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Histology and Comparative Pathology

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Bronx, New York, US

About Histology and Comparative Pathology

The Histotechnology and Comparative Pathology Facility provides comprehensive histology and histopathology support to investigators and the Animal Housing and Studies Facility. The facility performs most aspects of tissue evaluation, from necropsy to the final histological diagnostic evaluation. We support quality translational research by evaluating how the genetic background, environment and sex of the animals affect the study results or gene phenotype. The goal of the facility is to provide a high-quality histology service as well as to be a resource for understanding and translating in vivo data.

Selected Publications

  • Wang H, Bauzon F, Ji P, Xu X, Sun D, Locker J, Sellers RS, Nakayama K, Nakayama KI, Cobrinik D, Zhu L. Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice. Nature Genetics. 2010 Jan;42(1):83-8
  • Kon M, Kiffin R, Koga H, Chapochnick J, Macian F, Varticovski L, Cuervo AM. Chaperone-mediated autophagy is required for tumor growth. Science Translational Medicine. 2011 Nov 16;3(109):109ra117
  • Qian BZ, Li J, Zhang H, Kitamura T, Zhang J, Campion LR, Kaiser EA, Snyder LA, Pollard JW. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature. 2011 Jun 8;475(7355):222-5. doi: 10.1038
  • van Oers JM1, Roa S, Werling U, Liu Y, Genschel J, Hou H Jr, Sellers RS, Modrich P, Scharff MD, Edelmann W. PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance. Proceedings of the National Academy of Sciences of the USA. 2010 Jul 27;10

Our Services (9)


Animal Necropsy Services

Starting at $60.00 per animal

Price begins at $60.00 per animal for the necropsy service. Please note: We do not perform necropsies on cats or dogs.

We offer complete necropsy and histological analysis:

    * Full work up includes gross examination, as well as body and organ weights.

    * Histopathological evaluations of all systems (~40 selected sites)

    * Consultation and evaluation of histopathology in fixed tissue specimens collected

        by investigators.

    * Consultation for gene expression studies at the cellular level in histologic slides

      (including immunohistochemistry)

Please contact the lab at 718-678-1043 for additional information.


Preclinical Histology

Price on request
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Histopathological Examination

Price on request
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Immunohistochemistry (IHC)

Price on request

We offer a range of services such as BrdU, Ki67, Caspase 3, B-cell(CD45R/B220),T-Cell (CD3), macrophage (F4/80: iba1), neutrophil (MPO), cd34, endomucin, pan cytokeratin, PCNA, TUNEL, GFP.
We also work with PI supplied Antibodies and protocols. Pricing is available upon request.


Veterinary Laboratory Services

Starting at $22.50 per sample

FORCYTE Veterinary Hematology Analyzer . VetCyte Veterinary Hematology Control is run on the unit prior to running patient samples.
Requirements: 20 microliters of whole blood in a purple top EDTA Tube, is required for a sample analysis. Both RBC and WBC dilutions are made by the instrument utilizing the Vet-Set 2020 Reagents. Since no single Quality Control technique can routinely provide sufficient data for effective quality assurance, the recommended Quality Control Program for the FORCYTE includes the following three techniques:
• Daily Instrument Checks
• Use of Approved Commercial Patient Controls
• Manual Review of Patient Samples.


Paraffin Sectioning

Price on request

Sectioning paraffin service is available. Paraffin Cut Unstained slides, Paraffin Localized sectioning and Paraffin Interval cutting. Price is available upon request.



Price on request

All sectioning is performed on our Leica CM3050 S Cryostat.
Services perform here at the laboratory include Frozen cut unstained, Frozen cut slide for Enzyme Histochemistry, Frozen Interval Cutting, Frozen cut Localized sectioning. Frozen cut for IHC.
Pricing is available upon request.


Tissue Preparation

Price on request

Fixation or freezing, decalcification and routine processing to paraffin embedding


Veterinary Research & Diagnostics

Price on request
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Amanda Beck

Scientific Director

Nanette (Laura) Ramkissoon

Operations Director

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