ingenious targeting laboratory: A better model is within reach.
We are a leading global provider of custom genetically engineered mouse models, with over 20 years of published expertise. ingenious targeting laboratory has built its reputation for custom mouse model production on a foundation of over 2,000 completed projects, with many more underway.
We offer a full range of custom gene knockout or knockin model design options to meet your research needs including: CRISPR/Cas9 mouse models, conventional/conditional gene knockouts, point mutation and other types of knockins (tags, reporter genes, custom cassettes), ROSA26 cDNA overexpression models, and exclusive cutting edge technologies such as our inducible/reversible F.A.S.T.™ cassette knockin system and our TruHumanization™ knockin for producing next-generation mouse models.
In addition, we now offer catalog mouse models. Our selection of exclusive COVID-19 mouse models includes a large-scale humanized ACE2 mouse, available for preorder. This particular line provides a hybrid human/mouse ACE2 receptor, making it an ideal model for studying infection, viral life cycle, disease progression, and more.
ingenious has recently partnered with Shanghai Model Organisms Center to distribute catalog humanized mouse models in North America and Europe. Select single and double immune checkpoint humanized lines include PD-1/PD-L1, TIGIT, and SIRPA/CD47 strains. Our clients can now conveniently order these validated, study-ready models through ingenious as a trusted vendor.
We serve academic and medical institutes, government research centers, and pharmaceutical and biotechnology companies. Clients retain full intellectual property rights to their custom animal projects. Full service custom model projects are initiated immediately upon completion of design parameters, with progress to completion on-site.
We are a privately held service- and client-focused biotechnology company founded and located in Ronkonkoma, New York, USA.
- IACUC: 2010-1042-RI-3.17.16-MI
- OLAW (via the animal facility at Stony Brook University, covered under the umbrella): A3011-01
Relevant publications (more on our website):
Venturutti L, Teater M, Zhai A et al. 2020. TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate. Cell 182(2): 297-316.e27.
Seo JA, Kang MC, Yang WM et al. 2020. Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity. Nat Commun 11(1): 2024.
Fazel Darbandi S, Robinson Schwartz SE, Pai EL et al. 2020. Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants. Cell Rep 31(2): 107495.
Conley SM, Stuck MW, Watson JN, Zulliger R, Burnett JL, Naash MI. 2019. Prph2 initiates outer segment morphogenesis but maturation requires Prph2/Rom1 oligomerization. Hum Mol Genet 28(3): 459-475.
Salvatierra J, Diaz-Bustamante M, Meixiong J, Tierney E, Dong X, Bosmans F. 2018. A disease mutation reveals a role for NaV1.9 in acute itch. J Clin Invest 128(12): 5434-5447.
Uche UU, Piccirillo AR, Kataoka S, Grebinoski SJ, D’Cruz LM, Kane LP. 2018. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med 215(12): 3165-3179.
Li S, Franken P, Vassalli A. 2018. Bidirectional and context-dependent changes in theta and gamma oscillatory brain activity in noradrenergic cell-specific Hypocretin/Orexin receptor 1-KO mice. Sci Rep 8(1): 15474.
Gene Knock-out Mouse Model
Gene Knock-in Mouse Model
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