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IBT Bioservices

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Gaithersburg, Maryland, US

About IBT Bioservices

Founded: 2009 Type: Privately Held Size: 11-50 employees

IBT Bioservices is a research service organization that specializes in pre-clinical vaccines and therapeutics R&D.  As a section of Integrated BioTherapeutics, Inc., IBT Bioservices offers the combined experience of academic discipline and entrepreneurial efficiency for delivering quality data on time and on budget. IBT Bioservices is build on a collaborative “scientist-to-scientist” business model where creativity, client interaction, and expertise are emphasized. Our services are focused the critical non-GLP preclinical studies that are integral in making go, no-go  decisions in drug development. We offer a range of core functions for early R&D including initial screens in vitro and in vivo, immunogenicity testing, and serology testing. Our expertise includes animal model and custom assay development. IBT Bioservices can develop and establish custom animal disease models for your in vivo projects. We can perform up to BSL-2 work in our animal facilities. Through a network of partners we can design and manage your BSL-3 studies.

Standard deliverables:
Animal studies: serum/ tissues are mailed back
In vitro: results compiled in electronic format - raw data in excel, powerpoint for overall presentation, and formal reports in pdf

Certifications: AAALAC accredited for all animal services Instrumentation: MSD, Luminex and Flow cytometry multiplex platform, spectrophotometers, centrifuges 

Certifications & Qualifications

AAALAC BSL-1 BSL-2

Our Services (48)


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Flow Cytometry

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Influenza Animal Models

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Zika Antiviral Testing

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New! In Vitro testing and animal model


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Antiviral Testing

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Cell-based assays we offer include evaluation of cytopathic effect (cell death) or reduction of virus yield as well as plaque reduction neutralization assays for variety  of BSL2 viruses.  The available virus panel includes Chikungunya, Venezuelan Equine Encephalitis, Dengue 1-4, Japanese Encephalitis, Yellow Fever, Junin, Influenza H1N1, Influenza H3N2, Influenza B, Rift Valley Fever, La Crosse, Vaccinia, Zika Virus, and Respiratory Syncytial Virus. Tests are performed at BSL-2 where attenuated strains of high containment viruses are used at much lower cost than wild type.


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Assay Development

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IBT Bioservices has a core competency in the development of assays that support the early research and development of vaccines, biotherapeutics, and drugs. Our capabilities include assay feasibility, reagent sourcing and qualification, optimization, and sample analysis. Our team has extensive experience in molecular and enzymatic assays, and immunoassays as singleplex and multiplex platforms. Immunogenicity assays for vaccines and biologics are our specialty. By leveraging our vivarium we can perform your in vivo studies and then analyze samples using the serology assays that we have developed for your project, ensuring a consistent and cost effective process. Assays are developed using best practices that will allow them to be adapted for GLP use in the future. IBT Bioservices can source or develop the critical reagents necessary for your assays.          


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Bacterial Infection Animal Models

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The following infection models have been developed in-house by our scientists: Staphylococcus aureus pneumonia, Staph. aureus sepsis, Staph. and Strep. toxic shock, Enterotoxigenic E. coli intestinal colonization, Streptococcus pneumonia pneumonia.


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Biomarker Analysis

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Cytokine and Biomarker Analysis. Using a highly sensitive electrochemiluminescence technology developed by Meso Scale Discovery ™ IBT Bioservices offers custom services for testing cytokines, chemokines and other biomarkers in culture supernatants and sera. MSD is a revolutionary technology that utilizes electrochemiluminescence to detect binding events on patterned arrays. The combination forms a unique solution offering sensitivity (sub-picogram), dynamic range (10^3 to 10^4), and convenience (3 hours). MSD assays can be multiplexed up to 10 antigens per well.


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Cytokine Analysis

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IBT Bioservices offers custom services for testing cytokines, chemokines and other biomarkers in culture supernatants and sera. Assays can be multiplexed up to 10 antigens per well.

Cytokine and Biomarker Analysis. Using a highly sensitive electrochemiluminescence technology developed by Meso Scale Discovery ™ IBT Bioservices offers custom services for testing cytokines, chemokines and other biomarkers in culture supernatants and sera. MSD is a revolutionary technology that utilizes electrochemiluminescence to detect binding events on patterned arrays. The combination forms a unique solution offering sensitivity (sub-picogram), dynamic range (10^3 to 10^4), and convenience (3 hours). MSD assays can be multiplexed up to 10 antigens per well.


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ELISA

Enzyme-linked immunosorbent assay
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In vitro Immunogenicity Assays

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Immunogenicity assays for vaccines and biologics are our specialty.


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In vivo Immunogenicity Assays

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Immunogenicity assays for vaccines and biologics are our specialty.

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Minimal Bactericidal Concentration (MBC) Assay

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A PhD scientist will oversee antibiotic testing for disc diffusion, minimum inhibitory concentration (MIC), minimal bactericidal concentration (MBC), and minimal doubling time/growth curve (MDT). Bacteria currently available for testing include Methicillin-Sensitive Staph. aureus (MSSA), Methicillin-Resistant Staph. aureus (MRSA), Pseudomonas aeruginosa, Acinetobacter baumannii, Enterobacter aerogenes, Enterobacter cloacae, Streptococcus pneumonia, and Moraxella catarrhalis.


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Minimal Doubling Time/Growth Curve

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A PhD scientist will oversee antibiotic testing for disc diffusion, minimum inhibitory concentration (MIC), minimal bactericidal concentration (MBC), and minimal doubling time/growth curve (MDT). Bacteria currently available for testing include Methicillin-Sensitive Staph. aureus (MSSA), Methicillin-Resistant Staph. aureus (MRSA), Pseudomonas aeruginosa, Acinetobacter baumannii, Enterobacter aerogenes, Enterobacter cloacae, Streptococcus pneumonia, and Moraxella catarrhalis.


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Minimum Inhibitory Concentration (MIC) Assay

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A PhD scientist will oversee antibiotic testing for disc diffusion, minimum inhibitory concentration (MIC), minimal bactericidal concentration (MBC), and minimal doubling time/growth curve (MDT). Bacteria currently available for testing include Methicillin-Sensitive Staph. aureus (MSSA), Methicillin-Resistant Staph. aureus (MRSA), Pseudomonas aeruginosa, Acinetobacter baumannii, Enterobacter aerogenes, Enterobacter cloacae, Streptococcus pneumonia, and Moraxella catarrhalis.


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Serological Assays

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Vaccine Testing Services

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The scientists at IBT Bioservices have over 50 years of cumulative experience with vaccine studies in rodents and have formed strong relationships with government agencies and industry partners validating our experience. Our clients benefit from comprehensive sample collection capabilities including blood, tissue, and mucosal samples as needed. Samples can either be sent to your laboratory for further analysis or analyzed in our laboratories for pathogen-specific cellular and humoral immune responses or induction of cytokines and other biomarkers. Dosing routes available include intranasal, intragastric, subcutaneous, intramuscular, intraperitoneal, and intravenous.


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Viral Infection Animal Models

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The following infection models have been developed in-house by our scientists: Chikungunya, Venezuelan Equine Encephalitis, Dengue 2, Influenza H1N1, Influenza H3N2, Influenza B, Vaccinia, Cowpox. The new Dengue 2 model of hemorrhagic fever displays unique and powerful similarity to the disease progression observed in humans, making it particularly useful for drug and vaccine development.

VIral Infection Models:
Flaviviridae
Orthomyxoviridae
Poxviridae
Paramyxoviridae


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Biochemistry & Molecular Biology

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Clinical Hematology

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Drug Discovery & Development

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Cytometry

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Cells and Tissues

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Viral Assays

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Antimicrobial Activity Testing

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Project Management

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Pharmacology & Toxicology

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Clinical Laboratory Services

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Clinical Research

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Animal Models and Studies

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Drug Discovery

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Protein Services

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Protein Quantification

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Monoclonal Antibody (mAb) Production

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Polyclonal Antibody Production

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Recombinant Protein Expression

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Virus Production

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Flow Cytometry Data Analysis

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Virology Services

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Infectious Disease Animal Models

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In vivo Toxicity Testing

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Biomarkers

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Biology

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Toxicology

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Animal Models of Disease

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Vaccines

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Immunoassays

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Microbiology

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Bioanalysis

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