Immundnz Ltd.
About Immundnz Ltd.
Immundnz is a CRO specialised in immunology, immune modelling, immune response and tissue damage analysis, in vivo and in vitro cell culture systems and complex bioanalytical chemistry for preclinical drug research and development. We are located in the Netherlands and at the prestigious Alderley Park campus in Cheshire, UK, where we have an established immunology laboratory.
Our Services (49)
In vitro Immune Function Testing
- Consultants in designing the model for immune response in in vitro and in vivo
- Laboratory experiments (in vivo and/or in vitro) to test the model
- Human in vitro systems and mammalian in vivo systems
Why is Immune Modelling Important?
You will need an immune model if developing an immunotherapeutic that is expected... Show more »
- Consultants in designing the model for immune response in in vitro and in vivo
- Laboratory experiments (in vivo and/or in vitro) to test the model
- Human in vitro systems and mammalian in vivo systems
Why is Immune Modelling Important?
You will need an immune model if developing an immunotherapeutic that is expected to function through generating an immune response (e.g. against tumours) or if the drug targets an immune condition (e.g. autoimmunity) or if the drug might generate an adverse immune response.
The adaptive immune system is a very complex system that is structured through a cascade of cells, receptors and cytokines that process, respond, initiate, memorise and deliver an immune response.
In a sterile inflammatory state, as in a drug-induced effect, the immune effectors interact with the tissue of the body to produce a cell mediated and/or antibody mediated immunity.
This is studied through appropriate immune model that is designed by immunologists with the relevant experience and insight.
Immune Cell Assays
Cell Death Assays
Mammalian Cell Culture
Cell culture systems are at the heart of our expertise and services. We grow human and mammalian cells in various culture media, both adherent and non-adherent (e.g. lymphocytes) type. We grow various established and primary human cells in our lab that represent human tissue systems such as:
- Aortic smooth muscle cells... Show more »
Cell culture systems are at the heart of our expertise and services. We grow human and mammalian cells in various culture media, both adherent and non-adherent (e.g. lymphocytes) type. We grow various established and primary human cells in our lab that represent human tissue systems such as:
- Aortic smooth muscle cells (SMCs)
- Lung epithelial cells (A549)
- Embryonic renal cells (HEK293)
- Hepatic cells (HepG2)
- Cervical cancer cells (HeLa)
- Placental cells (BeWo)
- Retinal epithelial cells (ARPE19)
- Neuronal cells (SY5Y)
- Prostate cancer cells (PC3)
- Lymphocytic cells (THP1, TALL1, BALL1)
- Monocyte derived dendritic cells
Immunology Animal Models
- Consultants in designing the model for immune response in in vitro and in vivo
- Laboratory experiments (in vivo and/or in vitro) to test the model
- Human in vitro systems and mammalian in vivo systems
Why is Immune Modelling Important?
You will need an immune model if developing an immunotherapeutic that is expected... Show more »
- Consultants in designing the model for immune response in in vitro and in vivo
- Laboratory experiments (in vivo and/or in vitro) to test the model
- Human in vitro systems and mammalian in vivo systems
Why is Immune Modelling Important?
You will need an immune model if developing an immunotherapeutic that is expected to function through generating an immune response (e.g. against tumours) or if the drug targets an immune condition (e.g. autoimmunity) or if the drug might generate an adverse immune response.
The adaptive immune system is a very complex system that is structured through a cascade of cells, receptors and cytokines that process, respond, initiate, memorise and deliver an immune response.
In a sterile inflammatory state, as in a drug-induced effect, the immune effectors interact with the tissue of the body to produce a cell mediated and/or antibody mediated immunity.
This is studied through appropriate immune model that is designed by immunologists with the relevant experience and insight.
Necrosis Assays
Tissue Damage Assessment
The endogenous molecules or proteins that are released by cells through drug-induced necrosis or compromised membrane are activators of an immune response. By characterising these molecules in cells and cell fluids in combination with pathway analysis, we are able to assess drug-induced tissue... Show more »
Tissue Damage Assessment
The endogenous molecules or proteins that are released by cells through drug-induced necrosis or compromised membrane are activators of an immune response. By characterising these molecules in cells and cell fluids in combination with pathway analysis, we are able to assess drug-induced tissue damage. This is a very important step in drug risk assessment at preclinical stage.
Immunoassays
Immunoassays Services
Immunoassays Services
Bioanalytical Assays
Bioanalytical Assays Services
Bioanalytical Assays Services
Bioanalysis
Bioanalysis Services
Bioanalysis Services
Pharmacology & Toxicology
Pharmacology & Toxicology Services
Pharmacology & Toxicology Services
Bioanalytical Assay Validation
Bioanalytical Assay Development and Optimization
Liposome Immunoassay
Large Molecule Bioanalysis
Small Molecule Bioanalysis
Cell Permeability Assay
Apoptosis Assays
Cell Culture Consulting
Surface Plasmon Resonance (SPR)
Size Exclusion Chromatography (SEC)
HPLC assay for SEC, titer
HPLC assay for SEC, titer
Stem Cell Assays
Cell Disruption
Therapeutic Drug Monitoring
Experimental Services
Cell Invasion & Migration Assays
Primary Cell Culture
Subcellular Fractionation
Imaging & Spectroscopy
Cytokine Storm Testing
Cytokine Analysis
In vitro Immunogenicity Assays
Immunostaining
Immunostaining Services
Immunostaining Services
Protein Expression Visualization
Protein Expression Visualization Services
Protein Expression Visualization Services
Protein Services
Protein Services
Protein Services
Biochemistry & Molecular Biology
Biochemistry & Molecular Biology Services
Biochemistry & Molecular Biology Services
Immunohistochemistry (IHC)
Cell Lines
Project Management
Omics
Chromatography
Chromatography Services
Chromatography Services
Separation/Purification Services
Purification Services
Purification Services
Analytical Chemistry Services
Analytical Chemistry Services
Analytical Chemistry Services
Chemistry and Materials
Chemistry and Materials Services
Chemistry and Materials Services
Functional & Cell Type Specific Assays
Functional & Cell Type Specific Assays Services
Functional & Cell Type Specific Assays Services
Cell-Based Assays
Cell-Based Assays Services
Cell-Based Assays Services
Cell and Tissue Culture
Cell and Tissue Culture Services
Cell and Tissue Culture Services
Cells and Tissues
Cells and Tissues Services
Cells and Tissues Services
Biology
Biology Services
Biology Services
Custom Cell-Based Assay Development
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