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Hera BioLabs

Lexington, Kentucky, US

Hera BioLabs is a contract research organization (CRO) utilizing revolutionary gene editing technologies to create enabling preclinical research models for oncology & immuno-oncology. Hera’s platform model, the SRG rat™, is a SCID rat on the Sprague-Dawley background harboring a double knockout for the Rag2 and Il2rgamma genes. Hera provides oncology efficacy studies (xenograft and PDX) in our SRG rat including for prostate cancer and NSCLC. The SRG is currently being developed with a humanized immune system for immuno-oncology studies.

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Immunodeficient Animal Models
Starting at $400.00 per animal

SD Rag2 Il2rg Knockout Rat (SRG Rat)

The SRG rat (SD-Rag2tm2hera - Il2rgtm1hera ), contains a knockout of both the Rag2 and Il2rg genes on the Sprague Dawley background. This newly created immunodeficient rat model has a severely impaired immune system lacking B-cells, T-cells, and NK-cells. The SRG rat overcomes the... Show more »

SD Rag2 Il2rg Knockout Rat (SRG Rat)

The SRG rat (SD-Rag2tm2hera - Il2rgtm1hera ), contains a knockout of both the Rag2 and Il2rg genes on the Sprague Dawley background. This newly created immunodeficient rat model has a severely impaired immune system lacking B-cells, T-cells, and NK-cells. The SRG rat overcomes the limitations of less immunodeficient rat models and provides enhanced utility in comparison to immunodeficient mouse models including demonstrating high tumor take rates and favorable growth kinetics for both xenografts and PDX models.

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Rat
Human Tumor Xenograft Models
Price on request

Xenograft/PDX efficacy studies conducted in our newly created SRG rat model or other immunodeficient rodent strains.

--Basic Study Outline--
Species/Strain: SGR rat, and/or Mice.
Tumors Cells: Client specified
Tumor Implantation: Subcutaneous
Dosing Method: Oral Gavage
Study Length: 28 days
Study Groups: 5-arms (3... Show more »

Xenograft/PDX efficacy studies conducted in our newly created SRG rat model or other immunodeficient rodent strains.

--Basic Study Outline--
Species/Strain: SGR rat, and/or Mice.
Tumors Cells: Client specified
Tumor Implantation: Subcutaneous
Dosing Method: Oral Gavage
Study Length: 28 days
Study Groups: 5-arms (3 TAs and a positive and negative control groups)
Each study is fully customize-able to meet your needs, including implantation type, dosing method, a variety of measurements and endpoints. Additional toxicology or PK endpoints can be added to the study as well.

Total Estimated Timeline: 6 weeks

Why use SRG rats for xenograft studies?
- Larger samples & tumors.
- Easier, convenient, serial blood/serum collections
- More metabolically similar to humans, allowing for better translation reliability of the data.
- Precise surgical manipulations

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Mouse
Rat
Cancer
Oncology
xenograft
Prostate Cancer
Lung Cancer
Ovarian Cancer
PDX
Immunodeficient Rat
Oncology Animal Models
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Animal Models and Studies
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Cell-Based Assays
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Rat Models
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In vitro Disease Models
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Animal Model Housing and Maintenance
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Rodent Models
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Animal Models of Disease
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Pharmacology & Toxicology
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Mammalian Models
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Xenograft Models
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Specialized Cell-Based Assays
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Immunology Animal Models
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Biology
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Cells and Tissues
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2018-08-16 11:05:49 -0700

Net Promoter Score of 10 received for Human Tumor Xenograft Models.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-08-15 10:18:52 -0700

Net Promoter Score of 10 received for Human Tumor Xenograft Models.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2017-10-26 11:50:34 -0700

Net Promoter Score of 10 received for Human Tumor Xenograft Models.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.

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