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iRepertoire, Inc.

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Huntsville, Alabama, US

About iRepertoire, Inc.

iRepertoire was the first to develop and commercialize immune repertoire sequencing technology and products.

iRepertoire uses immune repertoire sequencing technology to access the body’s immunological memory, or “logbook” of all past infection and disease. Sequencing the immune repertoire can yield insights... Show more »

iRepertoire was the first to develop and commercialize immune repertoire sequencing technology and products.

iRepertoire uses immune repertoire sequencing technology to access the body’s immunological memory, or “logbook” of all past infection and disease. Sequencing the immune repertoire can yield insights into the nature of the body’s immune response to disease and infection. The future market for iRepertoire will be in clinical and research applications that require immune assessment such as drug treatment monitoring, identification of minimal residual disease (MRD), immune monitoring after stem cell transplantation, vaccine studies, and biomarker development.

iRepertoire provides primer kits and amplification to sequencing services to examine the TCR and BCR immune diversity in both humans and mice. iRepertoire also offers access to its proprietary repertoire analysis tools with the purchase of its regent systems.

iRepertoire’s reagent systems allow researchers to easily and inexpensively generate their own Next Generation Sequencing libraries in the convenience of their laboratory and analyze their data with the iRepertoire’s proprietary software pipeline at no additional cost.This year, iRepertoire has launched automated immune repertoire amplification and extraction on their sister company’s iC-processor (iCubate, Inc.).

Recent Publications

  • Lee, et. al. Characterization of T and B cell repertoire diversity in patients with RAG deficiency, Sci. Immunol. 1, eaah6109 (2016) 16 December 2016
    ​- Sims, J. et. al. Diversity and divergence of the glioma-infiltrating T-cell receptor repertoire. PNAS (2016) E3529-E3537.
    ​- Al-Hussaini, et. al. Targeting CD123 in acute myeloid leukemia using a T-cell--directed dual-affinity retargeting platform. Blood (2016). 127(1):122-131).
    ​- Yang, Yang, et al. Distinct mechanisms define murine B cell lineage immunoglobulin heavychain (IgH) repertoires. eLife 4 (2015): e09083.
    • Zhao et. al. Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells. Cell Stem Cell 17 (3 Sept 2015), 353-359.
    • O’Connell, Amy E. et al. Next Generation Sequencing Reveals Skewing of the T and B Cell Receptor Repertoires in Patients with Wiskott–Aldrich Syndrome. Frontiers in Immunology 5 (2014): 340. PMC. Web. 23 June 2015.
    • Sims, Jennifer, et al. IT-32 Divergence Of Intratumoral And Systemic T Cell Repertoires Reflects Local Monocyte Profiles During Glioma Progression. Neuro-Oncology 16.suppl 5 (2014): v116-v117.
    • Sims et al.: TCR repertoire divergence reflects micro-environmental immune phenotypes in glioma J ImmunoTherapy of Cancer 2014 2(Suppl 3):O19
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Diversity Certificates

Small business

Our Services (15)


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BCR Sequencing

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Sequencing Data Analysis and Management

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Illumina MiSeq Sequencing

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Next Generation Sequencing (NGS)

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We offer also offer BCR sequencing.

We offer also offer BCR sequencing.

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RNA Sequencing

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RNA Extraction and Purification

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Nucleic Acid Analysis

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Biology

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Biochemistry & Molecular Biology

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RNA Services

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Targeted Gene Sequencing

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DNA Sequencing

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Nucleic Acid Data Analysis

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DNA Services

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Nucleic Acid Services

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iRepertoire, Inc.

Field Applications Scientist

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