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Icagen

Durham, NC, US

Icagen partners with pharmaceutical and biotechnology companies to offer industry-leading scientific expertise and comprehensive access to technologies for ion channel and transporter drug discovery and development. With over 20 years of leadership in the ion channel field, the Icagen team offers an extensive track record of success in advancing molecules from drug discovery to clinical development across multiple therapeutic areas and ion channel classes.

Icagen has a growing portfolio of assay tools and technologies including an unmatched collection of cell lines and technologies for ion channel and transporter research, capped by the company’s proprietary, label-free XRpro® platform. XRpro® technology, based on X-ray fluorescence, is a novel method that enables high throughput assessment of ion channels and transporters, including direct measurements for otherwise challenging systems of high therapeutic... Show more »

Icagen partners with pharmaceutical and biotechnology companies to offer industry-leading scientific expertise and comprehensive access to technologies for ion channel and transporter drug discovery and development. With over 20 years of leadership in the ion channel field, the Icagen team offers an extensive track record of success in advancing molecules from drug discovery to clinical development across multiple therapeutic areas and ion channel classes.

Icagen has a growing portfolio of assay tools and technologies including an unmatched collection of cell lines and technologies for ion channel and transporter research, capped by the company’s proprietary, label-free XRpro® platform. XRpro® technology, based on X-ray fluorescence, is a novel method that enables high throughput assessment of ion channels and transporters, including direct measurements for otherwise challenging systems of high therapeutic interest.

Icagen’s scientific teams are a defining feature of our company with industry-leading expertise and a proven track record of drug discovery from target identification through clinical evaluation for multiple classes of ion channels. For example, our scientists were involved in the identification and development of the first selective small molecule inhibitors of Nav1.7 and Nav1.8 and more recently have generated a portfolio of tools and assays to prosecute the historically challenging Nav1.9 target.

Icagen’s mission is to harness the scientific expertise of our teams to provide the capability and know-how to advance our clients’ ion channel and transporter drug discovery programs. Our knowledge-base crosses multiple disciplines including molecular biology, cell biology, biochemistry, conventional and high throughput electrophysiology, and high throughput screening. We direct this experience to produce high quality data for our clients and collaborators leading to the development and progression of the most promising candidates even for challenging targets.

Gain access to Icagen’s scientific teams through our Discovery Services which range from cell generation, assay development, and high throughput screening to multi-stage collaborations spanning target identification through lead optimization.

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Icagen has not listed any services.

Stable Cell Line Generation
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Icagen has proven expertise in Ion Channel and other cell line development projects, especially for difficult to express proteins.

Icagen has proven expertise in Ion Channel and other cell line development projects, especially for difficult to express proteins.

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Hit Identification
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Calcium Channel Assays
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Potassium Channel Assays
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Compound Synthesis
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Sodium Channel Assays
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Icagen clients benefit from our scientists’ extensive experience in ion channel and transporter research and drug discovery. Whether interested in a specific class of ion channels or expanding into transporter research, Icagen Target Biology services can advance your early discovery initiatives.

Icagen clients benefit from our scientists’ extensive experience in ion channel and transporter research and drug discovery. Whether interested in a specific class of ion channels or expanding into transporter research, Icagen Target Biology services can advance your early discovery initiatives.

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Drug Mechanism of Action Studies
Mechanism of Action Studies
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In vitro Safety Evaluation
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Icagen’s expertise within the fields of ion channels and transporters enable us to efficiently advance lead compounds through detailed biophysical and pharmacological analysis including custom cell line development projects, selectivity assays, mechanism of action studies, in vitro pharmacology, and safety assays.

Icagen’s expertise within the fields of ion channels and transporters enable us to efficiently advance lead compounds through detailed biophysical and pharmacological analysis including custom cell line development projects, selectivity assays, mechanism of action studies, in vitro pharmacology, and safety assays.

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Virtual Drug Discovery
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Compound Library Design
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Assay Development
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From cell biology and assay development through conducting assays and analyzing data, our services cover every step of the assay process. Icagen has a scientific team with extensive experience developing and running high throughput ion channel and transporter assays using fluorescence, electrophysiology, XRpro® technology, and... Show more »

From cell biology and assay development through conducting assays and analyzing data, our services cover every step of the assay process. Icagen has a scientific team with extensive experience developing and running high throughput ion channel and transporter assays using fluorescence, electrophysiology, XRpro® technology, and radioactivity, as well as the facilities to perform assays ranging from primary screening of full files to focused libraries of thousands of compounds. We focus on producing high quality data to rapidly identify and confirm hits. No target is too challenging for us.

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High Throughput Screening
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Hit to Lead and Lead Optimization
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Icagen’s expertise within the fields of ion channels and transporters enable us to efficiently advance lead compounds through detailed biophysical and pharmacological analysis including custom cell line development projects, selectivity assays, mechanism of action studies, in vitro pharmacology, and safety assays.

Icagen’s expertise within the fields of ion channels and transporters enable us to efficiently advance lead compounds through detailed biophysical and pharmacological analysis including custom cell line development projects, selectivity assays, mechanism of action studies, in vitro pharmacology, and safety assays.

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Stem Cell Assays
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iPSC assays, iPSC cell differentiation Stem cell assaysfrom patient derived cells.

iPSC assays, iPSC cell differentiation Stem cell assaysfrom patient derived cells.

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Western Blot
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Amino acid analysis
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Experimental Design
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RNA Extraction
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Project Management & Consulting Services
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Immunofluorescence
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Cell-Based Assays
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Optical Microscopy
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Induced Pluripotent Stem Cell (iPSC) Generation
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Microscopy
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Protein Expression Visualization
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Protein Sequencing
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Protein Services
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Biology
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Immunostaining
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Cells and Tissues
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Fluorescence-Based Microscopy
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Imaging & Spectroscopy
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Cell and Tissue Culture
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Mammalian Cell Culture
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Chemistry and Materials
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Synthetic Chemistry
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Lead Identification and Validation
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RNA
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Pharmacology & Toxicology
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Safety Pharmacology & Efficacy Testing
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In vitro ADME
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Cellular Ion Channel Assays
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Medicinal Chemistry
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Drug Discovery & Development
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Functional & Cell Type Specific Assays
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Biochemistry & Molecular Biology
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Drug Discovery
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Compound Libraries
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Nucleic Acid Services
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