Default

Jerve Scientific Consulting, Inc

ic No Reviews Yet
ic No Completed Orders
San Francisco Bay Area, California, US

About Jerve Scientific Consulting, Inc

Jerve Scientific Consulting provides scientific consulting and laboratory support for DMPK, toxicology and bioanalytical issues. Specializing in using high resolution mass spectrometry to identify drug metabolite from in vitro (microsomes/hepatocytes) or in vivo (plasma/urine/bile) samples from drug... Show more »

Jerve Scientific Consulting provides scientific consulting and laboratory support for DMPK, toxicology and bioanalytical issues. Specializing in using high resolution mass spectrometry to identify drug metabolite from in vitro (microsomes/hepatocytes) or in vivo (plasma/urine/bile) samples from drug biotransformation studies.

Sr. Principal Scientist John Erve offers:

  • Experience conducting in vitro and in vivo studies to investigate xenobiotics metabolism
  • Understanding of reactive metabolites of pharmacological and toxicological significance
  • Extensive knowledge of metabolic transformations including bioactivation pathways
  • Skilled in both protein and small molecule characterization using mass spectrometry
  • Understanding of modern drug discovery and development from an ADMET perspective
  • Board Certified in Toxicology -D.A.B.T.

Recent Publications

  • John C L Erve, Shawn Gauby, John W Maynard, Mats A Svensson, George Tonn, Kevin P Quinn, Bioactivation of Sitaxentan in Liver Microsomes, Hepatocytes, and Expressed Human P450S with Characterization of the Glutathione Conjugate by Liquid Chromatography Tandem Mass Spectrometry. Chemical Research in Toxicology 26(6) · May 2013. 
  • Alan L Rockwood, John C L Erve, Mass Spectral Peak Distortion Due to Fourier Transform Signal Processing, Journal of the American Society for Mass Spectrometry. 25(12), September 2014.
  • Wei Jiang, John C L Erve, Spectral accuracy of a new hybrid quadrupole time-of-flight mass spectrometer: Application to ranking small molecule elemental compositions. Rapid Communications in Mass Spectrometry 26(9):1014-22, May 2012. 
  • Guosheng Wu, Sarvesh C Vashishtha, John C L Erve, Characterization of Glutathione Conjugates of Duloxetine by Mass Spectrometry and Evaluation of in Silico Approaches to Rationalize the Site of Conjugation for Thiophene Containing Drugs. Chemical Research in Toxicology 23(8):1393-404, August 2010.
  • G T Whiteside, J M Dwyer, J E Harrison, C E Beyer, T Cummons, L Manzino, L Mark, G H Johnston, B W Strassle, A Adedoyin, C M Pulicicchio, J C L Erve, B J Platt, ZA Hughes, K E Rogers, D C Deecher, E J Trybulski, J D Kennedy, P Zhang, L Leventhal, WAY-318068: A novel, potent and selective noradrenaline re-uptake inhibitor with activity in rodent models of pain and depression. British Journal of Pharmacology 160(5):1105-18, July 2010.
  • Appavu Chandrasekaran, Zeen Tong, Hongshan Li, John C L Erve, William DeMaio, Igor Goljer, Oliver McConnell, Yakov Rotshteyn, Theresa Hultin, Rasmy Talaat, JoAnn Scatina, Metabolism of Intravenous Methylnaltrexone in Mice, Rats, Dogs, and Humans. Drug metabolism and disposition: the biological fate of chemicals 38(4):606-16, April 2010.
Show less

Diversity Certificates

Small business

Our Services (11)


ic

ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
Price on request
Request a quote for more information about this service.

ic

Metabolite Profiling

Price on request

Metabolite profiling and metabolic identification in support of drug discovery and drug development programs.

Metabolite profiling and metabolic identification in support of drug discovery and drug development programs.

Show less

ic

High Resolution Mass Spectrometry

Price on request

Utilize high resolution mass spectrometry (LC/MS on an Orbitrap Q-Exactive) to identify and characterize drug metabolites (in vitro or in vivo) from biotransformation studies.

Utilize high resolution mass spectrometry (LC/MS on an Orbitrap Q-Exactive) to identify and characterize drug metabolites (in vitro or in vivo) from biotransformation studies.

Show less

ic

Mass Spectrometry

Price on request
Request a quote for more information about this service.

ic

Biology

Price on request
Request a quote for more information about this service.

ic

Spectroscopy

Price on request
Request a quote for more information about this service.

ic

Pharmacology & Toxicology

Price on request
Request a quote for more information about this service.

ic

Metabolomics

Price on request
Request a quote for more information about this service.

ic

Omics

Price on request
Request a quote for more information about this service.

ic

Imaging & Spectroscopy

Price on request
Request a quote for more information about this service.

ic

Specialty Mass Spectrometry Methods

Price on request
Request a quote for more information about this service.

Not finding what you're looking for?

Get info on this provider's capabilities without requesting a quote.
Missing Avatar

John Erve

Sr. Principal Scientist

Jerve Scientific Consulting, Inc has not received any reviews.

Jerve Scientific Consulting, Inc has not received any endorsements.