Ksgzly1hr0exwh3rtqa7 image

INOTIV

11 Orders Completed
West Lafayette, Indiana, US

About INOTIV

Founded: 1974 Type: Public Company Size: 201-500 employees

Analyze. Answer. Advance


Answering the right questions on time and with high-quality data is the key to achieving your objectives. At Inotiv, clinical decision support is our focus: We deliver the comprehensive and integrated range of right-size toxicology services, analysis, bioanalysis, and DMPK and consulting solutions essential to your success.


In choosing a laboratory partner, Expect more: more attention, more insight, and a superlative experience. You’ve worked hard to get this far, and you deserve a provider aligned to your needs and goals.


Through scientific leadership and ongoing investments, Inotiv delivers a comprehensive range of nonclinical and analytical services that will exceed your expectations. Benefit from our long and impeccable regulatory history, world-class team of scientists, and track record of providing attentive, decisive service.

Our Services (66)


ic

Toxicology

Price on request

Studies: Pilot/lead optimization, Acute, Sub-chronic, Chronic
Species: Rodents, Canines, Nonhuman Primates, Swine/Minipigs, Rabbits, Guinea pigs
Routes of Administration: Oral (Gavage, Capsule/tablet), Parenteral (Intramuscular, Intraperitoneal, Intravenous, Subcutaneous, Sublingual, Dermal, Intradermal, Ocular, Intravaginal, Rectal, Intranasal)


ic

In vivo PK/PD Studies

Price on request

Our in vivo automated sampling lab is one of the largest in the USA. We have stationed 48 automated sampling Culex systems for a quick turn-around of your PKPD data. Our goal is to provide you with studies that meet your unique information needs while minimizing the number of study animals.


ic

Humanized Mouse Models

Price on request

Seventh Wave offers pharmacology studies in liver humanized FRG® KO mice through a partnership with Yecuris to provide the most predictive approach available to study new human liver disease therapies. As with our other laboratory services, Seventh Wave supports our clients with study design, conduct, and result interpretation.

We have more than 2 years of experience developing and validating pharmacology studies in these models and have successfully executed multiple client sponsored studies.

Seventh Wave is the exclusive provider of services related to hepatitis B virus and C virus pharmacology studies using the humanized FRG® KO model. Yecuris’ models are highly repopulated with human liver cells, making them and ideal candidate for infectious disease and gene delivery/gene therapy studies:

Infectious disease: These models have been validated for hepatotropic disease, especially hepatitis. Please contact us to discuss additional applications in liver disease.

Gene Delivery/Gene therapy: We have demonstrated this model’s utility for evaluating gene therapy and gene delivery technology, evaluating expression using in vivo imaging.


ic

In vitro Bioavailability/Bioequivalence Studies

Price on request

BASi® has proven experience and expertise with the FDA guidance documents and regulations on In Vitro Bioequivalence studies. The group's pharmaceutical product testing expertise mixed with the corporation's knowledge of bioequivalence studies and regulations creates the perfect match for our In Vitro services. BASi leverages the FDA guidances and all applicable literature sources to develop a sound scientific, regulatory plan.


ic

Histology and Pathology Services

Price on request

All Seventh Wave pathologists are ACVP board certified and our service is fully GLP compliant. Seventh Wave pathologists have, on average, approximately 20 years of drug development experience.

We assign a pathologist to provide expert evaluation of your drug candidate whether your study is performed at Seventh Wave or at another laboratory. The same pathologist can stay with your candidate, providing scientific continuity and consistency of evaluations throughout the life cycle of your compound.

Services Include:

  • GLP Compliant processes, data and reporting systems
  • Rapid and flexible scheduling, fast turnaround times
  • Broad therapeutic expertise
  • Primary review, Peer Review or both for all study types
  • Necropsy participation
  • Reporting

Histology Lab Services:

  • GLP-compliant
  • Robust QC and QA staffing
  • Routine tissue trimming, paraffin embedding, and sectioning
  • H&E staining
  • Non-routine dissections and tissue harvesting
  • Customized trimming and sampling
  • Medical device support
  • Serial sectioning and serial step sectioning
    Special Histology and Pathology Services
  • Frozen sections including serial and step sectioning
  • Plastic embedding and sectioning
  • Immunohistochemistry and immunofluorescence
  • Image analysis (multiple platforms)
  • Stereology (multiple platforms)
  • Electron microscopy

Drug Discovery immunohistochemistry FFPE tissue Frozen Tissue Mouse Rat Rabbit Dog Pig Show 9 more tags Show less

ic

DART Studies

Developmental and Reproductive Toxicology Studies
Price on request
Request a quote for more information about this service.
Rat Mouse Non-human primates (NHP) Dog Pig Minipig Rabbit Guinea pig Show 8 more tags Show less

ic

LC-MS

Liquid Chromatography-Coupled Mass Spectrometry
Price on request
Request a quote for more information about this service.

ic

Hepatitis B Virus (HBV)-Infected Human Serum

Price on request
Request a quote for more information about this service.

ic

Assay Development

Price on request
Request a quote for more information about this service.

ic

Hepatitis B Virus (HBV)-Infected Human Plasma

Price on request
Request a quote for more information about this service.

ic

Small Molecule Bioanalysis

Price on request
Request a quote for more information about this service.

ic

Animal Necropsy Services

Price on request

Necropsy

  • On-site or remote necropsy
  • Specialized perfusions and/or dissections
  • Oversight by an ACVP-certified pathologist

Rat Mouse Rabbit Pig Dog

ic

Dermal Toxicity Studies

Price on request
Request a quote for more information about this service.
Rat Mouse Guinea pig Pig Minipig Dog Rabbit Non-human primates (NHP) Show 8 more tags Show less

ic

Microscopy

Price on request

Our laboratory provides industry-recognized expertise in quantitative microscopy. Consultation and design-based techniques coupled with broad histochemical/immunohistochemical capabilities and knowledge of various disease states create the best possible quantitative evaluations.
Image Analysis:

  • Computer assisted, high throughput capability
  • Multiple image analysis platforms are used, including Visiomorph™ and Halo™
    Stereology:
  • Unbiased, design-based, using statistically proven principals
  • Multiple stereology platforms are used, including NewCast™
    Examples include:
  • Muscle fiber cross-sectional area and Feret’s diameter
  • Co-expression of markers; double-stain positivity in the cytoplasm or nucleus
  • Area and area ratios; volume and volume ratios (e.g. volume of infarcted tissue, collagen, or mucus in an organ)
  • Membrane marker quantitation
  • Immune cells in tumors
  • Object quantitation (e.g. microvessels, amyloid plaque, glomeruli, islets)
  • Number of cells in a structure or organ
  • Microglial activation
  • Layer thickness
  • Proliferation assays
    Reporting:
  • Interpretive reports with illustrative images are prepared by Seventh Wave Pathologists

Visiopharm NewCast™ HALO™

ic

Immunofluorescence

Price on request
Request a quote for more information about this service.

ic

Liquid Chromatography (LC)

Price on request
Request a quote for more information about this service.

ic

Pharmacology & Toxicology

Price on request
Request a quote for more information about this service.

ic

Storage

Price on request
Request a quote for more information about this service.

ic

Immunohistochemistry (IHC)

Price on request
Request a quote for more information about this service.

ic

Drug Discovery & Development

Price on request
Request a quote for more information about this service.

ic

Image Analysis

Price on request
  • Computer assisted, high throughput capability
  • Multiple image analysis platforms are used, including Visiomorph™ and Halo™

Visiopharm HALO™

ic

R&D Services

Price on request
Request a quote for more information about this service.

ic

Stereology

Price on request
  • Unbiased, design-based, using statistically proven principals
  • Multiple stereology platforms are used, including NewCast™

NewCast™

ic

In vivo Toxicity Testing

Price on request
Request a quote for more information about this service.

ic

Preclinical Study Design

Price on request
Request a quote for more information about this service.

ic

Biochemistry & Molecular Biology

Price on request
Request a quote for more information about this service.

ic

Animal Model in vivo Analyses

Price on request
Request a quote for more information about this service.

ic

Clinical Laboratory Services

Price on request
Request a quote for more information about this service.

ic

Imaging & Spectroscopy

Price on request
Request a quote for more information about this service.

ic

HPLC

High Performance Liquid Chromatography
Price on request
Request a quote for more information about this service.

ic

Discovery Pathology

Price on request
Request a quote for more information about this service.

ic

Drug Discovery

Price on request
Request a quote for more information about this service.

ic

Project Management

Price on request
Request a quote for more information about this service.

ic

Contract Research

Price on request
Request a quote for more information about this service.

ic

Process Consulting

Price on request
Request a quote for more information about this service.

ic

Consulting

Price on request
Request a quote for more information about this service.

ic

Biology

Price on request
Request a quote for more information about this service.

ic

Clinical Sample Analysis

Price on request
Request a quote for more information about this service.

ic

Clinical and Anatomic Pathology

Price on request
Request a quote for more information about this service.

ic

Toxicity Animal Models

Price on request
Request a quote for more information about this service.
Rat Mouse Rabbit Guinea pig Pig Minipig Dog Non-human primates (NHP) Show 8 more tags Show less

ic

Cells and Tissues

Price on request
Request a quote for more information about this service.

ic

Biomarker Discovery

Price on request
Request a quote for more information about this service.

ic

Biological Testing

Price on request
Request a quote for more information about this service.

ic

Protein Services

Price on request
Request a quote for more information about this service.

ic

Bioanalytical Assays

Price on request
Request a quote for more information about this service.

ic

Immunostaining

Price on request
Request a quote for more information about this service.

ic

Bioanalytical Analysis LC/MS/MS

Price on request
Request a quote for more information about this service.

ic

Clinical Research

Price on request
Request a quote for more information about this service.

ic

Analytical Method Validation

Price on request
Request a quote for more information about this service.

ic

Data Services

Price on request
Request a quote for more information about this service.

ic

Animal Models and Studies

Price on request
Request a quote for more information about this service.

ic

Protein Expression Visualization

Price on request
Request a quote for more information about this service.

ic

Mass Spectrometry

Price on request
Request a quote for more information about this service.

ic

In vitro ADME/DMPK Studies

Price on request
Request a quote for more information about this service.

ic

Animal Models of Disease

Price on request
Request a quote for more information about this service.

ic

Bioanalysis

Price on request
Request a quote for more information about this service.

ic

Computational Modeling

Price on request
Request a quote for more information about this service.

ic

Chromatography

Price on request
Request a quote for more information about this service.

ic

Biospecimens

Price on request
Request a quote for more information about this service.

ic

Human Plasma and Serum

Price on request

Human Plasma and Serum Services


ic

Liquid Chromatography Coupled Mass Spectrometry Methods

Price on request
Request a quote for more information about this service.

ic

Human Biofluids

Price on request

Human Biofluids Services


ic

ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
Price on request
Request a quote for more information about this service.

ic

Human Biospecimens

Price on request

Human Biospecimens Services


ic

Safety Pharmacology

Price on request
Request a quote for more information about this service.

ic

Pharmacology

Price on request

Pharmacology Services


Not finding what you're looking for?

Get info on this provider's capabilities without requesting a quote.
CC

Callie Celichowski

Business Development Manager
SM

Stephanie Miller

Director, Client Services

INOTIV has not received any reviews.

INOTIV has not received any endorsements.