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Invicro

24 Orders Completed
Boston, Massachusetts, US

About Invicro

Founded: 2008 Type: Privately Held Size: 51-200 employees

inviCRO was founded with a mission of improving the role and function of imaging in translational drug discovery and development. To this effort we offer a suite of services and software with applications ranging from tissue to human, from target identification to Phase 3 trials across the entire electromagnetic spectrum of imaging techniques.

We start all projects with a data-driven mentality and the knowledge that quality data are the key to solving scientific challenges. Our analytics team is constantly innovating to develop the processes by which true and valuable quantitative information is extracted.

Our approach has always been one of a scientific partner and collaborator, offering the service of our 150+ researchers on our team from a broad array of disciplines.

Select Recent Publications

  • Optimizing Central Nervous System Drug Development Using Molecular Imaging. Clin Pharmacol Ther. 2015 Jul;98(1):47-60. doi: 10.1002/cpt.132. Epub 2015 May 19.
  • Whole-body organ-level and kidney micro-dosimetric evaluations of 64Cu-loaded HER2/ErbB2-targeted liposomal doxorubicin (64Cu-MM-302) in rodents and primates. EJNMMI Research 2015, 5:24
  • Receptor Tyrosine Kinase EphA5 Is a Functional Molecular Target in Human Lung Cancer. J Biol Chem. 2015 Mar 20; 290(12): 7345–7359.
  • CIQuanT – Bridging the Gap between In Vivo and Ex Vivo Imaging by using Quantitative Whole Body Autoradiography (QWBA), 3D Cryo-Imaging (3DC) Techniques, and PET/CT. 2015 International Symposium on Biomedical Imaging; Session: Imaging Applications in the Biopharmaceutical Industry.
  • A Gradient-Loadable (64)Cu-chelator for Quantifying Tumor Deposition Kinetics of Nanoliposomal Therapeutics by PET. Nanomedicine. 2015 Jan;11(1):155-65. doi: 10.1016/j.nano.2014.08.011. Epub 2014 Sep 6.
  • Muscle RING finger-1 promotes a maladaptive phenotype in chronic hypoxia-induced right ventricular remodeling. PLoS One. 2014 May 8;9(5):e97084. doi: 10.1371/journal.pone.0097084. eCollection 2014.
  • PET/CT clinical protocol design for the novel, first in class 68Ga labeled guanylyl cyclase C targeted peptide MLN6907. AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA.

Our Services (58)


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Clinical Magnetic Resonance Imaging (MRI)

Clinical Magnetic Resonance Imaging
Price on request
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Biomarkers

Price on request

Biomarker is a “biological indicator” used to measure onset and progression of a disease or as a marker of drug safety such as body temperature, blood pressure and heart rate. Imaging biomarkers (i-Biomarker) are used at Imanova to:

Determine if the candidate drug reaches and engages the target
Quantify the relationship between administered dose and target engagement
Investigate the relationship between target and disease
Demonstrate dose-dependent functional effects of candidate drug
Define the ‘therapeutic window’ to optimise dose selection and minimise side effects
Imaging biomarkers have the advantage of being non-invasive and can be used for early detection of diseases, patient stratification, and provide an objective assessment for the response to treatment.

The main limiting factor for using molecular imaging studies for early stage drug development decision-making is the lack of available biomarkers. Imanova is an advocate of using imaging as an integral part of clinical research to help understand the basis of disease and in the support of the drug development process and has a dedicated i-Biomarker discovery and development service.

Imanova has developed and implemented 21 imaging biomarkers to Good Manufacturing Practice (GMP) standard since its inception. We have the capability and experience to help identify, evaluate, develop and implement biomarker candidates for use in both preclinical models and clinical (in humans) studies.

In addition to neurosciences, Imanova offers i-Biomarker development for other key therapeutic areas including oncology, inflammation, cardiology and respiratory diseases.


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Clinical Positron Emission Tomography

Price on request
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Immunofluorescence

Price on request

Quantitative Immunohistochemistry and immunofluorescence

Phosphor integrated dot (PID) are novel nanoparticles that provides uniform, stable and high-intensity fluorescence, providing sensitive and quantitative IHC while overcoming limitations of conventional immunofluorescent and immunohistochemical methods. PID imaging technology utilize standard IHC workflow allowing easy integration with existing antibodies and protocols as well as custom assay development. Fresh frozen and/or FFPE samples can be stained and analyzed. The workflow is automated thus reducing variance and making it highly consistent and reproducible. Importantly, the technique utilizes a versatile optical system and a dedicated image-processing software for PID quantitation on images. PIDs characteristics together with image processing, provides a quantitative diagnostic technology to measure the expression levels of target proteins on tissues.
We offer Quantitative IHC of various validated markers as well as custom assay validation to marker of interest.
Typical deliverables are whole slide images, high-resolution images of ROIs and image segmentation and quantitation with PID/cell output.
Staining instrumentation include: leica Bond Rx, Tissue-Tek Glas automated cover slipper, Hamamatsu NanoZoomer S60


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Immunohistochemistry (IHC)

Price on request

Quantitative Immunohistochemistry and immunofluorescence

Phosphor integrated dot (PID) are novel nanoparticles that provides uniform, stable and high-intensity fluorescence, providing sensitive and quantitative IHC while overcoming limitations of conventional immunofluorescent and immunohistochemical methods. PID imaging technology utilize standard IHC workflow allowing easy integration with existing antibodies and protocols as well as custom assay development. Fresh frozen and/or FFPE samples can be stained and analyzed. The workflow is automated thus reducing variance and making it highly consistent and reproducible. Importantly, the technique utilizes a versatile optical system and a dedicated image-processing software for PID quantitation on images. PIDs characteristics together with image processing, provides a quantitative diagnostic technology to measure the expression levels of target proteins on tissues.
We offer Quantitative IHC of various validated markers as well as custom assay validation to marker of interest.
Typical deliverables are whole slide images, high-resolution images of ROIs and image segmentation and quantitation with PID/cell output.
Staining instrumentation include: leica Bond Rx, Tissue-Tek Glas automated cover slipper, Hamamatsu NanoZoomer S60


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Fluorescence-Based Assays

Price on request

In support of providing in-vivo imaging services, inviCRO’s histology and tissue imaging team has expertise in histology, IHC, quantitative whole-body autoradiography (QWBA), and micro- and immersion autoradiography, among other techniques. Notably, we have developed a method termed Cryo-Fluorescence Tomography (CFT) that enables 3D visualization of fluorescent compound distribution in frozen tissue. These studies are often included as an endpoint assessment for in vivo studies, expanding the value and information obtained. We have experience in many therapeutic areas – oncology, neuroscience, bone, ocular, renal, inflammation, cardiovascular.

Our histology facilities are fully-equipped with cryostats, whole-body cryomacrotomes for frozen sections, and microtomes for cutting paraffin and plastic sections (including EXAKT grinding system). We have expertise in IHC custom stain development, double or triple labeling on frozen and paraffin sections, as well as plastic sections.

inviCRO specializes in the development of novel image analysis methods, leveraging VivoQuant and other internal tools for the quantification of image features from digitized slides.


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Small Animal SPECT Scan

Small Animal Single Photon Emission Computed Tomography Scan
Price on request

Our diverse team of experts has experience in instrument engineering, signal processing, and pharmaceutical R&D; collectively resulting in a long history designing and executing in imaging studies. Our scientists have run hundreds of imaging studies across multiple therapeutic research areas – oncology, neuroscience, inflammation, cardiovascular, metabolic, and musculoskeletal – and our experience runs the gamut of applications. We understand the physiological and biochemical mechanisms that affect imaging – targets, models, kinetics, etc. This vast experience allows us to understand drug behavior and translate knowledge to effective studies and useful data.

We define imaging as assays that enable visualization of subcellular distribution and processes all the way to translational and diagnostic clinical imaging biomarkers – and everything in between. With all imaging techniques, we use methods to ensure data is quantifiable, and leverage our powerful analytics platform to ensure that results can be used to drive meaningful decisions.

Studies may be single or multi-modal and may combine multiple isotopes or contrast mechanisms. When designing any study, we combine imaging theory, published methods, and the technical and professional expertise of our staff.


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Small Animal PET Scan

Small Animal Positron Emission Tomography Scan
Price on request

Our diverse team of experts has experience in instrument engineering, signal processing, and pharmaceutical R&D; collectively resulting in a long history designing and executing in imaging studies. Our scientists have run hundreds of imaging studies across multiple therapeutic research areas – oncology, neuroscience, inflammation, cardiovascular, metabolic, and musculoskeletal – and our experience runs the gamut of applications. We understand the physiological and biochemical mechanisms that affect imaging – targets, models, kinetics, etc. This vast experience allows us to understand drug behavior and translate knowledge to effective studies and useful data.

We define imaging as assays that enable visualization of subcellular distribution and processes all the way to translational and diagnostic clinical imaging biomarkers – and everything in between. With all imaging techniques, we use methods to ensure data is quantifiable, and leverage our powerful analytics platform to ensure that results can be used to drive meaningful decisions.

Studies may be single or multi-modal and may combine multiple isotopes or contrast mechanisms. When designing any study, we combine imaging theory, published methods, and the technical and professional expertise of our staff.


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Imaging & Spectroscopy

Price on request

Our diverse team of experts has experience in instrument engineering, signal processing, and pharmaceutical R&D; collectively resulting in a long history designing and executing in imaging studies. Our scientists have run hundreds of imaging studies across multiple therapeutic research areas – oncology, neuroscience, inflammation, cardiovascular, metabolic, and musculoskeletal – and our experience runs the gamut of applications. We understand the physiological and biochemical mechanisms that affect imaging – targets, models, kinetics, etc. This vast experience allows us to understand drug behavior and translate knowledge to effective studies and useful data.

We define imaging as assays that enable visualization of subcellular distribution and processes all the way to translational and diagnostic clinical imaging biomarkers – and everything in between. With all imaging techniques, we use methods to ensure data is quantifiable, and leverage our powerful analytics platform to ensure that results can be used to drive meaningful decisions.

Studies may be single or multi-modal and may combine multiple isotopes or contrast mechanisms. When designing any study, we combine imaging theory, published methods, and the technical and professional expertise of our staff.


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Medicinal Chemistry

Price on request

inviCRO’s chemistry team has expertise in radiolabeling a wide range of compounds including small molecules, peptides, oligonucleotides, proteins, nanoparticles and cells to support nonclinical and translational research. Utilizing both in-house expertise and facilities along with a network of collaborators and consultants, we have access to a renowned network of knowledge in the field.

inviCRO’s capabilities include:

Strategy and method development for radiolabeling small molecules, peptides, oligonucleotides, proteins, nanoparticles and cells
Synthesis of PET and SPECT radiopharmaceuticals for related in vivo imaging and in vitro assays
A dedicated state-of-the-art cyclotron facility for production of short-lived isotopes
Quality control and immunoreactivity assays for tracer validation
Cell and/or tissue binding and cell internalization assay method development


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Radiolabeling/Radiosynthesis

Price on request

inviCRO’s chemistry team has expertise in radiolabeling a wide range of compounds including small molecules, peptides, oligonucleotides, proteins, nanoparticles and cells to support nonclinical and translational research. Utilizing both in-house expertise and facilities along with a network of collaborators and consultants, we have access to a renowned network of knowledge in the field.

inviCRO’s capabilities include:

Strategy and method development for radiolabeling small molecules, peptides, oligonucleotides, proteins, nanoparticles and cells
Synthesis of PET and SPECT radiopharmaceuticals for related in vivo imaging and in vitro assays
A dedicated state-of-the-art cyclotron facility for production of short-lived isotopes
Quality control and immunoreactivity assays for tracer validation
Cell and/or tissue binding and cell internalization assay method development


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Data Management

Price on request

iPACS® is inviCRO’s web-based project management system designed for image study management applications. This platform allows for the efficient management, distribution, analysis and presentation of images and data associated with studies. The iPACS study management analysis software is a sophisticated, time-saving, web-based resource designed for imaging laboratories. iPACS offers a wide range of functionality for the organizational, processing, reporting and regulatory needs of preclinical and clinical imaging efforts. World-wide internet access allows users to collaborate seamlessly. User activity, such as electronic signatures and an audit trail ensuring the necessary information for 21 CFR Part 11 compliance, can be tracked in the iPACS with version control. The iPACS portal has been widely accepted in top 25 pharmaceutical companies as their primary image study management system. The iPACS platform is available in four versions: the iPACS Discovery, VisualSonics iPACS, iPACS Clinical and the iPACS GLP.


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Image Analysis

Price on request

Our analytics platform lies at the heart of inviCRO’s unique capabilities. We employ a data-driven approach to study design and execution, which lends itself to meaningful data. Once the raw data are collected, inviCRO can leverage our computer science, biomedical engineering, mathematics, optics and image processing background for sophisticated analytics.

We have developed and validated analysis protocols across multiple imaging modalities, including but not limited to PET, SPECT, CT, MR, fluorescence, autoradiography, histology, and microscopy. These protocols have spanned numerous disease areas such as oncology, neurology, cardiology, and pulmonary in both the clinical and preclinical space.

Analysis and modeling can be customized to lab-specific efforts. We have built a team of analysts and developers covering a wide breadth and expertise and who pride themselves on both novel analysis development and fast, accurate turnaround for routine protocols. We can accommodate many applications, and studies of nearly any size.


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Histology and Pathology Services

Price on request

In support of providing in-vivo imaging services, inviCRO’s histology and tissue imaging team has expertise in histology, IHC, quantitative whole-body autoradiography (QWBA), and micro- and immersion autoradiography, among other techniques. Notably, we have developed a method termed Cryo-Fluorescence Tomography (CFT) that enables 3D visualization of fluorescent compound distribution in frozen tissue. These studies are often included as an endpoint assessment for in vivo studies, expanding the value and information obtained. We have experience in many therapeutic areas – oncology, neuroscience, bone, ocular, renal, inflammation, cardiovascular.

Our histology facilities are fully-equipped with cryostats, whole-body cryomacrotomes for frozen sections, and microtomes for cutting paraffin and plastic sections (including EXAKT grinding system). We have expertise in IHC custom stain development, double or triple labeling on frozen and paraffin sections, as well as plastic sections.

inviCRO specializes in the development of novel image analysis methods, leveraging VivoQuant and other internal tools for the quantification of image features from digitized slides.


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Microautoradiography

Price on request
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Small Animal Bioluminescence Imaging

Price on request

Our diverse team of experts has experience in instrument engineering, signal processing, and pharmaceutical R&D; collectively resulting in a long history designing and executing in imaging studies. Our scientists have run hundreds of imaging studies across multiple therapeutic research areas – oncology, neuroscience, inflammation, cardiovascular, metabolic, and musculoskeletal – and our experience runs the gamut of applications. We understand the physiological and biochemical mechanisms that affect imaging – targets, models, kinetics, etc. This vast experience allows us to understand drug behavior and translate knowledge to effective studies and useful data.

We define imaging as assays that enable visualization of subcellular distribution and processes all the way to translational and diagnostic clinical imaging biomarkers – and everything in between. With all imaging techniques, we use methods to ensure data is quantifiable, and leverage our powerful analytics platform to ensure that results can be used to drive meaningful decisions.

Studies may be single or multi-modal and may combine multiple isotopes or contrast mechanisms. When designing any study, we combine imaging theory, published methods, and the technical and professional expertise of our staff.


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MRI Data Analysis

Price on request

Our diverse team of experts has experience in instrument engineering, signal processing, and pharmaceutical R&D; collectively resulting in a long history designing and executing in imaging studies. Our scientists have run hundreds of imaging studies across multiple therapeutic research areas – oncology, neuroscience, inflammation, cardiovascular, metabolic, and musculoskeletal – and our experience runs the gamut of applications. We understand the physiological and biochemical mechanisms that affect imaging – targets, models, kinetics, etc. This vast experience allows us to understand drug behavior and translate knowledge to effective studies and useful data.

We define imaging as assays that enable visualization of subcellular distribution and processes all the way to translational and diagnostic clinical imaging biomarkers – and everything in between. With all imaging techniques, we use methods to ensure data is quantifiable, and leverage our powerful analytics platform to ensure that results can be used to drive meaningful decisions.

Studies may be single or multi-modal and may combine multiple isotopes or contrast mechanisms. When designing any study, we combine imaging theory, published methods, and the technical and professional expertise of our staff.


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Tomography Services

Computed tomography services
Price on request

Our diverse team of experts has experience in instrument engineering, signal processing, and pharmaceutical R&D; collectively resulting in a long history designing and executing in imaging studies. Our scientists have run hundreds of imaging studies across multiple therapeutic research areas – oncology, neuroscience, inflammation, cardiovascular, metabolic, and musculoskeletal – and our experience runs the gamut of applications. We understand the physiological and biochemical mechanisms that affect imaging – targets, models, kinetics, etc. This vast experience allows us to understand drug behavior and translate knowledge to effective studies and useful data.

We define imaging as assays that enable visualization of subcellular distribution and processes all the way to translational and diagnostic clinical imaging biomarkers – and everything in between. With all imaging techniques, we use methods to ensure data is quantifiable, and leverage our powerful analytics platform to ensure that results can be used to drive meaningful decisions.

Studies may be single or multi-modal and may combine multiple isotopes or contrast mechanisms. When designing any study, we combine imaging theory, published methods, and the technical and professional expertise of our staff.


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CT Image Analysis

Computed tomography image analysis
Price on request
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In vivo Protein Binding Assays

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VivoQuant Image Analysis

Price on request

VivoQuant™ is a DICOM compliant post-processing suite for image data combining fundamental viewing functionality with powerful analysis capabilities. VivoQuant (“VQ”) supports data from most imaging modalities including MR, PET, SPECT, CT, and Optical. Multiple display modes including orthogonal views, slice views, special co-registration multi-views as well as 3D MIPs and volume renderings allow users to optimally view information of interest. Built-in features allow imaging scientists to extract the information they need with minimal effort, including powerful tools for fine-tuning images and isolating, drawing and analyzing 3D regions of interest. VivoQuant’s integration with iPACS, a full image study data management platform, offers sophisticated data management, reporting and data sharing tools of VivoQuant-generated data.


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Cryo-Fluorescence Tomography

Cryo-Fluorescence Tomography
Price on request
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Quantitative Whole Body Autoradiography (QWBA)

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Imaging Technology Platforms

Price on request

Our diverse team of experts has experience in instrument engineering, signal processing, and pharmaceutical R&D; collectively resulting in a long history designing and executing in imaging studies. Our scientists have run hundreds of imaging studies across multiple therapeutic research areas – oncology, neuroscience, inflammation, cardiovascular, metabolic, and musculoskeletal – and our experience runs the gamut of applications. We understand the physiological and biochemical mechanisms that affect imaging – targets, models, kinetics, etc. This vast experience allows us to understand drug behavior and translate knowledge to effective studies and useful data.

We define imaging as assays that enable visualization of subcellular distribution and processes all the way to translational and diagnostic clinical imaging biomarkers – and everything in between. With all imaging techniques, we use methods to ensure data is quantifiable, and leverage our powerful analytics platform to ensure that results can be used to drive meaningful decisions.

Studies may be single or multi-modal and may combine multiple isotopes or contrast mechanisms. When designing any study, we combine imaging theory, published methods, and the technical and professional expertise of our staff.


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Medical Imaging Services

Price on request

Our diverse team of experts has experience in instrument engineering, signal processing, and pharmaceutical R&D; collectively resulting in a long history designing and executing in imaging studies. Our scientists have run hundreds of imaging studies across multiple therapeutic research areas – oncology, neuroscience, inflammation, cardiovascular, metabolic, and musculoskeletal – and our experience runs the gamut of applications. We understand the physiological and biochemical mechanisms that affect imaging – targets, models, kinetics, etc. This vast experience allows us to understand drug behavior and translate knowledge to effective studies and useful data.

We define imaging as assays that enable visualization of subcellular distribution and processes all the way to translational and diagnostic clinical imaging biomarkers – and everything in between. With all imaging techniques, we use methods to ensure data is quantifiable, and leverage our powerful analytics platform to ensure that results can be used to drive meaningful decisions.

Studies may be single or multi-modal and may combine multiple isotopes or contrast mechanisms. When designing any study, we combine imaging theory, published methods, and the technical and professional expertise of our staff.

As of February 2016, inviCRO has purchased MNI (Molecular Neuroimaging), a recognized leader in neurological-focused imaging and drug development. Now, with the exciting expansion of capabilities, inviCRO can provide a wide array of clinical imaging services through MNI as a division of inviCRO.

The research scientists and physicians at MNI have a unique capability in radioligand development and use of radioligands to establish target engagement in early clinical trials. We are proud to support the work of their internationally recognized team, and will together develop and execute large-scale clinical imaging trials for diagnosis, progression, and disease monitoring to support radiopharmaceutical and Phase 2-3 pharmaceutical development.


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Biochemistry & Molecular Biology

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Clinical Laboratory Services

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Biomolecular Interaction Analysis

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Animal Model in vivo Analyses

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Radiography

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Microscopy

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Radiochemistry

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Drug Discovery & Development

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Drug Discovery

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Biology

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Clinical and Anatomic Pathology

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Fluorescence Spectroscopy

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Animal in vivo Imaging

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Chemistry and Materials

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Clinical Research

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Spectroscopy

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Animal Models and Studies

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Pharmacology & Toxicology

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Pharmacology & Toxicology Services


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Bioanalysis

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Bioanalysis Services


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Bioinformatics

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Data Analysis

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Data Analysis Services


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Statistical Analysis

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Statistical Analysis Services


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Biostatistics & Bioinformatics

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Biostatistics & Bioinformatics Services


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DNA Sequencing

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Nucleic Acid Services

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Nucleic Acid Services


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DNA Services

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DNA Services


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Small Animal X-ray

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Protein Services

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Protein Services


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Protein Expression Visualization

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Protein Expression Visualization Services


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Immunostaining

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Immunostaining Services


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Pharmacology

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Pharmacology Services


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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
Price on request

ADME/DMPK Studies Services


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In vivo ADME/DMPK Studies

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In vivo ADME/DMPK Studies Services


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BC

Bill Cupelo

Sr. Director of Business Development
HD

Howard Dobson

Director, translational medicine

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