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Icaria Life Sciences Inc.

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LaFayette, New York, US

About Icaria Life Sciences Inc.

Icaria Life Sciences' "Structure People" are focused exclusively on providing the most comprehensive suite of instruments and expertise for Structure Based Drug Design (SBDD). We provide structural insight allowing for  highly confident decision-making early in the discovery... Show more »

Icaria Life Sciences' "Structure People" are focused exclusively on providing the most comprehensive suite of instruments and expertise for Structure Based Drug Design (SBDD). We provide structural insight allowing for  highly confident decision-making early in the discovery process. With a team of 34 scientists to date, the art of protein production, X-Ray crystallography, CryoEM grid optimization, SPR, SHG, NMR, Thermostability, and Fragment Based Screening, we  can support your most challenging research projects. In addition, our decade of experience has enabled us to jumpSTART your discovery pipeline by providing our  target enabling packages.  START(sm) packages including FBS validated hits, labeled protein for multiple orthogonal techniques, and target expertise. 

Since 2013, Ichor Therapeutics has provided boutique services in drug discovery and aging research to support a growing list of clients that span government, non-profit organizations, start-up companies, and pharma. In response to client demand for additional services, capabilities, and capacity, Ichor established Icaria Life Sciences, Inc. as its fully controlled and operated contract research arm in 2019. Icaria's  leadership have been responsible for multiple CROs in the space including  HarkerBIO, Emerald Biostructures, and Decode. They look forward to continuing to demonstrate how structure genomics and proteomics guides better early stage discovery for small  molecule chemistry and large molecule biology.

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Our Services (37)


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Analytical Chemistry Services

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Hit Identification

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Drug Discovery & Development

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Cell-Based Compound Screening

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X-ray Diffraction Data Analysis

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X-ray Diffraction (XRD) Data Collection

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Gene-to-Protein Services

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Cloning, Expression and Purification

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Cloning, Expression and Purification

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Structure Determination

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Three-Dimensional Crystallographic Structure Determination

Our research team provides a full suite of services to help you solve difficult structures with speed and accuracy. We utilize state of the art software, augmented by decades of solution and refinement experience, to rapidly solve crystal... Show more »

Three-Dimensional Crystallographic Structure Determination

Our research team provides a full suite of services to help you solve difficult structures with speed and accuracy. We utilize state of the art software, augmented by decades of solution and refinement experience, to rapidly solve crystal structures of macromolecules and complexes.

We have access to several high-brilliance synchrotron beam lines at APS and CLS - as well as access to SSRL via a partner company.

Our secure data server uses advanced encryption to safeguard the privacy of your proprietary data.

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Membrane Protein Crystallization

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Structural characterization of membrane proteins is a vital component in efforts to understand the processes behind many disease states. Crystallization of a membrane protein is hampered by the requirement of detergent, which is used to extract the protein from the lipid bilayer to form a protein-detergent complex (PDC).... Show more »

Structural characterization of membrane proteins is a vital component in efforts to understand the processes behind many disease states. Crystallization of a membrane protein is hampered by the requirement of detergent, which is used to extract the protein from the lipid bilayer to form a protein-detergent complex (PDC). Hartmut Michel and other early pioneers of membrane protein crystallization research observed the formation of crystals near the phase boundary of the detergent used to form the PDC. Understanding the variables associated with detergent phase behavior and crystallogenesis enables their rational modulation.

We have generated chemically diverse phase boundary data utilizing dye-based phase partitioning and eleven detergents commonly used to crystallize membrane proteins. The resulting data have been used to guide the formulation of a 1536-cocktail crystallization screen for membrane proteins. The experimentally derived phase boundary data and the 1536-well membrane screen are now available through the high-throughput crystallization facility 

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Fragment Screening

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We have expertise in structure-based drug discovery using fragment-based approaches acclerates lead discovery to drug optimization. Drug discovery is enhanced with complementary expertise in computational molecular docking and homology modeling.

Through our collaboration with AMRI we offer a number of compound libraries... Show more »

We have expertise in structure-based drug discovery using fragment-based approaches acclerates lead discovery to drug optimization. Drug discovery is enhanced with complementary expertise in computational molecular docking and homology modeling.

Through our collaboration with AMRI we offer a number of compound libraries for screening and selection.

We can also use client-supplied libraries (fragments or full-sized molecular scaffolds) for parallel co-crystallization or soaking.

Please contact us for details.

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Protein Crystallization Screening and Optimization

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Exclusive license to a patented high-throughput crystallization technology
Affiliation with established expertise and crystallization infrastructure

  •  $2M crystallization laboratory
  •  State-of-the-art SONICC imaging system
  • Highly experienced: 21.5 million unique protein... Show more »

Exclusive license to a patented high-throughput crystallization technology
Affiliation with established expertise and crystallization infrastructure

  •  $2M crystallization laboratory
  •  State-of-the-art SONICC imaging system
  • Highly experienced: 21.5 million unique protein crystallization experiments conducted
    - > 2X success rate for producing verified protein crystals
  • Proprietary Antibody Crystallization Screen, GRAS (Generally Recognized As Safe) Screening for formulation and delivery, etc.
  • Established protocols for sample anonymity and client confidentiality
  • Please request a quote for more accurate pricing information.
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SHG Conformational Analysis

Second Harmonic Generation
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Offering full assay development and screening using SPR, NMR, and SHG expertise and instruments. Understanding your Protein- Protein interactions via binding affinity, kinetic, (SPR) , conformational changes, (second-harmonic generation), or in solution by STD-NMR including DEEP NMR now, one can monitor structural changes at... Show more »

Offering full assay development and screening using SPR, NMR, and SHG expertise and instruments. Understanding your Protein- Protein interactions via binding affinity, kinetic, (SPR) , conformational changes, (second-harmonic generation), or in solution by STD-NMR including DEEP NMR now, one can monitor structural changes at any site within a protein, in real time. Since protein function is determined by its structure, and changes in structure cause changes in function, characterizing these changes will provide significant insights into how our bodies function and respond to treatments.

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X-ray Crystallography

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Surface Plasmon Resonance (SPR)

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We offer the newest Biacore S200 and newest team members Dr. Delphine Collin and Dr. Elizabeth Anderson now offer complex assay development and screening for difficult and challenging proteins

We offer the newest Biacore S200 and newest team members Dr. Delphine Collin and Dr. Elizabeth Anderson now offer complex assay development and screening for difficult and challenging proteins

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Cryo-Electron Microscopy

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NMR

Nuclear magnetic resonance spectroscopy
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Microscale Thermophoresis

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Differential Scanning Fluorimetry (DSF)

Differential Scanning Fluorimetry
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FRET

Fluorescence resonance energy transfer
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Protein Purification

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Pharmaceutical Due Diligence

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
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Medicinal Chemistry

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Assay Development

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Analytical Method Validation

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Peptide Synthesis

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Protein Production

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Recombinant Protein Expression

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Bacterial, Yeast, Insect Cell and Mammalian expression platforms.

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Bacterial, Yeast, Insect Cell and Mammalian expression platforms.

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Insects

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Protein Engineering/Directed Evolution

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Stem Cell Analysis and Characterization

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Animal in vivo Imaging

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Histology and Pathology Services

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Animal Husbandry

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Rodents

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Syngeneic (Allograft) Tumor Models

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Xenograft Models

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Surgical Animal Models

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Primary Cell Culture

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LS

Laura Sailor

Founder
AS

Adam Stein

Founder

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