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Horizon Discovery

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Waterbeach, GB

About Horizon Discovery

Horizon Discovery is a fully integrated life science company that provides enabling products, services and research programs to clients engaged at every stage of the healthcare continuum from sequence to treatment.

Horizon’s offerings are built around our proprietary translational genomics platform, a high-precision and flexible suite of gene editing tools able to alter almost any endogenous gene sequence of human or mammalian cell-lines. Based from that launch pad, Horizon now offers over 23,000 catalog products, almost all of which are based on the application of gene editing to generate cell lines that accurately model the disease-causing mutations found in genetically based diseases.

These ‘patients-in-a-test-tube’ are being used directly by customers of by Horizon on their behalf to identify the effect of individual or compound genetic mutations on drug activity, patient responsiveness, and resistance, which may lead to the successful prediction of which patient sub-groups will respond to currently available and future drug treatments.

Our Services (42)


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In situ Hybridization (ISH)

In Situ Hybridization
Price on request

Fluorescent or chromogenic IHC or ISH of single target
Combination fluorescent IHC/ISH


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Cell Proliferation Assays

Price on request

Our scientists are experts in the development and application of cell based assays for drug discovery projects and similar research. In addition to standard cell survival and proliferation assays, we can carry out co-culture assays to model the tumour microenvironment, analyse the effects of hypoxia through the use of spheroid assays or low oxygen incubators, grow cells in soft agar for medium throughput assessment of viability and proliferation, and examine senescence and autophagy induction.

Our ready-made and custom cell lines can be used in these assays and in oncology compound profiling, target validation, mechanism of action studies, patient stratification, and uncovering disease biology.

We will work closely with you to design suitable studies to ensure that we address your scientific questions, and will aid with data interpretation where needed, maximizing the success of your projects with us.

in vitro assays

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Immunohistochemistry (IHC)

Price on request

Fluorescent or chromogenic IHC or ISH of single target
Double fluorescent IHC
Combination fluorescent IHC/ISH


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3D Cell-Based Assays

Price on request

3D assays (soft agar) can be useful when studying pathways, mutations and drugs that produce a particular phenotype in 3D environment that maybe not be detected when cells are grown on tissue culture plastic. They can also be useful when assessing the effect of drugs that target pathways not directly involved in proliferation, such as adhesion and polarity.

Choose cell lines from selected Cell Lines and 45 standard cancer cell lines*
Soft agar assay with optimized growth and assay conditions
10 point dose response curve
7-14 days treatment time
Viability readout
Deliverables: Dose response curves and IC50 values
Can upgrade the standard package to include 2D vs 3D comparison


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3D Cell Culture Models

Price on request

3D assays (soft agar) can be useful when studying pathways, mutations and drugs that produce a particular phenotype in 3D environment that maybe not be detected when cells are grown on tissue culture plastic. They can also be useful when assessing the effect of drugs that target pathways not directly involved in proliferation, such as adhesion and polarity.

Choose cell lines from selected Cell Lines and 45 standard cancer cell lines*
Soft agar assay with optimized growth and assay conditions
10 point dose response curve
7-14 days treatment time
Viability readout
Deliverables: Dose response curves and IC50 values
Can upgrade the standard package to include 2D vs 3D comparison
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Western blotting RT-qPCR IHC ISH imaging services MRI

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In vivo Pharmacology Studies

Price on request
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Toxicology Toxicology Rodents Rat in vivo

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In vivo Drug Efficacy Testing

Price on request
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Drug Discovery Toxicology in vivo

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In vivo Studies

Price on request
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In vivo assays

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Animal Models and Studies

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Rodents

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Compound Profiling

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Immuno-oncology Assays

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Cell-Based Assays

Price on request
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Animal Model in vivo Analyses

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In vitro Drug-Drug Interaction Studies

Price on request
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Knockout Cell Lines

Price on request
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Functional Genomic Screening

Price on request
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Cell Line Generation

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Biology

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DNA Services

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Lead Identification and Validation

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Mammalian Cell Culture

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Safety Pharmacology

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Drug Discovery & Development

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In vivo PK/PD Studies

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Biochemistry & Molecular Biology

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Nucleic Acid Services

Price on request
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Pharmacology

Price on request

Pharmacology Services


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Cell Viability & Proliferation Assays

Price on request

Cell Viability & Proliferation Assays Services


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Specialized Cell-Based Assays

Price on request

Specialized Cell-Based Assays Services


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Cell and Tissue Culture

Price on request

Cell and Tissue Culture Services


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Animal Physiology Analyses

Price on request
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In vitro Genetic Screening

Price on request
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Cells and Tissues

Price on request
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Immunoassays

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Pharmacology & Toxicology

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Genetic Engineering

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Bioanalysis

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Drug Discovery

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DNA Hybridization

Price on request

DNA Hybridization Services


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Immunostaining

Price on request

Immunostaining Services


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Protein Expression Visualization

Price on request

Protein Expression Visualization Services


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Protein Services

Price on request

Protein Services


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