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IonDx, Inc.

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Monterey, California, US

About IonDx, Inc.

IonDx is a customer-centric analytical services laboratory equipped with disruptive BIG molecule technology.
We are your Electrospray Ion Mobility experts.

On Demand Direct Higher Order Structure: Our measurements cannot be made with any other instrument. We measure the size & shape (conformation)... Show more »

IonDx is a customer-centric analytical services laboratory equipped with disruptive BIG molecule technology.
We are your Electrospray Ion Mobility experts.

On Demand Direct Higher Order Structure: Our measurements cannot be made with any other instrument. We measure the size & shape (conformation) of giant biomolecules via a DIRECT ion mobility method that uses a combination of aerodynamics and electric fields.
Project Approach
1. Design: We plan your project as a seamless extension of your team, leveraging insights from our past projects. We thrive on tackling your analytical challenges involving macromolecules. We collaborate.
2. Method Development: Leverage our decades of experience electrospraying intact biomacromolecules to get the best biophysical fingerprints for your comparability studies.
3. IonDx Biophysical Fingerprint: Supplement your protein's biophysical fingerprint with IonDx's intact protein diagnostics. IonDx's value proposition provides gas-phase cross-sectional area of intact macromolecules. IonDx offers DIRECT higher order structure characterization, similar x-ray crystallography, NMR, cryo-EM, or SAXS. Unlike the other direct methods, IonDx's ion mobility spectrometer is compatible with high-throughput automated process development settings. We unravel conformational variability of biotherapeutic drug batches faster than existing indirect methods – providing cost-saving insights into batch purity & stability. Not only do we measure conformation - we also measure variation in conformation.
4. Data Analysis: Our proprietary IonDx biophysical fingerprints give you unique insight to stay ahead of the competition. Through data sharing, scientific collaboration, invoice management, a knowledgebase portal and case reporting, our customer community moves projects at your pace, and often even faster.

Our Experience:

>40 years focused on developing analytical instrumentation for biomacromolecules & nanomaterials

  • 100+ publications, >8000 citations, 20+ patents & >100 invited lectures
  • Key Scientists in the Human Genome Project and X-ray Free Electron Laser serial femtosecond crystallography
  • Decades of methods & technology development for mass spectrometry
  • Multiple licensed patents
  • Bioanalytical thought leaders published in Nature, Science, PNAS, Nature Methods, Analytical Chemistry, Journal of Biological Chemistry, Nature Communications, Physical Review Letters, Journal of Aerosol Science, Nature Physics, Journal of the American Society for Mass Spectrometry
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Our Services (22)


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Lipoprotein Analysis

Price on request
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Antibody Characterization

Price on request

Antibody Quality: Collision-cross sectional area by electrospray ion mobility (ESI-IMS)
Antibody Stability: Thermal Forced Degradation with ESI-IMS detection

Samples:
-monoclonal antibody (mAb)
-bispecific antibody
-antibody-drug conjugate
-biosimilar mAbs

Antibody Quality: Collision-cross sectional area by electrospray ion mobility (ESI-IMS)
Antibody Stability: Thermal Forced Degradation with ESI-IMS detection

Samples:
-monoclonal antibody (mAb)
-bispecific antibody
-antibody-drug conjugate
-biosimilar mAbs

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Stress Degradation Forced Degradation Electrospray Ion Mobility Differential Mobility Analysis stability Antibodies Proteins Biotherapeutics Biopharmaceuticals/Biologics Monoclonal antibodies IonDx Show 12 more tags Show less

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Forced Degradation Studies

Price on request

Thermal Forced Degradation Monitored by Electrospray Ion Mobility

Gain insights into intact protein higher order structure as a function of temperature. IonDx measures the collisional cross-sectional area of proteins by ion mobility to provide an orthogonal measure of stability to traditional DSC... Show more »

Thermal Forced Degradation Monitored by Electrospray Ion Mobility

Gain insights into intact protein higher order structure as a function of temperature. IonDx measures the collisional cross-sectional area of proteins by ion mobility to provide an orthogonal measure of stability to traditional DSC measurements.

Applications:
- Antibody drug stability
- Aggregation

Samples:
-monoclonal antibody (mAb)
-bispecific antibody
-antibody-drug conjugate
-biosimilar mAbs

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Forced Degradation stability Antibodies Proteins Monoclonal antibodies IonDx Show 6 more tags Show less

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ESI-IMS

Electrospray Ionization/Ion Mobility Spectrometry
Price on request

Macromolecule characterization by electrospray ion mobility

We can tackle any of your macromolecule challenges.
Biotherapeutic antibodies
Glycoproteins
Nanoparticles & conjugates
Exosomes
Lipoprotein particles
Viruses
Nanomaterials for non-biological complex drugs

All of these sample types, and more, have all been... Show more »

Macromolecule characterization by electrospray ion mobility

We can tackle any of your macromolecule challenges.
Biotherapeutic antibodies
Glycoproteins
Nanoparticles & conjugates
Exosomes
Lipoprotein particles
Viruses
Nanomaterials for non-biological complex drugs

All of these sample types, and more, have all been characterized using our mobility technology.

Most samples are characterized in 25-100mM ammonium acetate
Typical turn around is two weeks - but we are flexible to project needs
Typical Deliverables:
• Receiving samples at IonDx headquarters
• Analyze protein samples by native charge-reduced electrospray ion mobility
• Data analysis and interpretation of results
• Powerpoint presentation of results via BlueJeans web conferencing or client's provider
• Scientific report (Word Document)

We love a challenge!

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Electrospray Ion Mobility Differential Mobility Analysis Exosomes Proteins

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Polymer Characterization

Price on request

Polymer Quality: Collision-cross sectional area by electrospray ion mobility (ESI-IMS)
Polymer Stability: Thermal Forced Degradation with ESI-IMS detection

Measure higher order structures

Polymer conformations are related to physical properties like viscosity, and polymer-surfactant/ligand molecular interactions.

IonDx... Show more »

Polymer Quality: Collision-cross sectional area by electrospray ion mobility (ESI-IMS)
Polymer Stability: Thermal Forced Degradation with ESI-IMS detection

Measure higher order structures

Polymer conformations are related to physical properties like viscosity, and polymer-surfactant/ligand molecular interactions.

IonDx can differentiate structure variants/conformations not readily obtained with current analytical tools.

We will help to improve your process stream, monitor supply chain quality, or just get a better understanding of your macromolecules.

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Forced Degradation stability IonDx

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Protein Biophysical Characterization

Price on request

Intact Protein Higher Order Structure by Electrospray Ion Mobility

Samples:
Intact proteins & their covalent or noncovalent complexes
Typically >30kDa to 5 MDa

Applications:
-protein conformational analysis
-protein-protein interactions
-protein quantitation
-protein aggregation

Intact Protein Higher Order Structure by Electrospray Ion Mobility

Samples:
Intact proteins & their covalent or noncovalent complexes
Typically >30kDa to 5 MDa

Applications:
-protein conformational analysis
-protein-protein interactions
-protein quantitation
-protein aggregation

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Differential Mobility Analyzer Electrospray Ion Mobility Differential Mobility Analysis

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Material Testing Services

Price on request
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Protein Characterization

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Engineering and Fabrication

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Mass Spectrometry

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Spectroscopy

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Protein Services

Price on request
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Physical Analysis Methods

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Strength Analysis

Price on request
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Chemistry and Materials

Price on request
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Imaging & Spectroscopy

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Biochemistry & Molecular Biology

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Biology

Price on request
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Other Mass Spectrometry Methods

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Analytical Chemistry Services

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Antibody Services

Price on request
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Lipid Services

Price on request

Lipid Services

Lipid Services

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Mike Bogan

Director of Development
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www.iondx.com

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