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InDanio Bioscience Inc.

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Toronto, Ontario, CA

About InDanio Bioscience Inc.

InDanio Bioscience Inc., is a privately-held in vivo drug discovery company dedicated to developing New Chemical Entities (NCEs) targeting the pharmaceutically-important Nuclear Receptor (NR) protein families.

Our proprietary, Ligand Trap system, which includes 48 transgenic zebrafish lines, each singularly... Show more »

InDanio Bioscience Inc., is a privately-held in vivo drug discovery company dedicated to developing New Chemical Entities (NCEs) targeting the pharmaceutically-important Nuclear Receptor (NR) protein families.

Our proprietary, Ligand Trap system, which includes 48 transgenic zebrafish lines, each singularly expressing one of the 48 human Nuclear Receptors, allows simultaneous assessment of drug delivery, stability, specificity, tissue-selectivity and toxicity. Selective, highest-value target lines are being used to identify, extract and characterize new hormonal regulators, as well as to identify new tissue-selective drugs, co-factors and mechanisms of action for each Nuclear Receptor.

InDanio's genetically engineered Zebrafish lines provide a "highest human homology" in vivo HTS model, where not only are the binding and potency of lead compounds immediately identified, but target and tissue specificity, as well as vital organ accumulation, can for the first time, also be immediately realized.

Selected Publications:

  • The Zebrafish: A Powerful Platform for In Vivo, HTS Drug Discovery Delvecchio et al. (2011)
  • A Live Zebrafish-Based Screening System for Human Nuclear Receptor Ligand and Cofactor Discovery Tiefenbach et al. (2010)
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Our Services (19)


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In vivo Phenotypic Screening

Price on request

Use InDanio's proprietary transgenic zebrafish platform technology:

  • To identify NCE binding potency and selectivity
  • To pursue a re-positioning strategy for existing drugs as NR ligands
  • Identification of NR/cofactor responses
  • Tissue and receptor-specific responses
  • Conduct SAR studies

Use InDanio's proprietary transgenic zebrafish platform technology:

  • To identify NCE binding potency and selectivity
  • To pursue a re-positioning strategy for existing drugs as NR ligands
  • Identification of NR/cofactor responses
  • Tissue and receptor-specific responses
  • Conduct SAR studies
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Zebrafish

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High Throughput Screening (HTS)

Price on request

InDanio's genetically engineered Zebrafish lines provide a "highest human homology" in vivo HTS model, where not only are the binding and potency of lead compounds immediately identified, but target and tissue specificity, as well as vital organ accumulation, can for the first time, also be immediately realized.

InDanio's genetically engineered Zebrafish lines provide a "highest human homology" in vivo HTS model, where not only are the binding and potency of lead compounds immediately identified, but target and tissue specificity, as well as vital organ accumulation, can for the first time, also be immediately realized.

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Zebrafish

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Custom Cell-Based Assay Development

Price on request

Develop a custom assay for target protein(s) of interest.

Develop a custom assay for target protein(s) of interest.

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In vivo Nuclear Hormone Receptor Assays

Price on request

InDanio's ligand trap (LT) system is a multi-component system uses live zebrafish to indicate the presence of human nuclear receptor-directed hormones or drugs, and to isolate these small molecules from active molecules from responding tissues. Fourty eight transgenic ligand trap fish lines have been generated, each representing... Show more »

InDanio's ligand trap (LT) system is a multi-component system uses live zebrafish to indicate the presence of human nuclear receptor-directed hormones or drugs, and to isolate these small molecules from active molecules from responding tissues. Fourty eight transgenic ligand trap fish lines have been generated, each representing one of the 48 human Nuclear receptors, and each containing the components to identify and isolate small molecule ligands and protein cofactors.

  • The first LT technology component signals the presence of active hormones or drugs in the form of a green fluorescent signal (GFP). These fluorescent signals predict, with great credibility, which compounds have potential for further drug development, and which tissues or organs can be targeted.
  • The second LT component makes use of the nuclear receptors themselves, after they have been bound by hormones or drugs. The bound hormones/drugs are purified, extracted and identified using highly effective affinity tags attached to the receptor constructs.

In Vivo Zebrafish Nuclear Hormone Receptors Target Specific Assays

The following transgenic zebrafish assays are available for screening libraries of compounds:
ROR alpha
ROR gamma
ROR beta
FXR
PPAR alpha
PPAR gamma
RXR alpha
LXR alpha

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Zebrafish

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Targeted Drug Delivery Systems

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Drug Development

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Drug Discovery Consulting

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Specialized Cell-Based Assays

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Drug Discovery & Development

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Drug Discovery

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Animal Physiology Analyses

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In vivo Studies

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Hit Identification

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Cell-Based Assays

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Animal Models and Studies

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In vivo PK/PD Studies

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Pharmacology & Toxicology

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Biology

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Animal Model in vivo Analyses

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Jens Tiefenbach

Chief Scientific Officer
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A Live Zebrafish-Based Screening System for Human NR Ligand Cofactor Discovery.pdf

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Delvecchio Tiefenbach Krause et al The ZF platform for HTS.pdf

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InDanio Bioscience.pdf

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