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ImmunXperts SA

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Gosselies, BE

About ImmunXperts SA

ImmunXperts offers services to support your drug development process, be it by mitigating risks through immunogenicity assessment or by saving time and money through custom assay development.

In collaboration with our scientific advisors and international partners, ImmunXperts offers access to a unique team... Show more »

ImmunXperts offers services to support your drug development process, be it by mitigating risks through immunogenicity assessment or by saving time and money through custom assay development.

In collaboration with our scientific advisors and international partners, ImmunXperts offers access to a unique team of seasoned immunology experts. ImmunXperts provides a comprehensive package, allowing you to outsource the full immunology assessment, or to cherry-pick the solutions or technologies needed/that fit your exact requirements.

We offer great flexibility in dealing with your specific demands and changing priorities. Our creative mind-set, our strong and interactive relationship with our customers and our long term experience in the field make us a reliable partner to meet your specific needs.

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Our Services (35)


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In vitro Immunogenicity Assays

Price on request

The key process in T cell dependent antibody production is peptide presentation by antigen presenting cells to T cells, in combination with co-stimulatory signals and cytokine secretion. These three signals will stimulate the T cells to proliferate and differentiate, in order to be able to help the B cells to produce antibodies... Show more »

The key process in T cell dependent antibody production is peptide presentation by antigen presenting cells to T cells, in combination with co-stimulatory signals and cytokine secretion. These three signals will stimulate the T cells to proliferate and differentiate, in order to be able to help the B cells to produce antibodies towards the antigen. Antibodies produced towards the administered drug (anti-drug antibodies or ADAs) are the main clinical immunogenicity problem. These ADAs can lead to a decreased or enhanced clearance of the drug, or can have no effect at all. If the drug mimics an endogenous counterpart, the ADAs might also bind the endogenous protein, which can lead to severe consequences for the patients’ health. The process from antigen presentation until ADA production cannot (yet) be tested in vitro. Therefore, T cell proliferation is can be used as a surrogate marker to measure the immunogenic potential of a drug candidate in development.

T cell activation assays have a long tradition in vaccine testing (wanted immunogenicity), but are also employed to asses possible unwanted immunogenicity induced by therapeutic proteins.

ImmunXperts offers several types of T cell activation assays:

  • Whole PBMC assay: In the PBMC assay, complete test products are added to cultured peripheral blood mononuclear cells (PBMC). These cells contain all essential components to mount an immune reaction. After a period of incubation T cell activation is measured.
  • DC-T assay: When test products interfere with the formation of an immune response, the DC-T assay type is preferred. Here, the test product is first loaded onto the surface MHC molecules of professional Antigen Presenting Cells (APC) and leftover product will be washed away. The APC will present all epitopes to autologous T cells and T cell activation is measured.

ImmunXperts has experience with several readout formats:

  • Flow Cytometry: Multiparameter analysis on a single cell level
  • Cytokine Profile: Capture beads allow the multiplexed analysis of more than 10 inflammatory cytokines
  • ELISpot: Analysis of secreted molecules on a single cell level
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In vivo Immunogenicity Assays

Price on request

ImmunXperts offers a comprehensive package of tools and services to measure immunogenicity during pre-clinical and clinical studies.

  • In Vivo models for immunogenicity research
  • Pharmacokinetic (PK) assays
  • Pharmacodynamic (PD) marker analysis
  • Anti-drug antibody (ADA) analysis and characterisation
  • Neutralising antibody (NAB) analysis
  • Potency assays

ImmunXperts offers a comprehensive package of tools and services to measure immunogenicity during pre-clinical and clinical studies.

  • In Vivo models for immunogenicity research
  • Pharmacokinetic (PK) assays
  • Pharmacodynamic (PD) marker analysis
  • Anti-drug antibody (ADA) analysis and characterisation
  • Neutralising antibody (NAB) analysis
  • Potency assays
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Mixed Lymphocyte Reactions

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Immuno-oncology Assays

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Recent advances in the field of Immuno-oncology have shown great promise in the treatment of a wide variety of malignancies. Several strategies involving monoclonal antibodies (or other biologics platforms), cytokines, small molecule compounds or cellular therapies have been applied to modulate the immune system.

Early... Show more »

Recent advances in the field of Immuno-oncology have shown great promise in the treatment of a wide variety of malignancies. Several strategies involving monoclonal antibodies (or other biologics platforms), cytokines, small molecule compounds or cellular therapies have been applied to modulate the immune system.

Early evaluation and screening of the immunomodulatory effectiveness of candidate therapeutics using In Vitro bioassays is a critical step in the development of novel or combination immunotherapies.

ImmunXperts has extensive experience with In Vitro assays using human primary immune cells which can be implemented in the field of immuno-oncology, for instance:

  • Mixed Lymphocyte Reaction (MLR) Assays
  • Antigen specific T cell activation Assays
  • Macrophage Polarization Assays
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T Cell Activation and Proliferation Assays

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Custom Cell-Based Assay Development

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ImmunXperts has a unique knowledge in building custom assays that can be useful to cell therapy companies

Cell Therapy products offer the potential of curing diseases that today have only palliative treatments in the best case.

The ability to produce large quantities of biological products with predictable quality and... Show more »

ImmunXperts has a unique knowledge in building custom assays that can be useful to cell therapy companies

Cell Therapy products offer the potential of curing diseases that today have only palliative treatments in the best case.

The ability to produce large quantities of biological products with predictable quality and quantifiable potency is becoming critical. And this is also a regulatory requirement for phase III and commercialization.

ImmunXperts has the capacity to develop custom in vitro assays to screen immunomodulatory properties of Stem Cells, selecting the potency markers that make the most sense for each product.

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Flow Cytometry

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ELISpot Assays

Enzyme-Linked ImmunoSpot Assays
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Immunoassays

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Immunoassays Services

Immunoassays Services

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Bioanalytical Assays

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Bioanalytical Assays Services

Bioanalytical Assays Services

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Bioanalysis

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Bioanalysis Services

Bioanalysis Services

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Pharmacology & Toxicology

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Pharmacology & Toxicology Services

Pharmacology & Toxicology Services

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Immune Cell Assays

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Immune Cell Assays Services

Immune Cell Assays Services

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Functional & Cell Type Specific Assays

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Functional & Cell Type Specific Assays Services

Functional & Cell Type Specific Assays Services

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Specialized Cell-Based Assays

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Specialized Cell-Based Assays Services

Specialized Cell-Based Assays Services

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Cell-Based Assays

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Cell-Based Assays Services

Cell-Based Assays Services

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Biology

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Biology Services

Biology Services

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Cytometry

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Cytometry Services

Cytometry Services

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Cells and Tissues

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Cells and Tissues Services

Cells and Tissues Services

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In vivo Toxicity Testing

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In vivo Toxicity Testing Services

In vivo Toxicity Testing Services

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Toxicology

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Toxicology Services

Toxicology Services

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Protein Quantification

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Protein Quantification Services

Protein Quantification Services

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Protein Purification

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Protein Purification and Quantification Services

Protein Purification and Quantification Services

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Protein Services

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Protein Services

Protein Services

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Biochemistry & Molecular Biology

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Biochemistry & Molecular Biology Services

Biochemistry & Molecular Biology Services

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In silico Immunogenicity Assay

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ImmunXperts offers access to In Silico tools for immune profiling and lead optimization. In Silico tools are fast, sequence based and low cost, and thus are perfectly suited for assessing large numbers of lead candidates in an early development phase.

These tools can be used for:

  • Epitope Identification: Identify which part... Show more »

ImmunXperts offers access to In Silico tools for immune profiling and lead optimization. In Silico tools are fast, sequence based and low cost, and thus are perfectly suited for assessing large numbers of lead candidates in an early development phase.

These tools can be used for:

  • Epitope Identification: Identify which part of your sequence is at risk for being an epitope.
  • Immunogenicity Risk Assessment: Asses and compare the overall risk of your molecules for inducing Immunogenicity.
  • Deimmunisation (decrease unwanted immunogenicity): Small changes to your molecule’s sequence can lower the risk for immunogenicity, while retaining all functionality.
  • Customized services: ImmunXperts is open to discuss the many possibilities that these In Silico tools offer.
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Flow Cytometry Data Analysis

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Fluorescence Activated Cell Sorting (FACS)

Fluorescence Activated Cell Sorting
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Human Immune Cell Assays

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Cytokine Analysis

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Cytokine Storm Testing

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Custom Immunoassay Development

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Flow Cytometry Data Acquisition

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Flow Cytometry Training

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Luminex Multiplex Assays

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Mayuko Oh

Sales Manager

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