National Crystallization Center

Experimental screening 1,536 different chemical cocktails to find initial crystallization conditions for both soluble and membrane biological macromolecules.  Each condition is monitored with a robust imaging schedule using brightfield, SHG, and UV-TPEF imaging methods to quickly identify potential crystallization hits.  A major bottleneck in macromolecular crystallography remains identifying conditions to generate diffraction-quality crystals. The National Crystallization Center at HWI has been at the forefront of developing high-throughput crystallization methodology. Using patented technologies uniquely available at the National Crystallization Center allows for rapid, efficient screening and identification of crystal growth conditions.