Icaria Life Sciences' "Structure People" are focused exclusively on providing the most comprehensive suite of instruments and expertise for Structure Based Drug Design (SBDD). We provide structural insight allowing for highly confident decision-making early in the discovery process. With a team of 38 scientists to date, the art of protein production, X-Ray crystallography, CryoEM grid optimization, SPR, SHG, NMR, Thermostability, and Fragment Based Screening, we can support your most challenging research projects. In addition, our decade of experience has enabled us to jumpSTART your discovery pipeline by providing our target enabling packages. START(sm) packages including FBS validated hits, labeled protein for assaying in multiple orthogonal techniques, and target expertise.
Since 2013, Ichor Therapeutics has provided boutique services in drug discovery and aging research to support a growing list of clients that span government, non-profit organizations, start-up companies, and pharma. In response to client demand for additional services, capabilities, and capacity, Ichor established Icaria Life Sciences, Inc. as its fully controlled and operated contract research arm in 2019. Icaria's leadership have been responsible for multiple CROs in the space including HarkerBIO, Emerald Biostructures, and Decode. They look forward to continuing to demonstrate how structure genomics and proteomics guides better early stage discovery for small molecule chemistry and large molecule biology.
Target Enabled START Package
Lead Discovery package includes:
•Target expertise in construct design
•Highly Purified and Active Protein
(20-100+mgs) tailored to each orthogonal technique
•Screens of Novel libraries
Edelris (500-2200) novel 3D fragment library
Enamine – frag libraries
BioBlocks fragment or chemical libraries
Edelris 1M Eden ASMS screen
DNA Encoded Libraries
•Hits screened with a suite of state of art biophysics techniques
NMR,SPR, SHG,ITC, MST, TSS, HT Mass spec
X-ray crystallography/in-cell NMR/CryoEM/TeM
Soaking /co-crystallization systems
Data collection, Structure determination, visualization
Patent ready datasets, reports, file storage
•SBDD team visit to your lab, to help guide medicinal chemists and modeling team discussions
Imagine this entire START for maximizing your 2.5M Budget- a 1.5M dollar savings
Our START packages for named targets, such as STING, NDM1, JAK3, mTOR,Orexin Ready to go!
Cloning, Expression and Purification
Please request a quote for more accurate pricing information.
Structural characterization of membrane proteins is a vital component in efforts to understand the processes behind many disease states. Crystallization of a membrane protein is hampered by the requirement of detergent, which is used to extract the protein from the lipid bilayer to form a protein-detergent complex (PDC). Hartmut Michel and other early pioneers of membrane protein crystallization research observed the formation of crystals near the phase boundary of the detergent used to form the PDC. Understanding the variables associated with detergent phase behavior and crystallogenesis enables their rational modulation.
We have generated chemically diverse phase boundary data utilizing dye-based phase partitioning and eleven detergents commonly used to crystallize membrane proteins. The resulting data have been used to guide the formulation of a 1536-cocktail crystallization screen for membrane proteins. The experimentally derived phase boundary data and the 1536-well membrane screen are now available through the high-throughput crystallization facility
We have expertise in structure-based drug discovery using fragment-based approaches acclerates lead discovery to drug optimization. Drug discovery is enhanced with complementary expertise in computational molecular docking and homology modeling.
Through our collaboration with AMRI we offer a number of compound libraries for screening and selection.
We can also use client-supplied libraries (fragments or full-sized molecular scaffolds) for parallel co-crystallization or soaking.
Please contact us for details.
Exclusive license to a patented high-throughput crystallization technology
Affiliation with established expertise and crystallization infrastructure
Offering full assay development and screening using SPR, NMR, and SHG expertise and instruments. Understanding your Protein- Protein interactions via binding affinity, kinetic, (SPR) , conformational changes, (second-harmonic generation), or in solution by STD-NMR including DEEP NMR now, one can monitor structural changes at any site within a protein, in real time. Since protein function is determined by its structure, and changes in structure cause changes in function, characterizing these changes will provide significant insights into how our bodies function and respond to treatments.
We offer the newest Biacore S200 and 8000 and our biophysicics team lead now offer complex assay development and screening for difficult and challenging proteins
Bacterial, Yeast, Insect Cell and Mammalian expression platforms.
Please request a quote for accurate pricing information
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