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Immune Biosolutions

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Sherbrooke, Quebec, CA

About Immune Biosolutions

Immune Biosolutions has developed a new approach to therapeutic and diagnostic antibody discovery that tackles traditionally difficult targets such as GPCRs, integrins and ion channels. Fundamental limitations in commonly used strategies in antibody development for GPCRs and other membrane proteins are now... Show more »

Immune Biosolutions has developed a new approach to therapeutic and diagnostic antibody discovery that tackles traditionally difficult targets such as GPCRs, integrins and ion channels. Fundamental limitations in commonly used strategies in antibody development for GPCRs and other membrane proteins are now overcome with our proprietary Nebula antibody development platform. Our approach enables the discovery of novel antibodies suitable for any application, such as diagnostics, antibody drug conjugates (ADCs) and therapeutics.

The Nebula antibody development platform has three key features:

(1) ) Proprietary algorithm to drive the high-throughput design and synthesis of three dimensionally-constrained peptides mimicking the target’s spatial conformation.

For GPCRs, the peptides match the sequence and structure of extracellular loops (ECL). This approach overcomes immunization issues related to membrane-spanning GPCR expression and purification.

(2) Incremental chicken antibody generation platform.

Since mammalian proteins are conserved, their homology may be too high to trigger an immune response in mammalian hosts. Such issues are circumvented by the Nebula platform which taps into the unexplored chicken antibody repertoire and provides a new source of high-affinity antibodies for discovery and human therapeutics.

(3) High-throughput selection and validation strategies that harness the power of phage-display technologies.
The best recombinant antibody candidates are identified and isolated in order to evaluate their functional and therapeutic potential.

In short, the Nebula antibody platform enables the discovery of one-of-a-kind antibodies providing our partners with new candidates for diagnostics, antibody drug conjugates (ADCs) and therapeutics.

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Our Services (15)


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Recombinant Antibody Production

Price on request

To meet your specific needs and expectations, our antibody development process consists of 4 phases under strict confidentiality:
1- Designing a variety of antigens to address difficult proteins.
Unique antigen strategies including Spatial Peptides that are rationally designed and functionality-oriented synthetic 3D peptides... Show more »

To meet your specific needs and expectations, our antibody development process consists of 4 phases under strict confidentiality:
1- Designing a variety of antigens to address difficult proteins.
Unique antigen strategies including Spatial Peptides that are rationally designed and functionality-oriented synthetic 3D peptides that mimic native structure of challenging targets
2-Generating antibody diversity
Based on the chicken immune system: in vivo titer maturation, new epitopes, species cross-reactive abs…
Not limited by immunological tolerance: high success rate with mammalian conserved proteins
3-Selecting the best binders.
Efficient ex vivo phage-display selection coupled with NGS to explore the full diversity of chicken ab libraries
4-Formatting recombinant antibody for specific applications.
Highly successful formatting workflow with a variety of recombinant format to choose from. Validated human frameworks with ultra-low immunogenicity profiles for therapeutic applications available.

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Oncology Infectious Disease Inflammation Cancer Inflammatory Bowel Disease Gastric Cancer NGS phage display ultra-humanization Drug Discovery G-protein Ion Channel membrane protein Show 13 more tags Show less

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Polyclonal Antibody Production

Price on request

To meet your specific needs and expectations, our antibody development process consists of 3 phases under strict confidentiality:

  1. Design: We gather antibody requirements, evaluate the feasibility and submit a customized proposal that defines our peptide selection, timelines and cost.
  2. Generation: Following the design’s... Show more »

To meet your specific needs and expectations, our antibody development process consists of 3 phases under strict confidentiality:

  1. Design: We gather antibody requirements, evaluate the feasibility and submit a customized proposal that defines our peptide selection, timelines and cost.
  2. Generation: Following the design’s approval, the peptide (or other target molecule) is synthesized. We start with a 60-day immunization program with constant antibody titer monitoring.
  3. Validation +: We validate the antibody by ELISA (we guarantee positive ELISA against the immunizing peptide) and Western blot (when possible). Depending on the project, an affinity purification and direct coupling may be required. A complete technical report is delivered with generation details and suggested concentration of antibodies for the most common applications.
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Chicken Oncology Infectious Disease Inflammation Antibody Production immunization Biology Drug Discovery Show 8 more tags Show less

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Bioconjugation/Chemical Crosslinking

Price on request

We offer all type of custom bioconjugaison for a competitive price.

We offer all type of custom bioconjugaison for a competitive price.

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Antibody Purification

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Animal Immunization for Antibody Production

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Chicken

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Antibody Services

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Protein Services

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Pharmacology & Toxicology

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Protein Expression Visualization

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Immunostaining

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Biochemistry & Molecular Biology

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Biomarkers

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Cells and Tissues

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Antibody Modification

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Antibody Isotyping

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