JadeBio, Inc., is a contract research organization (CRO) providing comprehensive mass spectrometry based technology services to pharmaceuticals, biotechnology and academic organizations. We use our proprietary multi-stage platforms to make life science research and diagnostic development programs more efficient and effective. From biomarker discovery to Testing, our technologies provide greater in-depth, higher sensitivity, reproducibility and multiplexing capability compared to traditional immunoassays.
We specialize in quantification of protein biomarkers in complex matrices such as urine, plasma and cerebrospinal fluid (CSF). Our proprietary technology uses selective reaction monitoring mass spectrometry (SRM-MS) which allows for high throughput and multiplexing with unmatched specificity over ELISA. Through the use and development of (SRM-MS) our platform utilizes minimal sample quantities and is capable of absolute quantification of hundreds of proteins in a sample.
Our approach provides for rapid and cost effective development of protein quantification assays when compared to traditional immunoassays without any of the associated costs for the development and characterization of antibodies. Development time is typically only a matter of days for a small panel of proteins and up to 2 months for samples in a more challenging matrix.
We offer a portfolio of developed SRM panels of candidate biomarkers for different disease conditions such as neurodegenerative diseases. By using this multiplex assay panel we can detect the presence and the absolute concentration of the protein biomarkers directly from the sample. Our portfolio of SRM panels can be used for: Biomarker discovery, development and verification, companion diagnostic development, patient selection markers and clinical trial monitoring and mode of action studies (MOA).
For new biomarker discovery and development we offer a comprehensive proteomics platform to measure a proteome wide change in thousands of identified proteins and their precisely mapped post-translation modification.
We have also established other technology platforms for applications such as antibody characterization, peptide mapping, and immunoprecipitation etc.
Our co-founders and employees have extensive proteomics experience in industry and academia. We draw upon that expertise to deliver superior service and results. Our company is located in La Jolla, CA, in close proximity to the Biotech Bay, UCSD, and the surrounding research institutes. Our goal is to provide high quality protein quantitation and identification services to our academic, biotechnology and pharmaceutical clients at reasonable cost and fast turn-around time.
Our platforms have a wide variety of potential applications in a variety of fields including those outside of the biological sciences.
JadeBio can perform single protein analysis for identification of sites modification or additional sequence information. We also offer antibody sequencing for sibling identification or complete sequencing of an antibody. For pull down experiments we can provide immunoprecipitation characterization for identification of co-immunoprecipitating proteins.
We offer identification of unknown proteins from relatively simple mixtures and identification of antibody sequences without prior knowledge of sequence information.
Labeled or unlabeled profiling of fluids and solid tissues can be used for biomarker discovery, elucidating mechanism of action (MOA) or a therapeutic, or for understanding a biological system. Isobaric labeling allows for sample multiplexing of up to eight samples, providing for higher throughput and more robust statistics.
Our state of the art SRM technology can be applied for biomarker panels of up to one hundred proteins and targeted quantitation of proteins. Absolute quantitation can be done with isotopically labeled reference peptides.
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