Web: http://iabbiomedicine.wix.com/home
Founded by Hsih-Te Yang, PhD, currently a principle investigator or assistant professor of the laboratory of intelligent systems medicine, Institute of Medical Informatics, Department of Computer Science and Information Engineering, National Cheng Kung Univeristy, Taiwan. i-Ab brings together a group of researchers with backgrounds in medicine, engineeering and information science, with the aim of revolutionizing biologics discovery toward regulatory approval.

Conventionally, the brand new antibody leads were discovered by two or more screening cycles with bunch of materials and time. i-Ab's approaches (In-silico screening, ISS) will revolutionize the conventional processes of biologics discovery and development by increasing R&D productivity as well as reducing attrition rates of therapeutic antibodies against most diseases, such as cancers, metabolic disorders,... Show more »

Web: http://iabbiomedicine.wix.com/home
Founded by Hsih-Te Yang, PhD, currently a principle investigator or assistant professor of the laboratory of intelligent systems medicine, Institute of Medical Informatics, Department of Computer Science and Information Engineering, National Cheng Kung Univeristy, Taiwan. i-Ab brings together a group of researchers with backgrounds in medicine, engineeering and information science, with the aim of revolutionizing biologics discovery toward regulatory approval.

Conventionally, the brand new antibody leads were discovered by two or more screening cycles with bunch of materials and time. i-Ab's approaches (In-silico screening, ISS) will revolutionize the conventional processes of biologics discovery and development by increasing R&D productivity as well as reducing attrition rates of therapeutic antibodies against most diseases, such as cancers, metabolic disorders, infections and neuron degenerations. The target customers are big pharma, biotech or stakeholders. We help them to control the cost and facilitate the total product life cycle toward regulatory approval using our core technologies. Namely, our services and products shall enable R&D groups in identifying drug candidates with a higher probability of success.

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i-Ab has not listed any services.

Phage Display Library Construction and Screening
Price on request

Phage antibody library construction

Initialization: planning for the library size
1. Computationally random generations of CDR sequences
2. Human antibody frameworks and CDR combinations
3. Filtering by auto-immune and immunogenicity
4. Homology modeling for Fab antibody

Phage antibody library construction

Initialization: planning for the library size
1. Computationally random generations of CDR sequences
2. Human antibody frameworks and CDR combinations
3. Filtering by auto-immune and immunogenicity
4. Homology modeling for Fab antibody

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Hit to Lead and Lead Optimization
Price on request
  • Computational lead optimization and formulations (i-HitOptTM) for the improvement of pre-clinical tests.
  • Computational global optimization & local engineering for selected antibodies
  1. Input: Disease targets and the Hits selected from conventional platforms (customer provide)
  2. Structure and sequence (mouse)... Show more »
  • Computational lead optimization and formulations (i-HitOptTM) for the improvement of pre-clinical tests.
  • Computational global optimization & local engineering for selected antibodies
  1. Input: Disease targets and the Hits selected from conventional platforms (customer provide)
  2. Structure and sequence (mouse) similarity search against human i-AbDBTM (Humanization)
  3. Build up a customized i-TargetDBTM (Variants & 3D)
  4. Sequence and structure alignments searching antibodies against our i-TargetDBTM by iHT-AbTM (PESI)
  5. Screened antibody candidates is better than inputs and further evaluated by HitOptTM
  6. Final reports and products
    • Customized disease-based i-TagrtDB
    • Prioritizing 20 ~ 30 antibody leads with genomic, protein sequences, and predicted 3D models
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Antibody Screening
Price on request
  • A computational technology platform was successfully established for high-throughput antibody screening (iHT-AbTM), which incorporates two databases (i-TargetDBTM and i-AbDBTM) as value-added big biomedical data sources. i-Ab provides professional services in contrast with those experiments of conventional platform.

-... Show more »

  • A computational technology platform was successfully established for high-throughput antibody screening (iHT-AbTM), which incorporates two databases (i-TargetDBTM and i-AbDBTM) as value-added big biomedical data sources. i-Ab provides professional services in contrast with those experiments of conventional platform.

  • Screening antibody (i-Ab001, i-Ab002, …) candidates by Preclinical Efficacy and Safety Index (PESI): a perspective analysis of clinical trial

  1. Input: Identify disease target gene and the corresponding variants
  2. Build up i-TargetDBTM (Variants and 3D structures)
  3. Screen antibody by iHT-AbTM (PESI) against i-AbDBTM
  4. Further evaluated by HitOptTM
  5. Final reports or products:
    • Customized disease-based i-TagrtDB
    • Prioritizing 20 ~ 30 antibody leads with genomic, protein sequences, and predicted 3D models
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Protein Services
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Biology
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Lead Identification and Validation
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Therapeutic Monoclonal Antibody (mAb) Development
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Antibody Services
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Drug Discovery & Development
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Biochemistry & Molecular Biology
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Drug Discovery
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