1352612165965_7fffb663120dd173020ed4b9bc223583

Indiana University School of Medicine

Indianapolis, Indiana
1352612165965_7fffb663120dd173020ed4b9bc223583
Indiana University School of MedicineIndiana UniversityIndianapolis, Indiana
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  • 0 Members
1352612192088_7fffb663120dd173020ed4b9bc223583

Proteomics Core
1352612192088_7fffb663120dd173020ed4b9bc223583
Proteomics CoreIndiana University School of MedicineIndianapolis, Indiana
  • 11 Services
  • 1 Member

Indianapolis, Indiana
1352612192088_7fffb663120dd173020ed4b9bc223583
Proteomics CoreIndiana University School of MedicineIndianapolis, Indiana
  • 11 Services
  • 1 Member
  • No reviews
  • No completed projects
  • No endorsements

Indiana University School of Medicine Proteomics Core Facility provides protein and proteomic analysis services for protein identification, characterization, and quantification. The Core encourages collaborations that apply the tools of proteomics to cutting-edge biomedical... Show more »

Indiana University School of Medicine Proteomics Core Facility provides protein and proteomic analysis services for protein identification, characterization, and quantification. The Core encourages collaborations that apply the tools of proteomics to cutting-edge biomedical research.

Established in 2001, the Core has become a center not only for services but also for collaborative research and development of new technological platforms for proteomic research. The Core is available to Indiana Universities and the wider research community.

Over the years, our facility has worked with many pharmaceutical and biotech companies, and developed a number of SOPs for biomarker discovery, mass spec-based protein assays, and biomarker candidate validation.

Our major platforms are label-free protein quantification for biomarker discovery and multiple-reaction-monitoring (MRM) for protein assays and biomarker validation.

Our goal is to deliver value to our investigators and our community as a world-class proteomics core lab providing services to meet the critical needs of biomedical researchers in life science industries and academia.

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Angio BioCore (ABC)
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Angio BioCore (ABC)Indiana University School of MedicineIndianapolis, Indiana
  • 16 Services
  • 3 Members

Indianapolis, Indiana
A86lnqfmqnwfqblmi06e_abc logo
Angio BioCore (ABC)Indiana University School of MedicineIndianapolis, Indiana
  • 16 Services
  • 3 Members
  • 100% positive reviews
  • 2 Projects Completed
  • No endorsements

The Angio BioCore (ABC) is a state-of-the-art facility that has been established through the Indiana University Melvin and Bren Simon Cancer Center, a National Cancer Institute-designated cancer center, to conduct validated and highly reproducible in vitro and in vivo angiogenesis,... Show more »

The Angio BioCore (ABC) is a state-of-the-art facility that has been established through the Indiana University Melvin and Bren Simon Cancer Center, a National Cancer Institute-designated cancer center, to conduct validated and highly reproducible in vitro and in vivo angiogenesis, endothelial, hematopoietic and multi-parametric flow cytometry assays and their role in normal and patient-related hematologic and cardiovascular disorders.

In addition to possessing the in vitro and in vivo assays that define the endothelial progenitor outgrowth cells that possess in vivo vessel forming ability, the ABC recently stringently defined a population of pro-angiogenic and anti-angiogenic circulating hematopoietic stem and progenitor cells (CHSPCs) that has been shown to regulate angiogenesis. Discovery of these novel CHSPC subsets demonstrates the uniqueness and strength of the approach by the ABC that requires both phenotypic and functional data to validate specific circulating cells that participate in new blood vessel formation.

The specific assays offered by the ABC function as quantitative analytical tools, potential biomarkers of several hematopoietic diseases, and as experimental platforms for understanding the basic mechanisms of angiogenesis and the interplay between the endothelial and hematopoietic systems. For example, not only are CHSPCs critical for normal and abnormal angiogenesis, but we and others have reported that certain endothelial cells are critical for CHSPC expansion ex vivo and that endothelial cells promote CHSPC engraftment post-ablation.

The ABC serves to directly perform all of the assays required to analyze research samples, and as a consultation, education, and new assay development site for scientists within and outside the IU School of Medicine and Indiana University.

Furthermore, the ABC is one of only five nationally recognized Core Centers of Excellence in Molecular Hematology by the National Institutes of Health and is a certified core of the Indiana Clinical and Translational Sciences Institute (CTSI).

ABC has access to various mouse models through another Core facility here at Indiana University. We are also happy to order any cell lines.
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Lab staff:
Jamie Case, PhD.; Emily Sims, BS; Matthew Repass, BS; Julie Mund, MS.

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1352612264550_7fffb663120dd173020ed4b9bc223583

Physiological Proteomics Core Facility

Indianapolis, Indiana
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This facility enables researchers to identify and quantify proteins in simple or complex samples and characterize protein post-translational modifications or conjugates. Combining a new mass spectrometry-based analytical platform, IdentiQuantXL™, large format/high throughput gel-based... Show more »

This facility enables researchers to identify and quantify proteins in simple or complex samples and characterize protein post-translational modifications or conjugates. Combining a new mass spectrometry-based analytical platform, IdentiQuantXL™, large format/high throughput gel-based proteomics, and experienced proteomic researchers, the PPCF provides unique approaches to biomarker discovery in health and disease, equipment and software for 1D or 2D gel analyses, Western blotting, high throughput differential expression proteomics with LC-MS/MS, identification/characterization of peptide and protein modifications, MS/MS of purified peptides and proteins, protein identification via LC-MS/MS of gel-plug or solution tryptic digests, targeted analyses of specific molecules with selected reaction monitoring (SRM), and proteomics methods development, consultation, and bioinformatic analysis of complicated results.

We provide the following state-of-the-art mass spectrometry-based proteomics services:

Protein Identification
Protein Quantification
Differential Protein Expression Analysis
Protein Post-translational Modification Analysis
Bioinformatics and Pathway Analysis
Biomarker Discovery

Please note, a set up fee is applied when the number of samples is less than 10.

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Histology Core Facility

Indianapolis, Indiana
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The Histology Core of the Department of Anatomy and Cell Biology at the Indiana University School of Medicine provides histological services for basic science (non-clinical) research.

Both mineralized (plastic embedded) and soft tissue (paraffin embedded) specimens can be prepared.

1352612242103_7fffb663120dd173020ed4b9bc223583

Therapeutic Validation Core

Indianapolis, Indiana
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The Therapeutic Validation core (TVC) assists clinical investigators to develop and perform correlative biological assays needed to validate mechanism(s) of action of candidate drugs/therapies and to develop and test new hypotheses. The TVC also provides technical and intellectual... Show more »

The Therapeutic Validation core (TVC) assists clinical investigators to develop and perform correlative biological assays needed to validate mechanism(s) of action of candidate drugs/therapies and to develop and test new hypotheses. The TVC also provides technical and intellectual support in the development, implementation, and validation of predictive and pharmacodynamic biomarkers for novel, molecularly-targeted anticancer agents.

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