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Jaguar Pharma Consulting

Westfield, NJ, US

Dr. MacNeil is the Lead Consultant at Jaguar Pharma Consulting LLC, where he provides Early Drug Discovery consulting services for Academic Groups, Biotech Companies, and Research Foundations. For each client, he provides a customized research plan from an initial lead to the selection of a Clinical Candidate. He recommends the optimal mix of internal and CRO resources to assure a time- and resource-efficient plan from bench to the clinic. He is also a member of the Alzheimer’s Drug Discovery Foundation Scientific Review Board.

Dr. MacNeil has extensive experience in Early Drug Discovery and Development at major pharmaceutical companies. During his research career he rose from a bench level scientist to Director of In Vitro Sciences where he was responsible for in vitro assay support to over 40 research programs at Merck’s NJ research sites. He has a proven record of delivering development compounds, including... Show more »

Dr. MacNeil is the Lead Consultant at Jaguar Pharma Consulting LLC, where he provides Early Drug Discovery consulting services for Academic Groups, Biotech Companies, and Research Foundations. For each client, he provides a customized research plan from an initial lead to the selection of a Clinical Candidate. He recommends the optimal mix of internal and CRO resources to assure a time- and resource-efficient plan from bench to the clinic. He is also a member of the Alzheimer’s Drug Discovery Foundation Scientific Review Board.

Dr. MacNeil has extensive experience in Early Drug Discovery and Development at major pharmaceutical companies. During his research career he rose from a bench level scientist to Director of In Vitro Sciences where he was responsible for in vitro assay support to over 40 research programs at Merck’s NJ research sites. He has a proven record of delivering development compounds, including expertise in target identification, target validation, project support, and discovery team leadership. Dr. MacNeil initiated seven programs that delivered compounds for development; four achieved clinical proof of concept. He has deep capability in G-protein coupled receptors (GPCR), neuropeptides, energy homeostasis, neurodegeneration, and metabolic diseases. He is an expert at optimizing internal and external in vitro assays to support Lead Identification and Lead Optimization. He was responsible for 13 GPCR programs including agonist, antagonist, inverse agonist, allosteric modulators, and biased ligand projects. Dr. MacNeil has successfully managed international collaborations with partners in Japan, India, China, Germany and Denmark. He is recognized as an expert in cell-based assay development, assay validation, and CRO selection.

Selected Publications

  • Whitehead, B.R., Lo, M.M.-C., Ali, A., Park, M.K., Hoyt, S.B., Xiong, Y., Cai, J., Carswell, E., Cooke, A., MacLean, J., Ratcliffe, P., Robinson, J., Bennett, D.J., Wisniewski, T., Struthers, M., Cully, D., and MacNeil, D.J. ( 2017) Imidazopyridyl compounds as aldosterone synthase inhibitors. Bioorg. & Med. Chem. Let. 27:143-146.
  • Bayin, N.S., Frenster, J.D., Kane, R.J., Rubenstein, J., Modrek, A.S., Baitalmal, R., Dolgalev, I., Rudensky, K., Snuder, M., Golfinos, J.G., Doyle, W., Pacione, D., Parker, E.C., Chi, A.S., Heguy, A., MacNeil, D.J., Shohdy, N., Zagzag, D., Placantonakis, D.G. (2016) GPR133, an adhesion G-protein coupled receptor, is necessary for glioblastoma growth. Oncogenesis 5:e263
  • MacNeil, D.J. (2013) The role of melanin-concentrating hormone and its receptors in energy homeostasis. Frontiers in Neuroendocrine Science. 49: 1-14.
  • Wang, L., Hubert, J.A., Lee, S. J., Pan, J., Qian, S., Reitman, M.R., Strack, A.M., Weingarth, D. T., MacNeil, D.J., Weber, A.E., and Edmondson, S.D. (2011) Discovery of Pyrimidine Carboxamides as Potent and Selective CCK1R Agonists. Bioorg. & Med. Chem. Let. 15:2911-2915.
  • Zhong, H., Beaulaurier, J., Lum, P.Y., Molony, C., Yang, X., Zhang, B., Greenawalt, D., Ke, H., MacNeil, D.J., Qian, S., Tota, M., Weingarth, D.T., Sangsoon, W., Attie, A.D., Keller, M.P., Kaplan, L.M., Schadt E.E. (2010) Liver and adipose expression associated SNPs are enriched for association to Type 2 Diabetes. PLoS Genetics 6:e1000932.
  • Shearman, L.P., Stribling, D.S., Camacho, R.E., Rosko, K.M., Wang, J., Tong, S., Feng, Y., Marsh, D.J., Yu, H., Guan, X., Spann, S.K., MacNeil, D.J., Fong, T.M., Metzger, J.M., Goulet, M.T., Hagmann, W.K., Plummer, C.W., Finke, P.E., Mills, S.G., Shah, S.K., Truong, Q., Van der Ploeg, L.H., Macintyre, D.E., Strack, A.M. (2008) Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents. Eur. J. of Pharmacol. 579: 215-224.
  • Erondu, N., Gantz, I., Musser, B., Suryawanshi, S., Mallick, M., Addy, C., Cote, J., Bray, G., Fujioka, K., Bays, H., Hollander, P., Sanabria-Bohórquez, S.M., Eng, W., Långström, B., Hargreaves, R.J., Burns, H.D., Kanatani, A., Fukami, T., MacNeil, D.J., Gottesdiener, K.M., Amatruda, J.M., Kaufman, K.D., Heymsfield, S.B. (2006) Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults. Cell Metabolism. 4: 275-282.
  • Varnerin, J.P., Chung, C.C., Patel, S.B., Scapin, G., Parmee, E.R., Morin, N.R, MacNeil, D.J., Cully, D.F., Van der Ploeg, L.H.T., and Tota, M.R. (2004) Expression, Refolding and Purification of Recombinant Human Phosphodiesterase 3B: Definition of the N-Terminus of the Catalytic Core. Protein Expression and Purification. Protein Express. & Purificat. 35: 225-236.
  • MacNeil, D.J., Howard, A. D., Guan, X ., Fong, T., Nargund, R.P., Bednarek, M.A., Goulet, M.T., Weinberg, D.H., Strack, A.M., Marsh, D.J., Chen, H.Y., Shen, C.-P., Chen, A.S., Rosenblum, C.I., MacNeil, T., Tota, M.R., and Van der Ploeg, L.H.T. (2002) The role of Melanocortins in body weight regulation: opportunities for the treatment of obesity. E. J. Pharmacol. 440: 141-157.
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Drug Development Consulting
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Jaguar Pharma Consulting offers consulting services for all aspects of Early Drug Discovery. These include: Target ID and Validation, in vitro Assay Development and validation, Screening Assay Development, compound profiling Assay validation and data QC, compound selection criteria for in vivo POC studies, and compound selection... Show more »

Jaguar Pharma Consulting offers consulting services for all aspects of Early Drug Discovery. These include: Target ID and Validation, in vitro Assay Development and validation, Screening Assay Development, compound profiling Assay validation and data QC, compound selection criteria for in vivo POC studies, and compound selection criteria for clinical candidate selection. In addition, I provide

  • New project reviews
  • Development of time and cost effective research operating plans to progress initial hits towards clinical candidates
  • Selection and QC of data from the optimal CROs for each project.

Dr. MacNeil is an expert in in vitro cellular assays, in particular GPCR assays, with therapeutic experience in Diabetes, Obesity, Hypertension, Cardiovascular disease, Respiratory diseases, Fibrotic diseases, Oncology, and CNS diseases such as Alzheimer's and Parkinson's.

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Lead Identification and Validation
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Drug Discovery & Development
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Drug Discovery
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