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Integral Molecular

Philadelphia, Pennsylvania, US

Integral Molecular is a research-driven biotechnology company creating innovative technologies and a pipeline of therapeutic antibodies for under-exploited membrane protein targets, including GPCRs, ion channels, transporters, and viral envelopes. The Company has over a decade of experience in optimizing membrane proteins, enabling the isolation, characterization, and engineering of monoclonal antibodies against otherwise intractable membrane protein targets. Integral Molecular has worked with over 100 different partners and customers, including all of the top 10 pharmaceutical companies.

Integral membrane proteins include some of the most important therapeutic targets. Yet these types of proteins are very difficult to study due to their structural complexity and inability to be removed from the lipid membrane in conformationally-intact states. At Integral Molecular, we develop innovative technologies and products... Show more »

Integral Molecular is a research-driven biotechnology company creating innovative technologies and a pipeline of therapeutic antibodies for under-exploited membrane protein targets, including GPCRs, ion channels, transporters, and viral envelopes. The Company has over a decade of experience in optimizing membrane proteins, enabling the isolation, characterization, and engineering of monoclonal antibodies against otherwise intractable membrane protein targets. Integral Molecular has worked with over 100 different partners and customers, including all of the top 10 pharmaceutical companies.

Integral membrane proteins include some of the most important therapeutic targets. Yet these types of proteins are very difficult to study due to their structural complexity and inability to be removed from the lipid membrane in conformationally-intact states. At Integral Molecular, we develop innovative technologies and products that address these demanding yet important targets.

Founded in 2001, Integral Molecular holds intellectual property rights covering all aspects of its technologies, including core patents licensed exclusively from the University of Pennsylvania.

Recent Publications

  • Rapid isolation of Dengue-Neutralizing Antibodies from Single Cell-Sorted Human Antigen-Specific Memory B-Cell Cultures. COX, ET AL. 2016. mAbs 8(1):129-140.
  • Dengue Virus prM-Specific Human Monoclonal Antibodies with Virus Replication-Enhancing Properties Recognize a Single Immunodominant Antigenic Site.
    SMITH, ET AL. 2016. JOURNAL OF VIROLOGY 90(2):780-789.
  • Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection. FLYAK, ET AL. 2016. CELL 164(3):392-405.
  • Neutralizing Monoclonal Antibodies Block Chikungunya Virus Entry and Release by Targeting an Epitope Critical to Viral Pathogenesis. JIN, ET AL. 2016. CELL REPORTS 13(11): 2553-2564.
  • Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress. FOX, ET AL. 2015. CELL 163(5):1095-1107.
  • Cryo-EM structures Elucidate Neutralizing Mechanisms of anti-Chikungunya Human Monoclonal Antibodies with Therapeutic Activity. LONG, ET AL. 2015. PNAS 112(45):13898-13903.
  • Mechanism of Binding to Ebola Virus Glycoprotein by the ZMapp, ZMAb, and MB-003 Cocktail Antibodies. DAVIDSON, ET AL. 2015. JOURNAL OF VIROLOGY 89(21) 10982-10992.
  • Optimizing Membrane Protein Expression: Improving Surface Expression and Stability for Antibody and Vaccine Discovery. DORANZ, ET AL. 2015. GENETIC ENGINEERING NEWS VOL. 35, NO. 15.
  • Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus. SMITH, ET AL. 2015. CELL HOST MICROBE 18(1):86-95.
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Antibody Discovery
Price on request

The MPS Discovery Engine®
Discover MAbs against high-value difficult membrane protein targets.

This platform uses specialized techniques to discover and characterize conformation monoclonal antibodies against complex membrane protein targets. This includes the use of:
-Optimized native conformation antigens presented on... Show more »

The MPS Discovery Engine®
Discover MAbs against high-value difficult membrane protein targets.

This platform uses specialized techniques to discover and characterize conformation monoclonal antibodies against complex membrane protein targets. This includes the use of:
-Optimized native conformation antigens presented on Lipoparticles
-DNA + Lipoparticle immunization for robust immune responses
-Microfluidic B Cell cloning and phage display to isolate rare antibodies

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Antibody Affinity Maturation
Price on request

Comprehensive and combinatorial mutagenesis is used to identify protein and antibody variants with desired properties. Prior projects have included optimizing membrane protein surface expression, enhancing the solubility of membrane proteins, humanizing antibodies, and conducting antibody affinity maturation.

Comprehensive and combinatorial mutagenesis is used to identify protein and antibody variants with desired properties. Prior projects have included optimizing membrane protein surface expression, enhancing the solubility of membrane proteins, humanizing antibodies, and conducting antibody affinity maturation.

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Membrane Protein Expression
Price on request

Comprehensive and combinatorial mutagenesis is used to identify protein and antibody variants with desired properties. Prior projects have included optimizing membrane protein surface expression, enhancing the solubility of membrane proteins, humanizing antibodies, and conducting antibody affinity maturation.

Comprehensive and combinatorial mutagenesis is used to identify protein and antibody variants with desired properties. Prior projects have included optimizing membrane protein surface expression, enhancing the solubility of membrane proteins, humanizing antibodies, and conducting antibody affinity maturation.

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Epitope Mapping
Price on request

Using comprehensive mutation libraries, the binding site of an antibody, drug, or other protein can be mapped, even on conformationally-complex proteins such as GPCRs and viral envelope proteins with greater than 95% success.

Custom epitope mapping services include automated creation of a mutation library (e.g. Ala scan) for a... Show more »

Using comprehensive mutation libraries, the binding site of an antibody, drug, or other protein can be mapped, even on conformationally-complex proteins such as GPCRs and viral envelope proteins with greater than 95% success.

Custom epitope mapping services include automated creation of a mutation library (e.g. Ala scan) for a customer-specified target sequence and testing of antibody binding to determine contact residues.

Pre-validated Shotgun Mutagenesis libraries are also available for epitope and other mapping projects, allowing for expedited project turnaround time.

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epitope mapping
Shotgun Mutagenesis
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Shotgun Mutagenesis is Integral Molecular’s proprietary comprehensive protein structure mapping and engineering platform. Hundreds to thousands of mutations are introduced throughout a target protein and individually tested in human cells by high-throughput screening. The combination of large-scale mutagenesis and rapid cellular... Show more »

Shotgun Mutagenesis is Integral Molecular’s proprietary comprehensive protein structure mapping and engineering platform. Hundreds to thousands of mutations are introduced throughout a target protein and individually tested in human cells by high-throughput screening. The combination of large-scale mutagenesis and rapid cellular testing of natively folded proteins enables us to rapidly identify and engineer critical domains in structurally complex proteins within a fraction of the time conventionally required.

Applications include epitope mapping, antibody engineering (affinity maturation and humanization), and protein engineering.

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Reporter Virus Particles
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Reporter Virus Particles (RVPs) - Dengue Neutralization Assay
Use Dengue Reporter Virus Particles to measure antibody neutralization against each of the four Dengue serotypes.

Reporter Virus Particles enable viral infectivity, neutralization, and enhancement studies. RVPs are antigenically identical to wild-type viruses with a... Show more »

Reporter Virus Particles (RVPs) - Dengue Neutralization Assay
Use Dengue Reporter Virus Particles to measure antibody neutralization against each of the four Dengue serotypes.

Reporter Virus Particles enable viral infectivity, neutralization, and enhancement studies. RVPs are antigenically identical to wild-type viruses with a modified RNA genome that renders them replication incompetent. Infection of permissive cells using RVPs is monitored directly by expression of a reporter gene.

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Membrane Proteome Array
Price on request

Determine the target specificity of monoclonal antibodies using an array of proteins expressed in human cells, representing nearly the entire membrane proteome.

The Membrane Proteome Array evaluates antibody target specificity and off-target interactions, identifies the targets of orphan antibodies, and delivers detailed comparative binding profiles for biosimilars.

Determine the target specificity of monoclonal antibodies using an array of proteins expressed in human cells, representing nearly the entire membrane proteome.

The Membrane Proteome Array evaluates antibody target specificity and off-target interactions, identifies the targets of orphan antibodies, and delivers detailed comparative binding profiles for biosimilars.

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Lipoparticle Production
Price on request

Lipoparticles are virus-like particles (VLPs) containing high concentrations of specific membrane proteins in their native conformation. Lipoparticles capture conformationally-intact membrane proteins directly from the cell surface, enabling these complex proteins to be manipulated as soluble proteins for antibody immunization and screening.

Lipoparticles are virus-like particles (VLPs) containing high concentrations of specific membrane proteins in their native conformation. Lipoparticles capture conformationally-intact membrane proteins directly from the cell surface, enabling these complex proteins to be manipulated as soluble proteins for antibody immunization and screening.

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Therapeutic Monoclonal Antibody (mAb) Development
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Virology Services
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Antibody Services
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Protein Expression
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Virus Production
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