D.A.B.T.

Recent Publications

Jerve Scientific Consulting provides scientific consulting and laboratory support for DMPK, toxicology and bioanalytical issues. Specializing in using high resolution mass spectrometry to identify drug metabolite from in vitro (microsomes/hepatocytes) or in vivo (plasma/urine/bile) samples from drug biotransformation studies.

Sr. Principal Scientist John Erve offers:

  • Experience conducting in vitro and in vivo studies to investigate xenobiotics metabolism
  • Understanding of reactive metabolites of pharmacological and toxicological significance
  • Extensive knowledge of metabolic transformations including bioactivation pathways
  • Skilled in both protein and small molecule characterization using mass spectrometry
  • Understanding of modern drug discovery and development from an ADMET perspective
  • Board Certified in Toxicology -D.A.B.T.

Recent Publications

  • John C L Erve, Shawn Gauby, John W Maynard, Mats A Svensson, George Tonn, Kevin P Quinn, Bioactivation of Sitaxentan in Liver Microsomes, Hepatocytes, and Expressed Human P450S with Characterization of the Glutathione Conjugate by Liquid Chromatography Tandem Mass Spectrometry. Chemical Research in Toxicology 26(6) · May 2013. 
  • Alan L Rockwood, John C L Erve, Mass Spectral Peak Distortion Due to Fourier Transform Signal Processing, Journal of the American Society for Mass Spectrometry. 25(12), September 2014.
  • Wei Jiang, John C L Erve, Spectral accuracy of a new hybrid quadrupole time-of-flight mass spectrometer: Application to ranking small molecule elemental compositions. Rapid Communications in Mass Spectrometry 26(9):1014-22, May 2012. 
  • Guosheng Wu, Sarvesh C Vashishtha, John C L Erve, Characterization of Glutathione Conjugates of Duloxetine by Mass Spectrometry and Evaluation of in Silico Approaches to Rationalize the Site of Conjugation for Thiophene Containing Drugs. Chemical Research in Toxicology 23(8):1393-404, August 2010.
  • G T Whiteside, J M Dwyer, J E Harrison, C E Beyer, T Cummons, L Manzino, L Mark, G H Johnston, B W Strassle, A Adedoyin, C M Pulicicchio, J C L Erve, B J Platt, ZA Hughes, K E Rogers, D C Deecher, E J Trybulski, J D Kennedy, P Zhang, L Leventhal, WAY-318068: A novel, potent and selective noradrenaline re-uptake inhibitor with activity in rodent models of pain and depression. British Journal of Pharmacology 160(5):1105-18, July 2010.
  • Appavu Chandrasekaran, Zeen Tong, Hongshan Li, John C L Erve, William DeMaio, Igor Goljer, Oliver McConnell, Yakov Rotshteyn, Theresa Hultin, Rasmy Talaat, JoAnn Scatina, Metabolism of Intravenous Methylnaltrexone in Mice, Rats, Dogs, and Humans. Drug metabolism and disposition: the biological fate of chemicals 38(4):606-16, April 2010.
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ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
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Metabolite profiling and metabolic identification in support of drug discovery and drug development programs.

Metabolite profiling and metabolic identification in support of drug discovery and drug development programs.

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High Resolution Mass Spectrometry
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Utilize high resolution mass spectrometry (LC/MS on an Orbitrap Q-Exactive) to identify and characterize drug metabolites (in vitro or in vivo) from biotransformation studies.

Utilize high resolution mass spectrometry (LC/MS on an Orbitrap Q-Exactive) to identify and characterize drug metabolites (in vitro or in vivo) from biotransformation studies.

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