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ICE bioscience

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Daxing District, Beijing, CN

About ICE bioscience

ICE Bioscience Inc. is a premier R&D service provider expertise in ion channels and electrophysiology. Founded in 2010, our highly qualified team of scientists deliver pre-clinical research solutions in the area of protein expression, cell line development and target screening on ion channels, with... Show more »

ICE Bioscience Inc. is a premier R&D service provider expertise in ion channels and electrophysiology. Founded in 2010, our highly qualified team of scientists deliver pre-clinical research solutions in the area of protein expression, cell line development and target screening on ion channels, with particular focus on neuron system and cardio vascular system.

ICE has developed over 70 in house ion channel cell lines, covering most voltage-gated and ligand-gated ion channels, including Navs, Kvs, Cavs, GABAR, and TRP channels, etc. Our primary goal is to supply functionally validated, high quality ion channel cell lines suitable for use in both manual and automated electrophysiology assays as well as to rapidly increase our portfolio of available targets through cell line development.

Why ICE Bioscience?

  • In-depth electrophysiology expertise
  • Knowledgeable in nervous and cardiovascular pharmacology
  • A growing number of in house ion channel stable expression cell lines and primary cells (Table 1 shows ICE ready-to-use ion channel cell lines)
  • Validated state-of-the-art technological platforms
  • Flexible and high efficiency, rapid turnaround time
  • Cost effectiveness

Selected Publications

  1. Cold-Inducible RNA-Binding Protein Regulates Cardiac Repolarization by Targeting Transient Outward Potassium Channels. Li J, Xie D, Huang J, Lv F, Shi D, Liu Y, Lin L, Geng L, Wu Y, Liang D, Chen YH. Circ Res. 2015 May 8;116(10):1655-9. IF=11.019
  • Modeling Dravet syndrome using induced pluripotent stem cells (iPSCs) and directly converted neurons. Jiao J, Yang Y, Shi Y, Chen J, Gao R, Fan Y, Yao H, Liao W, Sun XF, Gao S. Hum Mol Genet. 2013 Nov 1;22(21):4241-52. IF=7.7
  • Tumor necrosis factor-α enhances voltage-gated Na(+) currents in primary culture of mouse cortical neurons. Chen W, Sheng J, Guo J, Gao F, Zhao X, Dai J, Wang G, Li K. J Neuroinflammation. 2015 Jun 26;12:126. IF=4.35
  • Retinoic acid receptor gamma (Rarg) and nuclear receptor subfamily 5, group A, member 2 (Nr5a2) promote conversion of fibroblasts to functional neurons. Shi Z, Shen T, Liu Y, Huang Y, Jiao J. J Biol Chem. 2014 Jan 23 IF=4.65
  • Enhanced rejuvenation in induced pluripotent stem cell-derived neurons compared with directly converted neurons from an aged mouse. Yang Y, Jiao J, Gao R, Le R, Kou X, Zhao Y, Wang H, Gao S, Wang Y. Stem Cells Dev. 2015 Jul 20. [Epub ahead of print] . IF=4.459
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Woman owned small business

Our Services (38)


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In vivo Electrophysiology

Price on request

ICE Bioscience applies electrophysiology techniques in neural drug target identification, efficiency evaluation, mechanism investigation. We study pharmacological and physiological properties of neuronal activities, including stroke, epilepsy, Parkinson’s disease, Alzheimer's disease, pain sensation or neuron plasticity.

*In... Show more »

ICE Bioscience applies electrophysiology techniques in neural drug target identification, efficiency evaluation, mechanism investigation. We study pharmacological and physiological properties of neuronal activities, including stroke, epilepsy, Parkinson’s disease, Alzheimer's disease, pain sensation or neuron plasticity.

In vivo electrophysiology
Firing recordings in vivo from brain regions and nuclei or peripheral nerves
In vivo animal models studies for animal behaviors, motor activity, and memory.

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Ex vivo Electrophysiology

Starting at $180.00 per unit

ICE Bioscience applies electrophysiology techniques in neural drug target identification, efficiency evaluation, mechanism investigation. We study pharmacological and physiological properties of neuronal activities, including stroke, epilepsy, Parkinson’s disease, Alzheimer's disease, pain sensation or neuron plasticity.

... Show more »

ICE Bioscience applies electrophysiology techniques in neural drug target identification, efficiency evaluation, mechanism investigation. We study pharmacological and physiological properties of neuronal activities, including stroke, epilepsy, Parkinson’s disease, Alzheimer's disease, pain sensation or neuron plasticity.

*In Vitro slice electrophysiology*
   Patch clamp recordings from brain and spinal cord slice
   Drug effect on synaptic activity and synaptic plasticity (miniature currents, paired pulse recordings and long-term recordings
   Field potential recordings, including measurement of LTP(long-term potentiation) /LTD(long-term depression recordings)
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Cell Electrophysiology

Starting at $180.00 per unit

ICE Bioscience applies electrophysiology techniques in neural drug target identification, efficiency evaluation, mechanism investigation. We study pharmacological and physiological properties of neuronal activities, including stroke, epilepsy, Parkinson’s disease, Alzheimer's disease, pain sensation or neuron plasticity.
... Show more »

ICE Bioscience applies electrophysiology techniques in neural drug target identification, efficiency evaluation, mechanism investigation. We study pharmacological and physiological properties of neuronal activities, including stroke, epilepsy, Parkinson’s disease, Alzheimer's disease, pain sensation or neuron plasticity.

Electrophysiology of primary cultured or acutely isolated neurons
Primary brain neurons: Pharmacology of voltage-gated or ligand gated channels, action potential in primary neurons (cortical, hippocampal or medulla oblongata…)
DRG neurons: Ion channel (eg. NaV) or action potential measurements for target identification or mechanism of analgesic drugs

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hERG Channel Inhibition Assay

Starting at $120.00 per unit

ICE Bioscience is a company focusing on ion channel drug discovery and safety screening. We now have 4 manual patch clamp sets and 1 automated Patch Liner patch clamp set in our facility.
Over 50% of Scientists in our facility are experts in cardiac ion channel drug screening and safety evaluation. One of our main projects is to... Show more »

ICE Bioscience is a company focusing on ion channel drug discovery and safety screening. We now have 4 manual patch clamp sets and 1 automated Patch Liner patch clamp set in our facility.
Over 50% of Scientists in our facility are experts in cardiac ion channel drug screening and safety evaluation. One of our main projects is to develop the Comprehensive in Vitro Proarrhythmia (CiPA) assay. We have developed cell lines for 12 ion channels that are related to cardiomyocytes, covering almost all channels activated during action potential in heart. Following is the list of ion channels in CiPA assay: hERG(IKr), Cav1.2 (ICa, L), Nav1.5, KCNQ1/KCNE(IKs), Kir2.1(IK1), HCN4(If), Kv4.3 (Ito), Kv1.5 (Ikur), HCN2, HCN4, Kir3.1/3.4 (IAch), and Kir6.2/SUR2A (KATP). Besides, we have developed over 60 ion channel cell lines, including voltage-gated and ligand-gated ion channels, and more than 100 cancer cell lines for screening as well as drug discovery.

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In vitro Cardiotoxicity Screening

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Cardiac Safety Assays

Comprehensive In Vitro Proarrhythmia Assay (CiPA)
Drug-induced Torsade de Pointes (TdP) is a lethal arrhythmia which is associated prolonged heart repolarization. Inhibition of hERG(IKr) channel induces QT interval prolongation, which is the major preclinical cardiac risk indicator in pro-arrhythmic... Show more »

Cardiac Safety Assays

Comprehensive In Vitro Proarrhythmia Assay (CiPA)
Drug-induced Torsade de Pointes (TdP) is a lethal arrhythmia which is associated prolonged heart repolarization. Inhibition of hERG(IKr) channel induces QT interval prolongation, which is the major preclinical cardiac risk indicator in pro-arrhythmic risk prediction. However, because the cardiac action potential is determined by a fine balance of cardiac ion channels, more evidences indicate that other channels, such as Nav, Cav, are also important in cardiac repolarization. Therefore, ICE Bioscience offers Comprehensive In Vitro Proarrhythmia Assay (CiPA) for the cardiac safety studies.
ICE CiPA panel:
Channels Species Assay Format
hERG(IKr) Human Manual / Automated Patch Clamp electrophysiology
Cav1.2 Human Manual / Automated Patch Clamp electrophysiology
Nav1.5 Human Manual / Automated Patch Clamp electrophysiology
KCNQ1/KCNE(IKs), Human Manual / Automated Patch Clamp electrophysiology
Kir2.1(IK1) Human Manual / Automated Patch Clamp electrophysiology
HCN4(If) Human Manual / Automated Patch Clamp electrophysiology
Kv1.5(Ikur), Human Manual / Automated Patch Clamp electrophysiology
Turnaround time: <5 business days from receiving compounds

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Cell Line Products - Ion Channels

Price on request
Voltage gated ion channels -
Sodium channels Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.6, Nav1.7, Nav1.8
Calcium channels Cav1.2, Cav2.1, Cav2.2, Cav3.2
Voltage-gated potassium channels Kv1.3, Kv1.5, Kv2.1, Kv3.4, Kv4.2, Kv7.1, Kv7.2/7.3, Kv7.4, Kv11.1... Show more »
Voltage gated ion channels -
Sodium channels Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.6, Nav1.7, Nav1.8
Calcium channels Cav1.2, Cav2.1, Cav2.2, Cav3.2
Voltage-gated potassium channels Kv1.3, Kv1.5, Kv2.1, Kv3.4, Kv4.2, Kv7.1, Kv7.2/7.3, Kv7.4, Kv11.1 (hERG)
Inward-rectifier potassium channels Kir2.1, Kir3.1/3.2
Calcium-activated potassium channels BKCa, SKCa1
Two-pore domain potassium channels TASK-1/TASK-3, TREK-1
Ligand gated ion channels -
GABA: α1- α5
NMDA: NR1/NR2A-2D
Ach: nAchR3, nAchR7
TRP channels: TRPV1, TRPM8, TRPC6, TRPC7
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Cell-Based Compound Screening

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Screening of drug effect on ion channels is routine work in ICE electrophysiology department. ICE Bioscience offers over 60 types of ion channel cell lines for physiological and pharmaceutical research.

Screening of drug effect on ion channels is routine work in ICE electrophysiology department. ICE Bioscience offers over 60 types of ion channel cell lines for physiological and pharmaceutical research.

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Induced Pluripotent Stem Cell (iPSC) Culture

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Luciferase Assays

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Cellular Metabolism Assays

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ELISA

Enzyme-linked immunosorbent assay
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Immunofluorescence

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Western Blot

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RT-PCR

Reverse transcription polymerase chain reaction
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PCR

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Drug Discovery & Development

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Biology

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Protein Quantification

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Cell and Tissue Culture

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Hit Identification

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Nucleic Acid Services

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DNA Services

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In vitro Reporter Gene Assays

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Cells and Tissues

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Cellular Health & Metabolism Assays

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Mammalian Cell Culture

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Transfection

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Electrophysiology

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Electrophysiology Services

Electrophysiology Services

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Protein Services

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Pharmacology & Toxicology

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Protein Expression Visualization

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Drug Discovery

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Cell-Based Assays

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Immunostaining

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Biochemistry & Molecular Biology

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Cell Lines

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Toxicology

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Toxicology Services

Toxicology Services

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In vitro Toxicity Testing

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In vitro Toxicity Testing Services

In vitro Toxicity Testing Services

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Li Yan

Senior director of business development

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