Every pharmaceutical company is in need of a reliable, efficient research services company. At Helix BioStructures, we provide just that. With an unmatched talent in structure-based drug discovery, Helix BioStructures is the Industry’s partner in delivering fast and efficient characterization services. We seek to drive the pharmaceutical industry to new destinations. Stop by our storefront and see why over 30 companies around the world use Helix Biostructures for drug discovery research services!
FULL-Service Synchrotron X-ray Data Collection.
Helix BioStructures purchases the beam time at Synchrotrons for X-ray Data Collection needs of the BioPharmaceutical Industry. With our extensive experience, we have utilized and are capable of offering Data Collection service at a variety of Synchrotrons across the world including but not limited to: APS, APS, CLS, DLS, ESRF, and ALBA. We know the staff, we know the system, we will carry out X-ray data collection efficiently.
Cost of Service includes: 1. Helix BioStructures takes care of all agreements and booking with beamline/synchrotoron 2. Helix BioStructures pays all beamline and synchrotron fees including proprietary fees 3. Helix BioStructures helps customer with shipping logistics to and from synchrotron 4. Helix BioStructures performs screening each sample at 0,90,180 degree rotations 5. Helix BioStructures Documents diffraction details online for customer to see live 6. Helix BioStructures performs collection of 200+ degree data sets for all samples that meet desired resolution and optimal collection criteria 7. Helix BioStructures reduces data with processing software (XDS, DIALS, XIA2) 8. All data, processed and raw images, are uploaded to secure server for customer to download
If you are interested in this type of Data Collection Service, please do not hesitate to contact us! We would be happy to have a discussion on the details of this FULL-Service option.
FULL-Service: Protein Crystallization to Structure Solution / Analysis
Helix BioStructures is capable of supplementing your Company's Structural Biology efforts to meet your overall goals. We have the experience and capabilities to take projects at any stage of protein crystallography to the final determined structure product.
For new targets of interest, we have resources to perform robotic high-throughput protein crystallography where the number of conditions screened is maximized with minimal sample usage. Crystallization experiments are monitored, imaged, and documented to elucidate best conditions leading to crystal formation. The same efforts can be utilized for targets with known crystallization conditions. We are adept in recapitulating protein crystallography methods for crystallization projects ranging from single protein, compound soaking or co-crystallization, or protein:DNA, protein:protein, protein:antibody complexes.
The service includes crystallization condition optimization in order to obtain crystal forms that are most favorable for crystal manipulation, harvesting, data collection, and subsequent structure determination.
The final completion of the project includes analysis of determined structure. This includes graphical as well as documented reporting to highlight the most pertinent interactive feature of your structure of interest.
If you are interested in this FULL-Service, please do not hesitate to contact us for discussion on the details. If you are interested in any portion/block of this FULL-Service capability, please look into the details for the separate services of:
Price for this FULL-Serive is per Refined Structure
Automated High-Throughput Protein Crsytallography
Protein crystallization in your structural biology project can be the bottleneck hindering advancement of your research agenda. Helix BioStructures can aid in your crystallization efforts with resources for robotic high-throughput protein crystallography. Drop setting robots help minimize the need for sample volume to maximize screening of a vast matrix of crystallization conditions. Experiments are routinely monitored, imaged, and documentation can be accessed/viewed remotely. From initial crystal formation, conditions can be customized to find the optimal crystallization condition leading to the formation of most favorable crystal for harvesting.
If interested, please Contact Us for details and discussion on protein crystallization project options.
Price is for Full Matrix Screen and Crystallization Condition Optimization leading to Optimal Crystal Form
Proficient and Efficient Structure Determination
At Helix BioStructures, we are adept in determining a structure solution for collected datasets from protein crystals in an efficient manner. Couple the services of data collection with dataset structure solution for process efficiency. For each collected dataset, we are able to carry the experiment to a fully refined structure with only minimal information, including target amino acid sequence, homolog search model, and any pertinent information of your target of interest.
If you are interested in this cost-effective and efficient service, please Contact Us!
Detailed Analysis of Determined Structural Model
Computational analysis of structural models is important in progressing efforts in structure based drug design. The efficiency of analysis contributes to results leading to optimal compound design. Let Helix BioStructures supplement your efforts by utilizing our experience in computational analysis on your Structure Model to expedite the process and streamline your Company's goals toward optimal compound/drug design.
We will provide detailed documentation supplemented with descriptive figures/images to provide clarity in our in-depth analysis.
If you are interested, please don't hesitate to Contact Us about details.
Helix BioStructures understands that supplementary characterization data can greatly contribute to the overall structural biology project for structure-based drug design. We have the resources to provide a variety of biophysical/biochemical techniques toward research endeavors into the structures, stabilities, and interactions of biomolecules.
Some instrumentation and their applications include:
Other techniques and instrumentation include: the KinTek SF-300X Stopped Flow spectrometer, the Wyatt HELOS-II multi-angle light scattering (MALS) instrument and OptiLab rEX reactive index detector, the Applied Biosystems StepOne Plus RT-PCR, and the Nanotemper Monolith NT.115 microscale thermophoresis (MST) instrument.
If you are interested, please Contact Us for details about the techniques available and how it can be utilized in your research program.
"We contracted Helix to complete protein expression and purification of an extremely difficult target for eventual crystallization. Helix worked as a partner throughout the entire process, from construct design to purification troubleshooting. They even went above and beyond by tracking down the authors to literature papers to get more details on the protein of interest. Their communication was excellent, including quick response time, amenability to suggestions for protocol changes, and nicely written experimental reports."
Helix BioStructures LLC has not received any endorsements.