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Integral Molecular

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Philadelphia, Pennsylvania, US

About Integral Molecular

Integral Molecular is a research-driven biotechnology company enabling antibody discovery against complex membrane proteins. The company provides characterization services, reagents, and a full antibody discovery platform optimized to work with membrane protien targets, including GPCRs, ion channels,... Show more »

Integral Molecular is a research-driven biotechnology company enabling antibody discovery against complex membrane proteins. The company provides characterization services, reagents, and a full antibody discovery platform optimized to work with membrane protien targets, including GPCRs, ion channels, and transporters.

Founded in 2001, Integral has worked with over 300 different partners and customers, including all top 10 pharmaceutical companies.

 

Recent Publications

Structural basis of a potent human monoclonal antibody against Zika virus targeting a quaternary epitope. LONG, ET AL. 2019. *PNAS* DOI: 10.1073/PNAS.1815432116.

Systematic analysis of monoclonal antibodies against Ebola virus GP defines features that contribute to protection. SAPHIRE, ET AL. 2018. *CELL* 174(4):938-952.

Isolation of state-dependent monoclonal antibodies against the 12-transmembrane domain glucose transporter 4 using virus-like particles. TUCKER, ET AL. 2018. *PNAS* 115(22):E4990-E4999.

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Our Services (3)


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Epitope Mapping

Price on request

Our high-throuput Shotgun Mutagenesis Epitope Mapping technology can map the binding site of an antibody or small molecule at single amino-acid resolution, even on conformationally-complex proteins such as GPCRs, ion channels, transporters, and viral envelope proteins.

Our high-throuput Shotgun Mutagenesis Epitope Mapping technology can map the binding site of an antibody or small molecule at single amino-acid resolution, even on conformationally-complex proteins such as GPCRs, ion channels, transporters, and viral envelope proteins.

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Antibody Discovery

Price on request

The MPS Antibody Discovery platform overcomes the key challenges in isolating antibodies against difficult targets by:

  1. Mainting antigens in their native cofnormation.
  2. Isolating diverse panels of MAbs to find rare agonists/antagonists.
  3. Obtaining high-titer responses, even for highly conserved proteins.

The MPS Antibody Discovery platform overcomes the key challenges in isolating antibodies against difficult targets by:

  1. Mainting antigens in their native cofnormation.
  2. Isolating diverse panels of MAbs to find rare agonists/antagonists.
  3. Obtaining high-titer responses, even for highly conserved proteins.
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Lipoparticle Production

Price on request

Lipoparticles are virus-like particles (~150nm) that capture concentrated, structurally intact membrane proteins directly from the cell surface. Each preparation of Lipoparticles contains a user-defined membrane protein and is tested using up to 16 quality control metrics.

Lipoparticles are virus-like particles (~150nm) that capture concentrated, structurally intact membrane proteins directly from the cell surface. Each preparation of Lipoparticles contains a user-defined membrane protein and is tested using up to 16 quality control metrics.

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