IDEXX BioAnalytics

Reduce research variables by gaining a deeper insight into your animal's Microbiome with state-of-the-art analysis and data comparison.

• Easy sample collection—just 2 frozen fecal pellets required
• Quick turnaround in just 4 weeks or less
• Cost-effective and efficient

Microbiome analysis includes:

• DNA isolation—from all bacteria in the sample
• Deep sequencing—generates 200–500 megabases of sequence
• Data comparison and analysis—our bioinformatics produce a comparative analysis to known bacterial sequences
• Bacterial Identification—identifies all bacteria present and their relative abundance
Expect greater insight—from the experts in animal health monitoring.

The prevalence of Mycoplasma contamination in cell lines and cell culture is approximately 10 percent. Testing for this contaminant is important to ensure the quality of your research, to confirm the validity of your results, and to align with regulatory guidance for products derived from mammalian cell cultures.

STAT-Myco™ is a highly sensitive real-time PCR assay that detects as few as 1-10 organisms, detects all Mycoplasma and Acholeplasma species known to contaminate cell culture and many species not detected by commercially available kits. Results in just 3 business days.

Volume discounts available for as few as 5 samples. Please request a quote.

Microbial contamination of cell culture is not a rare event. In fact, client samples tested during 2014 had a microbial contamination rate of bacteria and fungi, upwards of 15%. Sterility testing detects a wide variety of aerobic and microaerophilic bacteria, yeasts, and fungi. Our proprietary cultivation capabilities span hundreds of genera of bacteria and fungi, with three profile offerings that exceed the US CFR Section 21 requirements. Microbial identification is also offered through the use of MALDI-TOF™ mass spectrometry state-of-the-art technology.

Three profiles are available:
Profile 1 - Direct Inoculation Method
Profile 2F- Membrane Filter Concentration Method (Complies with FDA Title 21 Code of Federal Regulations 610.12 [21CFR610.12])
Profile 2C - Centrifugation Concentration Method

Trust our industry-leading expertise for independent confirmation of quality, safety, and
authenticity of your biological materials to advance your research with confidence. We provide
an unparalleled breadth of biological testing services. A single sample is all that is required
for a myriad of testing profiles including rodent and human viral pathogens, microbial and
fungal contamination and cell line authentication using rigorously validated technologies
and methodologies.

IMPACT™ and h-IMPACT™ detect the presence of infectious agents in biological specimens to protect your research, your researchers and your reputation.
• Detects most prevalent and concerning pathogens
• Also detects Mycoplasma spp. contamination
• Results in 5 days or less

CellCheck™ is a comprehensive cell line authentication service that uses STR-based (short tandem repeat) DNA profiling and multiplex PCR to detect both contamination and misidentification. CellCheck detects inter-species contamination (human, mouse, rat, African green monkey and Chinese hamster) and establishes a genetic STR profile with data interpretation as well as comparative analysis for the detection of intra-species contamination.

When To Test
• When a new cell line is acquired or when banking frozen materials for later use.
• As a standard quality control measure at the beginning and end of experiments.
• As a standard quality control measure for cell lines in continuous use.
• When cell line performance is inconsistent or results are unexpected.
• To establish a genetic profile for a new or unique human cell line for which a reference profile is not available.
• Prior to publication in some journals or, as discussed in recent NIH notice, prior to grant applications.

CellCheck cell line authentication services are available for Human, Mouse, Rat, Canine, and Feline.

IDEXX BioResearch helps you save time and money by eliminating assay development and improving the speed and flexibility of your research. Our high-capacity reference laboratory uses rigorously validated, state-of-the-art instruments and methodologies to deliver accurate, efficient and independent data. Our experienced staff includes board-certified veterinary clinical and anatomical pathologists. We offer comprehensive biochemistry, hematology, histology, immunology, microbiology, real-time PCR and anatomic and clinical pathology services so you can focus on study design and data interpretation.

Animal Pathology and Histopathology

IDEXX BioResearch offers a variety of scalable pathology evaluation options. Our pathologists’
skills and expertise in comparing morphologic changes with biological states help clients to
establish interpretation criteria for a variety of studies. Our team of board-certified anatomic
and clinical pathologists is dedicated to rapid preparation, evaluation and interpretation of tissues
to meet your research goals and has the experience and specialized skills to support a broad range of preclinical research, including:
• Toxicology (acute, subacute and chronic)
• Safety and efficacy
• Bone defect/growth
• Tumorgenicity
• Irritation (medical device implant) studies

IDEXX BioResearch helps you save time and money by eliminating assay development and improving the speed and flexibility of your research. Our high-capacity reference laboratory uses rigorously validated, state-of-the-art instruments and methodologies to deliver accurate, efficient and independent data. Our experienced staff includes board-certified veterinary clinical and anatomical pathologists. We offer comprehensive biochemistry, hematology, histology, immunology, microbiology, real-time PCR and anatomic and clinical pathology services so you can focus on study design and data interpretation.

As part of the world’s largest veterinary reference laboratory system, IDEXX BioResearch leverages its wide range of diagnostic and analytical testing technologies, facilities, equipment and expertise to help clients achieve efficient, reliable, and accurate results. We support both non-GCP and GCP studies, conducted in accordance with VICH GL9 guidelines for Good Clinical Practice (GCP), and deliver impartial, independent laboratory results to assist with new drug or indication submissions to the FDA. Our board-certified veterinary clinical and anatomical pathologists provide support throughout the duration of single-site and multicenter veterinary clinical studies to determine the safety and/or efficacy of new drug
candidates and therapies.

Analytical Expertise
• Complete range of testing, including biochemistry, hematology, histology, immunology, microbiology, real-time PCR and anatomic and clinical pathology
• Experienced board-certified veterinary clinical and anatomic pathologists available to consult on protocols and test results
• Staff familiar with testing protocols and customized study needs

Testing Support
• Collection supplies and guidelines sent to sites as needed
• Rapid turnaround time and result reporting to sites and/or trial monitor/sponsor
• Customized tracking, reporting and updates for multicenter trials
• Reliable reference ranges (for feline, canine, equine)

Project Management
• Dedicated project planner for duration of study
• Dedicated quality assurance team to audit results and oversee adherence to quality measures
• Results delivered via fax, available online, or delivered via client electronic data capture (EDC) systems
• Final study reports, including a detailed summary of study-related activities, suitable for FDA submission

IDEXX VetLab UA Analyzer

Comprehensive and convenient urinalysis testing with the IDEXX VetLab UA Analyzer. It is simple to operate and produces consistent, automatically printed results.

Research Advantages

• Eliminates the need to read color strips
• Simple, load-and-go operation
• Results in approximately 80 seconds
• Parameters provided: pH, LEU, PRO, GLU, KET, UBG, BIL, and BLD/HBG

Species
Mouse, rat, monkey, dog, cat, rabbit, gerbil, guinea pig, ferret, cow, pig, mini pig and horse

Technology Features

• Variable-wavelength light-emitting diodes (LEDs): reads results electro-optically
• Reflectance photometer: produces a semiquantitative result in approximately 80 seconds
• Integrated electronic reporting: built-in printer; connects with IDEXX VetLab Station

Accessories

• IDEXX UA Strips: use manually or with the IDEXX VetLab UA Analyzer
• IDEXX UA Calibration Strips: calibrates the IDEXX VetLab UA Analyzer

VetStat Electrolyte and Blood Gas Analyzer

Run the tests you need to support your research: electrolyte levels, acid-base status, respiratory and blood gas levels, and ionized calcium and glucose levels.

Research advantages

• Accurate results in less than 2 minutes
• Runs whole blood, plasma and serum on single-use cassettes
• Portable, with up to 4 hours of battery life

Technology features

• Optodes: accurately measures optical fluorescence from discrete sensors
• Disposable, single-use cassettes: calibration, sample measurement and waste containment, all-in-one
• Integrated electronic reporting: collects results in the electronic medical record using the IDEXX VetLab Station

Cassettes

• Electrolytes: Na+, K+, CL-
• Electrolytes 8 Plus: Na+, K+, Cl-, pH, PCO2, tCO2, HCO3-, and anion gap
• Respiratory/Blood Gases: Na+, K+, Cl-, pH, PCO2, tCO2, HCO3-, anion gap, PO2, SO2, tHb, and base excess
• Ionized Calcium: Ca++
• Glucose: GLUE

Drug Discovery & Development Services

Pharmacology Services

Cell and Tissue Culture Services

Microbiology Services

Microbiology Assays Services

Clinical Microbiology, Virology and Parasitology Services