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ICE Bioscience

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Daxing District, Beijing, CN

About ICE Bioscience

ICE Bioscience established in 2010, an Advent portfolio company is a leading life sciences research and development organization that provides biopharmaceutical clients and partners with widespread and specific drug discovery and development services. ICE Bioscience is specialized in delivering pre-clinical research solutions in the field of cell line development, protein extension and target-based drug screening on various druggable targets with a particular emphasis on the central nervous and cardiovascular systems. The company also focusses on QT prolongation related cardiac safety evaluation services. 
The company has established adaptable drug screening platform for more than 80 Ion channels, 80 GPCRs , 400 kinase targets and 40 nuclear receptors. We provide professional drug target screening  and off target panel for early stage safety evaluation. The company has established full ex vivo cardiac safety assessment panel for pro Arrhythmia .The company has also established numerous disease related animal model of Central Nervous (Pain/ Neurodegeneration disease (AD/PD)/ Epilepsy models) and Cardiovascular system (arrhythmia, myocardial ischemia, heart failure) in order to provide specific drug targets for new drug research and development (R&D) services. 
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Why ICE Bioscience?

  • In-depth electrophysiology expertise
  • Knowledgeable in CNS and cardiovascular pharmacology
  • A growing number of in house ion channel stable expression cell lines and primary cells (Table 1 shows ICE ready-to-use ion channel cell lines)
  • Validated state-of-the-art technological platforms
  • Flexible and high efficiency, rapid turnaround time
  • Cost effectiveness

Selected Publications

  1. Cold-Inducible RNA-Binding Protein Regulates Cardiac Repolarization by Targeting Transient Outward Potassium Channels. Li J, Xie D, Huang J, Lv F, Shi D, Liu Y, Lin L, Geng L, Wu Y, Liang D, Chen YH. Circ Res. 2015 May 8;116(10):1655-9. IF=11.019
  • Modeling Dravet syndrome using induced pluripotent stem cells (iPSCs) and directly converted neurons. Jiao J, Yang Y, Shi Y, Chen J, Gao R, Fan Y, Yao H, Liao W, Sun XF, Gao S. Hum Mol Genet. 2013 Nov 1;22(21):4241-52. IF=7.7
  • Tumor necrosis factor-α enhances voltage-gated Na(+) currents in primary culture of mouse cortical neurons. Chen W, Sheng J, Guo J, Gao F, Zhao X, Dai J, Wang G, Li K. J Neuroinflammation. 2015 Jun 26;12:126. IF=4.35
  • Retinoic acid receptor gamma (Rarg) and nuclear receptor subfamily 5, group A, member 2 (Nr5a2) promote conversion of fibroblasts to functional neurons. Shi Z, Shen T, Liu Y, Huang Y, Jiao J. J Biol Chem. 2014 Jan 23 IF=4.65
  • Enhanced rejuvenation in induced pluripotent stem cell-derived neurons compared with directly converted neurons from an aged mouse. Yang Y, Jiao J, Gao R, Le R, Kou X, Zhao Y, Wang H, Gao S, Wang Y. Stem Cells Dev. 2015 Jul 20. [Epub ahead of print] . IF=4.459

Diversity Certificates

Woman owned small business

Our Services (33)


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Patch Clamp Recording

Price on request

The neuronal clamp is performed in acutely isolated or cultured cortex, hippocampus, myelin and other neurons. The spinal cord’s Dorsal Root Ganglion (DRG) neurons acute separation, culture, nerve cell apoptosis, cell damage, hypoxia protection experiment. 

Electrophysiological research: voltage gated channel (Na, Ca or K channel, etc.) or ligand gated channel (GABA, NMDA, AMPA, etc.) as well as action potential, spontaneous synaptic post-potential, screening and mechanism study of analgesic drugs.

For further details please visit http://www.ice-biosci.com/product/product.php?lang=en&class2=55


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Cardiovascular Animal Models

Price on request

CE Bioscience have a competent & dedicated team working in cardiovascular pharmacology unit. Animal models of cardiovascular system diseases are an important tool for the evaluation of cardiovascular system drugs. In order to evaluate the cardiovascular pharmacology, ICE Bioscience has developed animal models for various cardiac disorders like arrhythmia, myocardial ischemia, heart failure etc. 

1.    Heart failure model: 

2. Increased rear load: 

i) aortic narrowing ii) salt sensitivity HF model. 

3.    Increased front load: 

i) venous fistula method ii) partial valve closure method iii) vein narrowing method. 

4. HF model of reduced myocardial contraction: 

i) coronary artery-causing ischemic cardiomyopathy ii) rapid ventricular pacing method. 

Drug Based Models 

ICE Bioscience INC has established Heart Failure (HF) models by using Sodium pentobarbital, Ethanol, Verapamil, Propranolol, Daunorubicin, Adriamycin and Isoprenaline. These drugs induced the decreased myocardial contraction leading to HF model. 

1.  Arrhythmia model: 

These are the strong Arrhythmia models. 

Calcium chloride , radon chloride and chloroform model. 

2.   Atrial fibrillation model: 

Myocardial ischemia model


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CNS/Neurology Animal Models

Price on request

ICE Bioscience INC has established CNS pharmacological research setups based on animal models of various CNS disorders. 

These are the animal models developed for CNS research 

Pain model 

Depression model 

Parkinson’s model 

Alzheimer’s model 

Learning and memory model 

Brain ischemia Model 

For further details please visit http://www.ice-biosci.com/product/showproduct.php?lang=en&id=117


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Kinase Screening and Profiling

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 Bioscience has developed more than 400 kinase biochemical assays  that allow  rapid determination of compound potency and selectivity. Our kinase assays also detect ATP-competitive, substrate competitive, and allosteric inhibitors, not to mention they are adaptable to any protein or peptide substrate without modification. Our scientist team   will offer unmatched expertise to assist you in kinase drug discovery. 

 

Services Available for Kinase Assays: 

High throughput screening assays 

Large scale single dose, duplicate profiling services IC50 profiling services — 5 or 10 dose with curve fitting Ki determination assay services 

Custom Assay development Substrate determination assay Research collaboration 

 

Detection Method: Activity Assay Turn Around Time: 5-10 Work Days 

For further details please visit 

http://www.ice-biosci.com/product/showproduct.php?lang=en&id=92



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TRP Channel Assays

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TRP ion channels are closely related to a variety of sensory reactions including heat, cold, pain, pressure, smell and taste, and are easily regulated by natural aromatic substances and are the therapeutic targets of many diseases. TRP Ion Channel Family. 

TRP channels are drug targets for pain, anxiety, depression, schizophrenia , tumor and cardiovascular related disorders.


ICE Biosciences has developed the TRP Channel Panel 


TRPV, TRPM, TRPC, TRPA  subfamilies. 

For further details please visit ,http://www.ice-biosci.com/product/showproduct.php?lang=en&id=140


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GPCR Screening and Profiling

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GPCR  forms the largest human membrane protein family of medicinal targets, with overall 800 members.GPCRs that serve as drug targets for the treatment of a multitude of conditions including hypertension, pain, ulcers, allergies, alcoholism, obesity, glaucoma, psychotic disorders , HIV, Lymphangiogenesis and lymphatic vascular disease etc.   

   

ICE has established more than 80 GPC receptors, 300+ stable GPCR cell lines development is in process.   

    

Why ICE Bioscience? We provide   

● More flexible collaboration choices.   

● Fast turnaround, 6-8 weeks for cell line, and 2 weeks for assay validation. 

For further details please visit  http://www.ice-biosci.com/product/showproduct.php?lang=en&id=66 


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Calcium Channel Assays

Price on request

Calcium channel is an important target for drug action, and is of key importance in the cardiovascular diseases, pain, Alzheimer's disease, etc.     

    

 ICE has established the stable cell line of the following calcium channels      

Cav 1.2 , Cav 2.1, Cav 2.2 , Cav 3.2    

For further validation details please visit   

http://www.ice-biosci.com/product/showproduct.php?lang=en&id=138 


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Potassium Channel Assays

Price on request

The potassium channel family includes more than 70 members of the voltage-gated potassium channel (Kv), the calcium-activated potassium channel (KCa), the introverted rectifier potassium channel (Kir), and the sub-type of double-well potassium channel (K2P).  

The potassium channels are linked with a variety of disorders like seizures, PD, AD, stroke, epilepsy, diabetes, cardiovascular disorders etc. Therefore, target for various drugs.  

ICE has developed a stable expression cell line of nearly 40 human-derived potassium channels for targeted drug screening

Voltage-gated potassium channels : Kv1.3, Kv1.5, Kv2.1, Kv3.4, Kv4.2, Kv7.1, Kv7.2/7.3, Kv7.4, Kv11.1 (hERG) 

Inward-rectifier potassium channels Kir2.1, Kir3.1/3.2 

Calcium-activated potassium channels : BKCa, SKCa1 

Two-pore domain potassium channels : TASK-1/TASK-3, TREK-1

For further details please visit 

http://www.ice-biosci.com/product/showproduct.php?lang=en&id=136


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Sodium Channel Assays

Price on request

  

ICE has established the stable expression cell line of human and mouse-derived sodium channels. The primary cell detection method for drug screening of sodium channel targets.   

Sodium channels represent well-precedented drug targets as antidysrhythmic, anticonvulsants and local anesthetics. To date, nine isoforms of the VGSCs have been discovered (Nav1.1-1.9).  

For further details please visit: http://www.ice-biosci.com/product/showproduct.php?lang=en&id=135 


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In vivo Electrophysiology

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ICE Bioscience uses electrophysiology techniques in neural drug target identification, efficiency evaluation and mechanism investigation. We conduct experiments for evaluating the pharmacological and physiological properties of neuronal activities, including stroke, epilepsy, Parkinson’s disease, Alzheimer's disease, pain  or neuron plasticity. 

In vivo electrophysiology recordings in vivo in different brain regions and nuclei or peripheral nerves In vivo animal models studies for animal behaviors, motor activity, and memory.


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hERG Channel Inhibition Assay

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ICE Bioscience is a company focusing on ion channel drug discovery and safety screening. We now have 4 manual patch clamp sets and 1 automated Patch Liner patch clamp set in our facility. Over 50% of Scientists in our facility are experts in cardiac ion channel drug screening and safety evaluation. One of our main projects is to develop the Comprehensive in Vitro Proarrhythmia (CiPA) assay. We have developed cell lines for 12 ion channels that are related to cardiomyocytes, covering almost all channels activated during action potential in heart. Following is the list of ion channels in CiPA assay: hERG(IKr), Cav1.2 (ICa, L), Nav1.5, KCNQ1/KCNE(IKs), Kir2.1(IK1), HCN4(If), Kv4.3 (Ito), Kv1.5 (Ikur), HCN2, HCN4, Kir3.1/3.4 (IAch), and Kir6.2/SUR2A (KATP). Besides, we have developed over 60 ion channel cell lines, including voltage-gated and ligand-gated ion channels, and more than 100 cancer cell lines for screening as well as drug discovery.


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In vitro Cardiotoxicity Screening

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Cardiac Safety Assays 

Comprehensive In Vitro Proarrhythmia Assay (CiPA) Drug-induced Torsade de Pointes (TdP) is a lethal arrhythmia which is associated prolonged heart repolarization. Inhibition of hERG(IKr) channel induces QT interval prolongation, which is the major preclinical cardiac risk indicator in pro-arrhythmic risk prediction. However, because the cardiac action potential is determined by a fine balance of cardiac ion channels, more evidences indicate that other channels, such as Nav, Cav, are also important in cardiac repolarization. Therefore, ICE Bioscience offers Comprehensive In Vitro Proarrhythmia Assay (CiPA) for the cardiac safety studies. ICE CiPA panel: Channels Species Assay Format hERG(IKr) Human Manual / Automated Patch Clamp electrophysiology Cav1.2 Human Manual / Automated Patch Clamp electrophysiology Nav1.5 Human Manual / Automated Patch Clamp electrophysiology KCNQ1/KCNE(IKs), Human Manual / Automated Patch Clamp electrophysiology Kir2.1(IK1) Human Manual / Automated Patch Clamp electrophysiology HCN4(If) Human Manual / Automated Patch Clamp electrophysiology Kv1.5(Ikur), Human Manual / Automated Patch Clamp electrophysiology Turnaround time: <5 business days from receiving compounds

For further details please visit : http://www.ice-biosci.com/product/showproduct.php?lang=en&id=112


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Cell Line Products - Ion Channels

Price on request
Voltage gated ion channels -
Sodium channels Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.6, Nav1.7, Nav1.8
Calcium channels Cav1.2, Cav2.1, Cav2.2, Cav3.2
Voltage-gated potassium channels Kv1.3, Kv1.5, Kv2.1, Kv3.4, Kv4.2, Kv7.1, Kv7.2/7.3, Kv7.4, Kv11.1 (hERG)
Inward-rectifier potassium channels Kir2.1, Kir3.1/3.2
Calcium-activated potassium channels BKCa, SKCa1
Two-pore domain potassium channels TASK-1/TASK-3, TREK-1
Ligand gated ion channels -
GABA: α1- α5
NMDA: NR1/NR2A-2D
Ach: nAchR3, nAchR7
TRP channels: TRPV1, TRPM8, TRPC6, TRPC7


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Cell-Based Compound Screening

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Cellular Metabolism Assays

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RT-PCR

Reverse transcription polymerase chain reaction
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Drug Discovery & Development

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Protein Quantification

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Cell and Tissue Culture

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Hit Identification

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Nucleic Acid Services

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DNA Services

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In vitro Reporter Gene Assays

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Cells and Tissues

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Cellular Health & Metabolism Assays

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Mammalian Cell Culture

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Transfection

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Protein Services

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Protein Expression Visualization

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Drug Discovery

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Cell-Based Assays

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In vitro Toxicity Testing

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In vitro Toxicity Testing Services


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Toxicology

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Toxicology Services


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Li Yan

Senior director of business development

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