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Innovative Informatica Technologies

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Miyapur, IN

About Innovative Informatica Technologies

Innovative Informatica Technologies is one of its kind Bioinformatics organization specialized in handling computer aided drug discovery research, training and consulting services. We provide R&D services and research oriented training in the area of structure and ligand based drug discovery, screening of... Show more »

Innovative Informatica Technologies is one of its kind Bioinformatics organization specialized in handling computer aided drug discovery research, training and consulting services. We provide R&D services and research oriented training in the area of structure and ligand based drug discovery, screening of large chemical space for potential lead molecules through virtual screening, docking, ADMET predictions and molecular dynamic simulation techniques. We provide academic project training in Chemo-informatics area to various participants ranging from life science students, academic faculty to industrial researchers.

Our vision is to establish and maintain collaborations with Laboratories and institutes in India and abroad which are involved in related areas of research area of Bioinformatics and Computational Biology. We are determined to strive constantly to make Innovative Informatica Technologies a leading high quality service provider in Computer aided drug discovery research domain.

Recent Publications

  • Characterization of kisspeptin receptor structural features and its plausible mechanism of activation by kisspeptin : Mohd Ashraf Rather, Syed Hussain Basha et.al., In review with Nature Scientific Reports. (2016)
  • Molecular Modeling, Docking, ADMET predictions, molecular dynamic simulation and MTT assay based studies of novel 1, 5 Benzothiazepine skeleton based compounds as anti-cancer agents targeting EGFR kinase domain receptor: CH.M.M.Prasada Rao, Rajendra Prasad Yejella, Rehman S.A, Syed Hussain Basha : In review with Anti-Cancer Agents in Medicinal Chemistry (2016).
  • Carborane substituted Withaferin A shows enhanced immunotherapeutic anticancer property by targeting indoleamine 2,3-dioxygenase plausibility evidenced by Molecular modeling, docking and molecular dynamic simulations study : Syed Hussain Basha, Abhishek Thakur, Firoz A Samad : In review with Journal of Computer-Aided Molecular Design. (2016)
  • A comprehensive Insilico analysis on the structural and functional impact of SNPs in the Congenital Heart Defects associated with NKX2-5 Gene - A Molecular Dynamic Simulation Approach: Firoz Abdul Samad, Bandar A Suliman, Syed Hussain Basha, Musthafa Mohamed Essa : Accepted with PlosOne. (2016)
  • Molecular docking based screening of G6PS with 1, 5 Benzothiazepine derivates for a potential inhibitor : Maruthi Malya Prasada Rao Chennu, Rahaman Shaik Abdul, Rajendra Prasad Yejella : Bioinformation 11(12): 525-528 (2015)
  • Noninvasive Cellular Internalization Of Silver Molecules By Chitosan Nanoneedles: A Novel Nanocarrier :BS Wakure, NM Bhatia, S Hussain Basha: Journal of Biomolecular Structure & Dynamics (2015), Doi:10.1080/07391102.2015.1062803.
  • Molecular docking and dynamic simulation studies evidenced plausible immuno therapeutic anticancer property by Withaferin A targeting indoleamine 2,3-dioxygenase: S V G Reddy; K.Thammi Reddy; V. Valli Kumari; Syed Hussain Basha: Journal of Biomolecular Structure & Dynamics (2014), Doi: 10.1080/07391102.2015.1004834
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Our Services (32)


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NGS Data Analysis

Next generation sequencing data analysis
Price on request

NGS data analysis Services:
We provide comprehensive high-throughput data analysis services. Our bioinformatics offerings include standard as well as highly customized data analysis services along with biological interpretation as per the requirement. Our expertise includes but is not limited to the major next generational... Show more »

NGS data analysis Services:
We provide comprehensive high-throughput data analysis services. Our bioinformatics offerings include standard as well as highly customized data analysis services along with biological interpretation as per the requirement. Our expertise includes but is not limited to the major next generational sequencing (NGS) workflows for DNA, RNA and small RNA, metadata overlay, data mining, biological contextualization, and pathway analysis. All workflow steps include data type specific alignment and QC, coupled with powerful Genome Browser explorations to enable visual validations.

Innovative Informatica Technologeis provides range of NGS Data Analysis services from different sequencing platform (illumina, 454, Ion-Torrent, PacBio, Nanopores etc) including

Whole Genome sequence analysis

Whole Exome sequence analysis

De novo genome and transcriptome assembly

Genome alignment and analysis

Variant calling

Visualization of genomics data

Chip-Seq Analysis

Methylome-Seq Analysis

Reference Based RNA-Seq Analysis

De-novo Based RNA-Seq Analysis

MicroRNA-Seq Analysis

Targeted re-sequencing (Exome-Seq) Analysis

DNA-Seq (Genome variant Detection) Analysis

Mapping, Annotation and Comparative Genomics Analysis (CGA)

16S / 28S / ITS rRNA Metagenomic Analysis

Metatranscriptome Analysis

One of our services specialty is co-relating the Genomics with Proteomics towards identifying the impact of identified SNPs / mutations on protein structure and functional aspects to their impact on drug discovery. Below are couple of our recent publications for reference:

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Cell-Based Compound Screening

Price on request

We offer both structure and ligand based high-throughput screening (HTS) of more than a million manually curated compounds database that can be deployed for identifiying potential target specific drug like small molecules for your target of interest. Outsource with confidence that our HTS is performed using state-of-art high... Show more »

We offer both structure and ligand based high-throughput screening (HTS) of more than a million manually curated compounds database that can be deployed for identifiying potential target specific drug like small molecules for your target of interest. Outsource with confidence that our HTS is performed using state-of-art high performance CPU + GPU based server and clusters thus providing you with valuable data towards driving your drug discovery programs in a short period of time. Our library screening services save you time and let you focus on highly potent & selective lead compounds for new drug discovery programs.

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Protein Modeling

Price on request

We offer high quality protein tertiary structures custom modeling services based on your own amino-acid sequences. Combination of modeling and short term simulations under controlled parameters will ensure the reliablity of modeled structure for further studies.

Features and Benefits of our Protein modeling service:

We offer high quality protein tertiary structures custom modeling services based on your own amino-acid sequences. Combination of modeling and short term simulations under controlled parameters will ensure the reliablity of modeled structure for further studies.

Features and Benefits of our Protein modeling service:

  • De novo protein modeling.
  • Analysis and high quality template selection after thorough literature search.
  • Sequence similarity analysis and validation.
  • Loop modeling and refinement.
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Peptide Derivatives

Price on request

Peptidomimetics

Our peptidomimetic designing service gives you an advantage of discoveing novel scaffold of small molecule for your target of interst mimicing the mode of binding of known active peptide for the same. Our Inhouse software rapidly generate hundreds to thousands of peptide analogs by altering the sequence, thus... Show more »

Peptidomimetics

Our peptidomimetic designing service gives you an advantage of discoveing novel scaffold of small molecule for your target of interst mimicing the mode of binding of known active peptide for the same. Our Inhouse software rapidly generate hundreds to thousands of peptide analogs by altering the sequence, thus giving the advantage of screening all possible peptide anlogs.

Features and Benefits of our Peptidomimetic service:

  • Designing and Identification of novel peptide analogs.
  • Novel small molecule scafflod designing to mimic peptide binding mode.
  • Understand the molecular interactions.
  • Solublity studies for the peptide library.
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Hit to Lead and Lead Optimization

Price on request

Our lead optimization service will provide you the advantage of making your lead like compound in to highly selective and potent drug like small molecule via employing rigorous iterative process of altering the chemical structure using sophisticated computational software and chemistry simulation techniques for better selectivity,... Show more »

Our lead optimization service will provide you the advantage of making your lead like compound in to highly selective and potent drug like small molecule via employing rigorous iterative process of altering the chemical structure using sophisticated computational software and chemistry simulation techniques for better selectivity, ADME and toxicology profile with the goal of progressing to a preclinical candidate.

Features and Benefits of our Lead Optimization service:

  • Increase the chances of designing a novel target specific small molecules by folds.
  • Better ADME and toxicology profiling of the compound.
  • Designing of novel scaffold in the process for patentability.
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Drug Repositioning

Price on request

Identify new targets for your lead molecule towards finding new therapeutic application oppurtunities.

Identify new targets for your lead molecule towards finding new therapeutic application oppurtunities.

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High Throughput Screening (HTS)

Price on request

We offer both structure and ligand based high-throughput screening (HTS) of more than a million manually curated compounds database that can be deployed for identifiying potential target specific drug like small molecules for your target of interest. Outsource with confidence that our HTS is performed using state-of-art high... Show more »

We offer both structure and ligand based high-throughput screening (HTS) of more than a million manually curated compounds database that can be deployed for identifiying potential target specific drug like small molecules for your target of interest. Outsource with confidence that our HTS is performed using state-of-art high performance CPU + GPU based server and clusters thus providing you with valuable data towards driving your drug discovery programs in a short period of time. Our library screening services save you time and let you focus on highly potent & selective lead compounds for new drug discovery programs.

Features and Benefits of our HTS service:

  • Drug Repurposing: Identify new targets for your lead molecule towards finding new therapeutic application oppurtunities.
  • Identify potent and selective high quality leads for your target of interest.
  • Manually curated ADMET screened compound database.
  • Accurary rate of upto ~80% when compared with experimental data.
  • Capacity to screen more than 1 lakh compounds per day.
  • Flexibility in choosing any number of compounds to be screened against any number of targets.
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In vitro ADME/DMPK Studies

Price on request

Absorption, distribution, metabolism, exertion and toxicity (ADMET) properties determination is an essential criteria should be considered during the initial stages of rational dug designing and a valuable tool in short listing potential drug candidates out of lacks of compounds.

Absorption, distribution, metabolism, exertion and toxicity (ADMET) properties determination is an essential criteria should be considered during the initial stages of rational dug designing and a valuable tool in short listing potential drug candidates out of lacks of compounds.

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Computational Modeling

Price on request

Homology modeling is a computational modeling technique used for generating high resolution hypothetical proteins by using the evolutionarily related protein structure information. This method is highly valuable when the structure of the protein target is not known. Presently available softwares allow us to build therapeutically... Show more »

Homology modeling is a computational modeling technique used for generating high resolution hypothetical proteins by using the evolutionarily related protein structure information. This method is highly valuable when the structure of the protein target is not known. Presently available softwares allow us to build therapeutically important drug targets with high accuracy and correlation with experimentally determined protein structures.

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Molecular Dynamics Simulations

Price on request

Our molecular simulation service helps you to determine how your molecular system plausibly works and provide valuable insights about the mode of action of your molecule via analyzing the conformer space in terms of their kinetic and thermodynamics.

Features and Benefits of our Protein modeling service:

Our molecular simulation service helps you to determine how your molecular system plausibly works and provide valuable insights about the mode of action of your molecule via analyzing the conformer space in terms of their kinetic and thermodynamics.

Features and Benefits of our Protein modeling service:

  • Understand protein-ligand interactions.
  • Get insights on binding pathways of your compound in action.
  • Complete energy landscape anlaysis.
  • Visualize allosteric modulatorybehaviour of receptor proteins.
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Protein-Protein Interaction Analysis

Price on request

Most of the biological functions depends upon the protein-protein interactions, especially signal transduction mechanisms, which is the core of the entire interactomics system of any living cell. Many disease pathways such as cancer, undesired protein-protein interactions are the key factors towards malfunctioning of the cells.... Show more »

Most of the biological functions depends upon the protein-protein interactions, especially signal transduction mechanisms, which is the core of the entire interactomics system of any living cell. Many disease pathways such as cancer, undesired protein-protein interactions are the key factors towards malfunctioning of the cells. Most of the anti cancer drugs have been identified by blocking the protein-protein interacting pathway. Hence, studying the network pathways involving many protein interactions is crucial towards finding novel drug targets and studying the protein-ligand interactions which can specifically target a particular protein-protein interaction is vital for novel drug discovery.

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Computational Drug Discovery

Price on request

Virtual screening is a computational technique used in drug discovery research for screening of large chemical space for potential lead drug candidates towards a known drug target, typically an enzyme or a protein receptor. As the accuracy and correlation of this method of screening with experimental results is increased, the... Show more »

Virtual screening is a computational technique used in drug discovery research for screening of large chemical space for potential lead drug candidates towards a known drug target, typically an enzyme or a protein receptor. As the accuracy and correlation of this method of screening with experimental results is increased, the application of this technique is being highly appreciated in pharma industries towards screening enormous chemical space of over 10 million chemical compounds. Based on the available knowledge regarding potential drug target/ligand, structure/ligand based virtual screening will be implemented either individually or in combination for identifying potential lead drug like compounds.

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De Novo Drug Design

Price on request

Novel Scaffold designing rapidly speeds up the identification of drug like molecules with high chances of getting them to clinical trials within a short period of time. Identification of small fragments of side chains with high affinity at the target binding site in combination with lead optmization approaches deliver high quality... Show more »

Novel Scaffold designing rapidly speeds up the identification of drug like molecules with high chances of getting them to clinical trials within a short period of time. Identification of small fragments of side chains with high affinity at the target binding site in combination with lead optmization approaches deliver high quality lead like novel scaffold of small molecules.

Features and Benefits of our Protein modeling service:

  • De novo scaffold designing.
  • Fragment based de novo molecule designing.
  • Target binding pocket based drug designing.
  • Novelty and patentability ease.
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Drug Discovery & Development

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Biology

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Synthetic Chemistry

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Pharmacology & Toxicology

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Lead Identification and Validation

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Chemistry and Materials

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Biochemistry & Molecular Biology

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Peptide Synthesis

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Biomolecular Interaction Analysis

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Drug Discovery

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Bioinformatics

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Data Services

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Data Services

Data Services

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Data Analysis

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Data Analysis Services

Data Analysis Services

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Statistical Analysis

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Statistical Analysis Services

Statistical Analysis Services

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Biostatistics & Bioinformatics

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Biostatistics & Bioinformatics Services

Biostatistics & Bioinformatics Services

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Nucleic Acid Services

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Nucleic Acid Services

Nucleic Acid Services

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DNA Services

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DNA Services

DNA Services

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DNA Sequencing

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DNA Sequencing Services

DNA Sequencing Services

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Sequencing Data Analysis and Management

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Sequencing Data Analysis Services

Sequencing Data Analysis Services

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Syed Hussain Basha

Head, R&D activities

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