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High-Throughput Crystallization Screening Center

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Buffalo, New York, US

About High-Throughput Crystallization Screening Center

The High-Throughput Crystallization Screening Center (HTCSC) at HWI performs crystal-growth screening experiments for both soluble and membrane biological macromolecules. www.getacrystal.org

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Protein Crystallization Screening and Optimization

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Experimental screening 1,536 different chemical cocktails to find initial crystallization conditions for both soluble and membrane biological macromolecules.  Each condition is monitored with a robust imaging schedule using brightfield, SONICC, and UV-TPEF imaging methods to quickly identify potential crystallization hits.  A major bottleneck in macromolecular crystallography remains identifying conditions to generate diffraction-quality crystals. The Crystallization Center at HWI has been at the forefront of developing high-throughput crystallization methodology. Using patented technologies uniquely available at the Crystallization Center allows for rapid, efficient screening and identification of crystal growth conditions.

crystallization screening protein crystallization X-ray crystallography structural biology

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