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Icaria Life Sciences Inc.

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LaFayette, New York, US

About Icaria Life Sciences Inc.

Icaria Life Sciences' "Structure People" are focused exclusively on providing the most comprehensive suite of instruments and expertise for Structure Based Drug Design (SBDD). We provide structural insight allowing for  highly confident decision-making early in the discovery process. With a team of 38 scientists to date, the art of protein production, X-Ray crystallography, CryoEM grid optimization, SPR, SHG, NMR, Thermostability, and Fragment Based Screening, we  can support your most challenging research projects. In addition, our decade of experience has enabled us to jumpSTART your discovery pipeline by providing our  target enabling packages.  START(sm) packages including FBS validated hits, labeled protein for assaying in multiple orthogonal techniques, and target expertise. 

Since 2013, Ichor Therapeutics has provided boutique services in drug discovery and aging research to support a growing list of clients that span government, non-profit organizations, start-up companies, and pharma. In response to client demand for additional services, capabilities, and capacity, Ichor established Icaria Life Sciences, Inc. as its fully controlled and operated contract research arm in 2019. Icaria's  leadership have been responsible for multiple CROs in the space including  HarkerBIO, Emerald Biostructures, and Decode. They look forward to continuing to demonstrate how structure genomics and proteomics guides better early stage discovery for small  molecule chemistry and large molecule biology.

Our Services (23)


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Lead Identification and Validation

Price on request

Target Enabled START Package

 

Lead Discovery package includes:

•Target expertise in construct design
•Highly Purified and Active Protein
   (20-100+mgs) tailored to each orthogonal technique
•Screens of Novel libraries
   Edelris (500-2200) novel 3D fragment library
   Enamine – frag libraries
   BioBlocks fragment or chemical libraries
   Edelris 1M Eden ASMS screen
   DNA Encoded Libraries 
•Hits screened with a suite of state of art biophysics techniques
      NMR,SPR, SHG,ITC, MST, TSS, HT Mass spec

•Structure platform
      X-ray crystallography/in-cell NMR/CryoEM/TeM
      Soaking /co-crystallization systems
      Data collection, Structure determination, visualization
      Patent ready datasets, reports, file storage

•SBDD team visit to your lab, to help guide medicinal chemists and modeling team discussions

Imagine this entire START for maximizing your 2.5M Budget- a 1.5M dollar savings


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Hit Identification

Starting at $500,000.00 per question

Our START packages for named targets, such as STING, NDM1, JAK3, mTOR,Orexin Ready to go!


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Cell-Based Compound Screening

Price on request
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X-ray Diffraction Data Analysis

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X-ray Diffraction (XRD) Data Collection

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Gene-to-Protein Services

Price on request

Cloning, Expression and Purification

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milligram ExpiCHO Expression System HKL2000 aged mice

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Membrane Protein Crystallization

Price on request

Structural characterization of membrane proteins is a vital component in efforts to understand the processes behind many disease states. Crystallization of a membrane protein is hampered by the requirement of detergent, which is used to extract the protein from the lipid bilayer to form a protein-detergent complex (PDC). Hartmut Michel and other early pioneers of membrane protein crystallization research observed the formation of crystals near the phase boundary of the detergent used to form the PDC. Understanding the variables associated with detergent phase behavior and crystallogenesis enables their rational modulation.

We have generated chemically diverse phase boundary data utilizing dye-based phase partitioning and eleven detergents commonly used to crystallize membrane proteins. The resulting data have been used to guide the formulation of a 1536-cocktail crystallization screen for membrane proteins. The experimentally derived phase boundary data and the 1536-well membrane screen are now available through the high-throughput crystallization facility 


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Fragment Screening

Price on request

We have expertise in structure-based drug discovery using fragment-based approaches acclerates lead discovery to drug optimization. Drug discovery is enhanced with complementary expertise in computational molecular docking and homology modeling.

Through our collaboration with AMRI we offer a number of compound libraries for screening and selection.

We can also use client-supplied libraries (fragments or full-sized molecular scaffolds) for parallel co-crystallization or soaking.

Please contact us for details.


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Protein Crystallization Screening and Optimization

Price on request

Exclusive license to a patented high-throughput crystallization technology
Affiliation with established expertise and crystallization infrastructure

  •  $2M crystallization laboratory
  •  State-of-the-art SONICC imaging system
  • Highly experienced: 21.5 million unique protein crystallization experiments conducted
    - > 2X success rate for producing verified protein crystals
  • Proprietary Antibody Crystallization Screen, GRAS (Generally Recognized As Safe) Screening for formulation and delivery, etc.
  • Established protocols for sample anonymity and client confidentiality
  • Please request a quote for more accurate pricing information.


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SHG Conformational Analysis

Second Harmonic Generation
Price on request

Offering full assay development and screening using SPR, NMR, and SHG expertise and instruments. Understanding your Protein- Protein interactions via binding affinity, kinetic, (SPR) , conformational changes, (second-harmonic generation), or in solution by STD-NMR including DEEP NMR now, one can monitor structural changes at any site within a protein, in real time. Since protein function is determined by its structure, and changes in structure cause changes in function, characterizing these changes will provide significant insights into how our bodies function and respond to treatments.


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X-ray Crystallography

Price on request
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Surface Plasmon Resonance (SPR)

Starting at $10,000.00 per study

We offer the newest Biacore S200 and 8000 and our biophysicics team lead now offer complex assay development and screening for difficult and challenging proteins


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Cryo-Electron Microscopy

Price on request
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NMR

Nuclear magnetic resonance spectroscopy
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Microscale Thermophoresis

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Differential Scanning Fluorimetry (DSF)

Differential Scanning Fluorimetry
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FRET

Fluorescence resonance energy transfer
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Protein Purification

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Medicinal Chemistry

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Peptide Synthesis

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Protein Production

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Recombinant Protein Expression

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Bacterial, Yeast, Insect Cell and Mammalian expression platforms.

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Insects

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Protein Engineering/Directed Evolution

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LS

Laura Sailor

Founder
AS

Adam Stein

Founder

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