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Industrial Pharmacy Laboratory (IPHL)

Philadelphia, Pennsylvania, US

A catalyst of scientific progress, the Industrial Pharmacy Laboratory (IPHL) at USciences is a GLP-compliant pharmaceutical research facility offering complete drug delivery research services.

Funded by the Burroughs Wellcome Fund and the Philadelphia College of Pharmacy, IPHL occupies 4,500 square feet of state-of-the-art space in the historic Griffith Hall.

In addition to the full array of instrumentation and equipment focused on cost-effective pharmaceutical drug delivery, IPHL clients have access to numerous resources available through USciences’ core facilities on campus, including chemistry, bioimaging, bioinformatics, and the vivarium.

The USciences Department of Pharmaceutical Sciences provides most key personnel for IPHL—scientists with an average experience of over 20 years in areas of drug discovery, drug delivery, formulations, and protein research.

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Spray Drying
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Protein Formulation
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Protein formulation analytical support

Liquid protein formulations, lyophilized product development, protein stability by RP and SEC HPLC, electrophoresis, circular dichroism, fluorescence spectroscopy, ELISA

Protein formulation analytical support

Liquid protein formulations, lyophilized product development, protein stability by RP and SEC HPLC, electrophoresis, circular dichroism, fluorescence spectroscopy, ELISA

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Analytical Method Development
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HPLC, LCMS, ELISA, cell-based biological assays, quality control, stability

HPLC, LCMS, ELISA, cell-based biological assays, quality control, stability

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Drug Preformulation
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Excipient compatibility, API characterization for particle size, morphology and polymorphism, DSC and TGA analysis, temperature and humidity studies, solubility screening, hot-melt feasibility, particle size reduction to micro or nano size, lyophilization cycle development

Excipient compatibility, API characterization for particle size, morphology and polymorphism, DSC and TGA analysis, temperature and humidity studies, solubility screening, hot-melt feasibility, particle size reduction to micro or nano size, lyophilization cycle development

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Pharmaceutical Formulation
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Solids dosage forms, dry and wet granulation, fluid bed coating, spray drying, oral, ophthalmic and injectable solutions, lipid based systems, disperse systems, biodegradable microsphere systems

Solids dosage forms, dry and wet granulation, fluid bed coating, spray drying, oral, ophthalmic and injectable solutions, lipid based systems, disperse systems, biodegradable microsphere systems

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Preclinical PK/PD Studies
in vivo Pharmacokinetics/Pharmacodynamics
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Full pharmacokinetic profile of new drug candidates

ADME studies in several animal species, metabolic profile using metabolomics software

Full pharmacokinetic profile of new drug candidates

ADME studies in several animal species, metabolic profile using metabolomics software

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Computational Chemistry
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WinNonlin, Analyst for MS analysis, metabolomics software, and a variety of computational chemistry software.

WinNonlin, Analyst for MS analysis, metabolomics software, and a variety of computational chemistry software.

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High Throughput Screening (HTS)
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Screening for solubility, stability, and formulation design

Screening for solubility, stability, and formulation design

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Product Stability Testing
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Bioavailability and Bioequivalence Studies
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Protein Services
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Biology
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Protein Expression
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Chemistry and Materials
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Formulation Services
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Product Development, Testing, and Packaging
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Pharmacology & Toxicology
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Analytical Chemistry Services
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Bioanalysis
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Bioanalytical Assays
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ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
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Hit Identification
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Drug Discovery & Development
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Biochemistry & Molecular Biology
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Drug Discovery
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