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In Vitro ADMET Laboratories

8 Orders Completed
Columbia, Maryland, US

About In Vitro ADMET Laboratories

Founded: 2004 Type: Privately Held Size: 11-50 employees

IVAL's products and contract services represent three decades of expertise in the application of in vitro experimental systems to evaluate drug absorption, metabolism, transporters, drug-drug interactions and drug toxicity. We focus on hepatocytes as a preferred test system, including co-cultures between... Show more »

IVAL's products and contract services represent three decades of expertise in the application of in vitro experimental systems to evaluate drug absorption, metabolism, transporters, drug-drug interactions and drug toxicity. We focus on hepatocytes as a preferred test system, including co-cultures between hepatocytes and other relevant cell types to suit each investigative purpose.

In addition to the broadly available “routine” in vitro ADME studies, we have also developed higher throughput screening assays to aid the selection of best drug candidates for during early phases of drug development.

We support a collaborative research environment, and appreciate receiving feedback from you on how to meet your needs, whether it's through contract services, hepatocytes, or training / education.

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Our Services (32)


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Reaction Phenotyping

Price on request

Predicting the potential for drug-drug interactions with co-administered compounds starts by understanding the metabolic pathway by which a compound is eliminated from the body. Compounds with a single route of elimination are at high risk of causing adverse events. To obviate any dangerous polypharmacy situations in patients,... Show more »

Predicting the potential for drug-drug interactions with co-administered compounds starts by understanding the metabolic pathway by which a compound is eliminated from the body. Compounds with a single route of elimination are at high risk of causing adverse events. To obviate any dangerous polypharmacy situations in patients, identifying the metabolic pathway(s) of a drug candidate is required by regulatory agencies prior to IND submission.

These studies are performed using liver microsomes in the presence of selective inhibitors for the major CYP isoforms, thus identifying the metabolic routes involved. Quantification of the parent compound and its metabolites are performed using HPLC-LC/MS, and the percent contribution of a specific CYP isoform towards metabolism of the test article is reported.

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Cryopreserved Human Hepatocytes

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Primary Cell Isolation

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Primary hepatocytes are widely used in evaluating metabolism, drug-drug interactions, drug transporter activity, and potential toxicity of drug candidates. As a CompleteHepatocyteSolutionTM company, our goal is to provide hepatocytes of the highest quality to ensure our customers can produce reliable, consistent data. With IVAL,... Show more »

Primary hepatocytes are widely used in evaluating metabolism, drug-drug interactions, drug transporter activity, and potential toxicity of drug candidates. As a CompleteHepatocyteSolutionTM company, our goal is to provide hepatocytes of the highest quality to ensure our customers can produce reliable, consistent data. With IVAL, you aren’t restricted by a pre-set isolation calendar—let us know when you need a fresh hepatocyte preparation and we’ll prepare it to fit your schedule.

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In vitro Metabolic Stability Assays

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Metabolic Stability is a key drug property. It is important for drug administration regimen design as well as toxicity. Species comparison in metabolic stability allows the determination of which animal species is the most appropriate model to estimate human metabolic stability. The use of human primary hepatocytes allows the... Show more »

Metabolic Stability is a key drug property. It is important for drug administration regimen design as well as toxicity. Species comparison in metabolic stability allows the determination of which animal species is the most appropriate model to estimate human metabolic stability. The use of human primary hepatocytes allows the evaluation of metabolic stability as a result of both phase I oxidation and phase II conjugation.

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In vitro Hepatotoxicity Testing

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In vitro testing using primary cells can quickly screen for new chemical entities with serious toxicology consequences. Using primary cells derived from human tissues, the relative risk can be determined in multiple organs over a population of donors.

The following in vitro cytotoxicity assays using the specified endpoints have... Show more »

In vitro testing using primary cells can quickly screen for new chemical entities with serious toxicology consequences. Using primary cells derived from human tissues, the relative risk can be determined in multiple organs over a population of donors.

The following in vitro cytotoxicity assays using the specified endpoints have been developed in our laboratory. With our ready inventory of human and cynomolgus monkey cells scheduling is not an issue. Contact us to customize your study today.

  • Cell viability (luminescence based ATP assay)
  • Cell growth and survival (MTT/WST-1 metabolism)
  • Apoptosis (luminescence based caspase activity assay)
  • Oxidative Stress (luminescence based glutathione assay)
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Cell Uptake/Transporter Assays

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Pravastatin Uptake Assessment: 96 well cultures at a cell density of 0.5 million hepatocytes/mL (50,000 hepatocytes/well) were used in the Pravastatin Uptake Assessment. After approximately 20-24 hours in culture, the hepatocytes were treated with 1 µM of Pravastatin with and without Rifampin for a time duration of 0,1, 2, 3, 4,... Show more »

Pravastatin Uptake Assessment: 96 well cultures at a cell density of 0.5 million hepatocytes/mL (50,000 hepatocytes/well) were used in the Pravastatin Uptake Assessment. After approximately 20-24 hours in culture, the hepatocytes were treated with 1 µM of Pravastatin with and without Rifampin for a time duration of 0,1, 2, 3, 4, and 5 minutes. Values reflect the mean of triplicate treatments (N=3). The metabolites were identified and analyzed using LCMS/MS.

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Human Hepatocytes

Price on request
  • Pre-screened and characterized for plateability, metabolic activity, CYP induction, and transporter efflux activity
  • Available from Human and multiple animal species, including Rat, Mouse, Dog, Non-Human Primates, etc
  • Maximized re-thaw viability (~90%), recovery, and plating efficiency
  • Available from single or multiple donors
  • Available Cryopreserved
  • Pre-screened and characterized for plateability, metabolic activity, CYP induction, and transporter efflux activity
  • Available from Human and multiple animal species, including Rat, Mouse, Dog, Non-Human Primates, etc
  • Maximized re-thaw viability (~90%), recovery, and plating efficiency
  • Available from single or multiple donors
  • Available Cryopreserved
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Animal Hepatocytes

Price on request

Available Cryopreserved

Available Cryopreserved

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Mouse Rat Dog Non-human primates (NHP)

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Transporter & Cell Uptake Assays

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Transporter & Cell Uptake Assays Services

Transporter & Cell Uptake Assays Services

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Cell Viability & Proliferation Assays

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Biology

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Pharmacology & Toxicology

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In vitro ADME/DMPK Studies

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Sulfotransferase

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N Acetyl Transferase

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CYP Inhibition Assay

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Microsomal Stability Assay

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Cell Permeability Assay

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CYP Induction Assay

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Cell Viability Assays

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Cells and Tissues

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Cell Death Assays

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
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Cell-Based Assays

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In vitro Toxicity Testing

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In vitro Toxicity Testing Services

In vitro Toxicity Testing Services

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Toxicology

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Toxicology Services

Toxicology Services

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Primary Cell Culture

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Primary Cell Culture Services

Primary Cell Culture Services

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Cell and Tissue Culture

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Cell and Tissue Culture Services

Cell and Tissue Culture Services

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Human Primary Cells

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Human Primary Cells Services

Human Primary Cells Services

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Human Biospecimens

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Human Biospecimens Services

Human Biospecimens Services

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Biospecimens

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Biospecimens Services

Biospecimens Services

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Animal Biospecimens

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Animal Biospecimens Services

Animal Biospecimens Services

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Nola Mahaney

Vice President, Operations

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