Imavita

Imavita proposes preclinical models which can be used alone or associated with imaging modalities to permit the evaluation of efficacy of new compounds / new therapeutics treatments in development phase.

Species / strains

• Rodents (rat / mouse / hamster / Guinea pig)
• Non rodents (rabbits / pig / sheep / goat)
• Fish (zebra fish)
• Healthy / normal models

Type of studies

• Pharmacokinetics / early PK
• Pharmacodynamics / PK/PD relationships
• Biodistribution / Elimination evaluation

Example of projects

• PK / early PK / PK/PD with serial or terminal sampling animals (in-life phase)
• PK on catheterized animals (jugular / femoral / combined) for PK and/or PK/PD studies (in-life phase)
• Bile / lymph / cerebrospinal fluid catheterized rats for pharmacokinetics evaluation / transport evaluation of molecules / PK/PD relationships (in-life phase)
• Telemetry studies (core temperature / ECG / EMG /EEG) combined or not with catheterized animals for PK/PD evaluation or safety pharmacology
• Pathological models / induced pathologies

Type of studies

• Evaluation of pharmacokinetics on pathological animals / impact of pathology on PK parameters
• Efficacy studies with different approaches:
• Classical approach / parallel groups
• Longitudinal study (repeated measure experiment) by applying imaging modalities

Example of projects

• Efficacy studies in myocardial infarction induced rat
• Efficacy of new molecules on bone healing in normal & osteoporosis rat model
• Efficacy of new molecules on skin healing (wound / burn in mice or rat)

Resources

• Access to conventional facilities / SPF / SOPF for rodents
• Access to conventional facilities for large species

Imavita proposes preclinical models which can be used alone or associated with imaging modalities to permit the evaluation of efficacy of new compounds / new therapeutics treatments in development phase.

Species / strains

• Rodents (rat / mouse / hamster / Guinea pig)
• Non rodents (rabbits / pig / sheep / goat)
• Fish (zebra fish)
• Healthy / normal models

Type of studies

• Pharmacokinetics / early PK
• Pharmacodynamics / PK/PD relationships
• Biodistribution / Elimination evaluation

Example of projects

• PK / early PK / PK/PD with serial or terminal sampling animals (in-life phase)
• PK on catheterized animals (jugular / femoral / combined) for PK and/or PK/PD studies (in-life phase)
• Bile / lymph / cerebrospinal fluid catheterized rats for pharmacokinetics evaluation / transport evaluation of molecules / PK/PD relationships (in-life phase)
• Telemetry studies (core temperature / ECG / EMG /EEG) combined or not with catheterized animals for PK/PD evaluation or safety pharmacology
• Pathological models / induced pathologies

Type of studies

• Evaluation of pharmacokinetics on pathological animals / impact of pathology on PK parameters
• Efficacy studies with different approaches:
• Classical approach / parallel groups
• Longitudinal study (repeated measure experiment) by applying imaging modalities

Example of projects

• Efficacy studies in myocardial infarction induced rat
• Efficacy of new molecules on bone healing in normal & osteoporosis rat model
• Efficacy of new molecules on skin healing (wound / burn in mice or rat)

Resources

• Access to conventional facilities / SPF / SOPF for rodents
• Access to conventional facilities for large species