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iQ Biosciences

Berkeley, California, US

At iQ Biosciences, we provide focused research support to the pharmaceutical, biotechnology, and diagnostic industries in the form of intelligent research services and quality biospecimens. We are driven to go beyond being reliable – we excel at being a trusted partner in the biomedical community to help cure disease.

iQ Biosciences offers Bioservices for Research Testing, Drug Discovery, and Preclinical Studies that can help determine a drug product’s safety and mechanism of action. These services include testing services, in-vitro based safety or toxicology assays, and functional characterization using in-vitro assays or in-vivo pharmacology models.

We believe it’s urgent to help the biomedical research community deliver on therapeutic promises today.

We believe all researchers should have access to the highest standards of testing services and investigative approaches for qualitatively assessing or... Show more »

At iQ Biosciences, we provide focused research support to the pharmaceutical, biotechnology, and diagnostic industries in the form of intelligent research services and quality biospecimens. We are driven to go beyond being reliable – we excel at being a trusted partner in the biomedical community to help cure disease.

iQ Biosciences offers Bioservices for Research Testing, Drug Discovery, and Preclinical Studies that can help determine a drug product’s safety and mechanism of action. These services include testing services, in-vitro based safety or toxicology assays, and functional characterization using in-vitro assays or in-vivo pharmacology models.

We believe it’s urgent to help the biomedical research community deliver on therapeutic promises today.

We believe all researchers should have access to the highest standards of testing services and investigative approaches for qualitatively assessing or quantitatively measuring their test compound’s bioactivity at practical prices.

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iQ Biosciences has not listed any services.

Cytokine Release Assay
Price on request

-Help predict cytokine release (i.e. cytokine storms) induced by antibody-based therapeutics in first in-human trials or primate safety studies with iQ’s Cytokine Release Assay
-Assess cytokine release in response to therapeutic molecules using appropriately designed studies based on our direct experience with FDA feedback... Show more »

-Help predict cytokine release (i.e. cytokine storms) induced by antibody-based therapeutics in first in-human trials or primate safety studies with iQ’s Cytokine Release Assay
-Assess cytokine release in response to therapeutic molecules using appropriately designed studies based on our direct experience with FDA feedback (pre-IND meeting comments, etc.)
-Data is provided in appropriate formats, including raw data, PowerPoint slide summary, and appropriate report format to supplement potential IND or EMA filings
-All assays and methods are performed according to FDA and EMA recommended guidelines
-Our high throughput system and work flow with qualified donors give you high quality results with rapid turnaround

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In vitro Hemolysis Assay
Price on request

-Evaluate your small molecule, biologic, or formulation excipients for its potential to lyse red blood cells
-Personalized experimental design to ensure the most relevant data is obtained with the options to examine all relevant in vivo pharmacologically relevant blood from appropriate species
-All assays are performed with high-quality reagents and strict controls by experienced immunologists

-Evaluate your small molecule, biologic, or formulation excipients for its potential to lyse red blood cells
-Personalized experimental design to ensure the most relevant data is obtained with the options to examine all relevant in vivo pharmacologically relevant blood from appropriate species
-All assays are performed with high-quality reagents and strict controls by experienced immunologists

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ADCC and CDC Assays
Price on request

-Examine ADCC activity of your therapeutic antibody with iQ’s antibody-dependent cellular cytotoxicity assay (ADCC assay)
-We utilize two different approaches to evaluate ADCC activity:
-ADCC reporter assays using cell lines that have either the V Variant or F Variant of position 158 of the FcgRIIIa receptor
-ADCC... Show more »

-Examine ADCC activity of your therapeutic antibody with iQ’s antibody-dependent cellular cytotoxicity assay (ADCC assay)
-We utilize two different approaches to evaluate ADCC activity:
-ADCC reporter assays using cell lines that have either the V Variant or F Variant of position 158 of the FcgRIIIa receptor
-ADCC assays using primary cells (PBMCs, isolated NK cells) that have been characterized for V Variant or F Variant of position 158 of the FcgRIIIa receptor
-Personalized experimental design to ensure the most biologically relevant data is obtained
-Assays can be performed with purified effector cells or PBMCs
-Cell line expressing target antigen can be developed
-All assays are performed with high-quality reagents and strict controls by experienced immunologists

CDC Assays
-Help predict the potential magnitude of complement-mediated target lysis conferred by your therapeutic antibody with iQ’s complement-dependent cytotoxicity (CDC) assay
-Personalized experimental design to ensure the most relevant CDC inhibition data (IC50s) are generated with your molecules
-All assays are performed with high-quality reagents and strict controls by experienced immunologists
-Data is provided in appropriate formats, including PowerPoint slides and/or direct data files

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In vitro Antibody-Drug Conjugate Toxicity Testing
Price on request

-Evaluate your therapeutic antibody for internalization and antibody drug conjugate cytotoxicity potential
-Our workflow utilizes a two-step approach to evaluate potential ADC activity:
-Measurement of internalization kinetics on appropriate cell lines using your antibody
-Measurement of ADC mediated cytotoxicity... Show more »

-Evaluate your therapeutic antibody for internalization and antibody drug conjugate cytotoxicity potential
-Our workflow utilizes a two-step approach to evaluate potential ADC activity:
-Measurement of internalization kinetics on appropriate cell lines using your antibody
-Measurement of ADC mediated cytotoxicity potential using appropriate secondary antibodies conjugated to a ribosome-inactivating protein
-Personalized experimental design to ensure the most relevant biological data is obtained
-All assays are performed with high-quality reagents and strict controls by experienced immunologists

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Immune Checkpoint Assays
Price on request

Immune Checkpoint Interaction Assay:

  • Evaluate your immune checkpoint (CTLA-4, PD-1, TIM-3, LAG-3, TIGIT, OX40, GITR, etc.) biologic or molecule for specific binding to the receptor using ELISA or iQ’s cell line-based binding assay
  • Binding affinities (EC50s) or binding inhibition (IC50s) can be generated with your... Show more »

Immune Checkpoint Interaction Assay:

  • Evaluate your immune checkpoint (CTLA-4, PD-1, TIM-3, LAG-3, TIGIT, OX40, GITR, etc.) biologic or molecule for specific binding to the receptor using ELISA or iQ’s cell line-based binding assay
  • Binding affinities (EC50s) or binding inhibition (IC50s) can be generated with your molecules
  • Personalized experimental design to ensure the most relevant data is obtained
  • All assays are performed with high-quality reagents and strict controls by experienced immunologists

Immune Checkpoint Functional Assay:

  • Evaluate your immune checkpoint (CTLA-4, PD-1, TIM-3, LAG-3, TIGIT, OX40, GITR, etc.) biologic or small molecules in functional assays
  • Assays to measure activity (CellTiter-Glo, LDH, etc.) can be performed with appropriate cell lines that express your biologically relevant target in presence of your biologic or molecules
  • Assays to measure proliferation, expression of cell surface activation markers, and cytokine expression can be performed with primary cells using non-antigen specific (superantigens) or antigen specific approaches in the presence of your molecule
  • Personalized experimental design to ensure the most relevant data is obtained
  • All assays are performed with high-quality reagents and strict controls by experienced immunologists
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Flow Cytometry
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Immunophenotyping
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Endotoxin Testing
Price on request

We measure the amount of endotoxin in a protein, peptide, or antibody sample using the Limulus Amebocyte Lysate (LAL) chromogenic assay. Known concentrations of E. coli O111:B4 are used as our standard for accurate endotoxin quantitation. The sensitivity of our assay can detect as little as 0.1 EU/mL (approximately 0.01ng... Show more »

We measure the amount of endotoxin in a protein, peptide, or antibody sample using the Limulus Amebocyte Lysate (LAL) chromogenic assay. Known concentrations of E. coli O111:B4 are used as our standard for accurate endotoxin quantitation. The sensitivity of our assay can detect as little as 0.1 EU/mL (approximately 0.01ng endotoxin per mL).

iQ Biosciences research professionals have performed thousands of endotoxin testing assays for clients. We provide a fast turnaround time and the highest quality testing to determine if test samples are endotoxin-free and safe for in-vitro or in-vivo research use.

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In vivo Immunogenicity Assays
Price on request
  • Evaluate your small molecule, biologic, or formulation excipients for its potential to bind or activate primary cells from multiple species (human, non-human primate, rodent)
  • We routinely perform immunophenotyping of in vitro or in vivo (safety, PD, xenograft, or clinical studies) treated samples (cell lines or primary cells)... Show more »
  • Evaluate your small molecule, biologic, or formulation excipients for its potential to bind or activate primary cells from multiple species (human, non-human primate, rodent)
  • We routinely perform immunophenotyping of in vitro or in vivo (safety, PD, xenograft, or clinical studies) treated samples (cell lines or primary cells) for specific protein target expression on cell subsets or biomarker detection indicative of bioactivity (cell surface activation markers, cytokine detection)
  • Personalized experimental design to ensure the most biologically relevant data is obtained
  • These assays are applicable to multiple species (human, non-human primates, & rodents) for cross-reactivity assessment of your molecules
  • All assays are performed with high-quality reagents and strict controls by experienced immunologists
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Human
Mouse
Rat
Rodents
Nonhuman Primate
In vitro Immunogenicity Assays
Price on request
  • Evaluate your small molecule, biologic, or formulation excipients for its potential to bind or activate primary cells from multiple species (human, non-human primate, rodent)
  • We routinely perform immunophenotyping of in vitro or in vivo (safety, PD, xenograft, or clinical studies) treated samples (cell lines or primary cells)... Show more »
  • Evaluate your small molecule, biologic, or formulation excipients for its potential to bind or activate primary cells from multiple species (human, non-human primate, rodent)
  • We routinely perform immunophenotyping of in vitro or in vivo (safety, PD, xenograft, or clinical studies) treated samples (cell lines or primary cells) for specific protein target expression on cell subsets or biomarker detection indicative of bioactivity (cell surface activation markers, cytokine detection)
  • Personalized experimental design to ensure the most biologically relevant data is obtained
  • These assays are applicable to multiple species (human, non-human primates, & rodents) for cross-reactivity assessment of your molecules
  • All assays are performed with high-quality reagents and strict controls by experienced immunologists
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T Cell Activation and Proliferation Assays
Price on request

-Personalized experimental design to ensure the most biologically relevant data is obtained
-These assays are applicable to multiple species (human, non-human primates, & rodents) for cross-reactivity assessment of your molecules
-All assays are performed with high-quality reagents and strict controls by experienced... Show more »

-Personalized experimental design to ensure the most biologically relevant data is obtained
-These assays are applicable to multiple species (human, non-human primates, & rodents) for cross-reactivity assessment of your molecules
-All assays are performed with high-quality reagents and strict controls by experienced immunologists
-Assays include SEB Stimulation Assay, PHA Stimulation Assay, and CD3/CD28 Stimulation Assay

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Human Primary Cells
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Mixed Lymphocyte Reactions
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Immune Cell Assays
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Human Dendritic Cells
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Human B Cells
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Cytotoxicity Assays
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Cryostorage and Cryoprocessing
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Cryopreservation
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Contract Research
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Biospecimens
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Cells and Tissues
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Cytometry
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Cell-Based Assays
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Immunoassays
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Small Animal Toxicology Studies
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Rabbit
Mouse
Rat
Rodents
Cell and Tissue Culture
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Cell and Tissue Culture Services

Cell and Tissue Culture Services

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Primary Cell Culture
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Natural Killer Cell Cytotoxicity Assay
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Phosphoflow
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Assay Development
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Adherent Cell Cytometry
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MACS
Magnetic activated cell sorting
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Biomarker Analysis
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Immunoglobulin Quantification
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Custom Immunoassay Development
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Cytokine Storm Testing
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Biology
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Bioanalytical Assays
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Bioanalytical Assays Services

Bioanalytical Assays Services

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Cytokine Analysis
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Flow Cytometry Data Analysis
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Animal Models and Studies
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Project Management
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Compound IC50 Assays
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Bioanalysis
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Drug Discovery & Development
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Drug Discovery & Development Services

Drug Discovery & Development Services

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Human Immune Cell Assays
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FACS
Fluorescence Activated Cell Sorting
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Toxicology
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In vivo Toxicity Testing
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Biomarkers
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Pharmacology & Toxicology
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In vitro Toxicity Testing
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Biospecimen Management and Storage
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Testing of Cell Lines
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Functional & Cell Type Specific Assays
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Human Biospecimens
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2018-01-16 10:34:14 -0800

Net Promoter Score of 10 received for Immune Checkpoint Assays.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.

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