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IsoSciences, an MPD Chemicals Co

King of Prussia, PA, US

IsoSciences, LLC was formed in April of 2002 by Scott W. Landvatter, and David Saunders. We were senior chemists and managers in the isotope labeling group at SmithKline Beecham Pharmaceuticals. Following the merger of SmithKline Beecham with Glaxo Wellcome, we decided to leave the newly formed GSK Pharmaceuticals and start IsoSciences, LLC.

IsoSciences was founded to fulfill the market need for stable label isotopes of advanced intermediates and final drug substances. We have over 60 years combined experience in isotopic labeling. Since 2007, we have utilized specially designed laboratories in King of Prussia, Pennsylvania, to meet the needs of our customers with a highly trained and experienced staff of chemists.

In December of 2011, IsoSciences became part of the MPD Holdings group of companies including Monomer-Polymer and Dajac Labs and Silar Labs. This integration will allow IsoSciences to continue... Show more »

IsoSciences, LLC was formed in April of 2002 by Scott W. Landvatter, and David Saunders. We were senior chemists and managers in the isotope labeling group at SmithKline Beecham Pharmaceuticals. Following the merger of SmithKline Beecham with Glaxo Wellcome, we decided to leave the newly formed GSK Pharmaceuticals and start IsoSciences, LLC.

IsoSciences was founded to fulfill the market need for stable label isotopes of advanced intermediates and final drug substances. We have over 60 years combined experience in isotopic labeling. Since 2007, we have utilized specially designed laboratories in King of Prussia, Pennsylvania, to meet the needs of our customers with a highly trained and experienced staff of chemists.

In December of 2011, IsoSciences became part of the MPD Holdings group of companies including Monomer-Polymer and Dajac Labs and Silar Labs. This integration will allow IsoSciences to continue growing its operations and capabilities to better serve our clients' needs.

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Compound Synthesis
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IsoSciences develops custom synthesized internal standards to satisfy the needs of world leaders in diagnostic testing laboratories, research universities, pharmaceuticals and government agencies including CDC, NIH and NIST. The diverse nature of our expertise in 2H, 13C and 15N labeling techniques in heterocyclic, steroid, sugar,... Show more »

IsoSciences develops custom synthesized internal standards to satisfy the needs of world leaders in diagnostic testing laboratories, research universities, pharmaceuticals and government agencies including CDC, NIH and NIST. The diverse nature of our expertise in 2H, 13C and 15N labeling techniques in heterocyclic, steroid, sugar, vitamin, natural product, homo-/heterogeneous catalysis and for organosilicon chemistry has allowed IsoSciences to tackle virtually any synthetic project.

IsoSciences’ main focus is isotope chemistry. We work with our customers to design a compound with strategically placed isotopes to meet their needs. If the application is LC-MS/MS, the isotopes are placed in non-exchangeable positions and in desired molecule fragments to ensure the internal standard allows for accurate measurements. By shifting to 13C and 15N isotopes the customer can be assured they will receive a superior standard that co-elutes exactly with their analyte.

A complete certificate of analysis is issued with every compound. This includes structural identity by 1H-NMR and 13C-NMR, purity assessment by HPLC-UV, GC-FID or HPLC-ELSD and isotope incorporation by LC-MS/MS or GC-MS. IsoSciences compounds routinely analyze over 98% pure and 98% isotope incorporation with no unlabeled material detected.

IsoSciences looks forward to working with customers on any synthetic process. Whether a synthetic scheme is provided or requires a novel route, IsoSciences can rapidly deliver a quotation with anticipated delivery times. Our customers are continuously updated throughout the process and the structure is treated with the upmost confidentiality.

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Chemistry and Materials
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Synthetic Chemistry
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