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ITR Laboratories Canada Inc.

Baie D'Urfe, Quebec, CA

ITR Canada provides preclinical testing services for the pharmaceutical and biotechnology industries. Since our founding in 1989 we have grown into a mid-sized Contract Research Organization (CRO).

The tests we conduct are vital to bringing new medicines into the world. We are committed to alleviating the suffering of patients by advancing medical progress. Our goal as a company is to help in the development of treatments for a wide array of diseases and ailments including cancer, malaria, AIDS, tuberculosis and Alzheimer’s disease. ITR Laboratories Canada does not test cosmetics or house hold products as they are not part of our mission to develop new medicines.

As a CRO, with extensive experience, we provide you with valuable input and best practices, which ultimately help you maximize the value of your research investment. We deliver on time project reporting that meets your company’s goals.

ITR Laboratories Canada Inc. has not listed any services.

Pharmacodynamic Biomarkers Discovery
Price on request

ITR Laboratories Canada has dedicated laboratories and made a commitment to fully support clients’ needs for pharmacodynamics biomarkers. This includes both in vitro and exvivo endpoints for drug potency.

Commonly these biomarkers are protein expression, signally pathway activation/inhibition, RNA expression or target... Show more »

ITR Laboratories Canada has dedicated laboratories and made a commitment to fully support clients’ needs for pharmacodynamics biomarkers. This includes both in vitro and exvivo endpoints for drug potency.

Commonly these biomarkers are protein expression, signally pathway activation/inhibition, RNA expression or target knockdown.

FACILITIES INCLUDE:

  • LIGAND BINDING LAB:
    • Flow cytometer (BD FacsCanto II -2 lasers, 6 colors)
    • Multiple plate washers and readers (Both MolDev and Biotek)
    • All necessary support equipment
  • TISSUE CULTURE ROOM (BSL2, 2+):
    • Laminar flow hood, CO2 incubators
    • Microscopes with image capture systems
    • All necessary support equipment (cell banking, etc.)
  • MOLECULAR BIOLOGY LAB:
    • Tissue extraction (TissueLyzer, Polytron)
    • nucleic acid characterization (Agilent bioanalyzer)
    • QPCR (ViiA7) and TLDA
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Biomarker Analysis
Price on request

Both GLP and non-GLP biomarker assays are used to elucidate pharmacodynamics, mechanisms of action, and toxicity. The ever growing list of assays established at ITR Laboratories Canada now includes markers of inflammation, bone metabolism, endocrinology and cardiac toxicity.

Both GLP and non-GLP biomarker assays are used to elucidate pharmacodynamics, mechanisms of action, and toxicity. The ever growing list of assays established at ITR Laboratories Canada now includes markers of inflammation, bone metabolism, endocrinology and cardiac toxicity.

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Bioanalytical Assays
Price on request

ITR Laboratories Canada offers a full range of GLP compliant bioassay services to support the needs of non-clinical pharmaceutical development. Matrices routinely utilized include; urine, whole blood, plasma, serum, cerebral spinal fluid, aqueous/vitreous humor, and tissue extracts.

Methodologies currently implemented include:... Show more »

ITR Laboratories Canada offers a full range of GLP compliant bioassay services to support the needs of non-clinical pharmaceutical development. Matrices routinely utilized include; urine, whole blood, plasma, serum, cerebral spinal fluid, aqueous/vitreous humor, and tissue extracts.

Methodologies currently implemented include: LC-MS-MS, HPLC, or ligand binding assay ligand binding assays, cell based assays and flow cytometry.

FULLY GLP COMPLIANT DATASETS SUPPORT:

  • Method development and validation for GLP application
  • Analysis of pharmacokinetics and biodistribution
  • Immunogenicity assays for detection of anti-drug antibodies and assessment of neutralizing activity

EQUIPMENT INCLUDES:

  • API 4000 Triple Quadrupoles LC-MS-MS
  • Various plate readers
  • ViiA7 QPCR
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Analytical Chemistry Services
Price on request

The Analytical and Immunology laboratories provide on demand GLP assay services to support preclinical drug development, including:

  • Analytical method development and validation
  • Analysis of test article (TA) formulations
    • Commonly used methods are HPLC, UV A280, BCA assay, or QPCR as appropriate
  • Analysis of... Show more »

The Analytical and Immunology laboratories provide on demand GLP assay services to support preclinical drug development, including:

  • Analytical method development and validation
  • Analysis of test article (TA) formulations
    • Commonly used methods are HPLC, UV A280, BCA assay, or QPCR as appropriate
  • Analysis of aerosolized drugs
    • The analytical department offers services to support inhalation toxicology studies that include determination of particle size distribution, analysis of inhalation mixtures for confirmation of aerosol homogeneity and concentration, and analysis of inhalation chamber atmospheres.

EQUIPMENT INCLUDES:

  • HPLCs equipped with UV, PDA, fluorescence, and evaporative light scattering detection
  • Various plate readers
  • ViiA7 QPCR
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Genotoxicity Testing
Price on request

ITR Laboratories Canada can assess the potential of your chemical or experimental therapy to cause genetic damage using a standard test battery for genotoxicity as specified in ICH S2 (R1) and OECD test guidelines.

ITR Laboratories Canada genetic toxicology services are performed to GLP standards in our modern facility in... Show more »

ITR Laboratories Canada can assess the potential of your chemical or experimental therapy to cause genetic damage using a standard test battery for genotoxicity as specified in ICH S2 (R1) and OECD test guidelines.

ITR Laboratories Canada genetic toxicology services are performed to GLP standards in our modern facility in Montreal, Canada.

CURRENT CAPABILITIES INCLUDE:

  • Bacterial reverse mutation assay
    • Screening assay non-GLP (between 2 and 5 strains)
    • Standard assay (5 strains)
  • In Vitro Assays
    • Chromosomal aberration
    • Mouse lymphoma
    • Micronucleus
    • Comet
    • Neutral red uptake
  • In Vivo Assays
    • Chromosomal damage assay using:
    • Micronucleus in bone marrow erythrocytes
    • Micronucleus in peripheral blood erythrocytes
    • Chromosomal damage in bone marrow cells
    • Comet
    • Gene mutation assay using:
    • Pig-A

In addition to the standard battery of tests, ITR Canada will validate additional assays to keep pace with the creativity and needs of its clients.

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In vivo Immunotoxicity Testing
Price on request

As part of its Investigational New Drug (IND) enabling services, ITR Laboratories Canada offers a complete core-battery of in-vivo safety pharmacology studies in accordance with the International Conference on Harmonisation (ICH) Tripartite Guidelines S7A and S7B.

Safety pharmacology studies conducted at ITR Laboratories Canada... Show more »

As part of its Investigational New Drug (IND) enabling services, ITR Laboratories Canada offers a complete core-battery of in-vivo safety pharmacology studies in accordance with the International Conference on Harmonisation (ICH) Tripartite Guidelines S7A and S7B.

Safety pharmacology studies conducted at ITR Laboratories Canada are designed to investigate the potentially undesirable effects of test items on vital organ systems such as the cardiovascular, respiratory and central nervous systems. All safety pharmacology studies are conducted using fully validated and Part 11 compliant systems.

CURRENT OFFERINGS INCLUDE:

  1. TDAR
    • Validated in vivo models using T-dependent antigen (KLH) for both adult and juvenile animals
    • ELISA assay to assess the formation of specific antibodies
  2. CELL MEDIATE IMMUNITY
    • Memory T cell response
    • Macrophage and neutrophil function assays
    • Phagocytosis
    • Oxidative burst
    • Migration
    • T and B cell mitogenesis
  3. MOA SPECIFIC ENDPOINTS which are customized to the test item
  4. ABSOLUTE LYMPHOCYTE COUNTS
    • Flow cytometric evaluation of lymphocyte lineages from various tissues; most commonly blood, spleen, lymph nodes or thymus.
    • Detailed analysis of cell phenotype
    • Lineage subsets
      • T/B/NK
      • T subsets (memory/naïve, Tregs)
      • Monocytes (classical/activated)
      • Plasmacytoid DCs
    • Activation markers
    • Intracellular protein expression and phosphorylation (ie. Ki67, FoxP3, pStat, cytokines)
  5. NK CELL FUNCTIONAL ASSAY
    • Performed on blood or spleen
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Safety Pharmacology
Price on request

As part of its Investigational New Drug (IND) enabling services, ITR Laboratories Canada offers a complete core-battery of in-vivo safety pharmacology studies in accordance with the International Conference on Harmonisation (ICH) Tripartite Guidelines S7A and S7B.

Safety pharmacology studies conducted at ITR Laboratories Canada... Show more »

As part of its Investigational New Drug (IND) enabling services, ITR Laboratories Canada offers a complete core-battery of in-vivo safety pharmacology studies in accordance with the International Conference on Harmonisation (ICH) Tripartite Guidelines S7A and S7B.

Safety pharmacology studies conducted at ITR Laboratories Canada are designed to investigate the potentially undesirable effects of test items on vital organ systems such as the cardiovascular, respiratory and central nervous systems. All safety pharmacology studies are conducted using fully validated and Part 11 compliant systems.

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Toxicology
Price on request

To meet our clients’ toxicology needs, ITR Laboratories Canada provides services from single dose/acute designs through to carcinogenicity utilizing appropriate rodent and non-rodent species along with a full array of routes of exposure. Standard toxicology designs are augmented by other pre-clinical disciplines such as safety... Show more »

To meet our clients’ toxicology needs, ITR Laboratories Canada provides services from single dose/acute designs through to carcinogenicity utilizing appropriate rodent and non-rodent species along with a full array of routes of exposure. Standard toxicology designs are augmented by other pre-clinical disciplines such as safety pharmacology, genetic toxicology and immunotoxicology. ITR Laboratories Canada’s experienced toxicologists are available to assist clients in customizing their toxicology program and providing them with appropriate study plans for their programs.

These studies may be characterized by various routes of administration, duration and species.

ITR Laboratories Canada premium services include infusion and inhalation, which are complemented by general toxicology dosing methodologies as well as the increasingly relevant ocular, dermal and otology routes.

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Aerosol
Histology & Pathology Services
Price on request

ITR Laboratories Canada has highly qualified and experienced employees to offer a fully functional Pathology department ensuring the best quality of tissue collection and slide preparation in compliance with OECD and FDA's GLP requirements.

Pathology facilities are equipped with latest technology instrumentation. The... Show more »

ITR Laboratories Canada has highly qualified and experienced employees to offer a fully functional Pathology department ensuring the best quality of tissue collection and slide preparation in compliance with OECD and FDA's GLP requirements.

Pathology facilities are equipped with latest technology instrumentation. The department can performed many special requests for example; electron microscopy sampling, Immunohistochemistry, etc.

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Clinical and Anatomic Pathology
Price on request

The Clinical Pathology department at ITR Laboratories Canada is equipped with the state-of-the-art laboratory equipment. The Clinical Pathology encompasses a plethora of toxicology laboratory testing for chemistry, hematology, coagulation, urinalysis, blood gases, semen analysis, parasitology to name a few.

Our dynamic and... Show more »

The Clinical Pathology department at ITR Laboratories Canada is equipped with the state-of-the-art laboratory equipment. The Clinical Pathology encompasses a plethora of toxicology laboratory testing for chemistry, hematology, coagulation, urinalysis, blood gases, semen analysis, parasitology to name a few.

Our dynamic and invigorating staff is constantly seeking ways to achieve greater accuracy, precision, specificity and sensitivity of laboratory tests.

The Clinical Pathology team is continually striving towards innovative ideas in developing a wide range of tests and validating new instruments, ITR Laboratories Canada always putting their client’s request first.

The quality work produced, backed with GLP compliance and meeting timelines is second nature to Clinical Pathology.

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Pharmacology & Toxicology
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Clinical Laboratory Services
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Clinical Research
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Bioanalysis
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Safety Pharmacology & Efficacy Testing
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In vivo Toxicity Testing
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Biomarkers
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Chemistry and Materials
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