Why ICE Bioscience?
The neuronal clamp is performed in acutely isolated or cultured cortex, hippocampus, myelin and other neurons. The spinal cord’s Dorsal Root Ganglion (DRG) neurons acute separation, culture, nerve cell apoptosis, cell damage, hypoxia protection experiment.
Electrophysiological research: voltage gated channel (Na, Ca or K channel, etc.) or ligand gated channel (GABA, NMDA, AMPA, etc.) as well as action potential, spontaneous synaptic post-potential, screening and mechanism study of analgesic drugs.
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CE Bioscience have a competent & dedicated team working in cardiovascular pharmacology unit. Animal models of cardiovascular system diseases are an important tool for the evaluation of cardiovascular system drugs. In order to evaluate the cardiovascular pharmacology, ICE Bioscience has developed animal models for various cardiac disorders like arrhythmia, myocardial ischemia, heart failure etc.
1. Heart failure model:
2. Increased rear load:
i) aortic narrowing ii) salt sensitivity HF model.
3. Increased front load:
i) venous fistula method ii) partial valve closure method iii) vein narrowing method.
4. HF model of reduced myocardial contraction:
i) coronary artery-causing ischemic cardiomyopathy ii) rapid ventricular pacing method.
Drug Based Models
ICE Bioscience INC has established Heart Failure (HF) models by using Sodium pentobarbital, Ethanol, Verapamil, Propranolol, Daunorubicin, Adriamycin and Isoprenaline. These drugs induced the decreased myocardial contraction leading to HF model.
1. Arrhythmia model:
These are the strong Arrhythmia models.
Calcium chloride , radon chloride and chloroform model.
2. Atrial fibrillation model:
Myocardial ischemia model
ICE Bioscience INC has established CNS pharmacological research setups based on animal models of various CNS disorders.
These are the animal models developed for CNS research
Learning and memory model
Brain ischemia Model
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Bioscience has developed more than 400 kinase biochemical assays that allow rapid determination of compound potency and selectivity. Our kinase assays also detect ATP-competitive, substrate competitive, and allosteric inhibitors, not to mention they are adaptable to any protein or peptide substrate without modification. Our scientist team will offer unmatched expertise to assist you in kinase drug discovery.
Services Available for Kinase Assays:
High throughput screening assays
Large scale single dose, duplicate profiling services IC50 profiling services — 5 or 10 dose with curve fitting Ki determination assay services
Custom Assay development Substrate determination assay Research collaboration
Detection Method: Activity Assay Turn Around Time: 5-10 Work Days
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TRP ion channels are closely related to a variety of sensory reactions including heat, cold, pain, pressure, smell and taste, and are easily regulated by natural aromatic substances and are the therapeutic targets of many diseases. TRP Ion Channel Family.
TRP channels are drug targets for pain, anxiety, depression, schizophrenia , tumor and cardiovascular related disorders.
ICE Biosciences has developed the TRP Channel Panel
TRPV, TRPM, TRPC, TRPA subfamilies.
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GPCR forms the largest human membrane protein family of medicinal targets, with overall 800 members.GPCRs that serve as drug targets for the treatment of a multitude of conditions including hypertension, pain, ulcers, allergies, alcoholism, obesity, glaucoma, psychotic disorders , HIV, Lymphangiogenesis and lymphatic vascular disease etc.
ICE has established more than 80 GPC receptors, 300+ stable GPCR cell lines development is in process.
Why ICE Bioscience? We provide
● More flexible collaboration choices.
● Fast turnaround, 6-8 weeks for cell line, and 2 weeks for assay validation.
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Calcium channel is an important target for drug action, and is of key importance in the cardiovascular diseases, pain, Alzheimer's disease, etc.
ICE has established the stable cell line of the following calcium channels
Cav 1.2 , Cav 2.1, Cav 2.2 , Cav 3.2
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The potassium channel family includes more than 70 members of the voltage-gated potassium channel (Kv), the calcium-activated potassium channel (KCa), the introverted rectifier potassium channel (Kir), and the sub-type of double-well potassium channel (K2P).
The potassium channels are linked with a variety of disorders like seizures, PD, AD, stroke, epilepsy, diabetes, cardiovascular disorders etc. Therefore, target for various drugs.
ICE has developed a stable expression cell line of nearly 40 human-derived potassium channels for targeted drug screening
Voltage-gated potassium channels : Kv1.3, Kv1.5, Kv2.1, Kv3.4, Kv4.2, Kv7.1, Kv7.2/7.3, Kv7.4, Kv11.1 (hERG)
Inward-rectifier potassium channels Kir2.1, Kir3.1/3.2
Calcium-activated potassium channels : BKCa, SKCa1
Two-pore domain potassium channels : TASK-1/TASK-3, TREK-1
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ICE has established the stable expression cell line of human and mouse-derived sodium channels. The primary cell detection method for drug screening of sodium channel targets.
Sodium channels represent well-precedented drug targets as antidysrhythmic, anticonvulsants and local anesthetics. To date, nine isoforms of the VGSCs have been discovered (Nav1.1-1.9).
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ICE Bioscience uses electrophysiology techniques in neural drug target identification, efficiency evaluation and mechanism investigation. We conduct experiments for evaluating the pharmacological and physiological properties of neuronal activities, including stroke, epilepsy, Parkinson’s disease, Alzheimer's disease, pain or neuron plasticity.
In vivo electrophysiology recordings in vivo in different brain regions and nuclei or peripheral nerves In vivo animal models studies for animal behaviors, motor activity, and memory.
ICE Bioscience is a company focusing on ion channel drug discovery and safety screening. We now have 4 manual patch clamp sets and 1 automated Patch Liner patch clamp set in our facility. Over 50% of Scientists in our facility are experts in cardiac ion channel drug screening and safety evaluation. One of our main projects is to develop the Comprehensive in Vitro Proarrhythmia (CiPA) assay. We have developed cell lines for 12 ion channels that are related to cardiomyocytes, covering almost all channels activated during action potential in heart. Following is the list of ion channels in CiPA assay: hERG(IKr), Cav1.2 (ICa, L), Nav1.5, KCNQ1/KCNE(IKs), Kir2.1(IK1), HCN4(If), Kv4.3 (Ito), Kv1.5 (Ikur), HCN2, HCN4, Kir3.1/3.4 (IAch), and Kir6.2/SUR2A (KATP). Besides, we have developed over 60 ion channel cell lines, including voltage-gated and ligand-gated ion channels, and more than 100 cancer cell lines for screening as well as drug discovery.
Cardiac Safety Assays
Comprehensive In Vitro Proarrhythmia Assay (CiPA) Drug-induced Torsade de Pointes (TdP) is a lethal arrhythmia which is associated prolonged heart repolarization. Inhibition of hERG(IKr) channel induces QT interval prolongation, which is the major preclinical cardiac risk indicator in pro-arrhythmic risk prediction. However, because the cardiac action potential is determined by a fine balance of cardiac ion channels, more evidences indicate that other channels, such as Nav, Cav, are also important in cardiac repolarization. Therefore, ICE Bioscience offers Comprehensive In Vitro Proarrhythmia Assay (CiPA) for the cardiac safety studies. ICE CiPA panel: Channels Species Assay Format hERG(IKr) Human Manual / Automated Patch Clamp electrophysiology Cav1.2 Human Manual / Automated Patch Clamp electrophysiology Nav1.5 Human Manual / Automated Patch Clamp electrophysiology KCNQ1/KCNE(IKs), Human Manual / Automated Patch Clamp electrophysiology Kir2.1(IK1) Human Manual / Automated Patch Clamp electrophysiology HCN4(If) Human Manual / Automated Patch Clamp electrophysiology Kv1.5(Ikur), Human Manual / Automated Patch Clamp electrophysiology Turnaround time: <5 business days from receiving compounds
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|Voltage gated ion channels||-|
|Sodium channels||Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.6, Nav1.7, Nav1.8|
|Calcium channels||Cav1.2, Cav2.1, Cav2.2, Cav3.2|
|Voltage-gated potassium channels||Kv1.3, Kv1.5, Kv2.1, Kv3.4, Kv4.2, Kv7.1, Kv7.2/7.3, Kv7.4, Kv11.1 (hERG)|
|Inward-rectifier potassium channels||Kir2.1, Kir3.1/3.2|
|Calcium-activated potassium channels||BKCa, SKCa1|
|Two-pore domain potassium channels||TASK-1/TASK-3, TREK-1|
|Ligand gated ion channels||-|
|TRP channels:||TRPV1, TRPM8, TRPC6, TRPC7|
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