Immundnz is a CRO specialised in immunology, immune modelling, immune response and tissue damage analysis, in vitro cell culture systems and complex bioanalytical chemistry for preclinical drug research and development. We are located in the Netherlands and in the UK, where we have an established immunology laboratory.
Cell co-culutures for in vitro immunology research
Dendritic cell generation and maturation assays
T-cell activation and proliferation assays for in vitro immunology research
T-Helper Cell Polarization Assays for in vitro immunology research
Mixed Lymphocyte eaction assays for immunology research
-Laboratory experiments (in vivo and/or in vitro) to test the model
-Human in vitro systems and mammalian in vivo systems
Cell culture systems are at the heart of our expertise and services. We grow human and mammalian cells in various culture media, both adherent and non-adherent (e.g. lymphocytes) type. We grow various established and primary human cells in our lab that represent human tissue systems such as:
Tissue Damage Assessment
The endogenous molecules or proteins that are released by cells through drug-induced necrosis or compromised membrane are activators of an immune response. By characterising these molecules in cells and cell fluids in combination with pathway analysis, we are able to assess drug-induced tissue damage. This is a very important step in drug risk assessment at preclinical stage.
•Intact mAb molecular mass analysis
•Fab, Fc, HC, LC
•Quantification of biopharmaceuticals in biological matrices
•Analysis of proteins involved in immune response
•Top-down (intact proteins)
•Bottom-up (digested proteins)
•Targeted (knowledge based)
•Multivariate data analysis
Protein Expression Visualization Services
Functional & Cell Type Specific Assays Services
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