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High-Throughput Peptide Synthesis and Array Core Facility

Chapel Hill, North Carolina, US

The UNC HTPSA Facility provides researchers with high quality services for peptide synthesis, purification, and characterization of synthetic peptides.
We specialize in synthesis of multiply modified peptides containing PTMs, unnatural amino acids, and fluorescent tags.
The UNC HTPSA facility uses two automated peptide synthesizers (PTI Symphony and PTI PS3) to make the synthetic peptides. We are routinely making 25-30-mer peptides. Usually 50-mer peptide synthesis is considered the upper limit for standard SPPS, but the real limits are highly dependent on the peptide sequence and a required purity level. Peptide homogeneity is evaluated by mass analysis (MALDI-TOF) and analytical HPLC. Usually we synthesize peptides on 10 to 100 µmol scale (~5 to 200 mg of crude peptide), but we can do a large scale synthesis if needed.

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Peptide Synthesis
Price on request

We specialize in synthesis of multiply modified peptides containing PTMs, unnatural amino acids, and fluorescent tags. Below are examples of the peptide modifications we can introduce into your peptide sequence:

  • acetylation (N-terminal or Lys(Ac))
  • biotinylation (C-, N-terminal or Lys(Biot))
  • methylation (on Lys or Arg... Show more »

We specialize in synthesis of multiply modified peptides containing PTMs, unnatural amino acids, and fluorescent tags. Below are examples of the peptide modifications we can introduce into your peptide sequence:

  • acetylation (N-terminal or Lys(Ac))
  • biotinylation (C-, N-terminal or Lys(Biot))
  • methylation (on Lys or Arg residues)
  • phosphorylation (on Ser, Thr, or Tyr residues)
  • fluorescent tags and quenchers (e.g 5-Fam, 5-Tamra, BBQ-650)
  • metal cations complexing tags (e.g., DOTA, NOTA)
  • D- forms of amino acids
  • unnatural amino acids (e.g. 6-Cl-Trp)
  • amino acids containing stable isotopes (e.g. 2H, 13C, 15N)
  • PEG linkers/spacers
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Peptide Purification and Analysis
Price on request

Reverse phase HPLC purification and analysis of purity of synthetic peptides using analytical HPLC and mass spectrometry (MALDI-TOF MS).

Reverse phase HPLC purification and analysis of purity of synthetic peptides using analytical HPLC and mass spectrometry (MALDI-TOF MS).

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Lyophilization
Price on request

Preparation of lyophilized aliquots of synthetic peptides, and small scale lyophilization of synthetic peptides.

Preparation of lyophilized aliquots of synthetic peptides, and small scale lyophilization of synthetic peptides.

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Chemistry and Materials
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Synthetic Chemistry
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Formulation Services
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