InVitroMetrix creates a self-contained, cell-based multi-well drug discovery system for cell assay investigation of phenotypic changes due to drugs and targets for R&D.
During drug discovery, molecular target-based screening methods cannot examine all possible molecule and specific target interaction in humans. Other binding sites or non specific binding may lead to unexpected secondary actions causing unwanted side effects in humans.
Invitrometrix multi-well cell-based quartz crystal microbalance (QCM) aims to address the shortage of phenotypic screens in drug discovery and development. Our device provides a quantitative phenotypic cell-based investigation method.
Our QCM is a living whole cell biosensor that detects measurable changes in cellular biomechanics: attachment, mass redistribution, viscoelasticity. The system creates real-time, reproducible and robust experiment data and can be used with any adherent cell type.
The QCM can detect phenotypic changes in the cells as they respond to agents. We have detected:
The Invitrometrix system is for live cell research and is designed based on cell culture wells instead of fluidics systems. Our novel patented higher throughput multi-well live-cell QCM device is calibrated to a standard and all wells run concurrently. It is the only method that can provide direct real-time second-to-second information of cells’ mass distribution and viscoelastic properties.
Invitrometrix has developed an array of cell based biosensors to determine efficacy and safety of existing and future drugs by detecting real time changes in living cells due to drugs over multiple days.T he multi-well sensor system is designed to use any adherent live cells in culture, and is well suited to perform phenotypic research for the molecule pre-discovery, target identification and validation phases of drug discovery.
The InVitro-Q system offers:
Drug Candidate Safety Testing - Hepatotoxicity
Invitrometrix can provide in vitro cell based hepatotoxicity services. We can provide a wide range of studies and techniques for non-GLP studies, in addition to unique data that is provided by our novel whole cell, real time biosensor.
Investigation of drug induced liver toxicity:
Dose dependent toxicity
InVitro-Q: Real time MOA with fluorescence time point investigation
Cell viability assessment: LDH, Neutral Red, MTT, XTT, DAPI
Cell Stress & Membrane integrity: LDH, Mitotracker, JC-9, Tubulin
Mitochondrial dysfunction & toxicity: Mitochondrial membrane potential: Mitotracker, JC-9, MTT
Cytotoxicity & Apoptosis: LDH, Mitotracker, Live/Dead, Mitotracker, JC-9, Neutral Red
Inhibition of cell proliferation: MTT, DAPI
Liver: Hep-G2, Sk-Hep-1, primary cells upon request
Invitrometrix has developed a whole cell based biosensors to elucidate the mechanism of action elucidation and drug down selection during drug discovery.
The multi-well sensor system is designed to use any adherent live cells in culture, and is well suited to perform biomechanical phenotypic research for the molecule pre-discovery, target identification and validation phases of drug discovery.
InVitroMetrix has not received any reviews.
InVitroMetrix has not received any endorsements.