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Immune Biosolutions

Sherbrooke, Quebec, CA

Immune Biosolutions has developed a new approach to therapeutic and diagnostic antibody discovery that tackles traditionally difficult targets such as GPCRs, integrins and ion channels. Fundamental limitations in commonly used strategies in antibody development for GPCRs and other membrane proteins are now overcome with our proprietary Nebula antibody development platform. Our approach enables the discovery of novel antibodies suitable for any application, such as diagnostics, antibody drug conjugates (ADCs) and therapeutics.

The Nebula antibody development platform has three key features:

(1) ) Proprietary algorithm to drive the high-throughput design and synthesis of three dimensionally-constrained peptides mimicking the target’s spatial conformation.

For GPCRs, the peptides match the sequence and structure of extracellular loops (ECL). This approach overcomes immunization issues related to... Show more »

Immune Biosolutions has developed a new approach to therapeutic and diagnostic antibody discovery that tackles traditionally difficult targets such as GPCRs, integrins and ion channels. Fundamental limitations in commonly used strategies in antibody development for GPCRs and other membrane proteins are now overcome with our proprietary Nebula antibody development platform. Our approach enables the discovery of novel antibodies suitable for any application, such as diagnostics, antibody drug conjugates (ADCs) and therapeutics.

The Nebula antibody development platform has three key features:

(1) ) Proprietary algorithm to drive the high-throughput design and synthesis of three dimensionally-constrained peptides mimicking the target’s spatial conformation.

For GPCRs, the peptides match the sequence and structure of extracellular loops (ECL). This approach overcomes immunization issues related to membrane-spanning GPCR expression and purification.

(2) Incremental chicken antibody generation platform.

Since mammalian proteins are conserved, their homology may be too high to trigger an immune response in mammalian hosts. Such issues are circumvented by the Nebula platform which taps into the unexplored chicken antibody repertoire and provides a new source of high-affinity antibodies for discovery and human therapeutics.

(3) High-throughput selection and validation strategies that harness the power of phage-display technologies.
The best recombinant antibody candidates are identified and isolated in order to evaluate their functional and therapeutic potential.

In short, the Nebula antibody platform enables the discovery of one-of-a-kind antibodies providing our partners with new candidates for diagnostics, antibody drug conjugates (ADCs) and therapeutics.

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Immune Biosolutions has not listed any services.

Recombinant antibody production
Price on request

To meet your specific needs and expectations, our antibody development process consists of 4 phases under strict confidentiality:
1- Designing a variety of antigens to address difficult proteins.
Unique antigen strategies including Spatial Peptides that are rationally designed and functionality-oriented synthetic 3D peptides... Show more »

To meet your specific needs and expectations, our antibody development process consists of 4 phases under strict confidentiality:
1- Designing a variety of antigens to address difficult proteins.
Unique antigen strategies including Spatial Peptides that are rationally designed and functionality-oriented synthetic 3D peptides that mimic native structure of challenging targets
2-Generating antibody diversity
Based on the chicken immune system: in vivo titer maturation, new epitopes, species cross-reactive abs…
Not limited by immunological tolerance: high success rate with mammalian conserved proteins
3-Selecting the best binders.
Efficient ex vivo phage-display selection coupled with NGS to explore the full diversity of chicken ab libraries
4-Formatting recombinant antibody for specific applications.
Highly successful formatting workflow with a variety of recombinant format to choose from. Validated human frameworks with ultra-low immunogenicity profiles for therapeutic applications available.

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Cancer
Drug discovery
NGS
inflammatory Bowel Disease
Inflammation
Cancer
G-protein
Infectious Disease
Infectious Disease
inflammation
Gastric Cancer
Ion Channel
phage display
ultra-humanization
membrane protein
recombinant antibody
Polyclonal Antibody Production
Price on request

To meet your specific needs and expectations, our antibody development process consists of 3 phases under strict confidentiality:

  1. Design: We gather antibody requirements, evaluate the feasibility and submit a customized proposal that defines our peptide selection, timelines and cost.
  2. Generation: Following the design’s... Show more »

To meet your specific needs and expectations, our antibody development process consists of 3 phases under strict confidentiality:

  1. Design: We gather antibody requirements, evaluate the feasibility and submit a customized proposal that defines our peptide selection, timelines and cost.
  2. Generation: Following the design’s approval, the peptide (or other target molecule) is synthesized. We start with a 60-day immunization program with constant antibody titer monitoring.
  3. Validation +: We validate the antibody by ELISA (we guarantee positive ELISA against the immunizing peptide) and Western blot (when possible). Depending on the project, an affinity purification and direct coupling may be required. A complete technical report is delivered with generation details and suggested concentration of antibodies for the most common applications.
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Chicken
Biology
Drug discovery
Inflammation
Cancer
Infectious Disease
Antibody Production
immunization
antibody production
custom antibody
polyclonal antibody
Protein Conjugation
Price on request

We offer all type of custom bioconjugaison for a competitive price.

We offer all type of custom bioconjugaison for a competitive price.

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Antibody Purification
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Animal Immunization for Antibody Production
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Chicken
Biology
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Antibody Services
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Protein Services
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Pharmacology & Toxicology
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Protein Expression Visualization
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Immunostaining
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Biochemistry & Molecular Biology
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Western Blot
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Immunofluorescence
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Flow Cytometry
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Cytometry
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Biomarkers
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Cells and Tissues
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Bioanalysis
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