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HealthCore, Inc.

Wilmington, Delaware, US

HealthCore provides a proprietary integrated research environment and deep understanding of the complexities of big data, HealthCore produces competitive evidence-based research advantage, through our multi-disciplinary research teams expert in conducting health outcomes, epidemiology & safety, and health services research.

Recent Publications

  • Quinlan SC, Lanes S, Holick CN, Mast TC. Accuracy of administrative claims data to identify dose specific rotavirus vaccination information: Implications for studies of vaccine safety. Vaccine. 2015 May 21;33(22):2517-20. doi: 10.1016/j.vaccine.2015.04.009. Epub 2015 Apr 14.
  • Lanes S, Quinlan SC, Mast TC, Greenland S, Holick CN. Assessing bias in administrative database studies of RotaTeq vaccine completion due to exclusion of subjects with incomplete follow-up. Emerg Themes Epidemiol. 2015 Apr 18;12:5. doi: 10.1186/s12982-015-0027-6. eCollection 2015.
    -... Show more »

HealthCore provides a proprietary integrated research environment and deep understanding of the complexities of big data, HealthCore produces competitive evidence-based research advantage, through our multi-disciplinary research teams expert in conducting health outcomes, epidemiology & safety, and health services research.

Recent Publications

  • Quinlan SC, Lanes S, Holick CN, Mast TC. Accuracy of administrative claims data to identify dose specific rotavirus vaccination information: Implications for studies of vaccine safety. Vaccine. 2015 May 21;33(22):2517-20. doi: 10.1016/j.vaccine.2015.04.009. Epub 2015 Apr 14.
  • Lanes S, Quinlan SC, Mast TC, Greenland S, Holick CN. Assessing bias in administrative database studies of RotaTeq vaccine completion due to exclusion of subjects with incomplete follow-up. Emerg Themes Epidemiol. 2015 Apr 18;12:5. doi: 10.1186/s12982-015-0027-6. eCollection 2015.
  • Placzek HE, Masters ET, Gu T, Cappelleri JC, Wasser TE, Clair AG, Cook JP, Eisenberg DF. Prior authorization in the treatment of patients with pDPN and FM. Pain Pract. 2015 Jan;15(1):E9-19. doi: 10.1111/papr.12258. Epub 2014 Nov 11.
  • Yih WK, Lieu TA, Kulldorff M, Martin D, McMahill-Walraven CN, Platt R, Selvam N, Selvan M, Lee GM, Nguyen M. Intussusception risk after rotavirus vaccination in U.S. infants. N Engl J Med. 2014 Feb 6;370(6):503-12. doi: 10.1056/NEJMoa1303164. Epub 2014 Jan 14.
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HealthCore, Inc. has not listed any services.

Health Economic Modeling
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Safety Pharmacology
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Data-driven approach

HealthCore’s safety and epidemiology efforts are aimed at the discovery of crucial evidence on the utilization, safety, and effectiveness of biopharmaceuticals and biomedical devices in large, real-world patient populations. Our research is powered by large automated repositories — linked medical,... Show more »

Data-driven approach

HealthCore’s safety and epidemiology efforts are aimed at the discovery of crucial evidence on the utilization, safety, and effectiveness of biopharmaceuticals and biomedical devices in large, real-world patient populations. Our research is powered by large automated repositories — linked medical, pharmacy, and laboratory results derived from administrative claims. The HealthCore Integrated Research EnvironmentSM constitutes a rare and valuable resource for conducting medical product safety and risk management studies because it gives our researchers and partners the ability to augment automated claims with clinical data from medical records, electronic health records, registries, and surveys with physicians and patients.

Talented team

Our multi-disciplinary team of pharmacoepidemiologists brings a broad range of scientific expertise and operational experience to the timely and accurate execution of safety and risk management studies in the real world setting. We have extensive experience in the design, analysis, and interpretation of research to support epidemiology, safety, and risk management activities. In collaboration with our pharmaceutical partners, as well as the FDA and international regulatory authorities, we have designed and conducted safety investigations of marketed medications. Our team has also implemented active surveillance studies and patient surveys to assess Risk Evaluation and Mitigation Strategies (REMS ).

Cutting-edge methods

With the use of rigorous study methodologies and analytical techniques, we have successfully designed and executed multiple safety surveillance studies using medical records, patient and physician surveys, automated database analyses, and electronic database linkage studies for corporate sponsors and regulatory authorities. Our researchers have led Post-Authorization Safety Studies (PASS) to ascertain utilization, safety, tolerability, and the overall safety profile of marketed biopharmaceuticals. These studies entail the careful use of observational techniques to identify, measure, and compare rates of adverse events in real-world patient cohorts across different therapeutic areas to provide early safety information on newly marketed products. In addition, we develop epidemiologic methods to advance the rapidly growing field of automated database research, such as strategies to develop and validate claims-based algorithms for outcome identification and statistical strategies such as propensity scores to achieve comparability of treatment groups and multiple imputation to mitigate the problem of missing data inherent in the use of secondary data sources.

  • Design, coordinate and conduct safety database studies in one or many automated databases
  • Understand prescribing patterns, utilization of available therapies, adherence, physician and patient preferences
  • Incidence and prevalence of adverse events
  • Medical chart abstraction
  • PASS/REMS studies
  • Prospective site-based studies using registries
  • Systematic literature reviews
  • Targeted literature reviews and rapid reviews
  • Validation studies to assess how to use claims data to accurately identify adverse events
  • Strategic consulting

-Assess protocol feasibility and inform study design
-Determine and confirm sample size
-Identify targeted physicians and patients to help ensure rapid study start up
-Improve the efficiency of recruitment, execution and site management for studies

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Real-World Evidence (RWE) Studies
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Health Economics and Outcomes Research (HEOR)
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  • Benefit design and intervention impact assessment
  • Burden of illness analysis
  • Compliance, persistence and adherence studies
  • Disease prevalence and incidence analysis
  • Longitudinal medical event database analysis (e.g., cost of care, natural disease history)
  • Medical chart abstraction
  • Pharmoeconomic modeling
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  • Benefit design and intervention impact assessment
  • Burden of illness analysis
  • Compliance, persistence and adherence studies
  • Disease prevalence and incidence analysis
  • Longitudinal medical event database analysis (e.g., cost of care, natural disease history)
  • Medical chart abstraction
  • Pharmoeconomic modeling
  • Survey Research (patient and physician reported)
  • Systematic literature reviews
  • Targeted literature reviews and rapid reviews
  • Strategic consulting

-Assess protocol feasibility and inform study design
-Determine and confirm sample size
-Identify targeted physicians and patients to help ensure rapid study start up
-Improve the efficiency of recruitment, execution and site management for studies
-Pragmatic trials

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Pharmaceutical Product Testing
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Medical Device Testing
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Clinical Research
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Epidemiology, HEOR, and Post-Authorization Studies
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Product Development, Testing, and Packaging
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Pharmacology & Toxicology
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Medical Devices & Diagnostics
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