Integrated Tissue Dynamics LLC

Intidyn was created to address the challenge of translating basic research into therapies...

The biopharmaceutical industry’s greatest challenge is translating basic molecular and cellular discoveries into useful therapies for humans.

A cost-effective solution...

Integrated Tissue Dynamics (INTIDYN) provides a solution to this problem with a highly cost-effective and informative technique for understanding signaling and basic biology in the context of complex systems. Our approach is an analytical method we call Intidyn ChemoMorphometric Analysis, or ITD-CMA™. This technique combines multi-molecular immunochemistry, genomic and morphological analyses of complex tissue to create a comprehensive and exceptionally informative picture of what’s happening not only at the site of interest, but in adjacent sites and systems as well. Using nonhuman or human tissue biopsies to: (1) analyze the safety and efficacy of therapeutics, (2) understand disease pathology, or (3) study the effect of toxins on living tissues, ITD-CMA™ can validate therapeutic strategies and also reveal previously unknown impacts and changes in underlying functional systems, such as the nerves and vasculature, and the immune, endocrine, regenerative and thermoregulatory systems. This technique is widely used by drug development companies and is applicable to any step in the process, from preclinical to Phase IV post-marketing studies.

Your Partner for developing the actionable data needed to advance your project...

INTIDYN partners with our clients to expand their knowledge and research capabilities, as evidenced by an established track record of contract work with industry, international collaborations and research publications.

Selected Publications

• Albrecht PJ, Hou Q, Argoff CE, Storey JR, Wymer JP, Rice FL (2013) Excessive peptidergic sensory innervation of cutaneous arteriole-venule shunts (avs) in the palmar glabrous skin of fibromyalgia patients: implications for widespread deep tissue pain and fatigue. Pain Med. [Epub ahead of print].
  
• Barr TP, Albrecht PJ, Hou Q, Mongin AA, Strichartz GR, Rice FL (2013) Air-stimulated ATP release from keratinocytes occurs through connexin hemichannels. PLoS One 8:e56744.
  
• Schley M, Bayram A., Rukweid R, Dusch M, Konrad C, Benrath J, Geber C, Birklein F, Hägglöf B, Sjögren N, Gee L, Albrecht PJ, Rice FL, Schmelz M (2012) Skin innervation at different depths correlates with small fibre function but not with pain in neuropathic pain patients. Eur J Pain 16:1414-1425.
  
• Abdo H, Li L, Lallemend F, Bachy I, Xu XJ, Rice FL, Ernfors P (2011) Dependence on the transcription factor Shox2 for specification of sensory neurons conveying discriminative touch. Eur J Neurosci 34: 1529-1541.
  
• Hou Q, Barr TP, Gee LE, Vickers JT, Wymer JP, Borsani E, Rodella LF, Getsios S, Burdo TH, Eisenberg E, Guha U, Lavker RM, Kessler JA, Chittur SV, Fiorino DF, Rice FL, Albrecht PJ (2011) Keratinocyte Expression of CGRPβ: Implications for Neuropathic and Inflammatory Pain Mechanisms. Pain 9:2036-2051.
  
• Hough LB, Rice FL (2011) H3 receptors and pain modulation: peripheral, spinal, and brain interactions. J Pharmacol Exp Ther, 336:30-37.
  
• Bowsher D, Woods CG, Nicholas A, Carvalho, OM, Haggett C, Tedman B, Mackenzie J, Crooks D, Mahmood N, Twomey A, Hann S, Jones D, Wymer JP, Albrecht PJ, Argoff CE, Rice FL (2009) Absence of pain with hyperhidrosis: a new syndrome where vascular afferents may mediate cutaneous sensation. Pain 147: 287-298.
  
• Luo W, Enomoto H, Rice FL, Milbrandt J, Ginty DD (2009) Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. Neuron 64, 841–856.