Invicro – Advanced Pathology Services, formerly Biocare Medical, LLC is an innovator in developing and supplying world class automated immunohistochemistry instrumentation and reagents for IHC, ISH and FISH testing. Our technical competencies lie within three core areas: (1) Immunohistochemistry and in situ hybridization, both chromogenic and fluorescent, for the analysis of solid tumor samples, (2) FISH probe design and manufacture, for both liquid based and solid tumor samples and (3) “boutique” CRO services.
Invicro – Advanced Pathology Service is a globally recognized leader in the development of innovative IHC and ISH assays and offers a comprehensive portfolio of IVD reagents and instrumentation for advanced staining. We understand the complex needs of both the research and clinical markets and have the ability to transform our scientific expertise into “real-world” applications designed to address critical diagnostic decision points, thus positively impacting patient outcomes. We have an established portfolio of detection reagents designed specifically for both human tissue (MACH™ detection systems) and animal tissue (promARK™ detection systems) which is used extensively in pharmaceutical research. Our Molecular division specializes in the discovery, development and manufacturing of FISH probes for the detection of genomic aberrations in both liquid based and solid tumor samples.
Given our expert technical knowledge and strong presence in the Pharma/Biotech sector through our commercial products, we have expanded our service offering to include CRO services which we refer to as our Diagnostic Development services. We provide our customers with full service R&D functions from assay development through commercialization on a fee per project basis.
Invicro – Advanced Pathology Service is headquartered, and has manufacturing facilities, in Concord, Calif., and has a global distribution network.
Staining of slides using dye based histology and histochemistry tests. Cut slides are preferred but paraffin wax block cutting is available at an extra charge . Stains include but are not limited to:
Periodic Acid Schiff's (PAS)
Picro Sirius Red
Turn around time - 1-2 weeks
Routine tissue processing and section cutting of formalin-fixed tissue, including H&E staining if required
Cryotomy of frozen tissue
Whole slide Imaging of stained slides
Quantitative Image analysis
Deliverables: cut sections, stained slides, slide images, quantitative analytical data or reports
Turnaround time: Typically 1-2 weeks but dependent on project scope
In CAP/CLIA accredited facility on frozen and FFPE sections. Sections can be provided directly by the researcher or cut in our lab.
IHC assay optimization including development of antibody cocktails to facilitate multiplex staining.
Micro-polymer based detection chemistries with high sensitivity and specificity optimized for a variety of species including human, monkey, rodent, rabbit, dog and cat.
Optimization of ISH assay conditions using your probe or custom Biocare design to your desired target
Complete assay development, implementation and training in your laboratory
Multiplex IHC and ISH assay feasibility and optimization
Combination gene and protein expression assays utilizing simultaneous colorimetric visualization on a single slide
Probe design, assay optimization and FISH staining on FFPE, blood and cytological fluids
DelTect technology available to reduce errors through truncation artifacts
Improved labeling technology and use of CGH and Patient Cohort data results in 'tight and bright' probes designed to reduce both false negatives and false positives
Samples can be sent as FFPE blocks, blood films or cytological preparations of body fluids including urine. Results can be imaged and made available electronically or returned as completed slides for the researchers own interpretation
Fluorescent labeling of primary antibodies utilizing a variety of different wavelength fluors and linker chemistries. Small volume feasibility lots to large volume batches for routine testing. RUO, IUO and IVD manufacture under GMP conditions
Screening of multiple clones of research antibody to determine optimum titer or target tissue
Sensitivity and specificity testing on multiple tissue and tumor types
Testing of a variety of antibody conditions to meet project requirements
Testing from multiple hostspecies, including rabbit, rodent, human
Invicro – Advanced Pathology Services has not received any reviews.
Invicro – Advanced Pathology Services has not received any endorsements.