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Hera BioLabs

Lexington, KY, US

Hera BioLabs, is a Contract Research Organization (CRO) based in Lexington, KY. Hera is developing fully severe combined immunodeficient (SCID) rats for humanized liver and immune system development with applications hepatotoxicity, cancer xenograft (PDX models), DDI, and immunogenicity testing. Our mission is to use our genetic engineering expertise to provide innovative precision-toxicity™ models and services.

Hera BioLabs has not listed any services.

SRG™ Rat
Price on request

The SRG™ rat (SD-Rag2tm2hera Il2rgtm1hera ), contains a knockout of both the Rag2 and Il2rg genes on the Sprague Dawley background. This newly created immunodeficient rat model has a severely impaired immune system lacking B-cells, T-cells, and NK-cells. The SRG rat overcomes the limitations of less immunodeficient rat models and... Show more »

The SRG™ rat (SD-Rag2tm2hera Il2rgtm1hera ), contains a knockout of both the Rag2 and Il2rg genes on the Sprague Dawley background. This newly created immunodeficient rat model has a severely impaired immune system lacking B-cells, T-cells, and NK-cells. The SRG rat overcomes the limitations of less immunodeficient rat models and provides enhanced utility in comparison to immunodeficient mouse models including demonstrating high tumor take rates and favorable growth kinetics for both xenografts and PDX models.

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Human Tumor Xenograft Models
Price on request

Xenograft/PDX efficacy studies conducted in immunodeficient mouse models or our newly created SCID rat models including our Rag2/Il2rg KO rat (the SRG rat).

--Basic Study Outline--
Species/Strain: SDR rat, SGR rat, and/or NSG Mice.
Tumors Cells: Client specified
Tumor Implantation: Subcutaneous
Dosing Method: Oral... Show more »

Xenograft/PDX efficacy studies conducted in immunodeficient mouse models or our newly created SCID rat models including our Rag2/Il2rg KO rat (the SRG rat).

--Basic Study Outline--
Species/Strain: SDR rat, SGR rat, and/or NSG Mice.
Tumors Cells: Client specified
Tumor Implantation: Subcutaneous
Dosing Method: Oral Gavage
Study Length: 28 days
Each study is fully customize-able to meet your needs, including implantation type, dosing method, a variety of measurements and endpoints.

Total Estimated Timeline: 4 weeks

Why use SCID rats for xenograft studies?
- Larger samples & tumors.
- Easier, convenient, serial blood/serum collections, perfect for leukemia.
- More metabolically similar to humans, allowing for better translation reliability of the data.
- Precise surgical manipulations & better in-vivo imaging.

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Mouse
Rat
Cancer
Oncology
xenograft
Immunodeficient Animal Models
Starting at $184.00 per animal

Rag2 knockout rat (Sprague Dawley)

Rag2 knockout rats lack mature B cells and T cells and are more immunodeficient than the commonly used Nude rnu rat line. The Rag2 knockout rat demonstrates efficient engraftment of cancer cell lines including human blood cancer lines and U87MG human glioblastoma. This model may also be used... Show more »

Rag2 knockout rat (Sprague Dawley)

Rag2 knockout rats lack mature B cells and T cells and are more immunodeficient than the commonly used Nude rnu rat line. The Rag2 knockout rat demonstrates efficient engraftment of cancer cell lines including human blood cancer lines and U87MG human glioblastoma. This model may also be used for humanization (liver and immune system) studies.
Characteristics
• Complete knockout of Rag2 protein
• Loss of B and T cells by FACS analysis
• Lack of circulating IgG & athymic
• Proven engraftment of multiple cancer cell lines

Request technical data sheet & more information.

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Rat
Oncology
Humanized mouse
immunodeficient rat
Rodent Breeding
Price on request

Hera BioLabs offers flexible and customized contract breeding, genotyping and other transgenic research model services including colony establishment and expansion, meaning you can streamline your R&D efforts and minimize your vivarium space needs by outsourcing the generation of cohorts of the exact age, sex and genotype... Show more »

Hera BioLabs offers flexible and customized contract breeding, genotyping and other transgenic research model services including colony establishment and expansion, meaning you can streamline your R&D efforts and minimize your vivarium space needs by outsourcing the generation of cohorts of the exact age, sex and genotype required for your studies.

Our services include:
- Mouse and rat breeding/husbandry
- Genotyping and phenotyping
- CRE/flp breeding
- Colony maintenance (production colonies or backup colonies)
- Downstream screening, toxicology, and efficacy studies.

Our brand new vivarium facilities are equipped with an all IVC Innovive system, featuring disposable/recyclable caging, are 100% HEPA filtered, have 24-hour security monitoring and are staffed by our ACLAM and AALAS certified veterinary team so that we can best support your preclinincal in-vivo research.

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In vivo Toxicity Testing
Price on request

Hera is equipped to dose rats through various routes (IP, IV, Subcutaneous injections and oral gavage). Hepatotoxicity assays include weight and body condition scoring, serum chemistry analysis, histology and gene expression analysis by real time PCR.

Hera is equipped to dose rats through various routes (IP, IV, Subcutaneous injections and oral gavage). Hepatotoxicity assays include weight and body condition scoring, serum chemistry analysis, histology and gene expression analysis by real time PCR.

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Rat
heptotoxicity
Custom Cell-Based Assays
Price on request

Gene editing tools (i.e CRISPR) have vastly expanded the ability to develop custom assays in any system, whether it be a particular cell line or animal model. The custom assay process at Hera: 1- Choose your system: Disease models, Reporter cell lines, Humanized rodents, Cancer xenografts. 2-Precision gene editing - Knockout,... Show more »

Gene editing tools (i.e CRISPR) have vastly expanded the ability to develop custom assays in any system, whether it be a particular cell line or animal model. The custom assay process at Hera: 1- Choose your system: Disease models, Reporter cell lines, Humanized rodents, Cancer xenografts. 2-Precision gene editing - Knockout, Knock-in, stable transgene. 3- We (or you) run your assay - hepatotoxicity, neurotoxicity, drug transport & DDI

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Human
Mouse
Rat
neuronal cell lines
stem cells
CRISPR
hepatocytes
In vitro Neural Models
Price on request

hNP1™ Human Neural Progenitor Expansion Kit $875

hNP1™ Human Neural Progenitor Cells express high levels of the proneural markers, and are amendable to high throughput scale up. hNP™ cells can be differentiated into various neuronal subtypes, including dopaminergic, cholinergic, glutamatergic, GABA-ergic, serotonergic and... Show more »

hNP1™ Human Neural Progenitor Expansion Kit $875

hNP1™ Human Neural Progenitor Cells express high levels of the proneural markers, and are amendable to high throughput scale up. hNP™ cells can be differentiated into various neuronal subtypes, including dopaminergic, cholinergic, glutamatergic, GABA-ergic, serotonergic and astrocytic lineages.

The hNP1™ Human Neural Progenitor Expansion Kit contains human neural progenitor cells and optimized AB2™ Neural Medium plus ANS™ Neural Supplement for the propagation and expansion of the cells.

hN2™ Human Neural Discovery Kit $598.50

This kit is ideal for pilot experiments and assay optimization. The kit contains the differentiated neural cells and optimized medium plus neural supplement for maintaining the cells in culture. After differentiation, the cells exhibit a characteristic neuronal morphology and are highly post-mitotic. These differentiated neural cells are cryopreserved for ready, convenient use, therefore eliminating lengthy differentiation procedures by the end user.

hN2™ Human Neural Screening Kit $1,195.00

hN2™ cells can be cultured in an adherent 96-well format with unique culture medium and neural supplement and can be maintained in culture for >2 weeks during which time we have shown them to demonstrate extensive neurite outgrowth and synapse formation. The hN2™ Screening Kit contains the differentiated neuronal cells and optimized medium plus supplement for thawing and maintaining the cells in culture and is an excellent choice for high-throughput (96- and 384-well) formatted assays.

hAstroPro Human Astrocytes Kit $775.00

Ideal for use in studies of glial development and for use in co-culture systems.
-Genetically uniform supply of human astrocyte cells
-Uniform adherent astrocyte morphology
-Express a repertoire of astrocytic genes
-Non-transformed
-Serum free

Co-Culture Kit hAstroPro-NeuroNet $1,217.00

This Kit is an ideal in vitro system that provides a more complete and robust means to address neurotoxicity and developmental neurotoxicity. This system models the later stages of neurons combined with astrocytes and is tunable and customizable to your application layouts.

NeuroNet Pure Human Neurons Discovery Kit $460.00

A highly pure population of hPSC derived neurons developed with versatility in mind. As a standalone model for studies of cellular and molecular neurobiology, drug discovery and neurotoxicity, NeuroNet™ Human Neurons enable rapid response in a relevant in vitro culture model system and have been strategically designed for co-planer cellular model studies with hAstroPro Human Astrocytes.

NeuroNet Pure Human Neurons Screening Kit $1,265.00

A highly pure population of hPSC derived neurons developed with versatility in mind. NeuroNet™ Screening Kit is the ideal neural cell choice for use in adherent 96-well format assays. NeuroNet cells have demonstrated extensive neurite outgrowth and synapse formation.

Mouse Motor Neurons GFP+ HTScreening Kit $272.60

Ideal for use in High-throughput fluorescent screening applications. Derived from transgenic mice expressing eGFP and using Hb9 motorneuron promoter enables easy tracking and visualization of spinal motor neurons without the need for additional fluorescent markers and extended cultures.

Mouse Motor Neurons - GFP+ HBG3Hb9 Quick Start Kit $378.20

Ideal for use in High-throughput fluorescent screening applications. Derived from transgenic mice expressing eGFP using Hb9 motorneuron promoter enables easy tracking and visualization of spinal motor neurons without the need for additional fluorescent markers and extended cultures.

AB2™ ArunA Neural Cell Culture Media Kit $198.00

The AB2™ Neural Cell Culture Media Kit contains AB2™ Basal Neural Medium and ANS™ Neural Medium Supplement. The medium and supplement are specifically engineered for versatility to meet all your neural cell culture needs.

AB2™ Basal Neural Medium $57.60

The AB2™ Basal Neural Medium and ANS™ Neural Medium Supplement are specifically engineered for neural cell culture versatility.

ANS™ Neural Medium Supplement $150.00

The AB2™ Basal Neural Medium and ANS™ Neural Medium Supplement are specifically engineered for neural cell culture versatility. The medium can also be used as the base media for differentiation of the neural progenitors toward multiple neural phenotypes.

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neurology
neuronal cell lines
stem cells
CRISPR
neurotoxicity
assay development
gene editing
SH-SY5Y
LUHMES
Animal Models and Studies
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Cell-Based Assays
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Oncology Animal Models
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Animal Models of Disease
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Biology
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Cells and Tissues
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Toxicology
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Rat Models
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Animal Housing and Maintenance
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Rodent Models
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Model Organisms
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In vitro Disease Models
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Immunology Animal Models
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Pharmacology & Toxicology
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Xenograft Models
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Specialized Cell-Based Assays
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Mammalian Models
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2017-10-26 14:50:34 -0400

Net Promoter Score of 10 received for Human Tumor Xenograft Models.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.

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